Genomics|Update|Current ► Ebola: Genomics & Public Health

Genomics|Update|Current

Ebola: Genomics & Public Health

CDC laboratories produce first genomic sequence of Liberian Ebola

Ebola 2014 — New challenges, new global response and responsibility.
Thomas R. Frieden et al. New England Journal of Medicine, August 20, 2014

CDC information: The 2014 Ebola outbreak is one of the largest Ebola outbreaks in history and the first in West Africa

CDC Disease Detectives respond to the 2014 Ebola outbreak

CDC information: Using next-generation sequencing to identify hemorrhagic fever viruses in bat populations of central Africa and Asia

Genome sequences filoviruses, including Ebola virus, are available and indexed on NCBI-genome
 
Phylogenetic analysis of Guinea 2014 EBOV Ebolavirus outbreak,
Gytis Dudas et al.  PLOS Pathogens Outbreaks, April 2014

CDC article: Whole-genome expression profiling reveals that inhibition of host innate immune response pathways by Ebola virus can be reversed by a single amino acid change in the VP35 protein.
Hartman AL, et al. J Virol. 2008 Jun;82(11):5348-58.

Tackling Ebola: new insights into prophylactic and therapeutic intervention strategies
Emmie de Wit et al. Genome Medicine (2011)

HSPA5 is an essential host factor for Ebola virus infection.
Patrick Reid S, et al. Antiviral Res. 2014 Jul 11. 

CDC article: Biomarker correlates of survival in pediatric patients with Ebola virus disease
McElroy AK, et al. Emerg Infect Dis, Oct 2014.

CDC article: Sequence-based human leukocyte antigen—B typing of patients infected with Ebola virus in Uganda in 2000: identification of alleles associated with fatal and nonfatal disease outcomes
Sanchez A, et al. J Infect Dis 2007; 196(S2): S329-S336.

How Ebola patients survived – Experts, Vanguard Report, Aug 18, 2014