Precision Medicine
Precision Medicine In Action - August 28, 2015
CDC Info
- Precision medicine, implementation science and public health: How do we scale up from 1 million to 300 million?By Muin J. Khoury, Blog Post, August 201
- A Public Health Perspective on a National Precision Medicine Cohort
Khoury MJ and Evans JP, JAMA. 2015;313(21):2117-2118.
- Precision Medicine and Public Health: Improving Health Now While Generating New Knowledge for the Future
- When a country cannot be a cohort: Challenges of implementing a large precision medicine cohort study in the United States
- Precision public health and precision medicine: two peas in a pod
- The success of precision medicine requires a public health perspective
- A population perspective on personalized medicine
- Population sciences, translational research, and the opportunities and challenges for genomics to reduce the burden of cancer in the 21st century
- Medicine. Big data meets public health
- The public health role in translating advances in genomics
- CDC Advanced Molecular Detection infectious disease initiative
The possibility—and pitfalls—of precision medicine, A O'Connor, St Louis Public Radio, Aug 25
A O'Connor, St Louis Public Radio, Aug 25Precision medicine, implementation science and public health: How do we scale up from 1 million to 300 million? By Muin J. Khoury, Blog Post, August 2015
Precision medicine: Beyond the inflection point
Hawgood S, et al. Science Translational Medicine 12 Aug 2015
Hawgood S, et al. Science Translational Medicine 12 Aug 2015
Public health in the precision-medicine era
Bayer R et al, NEJM, August 6, 2015
Bayer R et al, NEJM, August 6, 2015
Advancing precision medicine by enabling a collaborative informatics community, by Taha A. Kass-Hout et al, FDA Voice, August, 2015
by Taha A. Kass-Hout et al, FDA Voice, August, 2015Worth the money? Paying To ensure a representative cohort in the Precision Medicine Initiative, by C Plunkett et al, Health Affairs Blog, July 30, 2015
by C Plunkett et al, Health Affairs Blog, July 30, 2015Trans-Omics for Precision Medicine (TOPMed) Program, National, Heart, Lung and Blood Institute
National, Heart, Lung and Blood InstituteFrom evolution to revolution: Building the 21st century genomic infrastructure, Center for Data Innovation, July 23, 2015
Center for Data Innovation, July 23, 2015NIH videos: Faces of the Precision Medicine Initiative
US tailored-medicine project aims for ethnic balance. Massive study seeks to succeed where others failed, but faces tight deadline and questions about strategy, by Sara Reardon, Nature News, July 21, 2015
by Sara Reardon, Nature News, July 21, 2015Six months of progress on the Precision Medicine Initiative, by Brian Deese et al, White House Blog, Jul 8
by Brian Deese et al, White House Blog, Jul 8Ten things we have to do to achieve precision medicine
Kohane I, Science, July 3, 2015
Kohane I, Science, July 3, 2015
Planning for US Precision Medicine Initiative underway
Jaffe S, The Lancet, June 20, 2015
Jaffe S, The Lancet, June 20, 2015
Seven questions for personalized medicine
Joyner M et al. JAMA, June 22, 2015
Joyner M et al. JAMA, June 22, 2015
A Public Health Perspective on a National Precision Medicine Cohort
Khoury MJ and Evans JP, JAMA. 2015;313(21):2117-2118.
Khoury MJ and Evans JP, JAMA. 2015;313(21):2117-2118.
Something interesting is happening, NIMH Director's Blog, June 9
NIMH Director's Blog, June 9Precision medicine - personalized, problematic, and promising
Jameson JL et al. NEJM May 27, 2015
Jameson JL et al. NEJM May 27, 2015
No more hidden solutions in bioinformatics
Precision medicine cannot advance without full disclosure of how commercial genome sequencing and interpretation software works, says Mauno Vihinen, Nature News, May 20, 2015
Precision medicine cannot advance without full disclosure of how commercial genome sequencing and interpretation software works, says Mauno Vihinen, Nature News, May 20, 2015
Precision medicine in action: Genomics can help to target treatments for patients with cancer, rare inherited conditions, and infectious diseases, Genomics Education Program, May 12, 2015
Genomics can help to target treatments for patients with cancer, rare inherited conditions, and infectious diseases, Genomics Education Program, May 12, 2015New developments in personalized medicine could save billions of dollars in improved health
Personalised medical interventions to prevent heart disease could generate $114 billion worth of health gains in United States- Eureka Alert, May 6
Personalised medical interventions to prevent heart disease could generate $114 billion worth of health gains in United States- Eureka Alert, May 6
Aligning incentives to fulfil the promise of personalised medicine
Dzau VJ et al. Lancet May 2015
Dzau VJ et al. Lancet May 2015
The Precision Medicine Initiative - a new national effort
Ashley EA, JAMA 2015 Apr 30
Ashley EA, JAMA 2015 Apr 30
NIH's Collins on changing the future of medicine, Medscape Interview with Dr Eric Topol, March 2015
Medscape Interview with Dr Eric Topol, March 2015Obama catapults patient-empowered precision medicine
Fox JL. Nature Biotechnology, April 2015
Fox JL. Nature Biotechnology, April 2015
Is precision medicine the route to a healthy world?
Coote J et al. Lancet, April 2015
Coote J et al. Lancet, April 2015
Personalized medicine: Time for one-person trials
Precision medicine requires a different type of clinical trial that focuses on individual, not average, responses to therapy, says Nicholas J. Schork. Nature News, April 29, 2015
Precision medicine requires a different type of clinical trial that focuses on individual, not average, responses to therapy, says Nicholas J. Schork. Nature News, April 29, 2015
Precision Medicine: Building a Cohort of 1 Million People - April 28, 2015
NIH Workshop: Unique scientific opportunities for the Precision Medicine Initiative National Research Cohort
April 28-29, 2015 ~ Bethesda, MD
April 28-29, 2015 ~ Bethesda, MD
NIH request for information seeks feedback to help guide the longitudinal cohort of 1 million or more Americans who have volunteered to participate in research
As part of the President's proposed Precision Medicine Initiative
As part of the President's proposed Precision Medicine Initiative
Precision Medicine Initiative: Building a large U.S. research cohort 
[PDF 508.60 KB]
NIH Workshop February 2015 Summary
[PDF 508.60 KB]NIH Workshop February 2015 Summary
CDC blog post: When a country cannot be a cohort: Challenges of implementing a large precision medicine cohort study in the United States
Workshop Presentation Slides: Building a Large U.S. Research Cohort
Precision Medicine Initiative
Precision Medicine Initiative
FDA outlines plan for expected $10M under President's Precision Medicine Plan, Genome Web, Feb 18 [by free subscription only]
Genome Web, Feb 18 [by free subscription only]The NCI Cancer Epidemiology Descriptive Cohort Database
Provides descriptive information on cohorts studying cancer as a primary outcome.
Provides descriptive information on cohorts studying cancer as a primary outcome.
More on Precision Medicine - March 18, 2015
Precision medicine: The future or simply politics?
Rubin R, JAMA, March 17, 2015
Rubin R, JAMA, March 17, 2015
Precision Medicine Initiative.
Porche DJ et al. Am J Mens Health 2015 Mar 10.
Porche DJ et al. Am J Mens Health 2015 Mar 10.
Obama 2016 budget calls for precision medicine.
Nat. Biotechnol. 2015 Mar 6. (3) 216
Nat. Biotechnol. 2015 Mar 6. (3) 216
Putting precision medicine on the national agenda.
Tempero M et al. J Natl Compr Canc Netw 2015 Mar (3) 251
Tempero M et al. J Natl Compr Canc Netw 2015 Mar (3) 251
Making personalized medicine more affordable.
Aronson N et al. Ann. N. Y. Acad. Sci. 2015 Feb 27.
Aronson N et al. Ann. N. Y. Acad. Sci. 2015 Feb 27.
Editorial: rethinking the definition of diabetes for precision medicine.
Ahima RS et al. Mol. Endocrinol. 2015 Mar (3) 335-7
Ahima RS et al. Mol. Endocrinol. 2015 Mar (3) 335-7
Application of molecular profiling in clinical trials for advanced metastatic cancers.
Kummar S et al. J. Natl. Cancer Inst. 2015 Apr (4)
Kummar S et al. J. Natl. Cancer Inst. 2015 Apr (4)
Precision Public Health and Precision Medicine: An Evolving Relationship - March 2, 2015
New CDC blog post: Precision public health and precision medicine: two peas in a pod
CDC Advanced Molecular Detection infectious disease initiative
Will improve the ability of public health to detect outbreaks sooner and respond more effectively, saving lives and reducing cost
Will improve the ability of public health to detect outbreaks sooner and respond more effectively, saving lives and reducing cost
We screen newborns, don't we?: realizing the promise of public health genomics.
Evans James P et al. Genet. Med. 2013 May (5) 332-4
Evans James P et al. Genet. Med. 2013 May (5) 332-4
Precision medicine: Not just "genes, drugs, and disease", by William Riley, OBSSR, February 2, 2015
by William Riley, OBSSR, February 2, 2015Medicine. Big data meets public health.
Khoury Muin J et al. Science 2014 Nov 28. (6213) 1054-5
Khoury Muin J et al. Science 2014 Nov 28. (6213) 1054-5
CDC National Biomonitoring Program
Assesses nutritional status and the exposure of the U.S. population to environmental chemicals and toxic substances
Assesses nutritional status and the exposure of the U.S. population to environmental chemicals and toxic substances
Precision Medicine: Insights on Benefits, Harms & Costs - February 9, 2015
Genomics, the data revolution, and health economics - the 2015 Astellas Innovation Debate, BMJ Blog Post, James Buchanan, February 2, 2015
BMJ Blog Post, James Buchanan, February 2, 2015Precision medicine is already working to cure Americans: These are their stories, by Lindsay Holst, White House Blog Post, Jan 30
by Lindsay Holst, White House Blog Post, Jan 30The high price of precision healthcare, Joseph Guinto, Genome Magazine, January 2015
Joseph Guinto, Genome Magazine, January 2015Big precision medicine plan raises patient privacy concerns, Scientific American, Feb 3
Scientific American, Feb 3The problem with precision medicine, by Cynthia Graber , New Yorker, Feb 5
by Cynthia Graber , New Yorker, Feb 5Moving precision medicine beyond the hype, Genome Web, Feb 6 [by free subscription only]
Genome Web, Feb 6 [by free subscription only]Precision medicine: Friend or foe? By David May, ACC in Touch Blog, Feb 6
By David May, ACC in Touch Blog, Feb 6Medicine just for you, by the Editorial Board, New York Times, Feb 7
by the Editorial Board, New York Times, Feb 7More on Precision Medicine: Building a Cohort Consortium - February 2, 2015
Precision medicine initiative and cancer research, by Harold Varmus, NCI, Jan 30
by Harold Varmus, NCI, Jan 30The NCI Cohort Consortium
New models for large prospective studies: is there a better way?
Manolio TA, et al. Am J Epidemiol. 2012
New models for large prospective studies: is there a better way?
Manolio TA, et al. Am J Epidemiol. 2012
Precision medicine may never be very precise - but it may be good for public health, by Jeff Leek, SImPLYSTATS, Jan 30
by Jeff Leek, SImPLYSTATS, Jan 30Precision Medicine: Public Health Perspectives - January 30, 2015
Fact sheet: President Obama’s Precision Medicine Initiative, the White House, Jan 30
Jan 30President Obama versus the naysayers: A big week for "precision" medicine, by Mark Wanner, Jackson Laboratory, Jan 30
by Mark Wanner, Jackson Laboratory, Jan 30A new initiative on precision medicine
Francis S. Collins and Harold Varmus, New England Journal of Medicine January 30, 2015
Francis S. Collins and Harold Varmus, New England Journal of Medicine January 30, 2015
The Precision Medicine Initiative: Data-driven treatments as unique as your own body, Linsay Holtz, the White House, Jan 30
Linsay Holtz, the White House, Jan 30NIH information: the Precision Medicine Initiative
New CDC blog post: The success of precision medicine requires a public health perspective
CDC paper: A population approach to precision medicine.
Khoury MJ, et al. Am J Prev Med.
Khoury MJ, et al. Am J Prev Med.
CDC paper: The public health role in translating advances in genomics.
Khoury MJ, Bowen S. Clinical Omics, August 13, 2014
Khoury MJ, Bowen S. Clinical Omics, August 13, 2014
Precision medicine: Improving health and treating disease, by Jo Handelsman, Associate Director for Science at the White House Office of Science and Technology, HHS Blog, Jan 22
by Jo Handelsman, Associate Director for Science at the White House Office of Science and Technology, HHS Blog, Jan 22US President launches ‘precision medicine’ initiative, The Pharmaceutical Journal, Jan 23
The Pharmaceutical Journal, Jan 23Obama to request research funding for treatments tailored to patients’ DNA, New York Times, Jan 24
New York Times, Jan 24Obama precision medicine plan would create huge U.S. genetic biobank, by Jocelyn Kaiser, Science Magazine, Jan 29
by Jocelyn Kaiser, Science Magazine, Jan 29Precision Medicine: Cancer and Genomics - January 21, 2015
What is “precision medicine? Information from the National Cancer Institute
Information from the National Cancer InstituteImpact of cancer genomics on precision medicine for the treatment of cancer, from the Cancer Genome Atlas, NCI
from the Cancer Genome Atlas, NCIUS precision-medicine proposal sparks questions, by Sara Reardon, Nature News, Jan 22
by Sara Reardon, Nature News, Jan 22Obama's 'precision medicine' means gene mapping, NBC News, Jan 21
NBC News, Jan 21What is President Obama's 'precision medicine' plan, and how might it help you? By Lenny Bernstein, Jan 21
By Lenny Bernstein, Jan 21Obama proposes new Precision Medicine Initiative for genetic treatments, by Russell Brandom, The Verge, Jan 20
by Russell Brandom, The Verge, Jan 20U.S. developing large-scale genomics project, Biocentury, Jan 16
Biocentury, Jan 16Recent reviews
Companion diagnostics: the key to personalized medicine.
Jørgensen JT. Expert Rev Mol Diagn. 2015 Feb;15(2):153-6
Jørgensen JT. Expert Rev Mol Diagn. 2015 Feb;15(2):153-6
Promoting precision cancer medicine through a community-driven knowledgebase.
Geifman N, et al. J Pers Med. 2014 Dec 15;4(4):475-88.
Geifman N, et al. J Pers Med. 2014 Dec 15;4(4):475-88.
Toward a prostate cancer precision medicine.
Rubin MA. Urol Oncol. 2014 Nov 20.
Rubin MA. Urol Oncol. 2014 Nov 20.
Prioritizing targets for precision cancer medicine.
Andre F, et al. Ann Oncol. 2014 Dec;25(12):2295-303
Andre F, et al. Ann Oncol. 2014 Dec;25(12):2295-303
Toward precision medicine with next-generation EGFR inhibitors in non-small-cell lung cancer.
Yap TA, Popat S. Pharmgenomics Pers Med. 2014 Sep 19;7:285-95.
Yap TA, Popat S. Pharmgenomics Pers Med. 2014 Sep 19;7:285-95.
Genomically driven precision medicine to improve outcomes in anaplastic thyroid cancer.
Pinto N, et al. J Oncol. 2014;936285
Pinto N, et al. J Oncol. 2014;936285
Translating genomics for precision cancer medicine.
Roychowdhury S, Chinnaiyan AM. Annu Rev Genomics Hum Genet. 2014;15:395-415
Roychowdhury S, Chinnaiyan AM. Annu Rev Genomics Hum Genet. 2014;15:395-415
Cancer Precision Medicine: Where Are We? - September 18, 2014
National Cancer Institute's Precision Medicine Initiatives for the New National Clinical Trials Network.Jeffrey Abrams et al. ASCO Annual Meeting 2014
Jeffrey Abrams et al. ASCO Annual Meeting 2014 Personalized medicine: Special treatment.
Michael Eisenstein. Nature, September 11, 2014
Michael Eisenstein. Nature, September 11, 2014
Why the controversy? Start sequencing tumor genes at diagnosis. Tumor sequencing at the time of diagnosis can give significant insight for successful cancer treatment, by Shelly Gunn, Genetic Engineering & Biotechnology News, Sep 10
by Shelly Gunn, Genetic Engineering & Biotechnology News, Sep 10 National Cancer Institute information: Precision medicine and targeted therapy
Genomics and precision oncology: What's a targeted therapy for cancer? An updated list of approved drugs from the National Cancer Institute (2014)
An updated list of approved drugs from the National Cancer Institute (2014)Therapy: This time it's personal
Gravitz L Nature 509, S52-S54 2014 May 29
Gravitz L Nature 509, S52-S54 2014 May 29
Multi-marker solid tumor panels using next-generation sequencing to direct molecularly targeted therapies
Michael Marrone, et al. PLoS Currents Evidence on Genomic Tests 2014 May 27
Michael Marrone, et al. PLoS Currents Evidence on Genomic Tests 2014 May 27
Impact of cancer genomics on precision medicine for the treatment of cancer, from the National Cancer Institute
from the National Cancer InstituteCancer genomics and precision medicine in the 21st century [PDF 2.20 MB], power point presentation from the National Human Genome Research Institute
[PDF 2.20 MB], power point presentation from the National Human Genome Research InstitutePersonalized Medicine: Opportunities & Challenges - July 2, 2014
The Case for Personalized Medicine - 4th Edition,Personalized Medicine Coalition 2014
Personalized Medicine Coalition 2014Food and Drug Administration Report: Paving the way for personalized medicine [PDF 854.45 KB] (2013)
[PDF 854.45 KB] (2013)Policy and health profession must adapt to personalised medicine, PHG Foundation, June 26, 2014
PHG Foundation, June 26, 2014Reading between the lines; understanding drug response in the post genomic era.
Alifrangis CC1, McDermott U. Mol Oncol. 2014 Jun 10. pii: S1574-7891
Alifrangis CC1, McDermott U. Mol Oncol. 2014 Jun 10. pii: S1574-7891
How does genome sequencing impact surgery?
Marlies S. Reimers et al. Nature Reviews Clinical Oncology 2014 Jun 24
Marlies S. Reimers et al. Nature Reviews Clinical Oncology 2014 Jun 24
Lung-MAP launches: first precision medicine trial from National Clinical Trials Network, by the ASCO Post, Jun 25
by the ASCO Post, Jun 25
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