AHRQ WebM&M: Morbidity and Mortality Rounds on the Web

AHRQ WebM&M: Morbidity and Mortality Rounds on the Web

CYP450 Drugs: Expect the Unexpected

Scheduled for a hip replacement, a man with AIDS presented with sciatica. The spine surgeon administered a corticosteroid injection to control his symptoms. Soon after the patient experienced sweats, abdominal pain, weight gain, elevated blood pressure, insomnia, and anxiety. He was diagnosed with Cushing syndrome due to an adverse interaction between the HIV medication and the corticosteroid.
Commentary by Charles John Gonzalez, MD