NCTR Centers of Excellence > Bioinformatics

Bioinformatics

The Center for Bioinformatics conducts research in bioinformatics and chemoinformatics, and develops and coordinates informatics capabilities within NCTR, across FDA Centers, and in the larger toxicology community. The goal of the toxicoinformatics group is to develop methods for the analysis and integration of omics (genomic, transcriptomic, proteomic, and metabolomic) databases with the objective of knowledge discovery and the elucidation of mechanisms of toxicity.

Some of NCTR's toxicoinformatics projects and tools include:

* ArrayTrack
DNA microarray data management, mining, analysis, and interpretation software
ArrayTrack™

* Decision Forest
A novel pattern recognition method for analysis of data from microarray experiments, proteomics research, and predictive toxicology
Decision Forest

* Endocrine Disruptor Knowledge Base (EDKB)
Scientific resources to predict estrogen and androgen activity
Endocrine Disruptor Knowledge Base

* Gene Ontology for Functional Analysis (GOFFA)
ArrayTrack™ tool to identify terms in Gene Ontology associated with a list of genes
Bioinformatics Tools > Gene Ontology for Functional Analysis (GOFFA)

* Liver Toxicity Knowledge Base (LTKB)
Project to study drug-induced liver injury
Liver Toxicity Knowledge Base (LTKB)

* MicroArray Quality Control (MAQC) Project
Development of microarray quality control metrics and thresholds
MicroArray Quality Control (MAQC)

* Mold2
Generate molecular descriptors from two-dimensional structures
Mold2

* SNPTrack
An integrated solution for the management, analysis, and interpretation of genetic association study data
SNPTrack

Contact Information

For more information, please contact Dr. Weida Tong at 870-543-7142 or weida.tong@fda.hhs.gov.
NCTR Centers of Excellence > Bioinformatics