Call for Improved Design and Reporting in Soft Tissue Sarcoma Studies: A Systematic Review and Meta-Analysis of Chemotherapy and Survival Outcomes in Resectable STS - PubMed

Call for Improved Design and Reporting in Soft Tissue Sarcoma Studies: A Systematic Review and Meta-Analysis of Chemotherapy and Survival Outcomes in Resectable STS - PubMed

Call for Improved Design and Reporting in Soft Tissue Sarcoma Studies: A Systematic Review and Meta-Analysis of Chemotherapy and Survival Outcomes in Resectable STS

Alexandra C Istl 1 2, Jessica M Ruck 3, Carol D Morris 4, Adam S Levin 4, Christian F Meyer 5, Fabian M Johnston 3 6

Affiliations 

• PMID: 30737793
 
• DOI: 10.1002/jso.25401

Abstract

New evidence and systemic therapies demand an updated analysis of chemotherapy for soft tissue sarcoma. We completed a meta-analysis of chemotherapy in localized STS, assessing OS, PFS, and local and distant recurrence (local recurrence-free survival [LRFS] and distant recurrence-free survival [DRFS]). Ten studies, totaling 3157 patients, were included. A pooled analysis for 5-year OS, progression-free survival, LRFS, and DRFS showed no benefit of chemotherapy over locoregional therapy alone for all-comers or site-specific STS. We make recommendations to improve outcome reporting and quality indices.

Keywords: chemotherapy; localized; resectable; soft tissue sarcoma.

© 2019 Wiley Periodicals, Inc.

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