miércoles, 30 de enero de 2019

How realistic is an ‘off-the-shelf’ CAR-T drug? - STAT

How realistic is an ‘off-the-shelf’ CAR-T drug? - STAT

The Readout

Damian Garde

The state of ready-made CAR-T


With CAR-T therapies costing hundreds of thousands of dollars and taking weeks of painstaking labor to custom-make for each patient, some companies and scientists are forging ahead on a different path: developing mass-produced, off-the-shelf CAR-T cells that could be used with any patient.

There's a long road ahead — only three early-stage clinical trials are underway — but scientists say these therapies, if successful, could have some significant advantages.

But first, researchers will have to overcome a fundamental feature of the human immune system, STAT's Ike Swetlitz reports.

Read more.

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