Recovery LIVE!SAMHSA’s Bringing Recovery Supports to Scale Technical Assistance Center Strategy (BRSS TACS) invites you to learn about the Health Resources & Services Administration’s National Health Service Corps (NHSC) program. NHSC began in 1972 with the aim of building healthy communities by placing qualified healthcare practitioners in underserved areas of the United States. Today, the program continues to address healthcare worker shortages in rural, urban, and tribal communities, in an effort to ensure access to care for everyone, prevent disease and illness, and care for vulnerable and underserved people. Currently, more than 4,000 of the 13,000 members of the corps are mental and substance use disorder (SUD) clinicians. Recent awards from the U.S. Department of Health and Human Services will enable the NHSC to support an additional 1,250 clinicians who will provide SUD treatment in an effort to combat the opioid epidemic in underserved communities. Searchable on the Health Workforce Connector, there are more than 20,000 health care facilities approved by the NHSC. Eligible clinicians may apply for loan repayment during one cycle each year if they are employed at an NHSC-approved facility. Awards will be prioritized to those practicing in areas of greatest need. Eligible professions include:
Presenters will discuss the increasing need for providers who can treat mental and substance use disorders in underserved communities, describe their own experience in the NHSC, and provide information on the application process. Join us for this free, interactive virtual event, moderated by CAPT Wanda Finch, Health Services Officer in the U.S. Public Health Service. Register For The Virtual Event Presenters: Malissa Lewis, Chief, Loan Repayment Branch, Division of National Health Service Corps, Bureau of Health Workforce, Health Resources and Services Administration Dr. Mbeja Lomotey, DrPH, Substance Use Disorder Public Health Analyst, Division of Regional Operations, Bureau of Health Workforce, Health Resources and Services Administration Heather Rogers, LPC, National Health Service Corps Recipient at Change Point Integrated Health in Snowflake, AZ |
martes, 31 de diciembre de 2019
Recovery LIVE! From Sea to Shining Sea: Workforce Efforts to Build Healthy Communities through the National Health Service Corps Tickets, Wed, Jan 8, 2020 at 2:00 PM | Eventbrite
Recovery LIVE! From Sea to Shining Sea: Workforce Efforts to Build Healthy Communities through the National Health Service Corps Tickets, Wed, Jan 8, 2020 at 2:00 PM | Eventbrite
BMC Biomedical Engineering | Home
BMC Biomedical Engineering | Home
BMC Biomedical Engineering
BMC Biomedical Engineering
Exploring physiological signals on people with Duchenne muscular dystrophy for an active trunk support: a case study
Authors:Stergios Verros, Laura Peeters, Arjen Bergsma, Edsko E. G. Hekman, Gijsbertus J. Verkerke and Bart F. J. M. KoopmanContent type:Research article9 December 2019The problem with skeletal muscle series elasticity
Authors:Walter HerzogContent type:Review3 December 2019Models of tendon development and injury
Authors:Sophia K. Theodossiou and Nathan R. SchieleContent type:Review29 November 2019A portable assist-as-need upper-extremity hybrid exoskeleton for FES-induced muscle fatigue reduction in stroke rehabilitation
Authors:Ashley Stewart, Christopher Pretty and Xiaoqi ChenContent type:Research article19 November 2019
Journal of Nanobiotechnology | Home page
Journal of Nanobiotechnology | Home page
Journal of Nanobiotechnology
Journal of Nanobiotechnology
Articles
Biodegraded magnetosomes with reduced size and heating power maintain a persistent activity against intracranial U87-Luc mouse GBM tumors
Authors:Edouard Alphandéry, Ahmed Idbaih, Clovis Adam, Jean-Yves Delattre, Charlotte Schmitt, Florence Gazeau, François Guyot and Imène ChebbiContent type:Research23 December 2019Incorporation of drug efflux inhibitor and chemotherapeutic agent into an inorganic/organic platform for the effective treatment of multidrug resistant breast cancer
Authors:Yang Dong, Hongze Liao, Jian Yu, Hao Fu, De Zhao, Ke Gong, Qi Wang and Yourong DuanContent type:Research23 December 2019Size-dependent tissue-specific biological effects of core–shell structured Fe3O4@SiO2–NH2 nanoparticles
Authors:Jinquan Li, Zhongxue Yuan, Huili Liu, Jianghua Feng and Zhong ChenContent type:Research23 December 2019Novel nanomedicine with a chemical-exchange saturation transfer effect for breast cancer treatment in vivo
Authors:Yanlong Jia, Chaochao Wang, Jiehua Zheng, Guisen Lin, Dalong Ni, Zhiwei Shen, Baoxuan Huang, Yan Li, Jitian Guan, Weida Hong, Yuanfeng Chen and Renhua WuContent type:Research17 December 2019Nanotechnology advances towards development of targeted-treatment for obesity
Authors:Nicole Remaliah Samantha Sibuyi, Koena Leah Moabelo, Mervin Meyer, Martin Opiyo Onani, Admire Dube and Abram Madimabe MadieheContent type:Review16 December 2019
BMC Biotechnology | Home page
BMC Biotechnology | Home page
BMC Biotechnology
BMC Biotechnology
Articles
Development and applications of a monoclonal antibody against caprine interferon-gamma
Authors:Wen-Tao Ma, Qi Liu, Meng-Xia Ning, Yu-Xu Qi, Saad Rehman and De-Kun ChenContent type:Research article23 December 2019Optimized production of a biologically active Clostridium perfringens glycosyl hydrolase phage endolysin PlyCP41 in plants using virus-based systemic expression
Authors:Rosemarie W. Hammond, Steven M. Swift, Juli A. Foster-Frey, Natalia Y. Kovalskaya and David M. DonovanContent type:Research article21 December 2019The next generation of biopanning: next gen sequencing improves analysis of bacterial display libraries
Authors:Sarah D. Stellwagen, Deborah A. Sarkes, Bryn L. Adams, Mia A. Hunt, Rebecca L. Renberg, Margaret M. Hurley and Dimitra N. Stratis-CullumContent type:Research Article21 December 2019Fecal DNA isolation and degradation in clam Cyclina sinensis: noninvasive DNA isolation for conservation and genetic assessment
Authors:Min Zhang, Min Wei, Zhiguo Dong, Haibao Duan, Shuang Mao, Senlei Feng, Wenqian Li, Zepeng Sun, Jiawei Li, Kanglu Yan, Hao Liu, Xueping Meng and Hongxing GeContent type:Research article19 December 2019The oesophageal diverticulum of Dirioxa pornia studied through micro-CT scan, dissection and SEM studies
Authors:Kala Bhandari, Peter Crisp and Michael A. KellerContent type:Research18 December 2019
Journal of Translational Medicine | Home page
Journal of Translational Medicine | Home page
Journal of Translational Medicine
Journal of Translational Medicine
Articles
Overexpression of circulating MiR-30b-5p identifies advanced breast cancer
Authors:Helena Estevão-Pereira, João Lobo, Sofia Salta, Maria Amorim, Paula Lopes, Mariana Cantante, Berta Reis, Luís Antunes, Fernando Castro, Susana Palma de Sousa, Céline S. Gonçalves, Bruno M. Costa, Rui Henrique and Carmen JerónimoContent type:Research30 December 2019The important role of connexin 43 in subarachnoid hemorrhage-induced cerebral vasospasm
Authors:Le Yang, Jian Yan, Jin-An Zhang, Xin-Hui Zhou, Chao Fang, Er-Ming Zeng, Bin Tang, Jian Duan, Guo-Hui Lu and Tao HongContent type:Research30 December 2019Upregulation of mitotic bookmarking factors during enhanced proliferation of human stromal cells in human platelet lysate
Authors:Sandra Laner-Plamberger, Michaela Oeller, Cornelia Mrazek, Arnulf Hartl, Alina Sonderegger, Eva Rohde, Dirk Strunk and Katharina SchallmoserContent type:Research30 December 2019Roles of transforming growth factor-β and phosphatidylinositol 3-kinase isoforms in integrin β1-mediated bio-behaviors of mouse lung telocytes
Authors:Dongli Song, Li Tang, Jianan Huang, Lu Wang, Tao Zeng and Xiangdong WangContent type:Research30 December 2019Translational value of IDH1 and DNA methylation biomarkers in diagnosing lung cancers: a novel diagnostic panel of stage and histology-specificity
Authors:Ruochuan Zang, Xinfeng Wang, Runsen Jin, Yuanyuan Lei, Jianbing Huang, Chengming Liu, Sufei Zheng, Fang Zhou, Qian Wu, Nan Sun, Shugeng Gao and Jie HeContent type:Research30 December 2019
Relationship between the effects of food on the pharmacokinetics of oral antineoplastic drugs and their physicochemical properties | Journal of Pharmaceutical Health Care and Sciences | Full Text
Relationship between the effects of food on the pharmacokinetics of oral antineoplastic drugs and their physicochemical properties | Journal of Pharmaceutical Health Care and Sciences | Full Text
Journal of Pharmaceutical Health Care and Sciences
Journal of Pharmaceutical Health Care and Sciences
Relationship between the effects of food on the pharmacokinetics of oral antineoplastic drugs and their physicochemical properties
Journal of Pharmaceutical Health Care and Sciences volume 5, Article number: 26 (2019) Cite this article
- 227 Accesses
Abstract
Background
Food is known to affect drug absorption by delaying gastric emptying time, altering gastrointestinal pH, stimulating bile flow, increasing splanchnic blood flow, or physically interacting with drugs. Although food is known to affect the pharmacokinetics of oral antineoplastic drugs, the relationship between the effects of food and the physicochemical properties of drugs remains unclear.
Methods
In this study, we surveyed the literature on three kinds of pharmacokinetic changes, AUC ratio, Cmax ratio and Tmax ratio, in the fasted and fed state for 72 oral antineoplastic drugs that were listed on the drug price standard in May 2018 in Japan. We further predicted the physicochemical properties from the 2D chemical structure of the antineoplastic drugs using in silico predictions.
Results
As a result of analyzing the relationship between the effects of food and physicochemical properties, we found that compounds that show increased absorption in the fed state had higher logP and lower solubility in fasted-state simulated intestinal fluid (FaSSIF). However, compounds with delayed absorption had higher solubility in FaSSIF. Furthermore, as a result of decision tree analysis, it was classified as AUC increase with logP ≥4.34. We found that an AUC increase in the fed state did not occur with compounds with low lipid solubilities (logP < 1.59). From these results, it is predicted that 7 compounds out of the 24 compounds for which the effects of food are unknown are at risk for increased absorption in the fed state and that no increase in absorption would occur in 13 compounds.
Conclusion
In this study, we found that drugs that will show increased absorption in the fed state and drugs for which absorption is not dependent on food can generally be predicted by logP. These results suggest that logP can be a useful parameter for predicting the effects of food on drug absorption.
Physical, chemical, and microbiological stability study of diluted atropine eye drops | Journal of Pharmaceutical Health Care and Sciences | Full Text
Physical, chemical, and microbiological stability study of diluted atropine eye drops | Journal of Pharmaceutical Health Care and Sciences | Full Text
Journal of Pharmaceutical Health Care and Sciences
Journal of Pharmaceutical Health Care and Sciences
Physical, chemical, and microbiological stability study of diluted atropine eye drops
Journal of Pharmaceutical Health Care and Sciences volume 5, Article number: 25 (2019) Cite this article
- 368 Accesses
Abstract
Background
Atropine eye drops are indicated for juvenile myopia progression, cycloplegia, amblyopia, and strabismus. According to the package insert, 10 mg/mL atropine eye drops must be diluted for pediatric patients to prevent systemic adverse effects. Compounding units in hospital pharmaceutical departments or community pharmacies are compelled to prepare this essential medication; however, validated atropine stability data is limited and the shelf life after preparation is extremely short. As it is a long-term treatment, a longer shelf life is necessary to improve patient care. This study aimed to demonstrate the physical, chemical, and microbiological stability of diluted atropine eye drops over a period of six months.
Methods
Preparation consists of dilution of a 10 mg/mL atropine solution (Nitten Atropine Ophthalmic Solution 1%; Nitten Pharmaceutical Co., Ltd.) in 0.9% NaCl to concentrations of 0.1, 1.0, 2.5, and 5.0 mg/mL, followed by a sterilizing filtration procedure and then an aseptic filling process of 5 mL in 5 mL polyethylene eyedropper bottles. The entire process is carried out in an overpressure isolator. All concentration products were kept for six months at 25 °C or 5 °C. Visual inspection was conducted and pH, osmolality, and atropine concentration were measured at day 0, day 14, day 28, and every month until six months. Atropine concentration was measured using liquid chromatography tandem mass spectrometry. The sterility was monitored using a method adapted from the Japanese Pharmacopoeia sterility assay.
Results
Atropine remained within ±5% of the target value in the six batches. Osmolality (285 mOsm/kg) as well as pH (5.88) were kept constant. No variations in solution characteristics (crystallization, discoloration) were noted. Sterility was maintained.
Conclusions
This study validated the physical, chemical, and microbiological stability of 0.1, 1.0, 2.5, and 5.0 mg/mL atropine sulfate eye drops conserved inside polyethylene eyedroppers for six months at 25 °C or 5 °C.
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