martes, 27 de febrero de 2018

HEPATITIS E - JAPAN: TRANSFUSION, FATAL

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Published Date: 2018-02-27 05:20:57
Subject: PRO/AH/EDR> Hepatitis E - Japan: transfusion, fatal
Archive Number: 20180227.5653008
HEPATITIS E - JAPAN: TRANSFUSION, FATAL
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Date: 1 Feb 2018
Source: Japan Times [edited]
https://www.japantimes.co.jp/news/2018/02/01/national/world-first-womans-death-linked-hepatitis-e-infection-blood-transfusion-japanese-facility/


A woman in her 80s died in November 2017 after being infected with the hepatitis E virus [HEV] through a blood transfusion at a Japanese facility in what is believed to be the world's 1st fatal case of this type, according to a report by the Japanese Red Cross Society. The organization reported to a government panel on Wed 31 Jan 2018 that the person who donated the blood may have been infected with the virus after eating raw deer meat. The same type of virus was found in the donor's blood and the woman who died. No one else received the infected blood.

The hepatitis E virus can be found in deer and wild boar meat. Pregnant women and elderly people may suffer severe symptoms from the virus [although the genotypes associated with severe infection in pregnancy are not those that are zoonotic. - Mod.LL].

The elderly woman, who was receiving treatment for multiple myeloma, received the blood transfusion in July 2017. Her liver functions deteriorated in October 2017, and she stopped receiving anti-cancer agents. Her condition then improved temporarily, and her cancer treatment resumed before she worsened again prior to her death.

The woman already had weakened liver functions caused by cancer treatment, leading her to develop fulminant hepatitis after being infected, the organization said.

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[There are currently 7 genotypes of HEV, and genotypes 1 and 2 are not zoonotic and cause most of the HEV infections in Africa and Asia. It is these genotypes that cause increased morbidity and mortality in pregnant women. Most of the zoonotic hepatitis E cases have been recognized in the developed world, are associated with foodborne disease (usually undercooked pork products), and are caused by genotype 3. In addition, infection with genotype 3 when occurring in immunocompromised hosts (especially solid organ transplant recipients) can cause chronic infection which can progress to cirrhosis. Ribavirin has been used to treat such individuals with chronic infection. - Mod.LL

HealthMap/ProMED-mail map of Japan: http://healthmap.org/promed/p/156.]

See Also

2017
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Hepatitis E - UK (03): gt 3, European sausage 20170821.5264392
Hepatitis E - Europe (02): 2005-2015 20170629.5140079
Hepatitis E - UK (02): EU pork products, commentary 20170523.5057366
Hepatitis E - UK: EU pork products 20170522.5055004
Hepatitis E - France (03): rabbit source 20170517.5042542
Hepatitis E - Australia: 1st postransfusion case, zoonotic 20170426.4996999
Hepatitis E - Europe: blood donation screening 20170423.4983952
Hepatitis E - France (02): comment 20170116.4769936
Hepatitis E - France: platelet transfusion-related 20170115.4763642
2016
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Hepatitis E - Germany: gt 3, asymptomatic, 2011 20160904.4461204
Hepatitis E - Europe: zoonotic 20160828.4445881
2015
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Hepatitis E - Japan: 1st chronic cases 20151027.3747156
Hepatitis E - France: 2013, raw pork stuffing 20151021.3733016
Hepatitis E - UK: undercooked imported pork sausage, 2014 20150908.3631747
Hepatitis E, pet rabbit - Italy 20150517.3367922
Hepatitis E - Spain: HIV infected individuals 20150314.3230174
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