miércoles, 24 de julio de 2024

Evaluating the Immunogenicity Risk of Host Cell Proteins in Follow-On Recombinant Peptide Products

https://www.federalregister.gov/public-inspection/2024-16356/evaluating-the-immunogenicity-risk-of-host-cell-proteins-in-follow-on-recombinant-peptide-products?utm_medium=email&utm_source=govdelivery Today, FDA issued a Federal Register notice, “Evaluating the Immunogenicity Risk of Host Cell Proteins in Follow-on Recombinant Peptide Products: Establishment of a Public Docket: Request for Information and Comments.” This notice establishes a public docket seeking substantive comments from interested parties on evaluating the immunogenicity risk of host cell proteins. For the purposes of this request, FDA is specifically interested in comments on suitable methods to detect, identify and control host cell proteins in commercial lots of recombinant peptide products (including information on achievable residual amounts of host cell proteins in the drug product) as well as in vitro, in silico immunogenicity assessment (IVISIA) of host cell proteins in recombinant peptide products. Although follow-on recombinant peptide products can rely on FDA’s findings of safety and effectiveness for a listed drug that is a peptide product, differences in recombinant expression systems used during the peptide production could result in quality attribute differences, including in the host cell protein profile, which in turn, could contribute to differences in immunogenicity risk between a follow-on peptide product and the relied upon listed drug. Public comments will help FDA develop recommendations for evaluation and mitigation of the immunogenicity risk associated with differences in host cell protein profiles between the follow-on and listed drug. See the FRN for additional information about this open docket, including what information to include when submitting comments.

Trauma Informed Care

Trauma Informed Care Evidence was insufficient to draw conclusions about the effects of Trauma Informed Care (TIC) in primary care or psychiatric hospitals for adult patients for any outcome. Evidence was insufficient to draw conclusions about the effects of TIC in any setting for children or youth patients/clients for any outcome. TIC models vary considerably in their socioecological components (cultural relevance, training, screening, system embedding) from youth to adult services across settings and disciplines. Current organizational and clinical components encompass a broad range of considerations with only some overlap within both the organizational and clinical domains. A few models of TIC had specific elements of cultural competence and/or humility (e.g., emphasizing a need to understand patient/client symptoms within the context of life experiences, culture, and historical issues)

Risk Mitigation Using the Anesthesia Risk Alert Program: Applying a Proactive Approach With Data Review & Collaborating With a Second Practitioner

https://psnet.ahrq.gov/innovation/risk-mitigation-using-anesthesia-risk-alert-program-applying-proactive-approach-data North American Partners in Anesthesia (NAPA) is a nationwide anesthesia practice with more than 450 facilities in 21 states. NAPA employs anesthesiologists, certified registered nurse anesthetists, and certified anesthesiologist assistants. The Anesthesia Risk Alert program is a protocol created as a work product by NAPA’s component Patient Safety Organization, the NAPA Anesthesia Patient Safety Institute (NAPSI), which monitors patients for specific high-risk clinical factors and trains providers to apply targeted mitigation interventions when patients are considered at risk.1 The interventions are based on well-researched practices and clinical guidelines and were informed by an analysis of three years of adverse event data across NAPA by NAPSI, referred to throughout as the innovator. This data analysis revealed five high-risk clinical scenarios. The NAPSI team created a detailed program for providers to respond to each of the five scenarios.

Development of patient safety measures to identify inappropriate diagnosis of common infections.

https://psnet.ahrq.gov/issue/development-patient-safety-measures-identify-inappropriate-diagnosis-common-infections Misdiagnosis of infections can lead to overuse of antibiotics and threaten patient safety. This article describes the development of two National Quality Forum (NQF)-endorsed measures of inappropriate diagnosis of urinary tract infection (UTI) and community-acquired pneumonia (CAP). Both measures demonstrated strong validity and reliability through testing with patient focus groups and case review. Implementation evaluation across more than 40 Michigan hospitals demonstrated significant decreases in inappropriate diagnoses of UTI and CAP, indicating broad usability of these measures to support improved outcomes.

Systematic review of types of safety incidents and the processes and systems used for safety incident reporting in care homes.

https://psnet.ahrq.gov/issue/systematic-review-types-safety-incidents-and-processes-and-systems-used-safety-incident Incident reporting systems are commonly used to detect threats to patient safety. This systematic review of 106 studies examined the characteristics of incident reporting processes in residential care facilities and nursing homes in high-income countries. The authors summarize how incidents are detected; common contributing, mitigating, and ameliorating factors; as well as actions and interventions to reduce the risk of patient safety incidents.

A symptom-checker for adult patients visiting an interdisciplinary emergency care center and the safety of patient self-triage: real-life prospective evaluation.

https://psnet.ahrq.gov/issue/symptom-checker-adult-patients-visiting-interdisciplinary-emergency-care-center-and-safety Patients presenting to the emergency department (ED) are triaged to prioritize care based on level of illness. In this study, 2,543 patients presenting to an ED in Switzerland were asked to self-triage using an electronic symptom-checker. (Patients were triaged and treated based on standard-of-care nurse triage.) Recommendations were given regarding time to treat (e.g., emergency) and point-of-care (e.g., self-care) and subsequently evaluated by three panels of experts. Fifty of the 2,543 patients were judged as undertriaged, but none were judged as potentially hazardous.

Emergency Department Visits And Hospital Capacity In The US: Trends In The Medicare Population During The COVID-19 Pandemic

https://pubmed.ncbi.nlm.nih.gov/38950291/

Measuring Primary Care Spending in the US by State

https://pubmed.ncbi.nlm.nih.gov/38758567/

AHRQ Papers on Diagnostic Safety Topics

AHRQ Papers on Diagnostic Safety Topics: Diagnostic errors occur in all settings of care, contribute to about 10 percent of patient deaths, and are the primary reason for medical liability claims. AHRQ is the lead Federal agency investing in research to improve diagnostic safety and reduce diagnostic error. AHRQ is currently developing a series of papers on different diagnostic safety issues, which will be released over the next year.

Documenting Diagnosis: Exploring the Impact of Electronic Health Records on Diagnostic Safety

Documenting Diagnosis: Exploring the Impact of Electronic Health Records on Diagnostic Safety: This issue brief reviews the history of documentation legislation, including rules and regulations, and outstanding challenges and best practices to improve documentation. It also identifies future developments and opportunities for improvement, including emerging technology-based strategies to improve the traditional documentation process.

Which older adults are at highest risk of prescribing cascades? A national study of the gabapentinoid-loop diuretic cascade

https://pubmed.ncbi.nlm.nih.gov/38547357/

Safety of primary nasotracheal intubation in the pediatric intensive care unit (PICU)

https://pubmed.ncbi.nlm.nih.gov/38404646/

Prospective validation of clinical deterioration predictive models prior to intensive care unit transfer among patients admitted to acute care cardiology wards

https://pubmed.ncbi.nlm.nih.gov/38772399/ An AHRQ-funded study published in Physiological Measurement concluded that a predictive analytics tool called CoMET, developed five years before the COVID-19 pandemic, was very accurate in predicting which patients declined in the hospital during the pandemic. Tested in a randomized controlled trial with more than 10,000 patient visits, the tool accurately predicted significant health declines, primarily due to respiratory issues. The study found that the tool’s predictions remained accurate despite changes in clinical practices over time, including during the pandemic. The analysis underscores the importance of real-world validation for predictive models, researchers concluded.

Supporting ColoREctal Equitable Navigation (SCREEN): a protocol for a stepped-wedge cluster randomized trial for patient navigation in primary care

https://pubmed.ncbi.nlm.nih.gov/38831365/

Geographic and Physician-Level Variation in the Use of Hypofractionated Radiation Therapy for Breast Cancer in the U.S.: A Cross-Classified Multilevel Analysis

https://pubmed.ncbi.nlm.nih.gov/38725638/

Acceptance of Automated Social Risk Scoring in the Emergency Department: Clinician, Staff, and Patient Perspectives

https://pubmed.ncbi.nlm.nih.gov/39028248/

Clinical outcomes of female external urine wicking devices as alternatives to indwelling catheters: a systematic review and meta-analysis

https://pubmed.ncbi.nlm.nih.gov/38706216/

Using 42 CFR part 2 revisions to integrate substance use disorder treatment information into electronic health records at a safety net health system

https://pubmed.ncbi.nlm.nih.gov/38849888/ Using 42 CFR part 2 revisions to integrate substance use disorder treatment information into electronic health records at a safety net health system. Tillman AR, Bacon E, Bender B, et al.

Clinical Conditions With Frequent, Costly Hospital Readmissions by Payer, 2020 STATISTICAL BRIEF #307 April 2024 H. Joanna Jiang, Ph.D., and Marguerite L. Barrett, M.S.

https://hcup-us.ahrq.gov/reports/statbriefs/sb307-readmissions-2020.jsp AHRQ Stats: Disorders Commonly Associated With Readmission Sepsis, heart failure and complications from diabetes were the most common conditions associated with hospital readmissions in 2020, accounting for nearly 20 percent of all adult readmissions.

Environmental Monitoring in Compounding JULY 30, 2024

https://www.fda.gov/drugs/news-events-human-drugs/environmental-monitoring-compounding-07302024?utm_medium=email&utm_source=govdelivery July 30, 2024 | 2:00 PM - 3:30 PM ET Attendees will hear an overview of Environmental Monitoring for compounding facilities and the role environmental monitoring plays in ensuring product quality and patient safety. Presenters will discuss the statutory and regulatory requirements for environmental monitoring. FDA also will describe the agency’s expectations for compounding pharmacies (under section 503A) and outsourcing facilities (under section 503B) for environmental monitoring. Finally, FDA will discuss different methods specific to environmental monitoring.

SOPP 8101.1: Regulatory Meetings with Sponsors and Applicants for Drugs and Biological Products

https://www.fda.gov/media/84040/download?attachment=&utm_medium=email&utm_source=govdelivery

Testing Human Cells, Tissues, and Cellular and Tissue-Based Product (HCT/P) Donors for Relevant Communicable Disease Agents and Diseases

https://www.fda.gov/vaccines-blood-biologics/safety-availability-biologics/testing-human-cells-tissues-and-cellular-and-tissue-based-product-hctp-donors-relevant-communicable?utm_medium=email&utm_source=govdelivery

Postapproval Manufacturing Changes to Biosimilar and Interchangeable Biosimilar Products Questions and Answers JULY 2024

https://www.fda.gov/regulatory-information/search-fda-guidance-documents/postapproval-manufacturing-changes-biosimilar-and-interchangeable-biosimilar-products-questions-and

martes, 23 de julio de 2024

An isolated viral load test may generate false positive results for people using long-acting PrEP Analysis from large NIH study offers new insight on clinical utility of current U.S. testing algorithm.

https://www.nih.gov/news-events/news-releases/isolated-viral-load-test-may-generate-false-positive-results-people-using-long-acting-prep A single laboratory-based HIV viral load test used by U.S. clinicians who provide people with long-acting, injectable cabotegravir (CAB-LA) HIV pre-exposure prophylaxis (PrEP) did not reliably detect HIV in a multi-country study.

China–US research collaborations are in decline — this is bad news for everyone

China–US research collaborations are in decline — this is bad news for everyone Scientists say that the drop in partnerships between the scientific powerhouses will hold back research on priorities such as global warming. By Gemma Conroy https://www.nature.com/articles/d41586-024-02046-9?utm_source=Live+Audience&utm_campaign=4f7f28dc60-nature-briefing-daily-20240722&utm_medium=email&utm_term=0_b27a691814-4f7f28dc60-50432164

Safeguarding Health Information: Building Assurance through HIPAA Security 2024

https://www.nist.gov/news-events/events/2024/10/safeguarding-health-information-building-assurance-through-hipaa-security The U.S. Department of Health and Human Services (HHS) Office for Civil Rights (OCR) and the National Institute of Standards and Technology (NIST) Information Technology Laboratory (ITL) are excited to announce the return of the “Safeguarding Health Information: Building Assurance through HIPAA Security” conference for October 2024. After a 5-year absence, the conference is now returning to Washington, D.C. at the HHS Headquarters. The conference will explore the current healthcare cybersecurity landscape and the Health Insurance Portability and Accountability Act (HIPAA) Security Rule. This event will highlight the present state of healthcare cybersecurity, and practical strategies, tips, and techniques for implementing the HIPAA Security Rule. The conference will also offer sessions that explore best practices in managing risks to—and the technical assurance of—electronic health information. Presentations will cover a variety of topics including managing cybersecurity risk and implementing practical cybersecurity solutions, understanding current cybersecurity threats to the healthcare community, cybersecurity considerations for the Internet of Things (IoT) in healthcare environments, updates from federal healthcare agencies, and more.

USAID launches the 2024 Preventing Child and Maternal Deaths Annual Report to Congress

https://www.usaid.gov/PreventingChildAndMaternalDeaths This year’s report illuminates how the United States’ sustained commitment, financial investment, and responsive programming continues to make major strides in advancing maternal and child survival." — Dr. Atul Gawande, Assistant Administrator for Global Health

COVID-19's impact on maternal mortality demands rethink of public health strategies

https://www.news-medical.net/news/20240723/COVID-19s-impact-on-maternal-mortality-demands-rethink-of-public-health-strategies.aspx

Why millions are trying FDA-authorized alternatives to big pharma’s weight loss drugs

https://www.news-medical.net/news/20240723/Why-millions-are-trying-FDA-authorized-alternatives-to-big-pharmae28099s-weight-loss-drugs.aspx

New method can rapidly determine virus infectivity

https://www.news-medical.net/news/20240723/New-method-can-rapidly-determine-virus-infectivity.aspx

New findings shed light on AI's potential in clinical settings

https://www.news-medical.net/news/20240723/New-findings-shed-light-on-AIs-potential-in-clinical-settings.aspx

Virtual Public Meeting – Home as a Health Care Hub – Stakeholder Listening Session; July 25, 2024 JULY 25, 2024

Virtual Public Meeting – Home as a Health Care Hub – Stakeholder Listening Session; July 25, 2024 JULY 25, 2024 https://www.fda.gov/medical-devices/medical-devices-news-and-events/virtual-public-meeting-home-health-care-hub-stakeholder-listening-session-july-25-2024-07252024?utm_medium=email&utm_source=govdelivery Register for the FDA’s Home as a Health Care Hub Virtual Meeting Later this week, the U.S. Food and Drug Administration (FDA) will host a virtual public meeting to discuss the Home as a Health Care Hub initiative. During this meeting, we will review the Home as a Health Care Initiative, seek input from the public, and start a dialogue about barriers and opportunities associated with making the home part of the health care system. Important information for the virtual public meeting: Date: July 25, 2024 Time: 12:00 p.m. to 4:00 p.m. ET Registration deadline: July 25, 2024, at 11 a.m. ET

AI disease modelling startup CytoReason to scale up in US The company aims to reach more biotech and pharma companies, increase the speed and accuracy of drug development and benefit patients.

https://www.israel21c.org/ai-disease-modelling-startup-cytoreason-to-scale-up-in-us/ Israeli startup CytoReason, which develops computational disease models for predictive insights, has secured $80 million in funding that will scale up its AI disease models and enable it to establish a hub in the United States.

Three take aways from Tel Aviv’s AI and cybersecurity conferences

Three take aways from Tel Aviv’s AI and cybersecurity conferences Over nine months into the Gaza war, professionals and a few international visitors are still connecting, building and working to make things happen at a host of AI and cybertech events. The packed tech conferences, hackathons, and events taking place in the Startup Nation during this challenging time serve as positive indicators of the vitality of the local ecosystem. https://www.israel21c.org/three-take-aways-from-tel-avivs-ai-and-cybersecurity-conferences/

Can liquid biopsy revolutionize cancer treatment? One innovation in diagnostic technology is paving the way for huge shifts in the way experts diagnose, monitor and treat diseases — especially cancer.

https://www.israel21c.org/can-liquid-biopsy-revolutionize-cancer-treatment/ Back in ancient Greece, medical whiz kids like Hippocrates and Alcmaeon of Croton were hot on the idea that blood, phlegm, yellow bile and black bile — known as the body’s “humors” — held the keys to the kingdom of good health and a long life.

Alcon eyecare leader acquires Israeli glaucoma care company Belkin Vision, founded in 2013, developed an effective first-line laser treatment for glaucoma that is easily accessible to doctors and patients.

https://www.israel21c.org/alcon-eyecare-leader-acquires-israeli-glaucoma-care-company/ Geneva-based Alcon, the world’s largest eye care devices company, has closed deal to acquire Israeli company Belkin Vision for $81 million, including a cash payment of approximately $65 million.

NEW POWDER REMOVES CANCER-CAUSING COMPOUNDS FROM FRIED FOOD Beyond Oil absorbs carcinogenic toxins that build up in reused frying oil at eateries, offering benefits to health and environment.

https://www.israel21c.org/new-powder-removes-cancer-causing-compounds-from-fried-food/ French fries, chicken nuggets, onion rings, eggrolls and other fried favorites in restaurants and cafeterias are cooked in oil that gets reused hundreds of times.

ACI’s Legal, Regulatory, and Compliance Forum on Cosmetics & Personal Care Products – West Coast Edition

https://www.thefdalawblog.com/2024/07/acis-legal-regulatory-and-compliance-forum-on-cosmetics-personal-care-products-west-coast-edition/?utm_source=rss&utm_medium=rss&utm_campaign=acis-legal-regulatory-and-compliance-forum-on-cosmetics-personal-care-products-west-coast-edition The American Conference Institute (“ACI”) is holding its 2nd West Coast Editionof its Legal, Regulatory, and Compliance Forum on Cosmetics & Personal Care Products from September 25-26 at the Le Meridien Delfina, Santa Monica, California.

2024 CBER Patient and Care Partner Listening Meetings September 20, 2024

Gene therapy has recently emerged as a treatment option for some rare diseases with unmet needs. The FDA approved the first gene therapy in 2017 and 19 gene therapies as of June 2024, many of which are for rare diseases. Clinical trials that support approval of gene therapy products provide the needed information about the risks and benefits of the product so that patients and care partners can make informed decisions regarding treatment. https://www.fda.gov/news-events/2024-cber-patient-and-care-partner-listening-meetings?utm_medium=email&utm_source=govdelivery

OTP Town Hall: Cell Therapy CMC Readiness for Late-Stage INDs SEPTEMBER 5, 2024

https://www.fda.gov/news-events/fda-meetings-conferences-and-workshops/otp-town-hall-cell-therapy-cmc-readiness-late-stage-inds-09052024?utm_medium=email&utm_source=govdelivery

Recommendations for Investigational and Licensed COVID-19 Convalescent Plasma Guidance for Industry JULY 2024

https://www.fda.gov/regulatory-information/search-fda-guidance-documents/recommendations-investigational-and-licensed-covid-19-convalescent-plasma?utm_medium=email&utm_source=govdelivery What’s New for Biologics Latest News from the Center for Biologics Evaluation and Research at FDA https://www.fda.gov/vaccines-blood-biologics/news-events-biologics/whats-new-biologics?utm_medium=email&utm_source=govdelivery

Postapproval Manufacturing Changes to Biosimilar and Interchangeable Biosimilar Products Questions and Answers JULY 2024

https://www.fda.gov/regulatory-information/search-fda-guidance-documents/postapproval-manufacturing-changes-biosimilar-and-interchangeable-biosimilar-products-questions-and

Disease Awareness and Prescription Drug Communications on Television: Evidence for Conflation and Misleading Product Impressions

https://www.fda.gov/drugs/spotlight-cder-science/disease-awareness-and-prescription-drug-communications-television-evidence-conflation-and-misleading?utm_medium=email&utm_source=govdelivery In this Spotlight on CDER science, CDER researchers conducted two experimental studies among adult asthma patients to determine how the similarity, proximity, and frequency of exposure to a disease awareness communication and prescription drug television advertisement impact consumer perception and understanding of the benefits and risks of a prescription drug. Consumers sometimes conflate the information in disease awareness communications with information presented in prescription drug promotional materials. Previous CDER research has found that conflation occurs when disease awareness and drug promotional materials are viewed in print or on the web. Knowing which advertising features cause conflation is important because it offers an opportunity for pharmaceutical companies to consider these features when developing prescription drug advertising and disease awareness communications.

NIST Announces Funding Opportunity for AI-Focused Manufacturing USA Institute Deadline for submitting concept papers during the first stage of the application process is Sept. 30, 2024. July 22, 2024

https://www.nist.gov/news-events/news/2024/07/nist-announces-funding-opportunity-ai-focused-manufacturing-usa-institute The U.S. Department of Commerce’s National Institute of Standards and Technology (NIST) has announced an open competition for a new Manufacturing USA institute focused on the use of artificial intelligence (AI) to increase the resilience of U.S. manufacturers. The Notice of Funding Opportunity was published today on Grants.gov. NIST anticipates funding up to $70 million over a five-year period, subject to the availability of federal funds, for the recipient to establish and operate the new institute. The institute will be required to obtain cost-share funds from nonfederal sources.

lunes, 22 de julio de 2024

Colorectal Cancer On the Rise in Young Adults David J. Kerr, CBE, MD, DSc | July 15, 2024

https://www.medscape.com/viewarticle/colorectal-cancer-rise-young-adults-2024a1000cta

'Chemoresistance Can Be Reversed': Toughest Cancers Targeted Lisa Marshall July 18, 2024

https://www.medscape.com/viewarticle/chemoresistance-can-be-reversed-toughest-cancers-targeted-2024a1000d7s

Stand by Your Case? Without Standing, Supreme Court Precedent Means You’ll Have More Bad Times than Good July 22, 2024 By John W.M. Claud —

https://www.thefdalawblog.com/2024/07/stand-by-your-case-without-standing-supreme-court-precedent-means-youll-have-more-bad-times-than-good/?utm_source=rss&utm_medium=rss&utm_campaign=stand-by-your-case-without-standing-supreme-court-precedent-means-youll-have-more-bad-times-than-good Sometimes it’s difficult to be a plaintiff, putting all your work into just one case. That’s especially true if recent Supreme Court rulings have rendered your matter a quixotic pursuit, doomed to fail for lack of direct causation. That’s what happened last week in District Court in Maryland. Following the precedent on standing that the Supreme Court handed down in June in FDA v. Alliance for Hippocratic Medicine et al., a judge in Maryland dismissed another suit against FDA for lack of standing.

Bird flu that infected 6 Colorado poultry workers is closely related to the virus in cows Megan Molteni By Megan Molteni July 22, 2024

https://www.statnews.com/2024/07/22/bird-flu-infects-colorado-poultry-workers-related-to-h5n1-in-cows/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-_BdReZOW0twYsVEmcUb6Kd_36RhjPNKR0iKcovxSbpoz73e8RrzyXaT20tmRit1ZtlGY7thC2CAPNs97OlPBHpYNqEEA&_hsmi=316676560&utm_content=316676560&utm_source=hs_email Bird flu Snapshot: Virus that infected 6 people closely related to the one in cows Public health experts who’ve been following the surprising spillover of bird flu into America’s dairy cattle herds now have all eyes on Colorado, waiting to see if a cluster of human cases there might balloon into something bigger. On July 14, Colorado officials announced that five workers involved in the culling of 1.8 million chickens at a large H5N1-infected egg farm in Weld County had tested positive for the virus. On Friday, the CDC confirmed a sixth case of bird flu among the workers. The six Colorado cases were all mild, but it’s the first time multiple human cases have been reported on a single farm in the U.S. Read more from STAT’s Megan Molteni on what questions this raises about the virus and how it spreads. https://cdphe.colorado.gov/press-release/health-officials-confirm-human-cases-of-avian-flu-in-colorado-poultry-workers?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-_0unJii_iTEl-S-WAVrcK24nllstzLaypALC_eJWHoeQNoV_HC1Wn2ztoIhTiCFh3aqX9XYUsMLmBDW_oZIwehzuHtcw&_hsmi=316676560&utm_content=316676560&utm_source=hs_email

At a Mass General perfusion lab, a push to make more and more hearts viable for transplant Deborah Balthazar By Deborah Balthazar July 22, 2024

https://www.statnews.com/2024/07/22/mass-general-perfusion-lab-heart-transplants/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz--4Vcn7pHI9gTP9q7ZmL-KLPCRvwQoEw3CrulijWD1VN6xpXbvCNQlLOTA06dPYQbN3Dhqdw8oqV6B5TDQUdxuj0w6zOw&_hsmi=316676560&utm_content=316676560&utm_source=hs_email There are two holy grails in solid organ transplantation, says surgeon Dominic Emerson. First: Finding a way for transplanted organs to evade rejection. Second: Figuring out how to sustain organs outside of donors and recipients for longer periods of time, and how to rehabilitate them. At a lab in Boston, researchers are chilling hearts in pursuit of the latter goal. A Mass General Hospital team is working to improve a technique known as organ perfusion — taking an organ that has been kept cold for several hours and reviving it, maintaining the organ outside of the body in a box, and pumping it with blood to keep the tissues alive. Typically, hearts can’t be kept on ice for much more than four hours before the cold wrecks it. But after about a year and a half of work, the MGH team has used their new technique on 57 pig hearts and 11 human hearts that weren’t fit for transplantation. They were even able to reanimate a human heart for six hours, even though it had already been on ice for five to six.

Exhausted by prior auth, many patients abandon care: AMA survey JUL 18, 2024

https://www.ama-assn.org/practice-management/prior-authorization/exhausted-prior-auth-many-patients-abandon-care-ama-survey?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz--35uNu61f8MF_BYN_4Mje6NhmJUzz9sCws3V4RByj2KpZGbxF2oJHRAluhBasmthp1aQ1v2kl8Y826LxDBIL_dmoRemg&_hsmi=316676560&utm_content=316676560&utm_source=hs_email Prior authorization hurts patient care: Survey Seventy-eight percent of physicians say that the prior authorization process “often or sometimes” leads their patients to abandon treatment, according to an AMA survey of 1,000 practicing physicians. Prior authorization requires clinicians to get approval from an insurer to pay for a medication or service before actually providing it. The vast majority of physicians surveyed (94%) responded that prior authorization sometimes, often, or always delays patients trying to access necessary care. Almost 20% said that prior authorization has resulted in a serious adverse event that hospitalized someone. The stakes are high and insurers have a lot of power, which is why clinicians were outraged last summer when UnitedHealthcare attempted to instate a prior authorization policy for colonoscopies. Earlier this year, the Biden administration finalized a rule forcing insurance companies to give specific reasons for denying coverage. https://www.statnews.com/2024/01/17/prior-authorization-health-insurance-white-house/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-_aHtyaIlQXAtes4On3S8Du76XrOIine-BqXT10z75LfrXkhABpOwZugZCMPqso4SQhrVZrnUI6ZLaZNum2DsJyH0bJxg&_hsmi=316676560&utm_content=316676560&utm_source=hs_email

Microsoft global outage forces health systems to cancel appointments, delay procedures Katie Palmer Brittany Trang Casey Ross By Katie Palmer , Brittany Trang , and Casey Ross July 19, 2024

https://www.statnews.com/2024/07/19/microsoft-crowdstrike-outage-hospitals-cancellations/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-_veP7T5cjL6TEUYbkGswhZjIAWuhHdQ7iknOIHC24novGQHYglGcJuu9QZ2_XWmdyzMoLIvX5Hgw1aNvAKt8jGMXzB6A&_hsmi=316676560&utm_content=316676560&utm_source=hs_email Health systems scramble after global outages A global outage to Microsoft systems disrupted care at health systems across the country Friday, STAT’s health tech team reports. Hospital networks including Mass General Brigham canceled all non-urgent appointments and surgeries. Others, like Cincinnati Children’s, were able to keep a regular schedule, but warned about delays. The issue seemingly stemmed from a software update by the cybersecurity firm Crowdstrike, which then disabled computers running Microsoft Windows. While the use of Microsoft machines and software is extensive in health care, some systems, like Johns Hopkins Medicine, were not affected. Studies show that patient outcomes during cyberattacks are worse — and while this outage isn’t a hack, it still cripples many of the same systems. Read more on the latest.

Trump rallies his base on bolstering health care, avoiding thorny questions about health rights Sarah Owermohle By Sarah Owermohle July 19, 2024

https://www.statnews.com/2024/07/19/donald-trump-healthcare-abortion-transgender-medicare-right-to-try/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-94wDMryM81UNkDMt2xAxU3hmiN01idOCntSC3OfymSVsUxT7yyB7RhX06A7D3rP4Zr_wMLqkFmBaMf3m3Y74FvuhOBlw&_hsmi=316676560&utm_content=316676560&utm_source=hs_email Trump campaign provides details on his ear wound after rallying the base on health care at the RNC Former President Donald Trump required no stitches after a gunshot grazed his ear at a campaign rally July 13, his former White House doctor said in a memo released Saturday by Trump’s campaign. The bullet passed less than a quarter inch from the former president’s head, causing a two-centimeter-wide wound and “significant bleeding, followed by marked swelling of the entire upper ear,” Rep. Ronny Jackson (R-Texas) said in the letter. But “given the broad and blunt nature of the wound itself, no sutures were required,” Jackson wrote. Experts in trauma medicine told STAT earlier last week that the ear was likely to heal and fill in without stitches. The update comes after a week of public appearances at the RNC’s campaign convention, where Trump appeared with a large bandage on his right ear and told attendees that the bullet came perilously close to killing him. On Thursday night, Trump gave a 90-minute acceptance speech for the Republican nomination to the presidency. While the vast majority of his hour-and-a-half speech rallied convention-goers on the economy, border control, and foreign relations, the former president hit on some health care issues, such as Right to Try legislation, that have polled well with voters even if they have seen little impact so far. Read more in two stories from STAT’s Sarah Owermohle on how the wound is healing and what health care issues Trump did and didn’t touch in his nomination acceptance speech last week. https://www.statnews.com/2024/07/17/trump-ear-injury-gunshot-trauma-experts-weigh-in-2/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-9qMiwyny5-Rd-hw30tmB2J9gsXqV5QG01fi2V7xoZgdAlC7OzYnNC_ZjUB_tQ5EzG9ZmCelAa5fiJ_ns9apIfDt7KvIw&_hsmi=316676560&utm_content=316676560&utm_source=hs_email Trump campaign provides new details on his ear wound and treatment Sarah Owermohle By Sarah Owermohle July 20, 2024 https://www.statnews.com/2024/07/20/trump-ear-former-doctor-ronny-jackson-memo-on-wound-treatment/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz--T2Yg3TuhL21eAGP5xjVqo7h5vbuDJ1UvjafCiSljWwuVn8LTOFQ_ZEh40ijaxfsaYLsxC7PkvTCv-wgC_VUK79J4G7g&_hsmi=316676560&utm_content=316676560&utm_source=hs_email

Kamala Harris, endorsed by Biden to replace him, is left of the president on health care Rachel Cohrs Zhang Sarah Owermohle By Rachel Cohrs Zhang and Sarah Owermohle July 21, 2024

https://www.statnews.com/2024/07/21/kamala-harris-on-healthcare-abortion-rights-medicare-for-all-drug-price-caps/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz--NK8X7fEyNC2bcnmbts6KcEtxVYbqda-h6vEimhT4TRxYmUlMyKUXwnogyfGoX431aQQyja2ByPOGClaprnhBBHIg0Gw&_hsmi=316676560&utm_content=316676560&utm_source=hs_email President Biden has officially ended his bid for a second term in the White House and endorsed Vice President Kamala Harris to take his place, he announced yesterday. STAT’s DC team reports that while Harris shares similar views as Biden on many issues, she stands left of the president on health care. Harris has positioned herself as tougher on the industry by endorsing a transition to Medicare for All (though she still envisioned some sort of role for private plans) and calling for more aggressive drug pricing policies than Biden has been willing to employ. But her strongest health care issue by far is her advocacy for reproductive rights following the fall of Roe v. Wade. She was the first vice president to visit an abortion provider. Unlike Biden, who earlier in his political career held anti-abortion views, Harris has been consistent in her support of access to abortions. Read more from STAT’s Rachel Cohrs Zhang and Sarah Owermohle on Harris’s health care positions, and check out their story on what reproductive rights advocates and others in health and medicine think about Harris. And don’t forget — she’ll only become the official nominee if the party backs her at the convention next month. Read more from STAT’s John Wilkerson and Rachel about the other potential nominees. https://www.statnews.com/2024/07/21/kamala-harris-health-care-agenda-endorsed-by-abortion-rights-gruops-progressives/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-800FwVivXTAeJ2Iqb2S97hZHno6NfRZEnV2SNS88GoBSwXh2qx_e77YIX3rpBUmn_TSjdi5_yWx-z8ndQaGX7wQVeeoQ&_hsmi=316676560&utm_content=316676560&utm_source=hs_email Where 3 Democrats who could replace Biden atop the ticket stand on health care John Wilkerson Rachel Cohrs Zhang By John Wilkerson and Rachel Cohrs Zhang July 21, 2024 https://www.statnews.com/2024/07/21/biden-replacements-harris-whitmer-newsom-healthcare/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-_7fadBYXLcdDVk-d0JdxWI5qIf59A5e2Bp44m4Aujczrv1g5qZ38wE-Q158oV63EYCY7VhTXO7BQ0bOp8S5XMaHNVbpw&_hsmi=316676560&utm_content=316676560&utm_source=hs_email

Rise in social media's harms The Lancet Regional Health – Southeast Asia

https://www.thelancet.com/journals/lansea/issue/vol26nonull/PIIS2772-3682(24)X0007-4

Policy implementation and recommended actions to create healthy food environments using the Healthy Food Environment Policy Index (Food-EPI): a comparative analysis in South Asia

https://www.thelancet.com/journals/lansea/article/PIIS2772-3682(24)00078-7/fulltext?dgcid=hubspot_update_feature_updatealerts_lansea&utm_campaign=update-lansea&utm_medium=email&_hsenc=p2ANqtz-9N4ew8H4PyRSaB3pH6bXRJXntDLQ8CcrjXzb2BanXsvh7HAWHxAqsgZZ5ktrtes0kH5WoBMbr-uZPEziuUtNfb32XqeQ&_hsmi=316670270&utm_content=316447178&utm_source=hs_email

Household food insecurity, dietary diversity with undernutrition among children younger than five years in Indian subcontinent–a narrative review

https://www.thelancet.com/journals/lansea/article/PIIS2772-3682(24)00076-3/fulltext?dgcid=hubspot_update_feature_updatealerts_lansea&utm_campaign=update-lansea&utm_medium=email&_hsenc=p2ANqtz-8Bjif9NUgIvyLlc8L0U23QtPfb0jT9ZrHqEKF09YIkAzm6ShgB5-nNXU6062ewNL0MT2-8fH6-mZwKGJRa71as1VLOtw&_hsmi=316670270&utm_content=316447178&utm_source=hs_email

The Rising Tide: Trends and Challenges of Lung Cancer in Asia Published: July 8, 2024

Lung cancer is a significant public health issue in Asia, representing one of the leading causes of cancer-related mortality. The incidence of both non-small cell lung cancer and small-cell lung cancer in this region is high, driven by high rates of smoking, air pollution, and specific genetic mutations. Despite ongoing research and health-care efforts, the rising incidence and mortality rates of lung cancer pose an urgent challenge for health-care systems across Asia. In this Series of three Review articles published in eClinicalMedicine, The Lancet Regional Health – Western Pacific, and The Lancet Regional Health – Southeast Asia, Roselle de Guzman and colleagues explore the impact of climate change on lung cancer rates in the region, including screening, early detection, management, and treatment; Yi-Long Wu and colleagues highlight the development of genetic testing technology in the Western Pacific region; and Kumar Prabhash and colleagues examine the unique factors that are associated with lung cancer in Southeast Asian population. https://www.thelancet.com/series/lung-cancer-asia?dgcid=hubspot_update_feature_infocusoncology_lungcancerasia24_lansea&utm_campaign=update-lansea&utm_medium=email&_hsenc=p2ANqtz-96Coj3hok4mknkNShplGx3lQvPTmVvt6XHdMJbKyQgFUFLUJe7-WVKcmSrQsCwvrGjorQLLvYXXQXRJgOr27aJMSb_4Q&_hsmi=316670270&utm_content=316447178&utm_source=hs_email

IAPAC-Lancet HIV Commission on the future of urban HIV responses

Cities are home to a disproportionate number of many countries’ population of people living with HIV. The future of urban HIV responses is therefore crucial to the future of the global HIV epidemic. The Commission report offers cities and their communities an equity-centred, rights-based framework to guide the future direction of urban HIV responses in line with Sustainable Development Goal (SDG) 3.3 of ending the HIV epidemic by 2030. https://www.thelancet.com/infographics-do/urban-hiv-responses?dgcid=hubspot_email_conferencealerts_lanhivftc24&utm_campaign=conferencealerts&utm_medium=email&_hsenc=p2ANqtz--0Bxqx5CdG9mO7hDYtR89lgcuQz0ZRQCVXk3FbNhs-OqIlnifXmkiFh__xkDmXNoPYHcgWBvHs1qTfDbXPG6P1Y6tvFg&_hsmi=316285152&utm_content=316285152&utm_source=hs_email

The IAPAC–Lancet HIV Commission on the future of urban HIV responses Published: July 20, 2024

With urbanisation trends projecting more than twice as many people in the world will be living in urban versus rural settings by 2050, cities have an increasingly important role to play in achieving the health-related Sustainable Development Goals (SDGs), including ending the HIV epidemic by 2030 (SDG 3.3). The International Association of Providers of AIDS Care (IAPAC)–Lancet HIV Commission on the Future of Urban HIV Responses report centres health equity in urban HIV responses, with cross-cutting recommendations made across intersectional domains. Among these domains are the right to health, health system resilience, syndemic conditions and comorbidities, social determinants of health, and data-driven accountability. The report also proposes opportunities to accelerate progress towards SDG 3.3, and more broadly SDG 10 (making cities inclusive, safe, resilient, and sustainable), with the aim of guiding local, national, and international stakeholders in their efforts to optimise urban HIV responses. https://www.thelancet.com/commissions/urban-hiv-responses?dgcid=hubspot_email_conferencealerts_lanhivftc24&utm_campaign=conferencealerts&utm_medium=email&_hsenc=p2ANqtz-83ILwGKcuP14L-PTkoz0ojfFgNC6b3JOlRCn6YLAZdQSJrNEjcMnluuAoVVAywDj8ej6USKfaPGhjWV4Lo6ZSKRwqtrg&_hsmi=316285152&utm_content=316285152&utm_source=hs_email

Additive Construction – The Path to Standardization II

https://www.nist.gov/news-events/events/2024/08/additive-construction-path-standardization-ii Join us on August 20th and 21st at the National Cybersecurity Center of Excellence for the 2nd annual in-person, hands-on workshop focusing on standardization for additive construction, or 3D printing with concrete. Registration closes August 9th so don't delay! Sponsored by NIST in partnership with the US Army Engineer Research and Development Center (ERDC), the two-day event will drill down on core issues in standards, codes, and design guidelines. Discussions will contribute to the development of a roadmap for standardization of printing and testing methods. Also, the consortium, Additive Construction by Extrusion (ACE) Consortium, is active on the Federal Register. The Consortium will bring together stakeholders to identify and address gaps in current standards related to materials, methods, structural performance, and engineering design. The Consortium efforts are intended to study the measurement science needs for the successful adoption of ACE by the construction industry, and to identify and propose new standards to address industry needs not met by existing standards. The next meeting will take place at the conclusion of the ACE workshop on the 21st. Followed by ASTM F42.07.07 committee meetings.

Drug Trials Snapshots: DAYBUE (trofinetide)

DAYBUE is a prescription medicine that is used to treat Rett syndrome in adults and children 2 years of age and older. https://www.fda.gov/drugs/drug-approvals-and-databases/drug-trials-snapshots-daybue

Clinical Pharmacology Considerations for Human Radiolabeled Mass Balance Studies JULY 2024

https://www.fda.gov/regulatory-information/search-fda-guidance-documents/clinical-pharmacology-considerations-human-radiolabeled-mass-balance-studies

CDRHNew - News and Updates A comprehensive list of the latest CDRH updates.

https://www.fda.gov/medical-devices/medical-devices-news-and-events/cdrhnew-news-and-updates

Rescue From Above: How Drones May Narrow Emergency Response Times By Michelle Andrews JULY 22, 2024

https://kffhealthnews.org/news/article/drone-emergency-medical-response-times/ Starting in September, if someone in Clemmons, North Carolina, calls 911 to report a cardiac arrest, the first responder on the scene may be a drone carrying an automated external defibrillator, or AED.

Harris, Once Biden’s Voice on Abortion, Would Take an Outspoken Approach to Health By Stephanie Armour and Julie Appleby and Julie Rovner JULY 21, 2024

https://kffhealthnews.org/news/article/kamala-harris-health-agenda-abortion-womens-health-2024-election/ Throughout Joe Biden’s presidency, he leaned on the outspoken former prosecutor and senator he selected as his vice president, Kamala Harris, to be the White House’s voice of unflinching support for reproductive health rights.

domingo, 21 de julio de 2024

Glial cell transplant for brain diseases: the supportive saviours?

https://transmedcomms.biomedcentral.com/

COVID-19 antibody responses in individuals with natural immunity and with vaccination-induced immunity: a systematic review and meta-analysis

https://systematicreviewsjournal.biomedcentral.com/

Psychometric validation of the Chinese Version of the stimulant relapse risk scale (SRRS) in patients with methamphetamine use disorder

https://substanceabusepolicy.biomedcentral.com/

Job demands and resources perceived by hybrid working employees in German public administration: a qualitative study

https://occup-med.biomedcentral.com/

Nutritional status, dietary quality and eating disturbance issues among people with dementia in Vietnam: evidence of a cross-sectional study

https://jhpn.biomedcentral.com/

Comparing online and onsite simulation modules for improving knowledge and confidence in disaster preparedness among undergraduate medical students

https://intjem.biomedcentral.com/

International Journal of Mental Health Systems

https://ijmhs.biomedcentral.com/

Frailty and its association with long-term mortality among community-dwelling older adults aged 75 years and over

https://ijhpr.biomedcentral.com/

Comparative study on the impact of ‘Infographic versus video feedback’ on enhancing students’ clinical skills in basic life support

https://bmcmededuc.biomedcentral.com/

The impact of deep learning on environmental science

https://bmcenvsci.biomedcentral.com/

Computing cell state discriminates the aberrant hematopoiesis and activated microenvironment in Myelodysplastic syndrome (MDS) through a single cell genomic studyComputing cell state discriminates the aberrant hematopoiesis and activated microenvironment in Myelodysplastic syndrome (MDS) through a single cell genomic study

https://translational-medicine.biomedcentral.com/

Case report of pharmacokinetic analysis of continuous intravenous infusion of fentanyl in a patient with severe burn: burn shock stage complicates pain management

https://jphcs.biomedcentral.com/

Differential training benefits and motor unit remodeling in wrist force precision tasks following high and low load blood flow restriction exercises under volume-matched conditions

https://jneuroengrehab.biomedcentral.com/

Effect of VAChT reduction on lung alterations induced by exposure to iron particles in an asthma model

https://journal-inflammation.biomedcentral.com/

The cross-talk between the macro and micro-environment in precursor lesions of pancreatic cancer leads to new and promising circulating biomarkers

https://jeccr.biomedcentral.com/

Spatial intra-tumour heterogeneity and treatment-induced genomic evolution in oesophageal adenocarcinoma: implications for prognosis and therapy

https://genomemedicine.biomedcentral.com/

Mapping the influence of hydrocarbons mixture on molecular mechanisms, involved in breast and lung neoplasms: in silico toxicogenomic data-mining

https://genesenvironment.biomedcentral.com/

The potential impact of dietary choices on melanoma risk: an anti-inflammatory diet

https://genesandnutrition.biomedcentral.com/

Cellular and molecular mechanisms of the blood–brain barrier dysfunction in neurodegenerative diseases

https://fluidsbarrierscns.biomedcentral.com/

Gestational exposure to environmental chemicals and epigenetic alterations in the placenta and cord blood mononuclear cells

https://epicom.biomedcentral.com/

Reproductive history is associated with functional disabilities and symptoms in women with knee osteoarthritis: a case-control study

https://bmcresnotes.biomedcentral.com/

A systematic review of the drug-drug interaction between Statins and Quinolones

https://bmcpharmacoltoxicol.biomedcentral.com/

sábado, 20 de julio de 2024

Journalists Discuss FTC and Supreme Court Actions — And What’s Up With the Bird Flu JULY 13, 2024

https://kffhealthnews.org/news/article/on-air-july-13-2024-ftc-pbm-bird-flu-purdue-pharma/?utm_campaign=KHN%20-%20Weekly%20Edition&utm_medium=email&_hsenc=p2ANqtz-9tEHWv9Y45F3KRGU-K77G4f3zJsBEfe0ZSFpu2YHZpBvwE36-WTuwpapEidddRTPiOycWufrEkSrS1XUIRI9qypZfjWA&_hsmi=316539109&utm_content=316539109&utm_source=hs_email Journalists Discuss FTC and Supreme Court Actions — And What’s Up With the Bird Flu KFF Health News and California Healthline staff made the rounds on national and local media in recent weeks to discuss topical stories. Here’s a collection of their appearances.

Listen to the Latest ‘KFF Health News Minute’ JULY 16, 2024

https://kffhealthnews.org/news/article/listen-to-the-latest-kff-health-news-minute-2024/?utm_campaign=KHN%20-%20Weekly%20Edition&utm_medium=email&_hsenc=p2ANqtz--NDxKPag1xUOqxrJLFdvDiteWV9waN5Acvgh_vZUsqhbAzELoawP0azulZFSs7PgHzmTyZXM51-fFWJZExTTQEDalYDA&_hsmi=316539109&utm_content=316539109&utm_source=hs_email Listen to the Latest 'KFF Health News Minute' "Health Minute" brings original health care and health policy reporting from the KFF Health News newsroom to the airwaves each week.

The Woman Who Beat an $8,000 Hospital Fee SEASON 11, EPISODE 9 JULY 17, 2024

https://kffhealthnews.org/news/podcast/woman-who-beat-hospital-facility-fee/?utm_campaign=KHN%20-%20Weekly%20Edition&utm_medium=email&_hsenc=p2ANqtz-8ygZFarbLgnuK9oAv7iXtIM984nfPjEXiozDTjGaBjCShTul6fAMWjkJS3txxvDhqWnBLz6UhaOqvVI7b3l-mbO0KMvw&_hsmi=316539109&utm_content=316539109&utm_source=hs_email An Arm and a Leg: The Woman Who Beat an $8,000 Hospital Fee By Dan Weissmann In this episode of “An Arm and a Leg,” host Dan Weissmann speaks with Georgann Boatright, a patient in Mississippi who was willing to drive to another state to avoid paying a steep fee to her local hospital.

Tennessee Agrees To Remove Sex Workers With HIV From Sex Offender Registry By Brett Kelman JULY 17, 2024

https://kffhealthnews.org/news/article/tennessee-sex-offender-registry-removing-sex-workers-hiv/?utm_campaign=KHN%20-%20Weekly%20Edition&utm_medium=email&_hsenc=p2ANqtz-8D4XP9ZMXP6gQxO1VskN6t0p0Fz1xUq1IopNgmeYhEE9j_ahk0_YnYGmamBLr8-JyzPDEq3BRQ7wd3IWgmTWpPTYQgtg&_hsmi=316539109&utm_content=316539109&utm_source=hs_email Tennessee Agrees To Remove Sex Workers With HIV From Sex Offender Registry By Brett Kelman For years, Tennessee has required anyone convicted of prostitution while HIV-positive to register as a sex offender for life. To settle DOJ and ACLU discrimination suits, the state has agreed to reverse course.

Before Michigan Legalized Surrogacy, Families Found Ways Around the Ban By Kate Wells, Michigan Public JULY 16, 2024

https://kffhealthnews.org/news/article/michigan-surrogacy-now-legal-parent-strategies/?utm_campaign=KHN%20-%20Weekly%20Edition&utm_medium=email&_hsenc=p2ANqtz--mCtcpbpScukU16YhiAUaTT_X36Smt7dPx5cBl1X00T-4p3134c0d95LNoPXxYFVccmpNEE4bIy9jv2oUk7_h4fPm9aw&_hsmi=316539109&utm_content=316539109&utm_source=hs_email Before Michigan Legalized Surrogacy, Families Found Ways Around the Ban By Kate Wells, Michigan Public Until this spring, Michigan was the only state that had a broad criminal ban on surrogacy. Many families say that left them in limbo: forcing them to leave the state to have children, finding strangers on Facebook who would carry their child, or going through the legal hassle of having to adopt their biological children.

Despite Past Storms’ Lessons, Long-Term Care Residents Again Left Powerless By Sandy West JULY 15, 2024

https://kffhealthnews.org/news/article/texas-blackouts-nursing-homes-long-term-care-disaster-preparedness-power-outage-generators/?utm_campaign=KHN%20-%20Weekly%20Edition&utm_medium=email&_hsenc=p2ANqtz--nWUolAOF47uW5GNsl6_EFw2meb7R46Nz6Euv-IkKPjiFxPvx9ddVycnT83aHIjOXiMjEUb-_vfexBKq_0ts3mDZ2d6A&_hsmi=316539109&utm_content=316539109&utm_source=hs_email Despite Past Storms’ Lessons, Long-Term Care Residents Again Left Powerless By Sandy West Even after multiple massive power outages — including one from a 2021 winter storm in Texas that prompted a U.S. Senate investigation — little has changed for older Americans in senior living facilities when natural disasters strike.

Colorado Poultry Workers Battle Bird Flu in Heat Wave as US Struggles to Contain Outbreak By Amy Maxmen UPDATED JULY 19, 2024 ORIGINALLY PUBLISHED JULY 15, 2024

https://kffhealthnews.org/news/article/bird-flu-cases-colorado-poultry-workers-virus-spread/ Colorado Poultry Workers Battle Bird Flu in Heat Wave as US Struggles to Contain Outbreak By Amy Maxmen So far, all nine cases reported nationally this year at dairy and poultry farms have been mild, consisting of respiratory symptoms and eye irritation. Scientists have warned that the virus could mutate to spread from person to person, like the seasonal flu, and spark a pandemic.

Montana’s Plan To Curb Opioid Overdoses Includes Vending Machines By Mara Silvers, Montana Free Press JULY 18, 2024

https://kffhealthnews.org/news/article/montana-opioid-overdoses-naloxone-narcan-vending-machines/?utm_campaign=KHN%20-%20Weekly%20Edition&utm_medium=email&_hsenc=p2ANqtz--qku5I5qfxSKMWZA2mWUyiifnl5ghA1GypSk20ehViza_grLfDEcXnlLL04iBUu-aLmo7tj-uo6xnyt0bhvppdfD2vhQ&_hsmi=316539109&utm_content=316539109&utm_source=hs_email Montana’s Plan To Curb Opioid Overdoses Includes Vending Machines By Mara Silvers, Montana Free Press Details about where the machines would go — and how they would help those most at risk — are sparse. The state has proposed using them to distribute naloxone and fentanyl testing strips.

California Health Care Pioneer Goes National, Girds for Partisan Skirmishes By Samantha Young JULY 15, 2024California Health Care Pioneer Goes National, Girds for Partisan Skirmishes By Samantha Young JULY 15, 2024

https://kffhealthnews.org/news/article/anthony-wright-qa-families-usa-health-policy/?utm_campaign=KHN%20-%20Weekly%20Edition&utm_medium=email&_hsenc=p2ANqtz-9lR08CZO4WeEIYsu2rFDQGCGoDLAI6cQTBUCuZupfkxRODP5TDks_OTLnCZDUXCArwo3lTm7zfzXXX0FoHSHcC3FTWzg&_hsmi=316539109&utm_content=316539109&utm_source=hs_email California Health Care Pioneer Goes National, Girds for Partisan Skirmishes By Samantha Young Anthony Wright, a champion for Californians’ health care rights, will take the helm of Families USA in Washington, D.C., where he plans to campaign for more affordable and accessible care nationally. He leaves Health Access California, where he helped outlaw surprise medical billing, require companies to report drug price increases, and cap hospital bills for uninsured patients.

HealthSherpa and Insurers Team Up To Curb Unauthorized ACA Enrollment Schemes By Julie Appleby JULY 16, 2024

https://kffhealthnews.org/news/article/healthsherpa-insurance-unauthorized-obamacare-signups/?utm_campaign=KHN%20-%20Weekly%20Edition&utm_medium=email&_hsenc=p2ANqtz-8znNakCyVDbdS0tpq5WaMAts6Z4FmP39AsfKYEMbcaBs8-j2UZtrPEBnNIdIpWFt31UxVjH6NPGNSQDP3zE0qcdV8HJg&_hsmi=316539109&utm_content=316539109&utm_source=hs_email HealthSherpa and Insurers Team Up To Curb Unauthorized ACA Enrollment Schemes By Julie Appleby The initiative targets the biggest incentive driving fraudulent sign-ups and plan switches: the commissions that rogue agents or large call centers seek

Misleading Ads Play Key Role in Schemes to Gin Up Unauthorized ACA Sign-Ups, Lawsuit Alleges By Julie Appleby JULY 19, 2024

https://kffhealthnews.org/news/article/aca-fraud-misleading-ads-unauthorized-signups-switches-obamacare/?utm_campaign=KHN%20-%20Weekly%20Edition&utm_medium=email&_hsenc=p2ANqtz-8J28QG3pADroj8joksdZ1zJhb4bfOxOwxBwCHkdyElJ_1N_V-1vu5jXOUU0Ay6CwLlOfKAxFSS7k_agKzZs0aMsZinLQ&_hsmi=316539109&utm_content=316539109&utm_source=hs_email Misleading Ads Play Key Role in Schemes to Gin Up Unauthorized ACA Sign-Ups, Lawsuit Alleges By Julie Appleby Misleading money-for-groceries ads helped lure people to call centers where some were enrolled in Affordable Care Act coverage — or switched from their existing plans — without their express permission, a new lawsuit alleges.

The Nation’s 911 System Is on the Brink of Its Own Emergency By Stephanie Armour JULY 17, 2024

https://kffhealthnews.org/news/article/911-outages-emergency-response-cellphone/?utm_campaign=KHN%20-%20Weekly%20Edition&utm_medium=email&_hsenc=p2ANqtz-89uGJL51yGBavCXT_tbfoUIJ3nK4CFnVp56xt95FzRYZ4j2GVFp8rgYrDCtXIPbUvQUMbWE2Ce7c6eTtNT9_BO4bbO2w&_hsmi=316539109&utm_content=316539109&utm_source=hs_email The Nation’s 911 System Is on the Brink of Its Own Emergency By Stephanie Armour 911 outages have hit at least eight states this year. They’re emblematic of problems plaguing emergency response communications due in part to wide disparities in capabilities and funding.

Rural Hospitals Built During Baby Boom Now Face Baby Bust By Tony Leys JULY 15, 2024

https://kffhealthnews.org/news/article/rural-hospitals-obstetrics-gynecology-birth-decline-labor-delivery/?utm_campaign=KHN%20-%20Weekly%20Edition&utm_medium=email&_hsenc=p2ANqtz-8WlQcrmzo6qMLff1pAxeIXesMTYWX5LXChBmdZtloqTxlVx-qIkR8eKziVNm8VBvunYAK9JXYH1_hiPA001y6kOOBE2g&_hsmi=316539109&utm_content=316539109&utm_source=hs_email Rural Hospitals Built During Baby Boom Now Face Baby Bust By Tony Leys Fewer than half of rural U.S. hospitals offer labor and delivery services. In some areas, births have dropped by three-quarters since the baby boom’s peak.

A California Medical Group Treats Only Homeless Patients — And Makes Money Doing It By Angela Hart JULY 19, 2024

https://kffhealthnews.org/news/article/california-homeless-medical-care-healthcare-in-action/?utm_campaign=KHN%20-%20Weekly%20Edition&utm_medium=email&_hsenc=p2ANqtz-_FU6udQE1D9cY7yvmz2aPm5sNTxhH-0ebNHCpVnnefPUAE0tKN00fYXi0W8NVZIHvp9k1DRRku-W7I-BEI37OMSQ6THg&_hsmi=316539109&utm_content=316539109&utm_source=hs_email A California Medical Group Treats Only Homeless Patients — And Makes Money Doing It By Angela Hart Healthcare in Action, a California medical group that exclusively serves homeless people, has tapped into growing demand and funding for street medicine services. Three years in, the innovative nonprofit is raking in revenue and serving thousands of people who otherwise might flock to the hospital for high-cost care.

Trump Is Wrong in Claiming Full Credit for Lowering Insulin Prices By Jacob Gardenswartz JULY 18, 2024

https://kffhealthnews.org/news/article/fact-check-trump-lower-insulin-prices-false/?utm_campaign=KHN%20-%20Weekly%20Edition&utm_medium=email&_hsenc=p2ANqtz--tZCssX7C08bE-RGaEjQTDOqMe_3N7Ysg0V_-fsmqYnUt6_DRjmB2AZAY_BKXa0zNvYE3lH2TEGSMGtChhpaddZ6InKw&_hsmi=316539109&utm_content=316539109&utm_source=hs_email Fact Check: Trump Is Wrong in Claiming Full Credit for Lowering Insulin Prices By Jacob Gardenswartz Though the Trump administration established a voluntary, temporary program lowering insulin costs for some older Americans on Medicare, the mandatory price caps implemented through Biden’s Inflation Reduction Act go significantly further.

JD Vance, Trump’s VP Pick, Says Media Twisted His Remarks on Abortion and Domestic Violence By Maria Ramirez Uribe, PolitiFact JULY 16, 2024

https://kffhealthnews.org/news/article/fact-check-jd-vance-trump-vice-president-nominee-views-on-abortion-domestic-violence/?utm_campaign=KHN%20-%20Weekly%20Edition&utm_medium=email&_hsenc=p2ANqtz-9Ekd5flFfsjYs14pBhGqiegtKojQQSokA2XylEI5JAfMSM3XV5GIX23FMkR95N209pcREiWy6MVt_7so7pphw5KWz8rA&_hsmi=316539109&utm_content=316539109&utm_source=hs_email JD Vance, Trump’s VP Pick, Says Media Twisted His Remarks on Abortion and Domestic Violence By Maria Ramirez Uribe, PolitiFact In his first interview after being named as the vice presidential pick by former President Donald Trump, Sen. JD Vance (R-Ohio) spoke about his previous statements on topics like abortion.

At GOP Convention, Health Policy Is Mostly MIA EPISODE 356 JULY 18, 2024

https://kffhealthnews.org/news/podcast/what-the-health-356-republican-convention-health-policy-july-18-2024/?utm_campaign=KHN%20-%20Weekly%20Edition&utm_medium=email&_hsenc=p2ANqtz-9uX2J2WV_Q4QkeJ0x2g8UBDvWl-f8_Mx3jj5qWVRvrYwApuzsZ57ThgcfKlDeOSgcdsC9r4R9Y463bJCpwc24SOeDGWg&_hsmi=316539109&utm_content=316539109&utm_source=hs_email KFF Health News' 'What the Health?' Podcast: At GOP Convention, Health Policy Is Mostly MIA After an assassination attempt last weekend sent former President Donald Trump to the hospital with minor injuries, the Republican National Convention went off with little mention of health care issues. And Trump’s newly nominated vice presidential pick, Sen. J.D. Vance of Ohio, has barely staked out a record on health during his 18 months in office — aside from being strongly opposed to abortion. Alice Miranda Ollstein of Politico, Sarah Karlin-Smith of the Pink Sheet, and Joanne Kenen of Johns Hopkins University and Politico Magazine join KFF Health News’ Julie Rovner to discuss these stories and more. Also this week, Rovner interviews KFF Health News’ Renuka Rayasam, who wrote June’s installment of KFF Health News-NPR “Bill of the Month,” about a patient who walked into what he thought was an urgent care center and walked out with an emergency room bill. 

At Trump’s GOP Convention, There’s Little To Be Heard on Health Care By Phil Galewitz JULY 19, 2024

https://kffhealthnews.org/news/article/donald-trump-gop-convention-platform-health-care-abortion/?utm_campaign=KHN%20-%20Weekly%20Edition&utm_medium=email&_hsenc=p2ANqtz-8Qv2K7Yu1NwCkpT47RbEXe9ecDJ_UAIkY1FA6fSZNgU32CpX_znmjwK5TQLyEnNEA9j-mq6kBn4wZvvJqrBTyIJ4sLOQ&_hsmi=316539109&utm_content=316539109&utm_source=hs_email At Trump’s GOP Convention, There’s Little To Be Heard on Health Care By Phil Galewitz Republicans were once the party of Obamacare repeal and abortion opposition. They’ve said little about either issue in Milwaukee.

Bill of the Month

Bill of the Month This crowdsourced investigation by KFF Health News and NPR dissects and explains your medical bills every month in order to shed light on U.S. health care prices and to help patients learn how to be more active in managing costs. Do you have a medical bill that you’d like us to see and scrutinize? https://kffhealthnews.org/news/tag/bill-of-the-month/?utm_campaign=KHN%20-%20Weekly%20Edition&utm_medium=email&_hsenc=p2ANqtz--8FB-noRgaHKWOoSa3ffNMqWwzD6mXDlyAdZvcyS_gs74M3-YuNKRWNlZEwhWAWlK-sn2J1uF7OKN2Iw30ilvuCwl2PA&_hsmi=316539109&utm_content=316539109&utm_source=hs_email

Her Hearing Implant Was Preapproved. Nonetheless, She Got $139,000 Bills for Months. By Elisabeth Rosenthal JULY 17, 2024

Her Hearing Implant Was Preapproved. Nonetheless, She Got $139,000 Bills for Months. By Elisabeth Rosenthal JULY 17, 2024 https://kffhealthnews.org/news/article/hearing-implant-preapproved-met-deductible-bill-of-the-month/?utm_campaign=KHN%20-%20Weekly%20Edition&utm_medium=email&_hsenc=p2ANqtz--_PYwuvfAaYsh8R_CL14YtRdZFc0NWJlovH4_6Lw8vBnIlhY1Ui7_ZmQ6auxmT-sMrMPNhGJgi9PYCa-KkfUSXfwAveA&_hsmi=316539109&utm_content=316539109&utm_source=hs_email Her Hearing Implant Was Preapproved. Nonetheless, She Got $139,000 Bills for Months. By Elisabeth Rosenthal Even when patients double-check that their care is covered by insurance, health providers often send them bills as they haggle with insurers over reimbursement, which can last for months. It’s stressful and annoying — but legal.

viernes, 19 de julio de 2024

In Conversation with...Jodi Sherman about Climate Change and Patient Safety Jodi Sherman, MD |

https://psnet.ahrq.gov/perspective/conversation-withjodi-sherman-about-climate-change-and-patient-safety

The Relationship Between Climate Change and Healthcare Quality and Safety Jodi Sherman, MD, Merton Lee, PharmD, PhD, Sarah Mossburg, RN, PhD |

https://psnet.ahrq.gov/perspective/relationship-between-climate-change-and-healthcare-quality-and-safety Climate change–related weather events are straining healthcare workers, disrupting physical infrastructure, and interrupting supply chains, making it more difficult to treat patients and threatening healthcare quality and safety.

UCSF Coordinating Center for Diagnostic Excellence (CoDEx). July 17, 2024

https://psnet.ahrq.gov/issue/ucsf-coordinating-center-diagnostic-excellence-codex

Total systems safety supports practitioners in partnering with families to protect patients. July 17, 2024

https://psnet.ahrq.gov/issue/total-systems-safety-supports-practitioners-partnering-families-protect-patients

AHRQ-Funded Patient Safety Project Highlights: Improving Patient Safety by Enhancing Care Coordination. July 17, 2024

https://psnet.ahrq.gov/issue/ahrq-funded-patient-safety-project-highlights-improving-patient-safety-enhancing-care

Rapid response systems, antibiotic stewardship and medication reconciliation: a scoping review on implementation factors, activities and outcomes. July 17, 2024

https://psnet.ahrq.gov/issue/rapid-response-systems-antibiotic-stewardship-and-medication-reconciliation-scoping-review

Lost, mislabeled, and mishandled surgical and clinical pathology specimens: a systematic review of published literature. July 17, 2024

https://psnet.ahrq.gov/issue/lost-mislabeled-and-mishandled-surgical-and-clinical-pathology-specimens-systematic-review

Telehealth safety framework: addressing a new frontier in patient safety. July 17, 2024

https://psnet.ahrq.gov/issue/telehealth-safety-framework-addressing-new-frontier-patient-safety

Methods to increase reliability in quality improvement projects. July 17, 2024

https://psnet.ahrq.gov/issue/methods-increase-reliability-quality-improvement-projects

"What do health inequities have to do with anything?". July 17, 2024

https://psnet.ahrq.gov/issue/what-do-health-inequities-have-do-anything

Towards understanding and improving medication safety for patients with mental illness in primary care: a multimethod study. July 17, 2024

https://psnet.ahrq.gov/issue/towards-understanding-and-improving-medication-safety-patients-mental-illness-primary-care

Physician specialty differences in unprofessional behaviors observed and reported by coworkers. July 17, 2024

https://psnet.ahrq.gov/issue/physician-specialty-differences-unprofessional-behaviors-observed-and-reported-coworkers

Performance of large language models on medical oncology examination questions. July 17, 2024v

https://psnet.ahrq.gov/issue/performance-large-language-models-medical-oncology-examination-questions

Impact of pharmacist-led discharge medication reconciliation on error and patient harm prevention at a large academic medical center. July 17, 2024

https://psnet.ahrq.gov/issue/impact-pharmacist-led-discharge-medication-reconciliation-error-and-patient-harm-prevention

From identifying patient safety risks to reporting patient complaints: a grounded theory study on patients' hospital experiences. July 17, 2024

https://psnet.ahrq.gov/issue/identifying-patient-safety-risks-reporting-patient-complaints-grounded-theory-study-patients

BONE break: a hot debrief tool to reduce second victim syndrome for nurses. July 17, 2024

https://psnet.ahrq.gov/issue/bone-break-hot-debrief-tool-reduce-second-victim-syndrome-nurses

A symptom-checker for adult patients visiting an interdisciplinary emergency care center and the safety of patient self-triage: real-life prospective evaluation. July 17, 2024

https://psnet.ahrq.gov/issue/symptom-checker-adult-patients-visiting-interdisciplinary-emergency-care-center-and-safety

Development of patient safety measures to identify inappropriate diagnosis of common infections. July 17, 2024

https://psnet.ahrq.gov/issue/development-patient-safety-measures-identify-inappropriate-diagnosis-common-infections Development of patient safety measures to identify inappropriate diagnosis of common infections. White AT, Vaughn VM, Petty LA, et al. Clin Infect Dis. 2024;78(6):1403-1411. Misdiagnosis of infections can lead to overuse of antibiotics and threaten patient safety. This article describes the development of two National Quality Forum (NQF)-endorsed measures of inappropriate diagnosis of urinary tract infection (UTI) and community-acquired pneumonia (CAP). Both measures demonstrated strong validity and reliability through testing with patient focus groups and case review. Implementation evaluation across more than 40 Michigan hospitals demonstrated significant decreases in inappropriate diagnoses of UTI and CAP, indicating broad usability of these measures to support improved outcomes.

Systematic review of types of safety incidents and the processes and systems used for safety incident reporting in care homes. July 17, 2024

https://psnet.ahrq.gov/issue/systematic-review-types-safety-incidents-and-processes-and-systems-used-safety-incident Systematic review of types of safety incidents and the processes and systems used for safety incident reporting in care homes. Scott J, Sykes K, Waring J, et al. J Adv Nurs. 2024;Epub Jun 19. Incident reporting systems are commonly used to detect threats to patient safety. This systematic review of 106 studies examined the characteristics of incident reporting processes in residential care facilities and nursing homes in high-income countries. The authors summarize how incidents are detected; common contributing, mitigating, and ameliorating factors; as well as actions and interventions to reduce the risk of patient safety incidents.

A symptom-checker for adult patients visiting an interdisciplinary emergency care center and the safety of patient self-triage: real-life prospective evaluation. July 17, 2024

https://psnet.ahrq.gov/issue/symptom-checker-adult-patients-visiting-interdisciplinary-emergency-care-center-and-safety A symptom-checker for adult patients visiting an interdisciplinary emergency care center and the safety of patient self-triage: real-life prospective evaluation. Meer A, Rahm P, Schwendinger M, et al. J Med Internet Res. 2024;26:e58157. Patients presenting to the emergency department (ED) are triaged to prioritize care based on level of illness. In this study, 2,543 patients presenting to an ED in Switzerland were asked to self-triage using an electronic symptom-checker. (Patients were triaged and treated based on standard-of-care nurse triage.) Recommendations were given regarding time to treat (e.g., emergency) and point-of-care (e.g., self-care) and subsequently evaluated by three panels of experts. Fifty of the 2,543 patients were judged as undertriaged, but none were judged as potentially hazardous.

jueves, 18 de julio de 2024

Men’s Health is Falling Behind – Some Thoughts About Why

https://www.fda.gov/news-events/fda-voices/mens-health-falling-behind-some-thoughts-about-why?utm_medium=email&utm_source=govdelivery As I described in my previous blog, the trajectory of men’s health in the U.S. is headed in a negative direction. As we develop approaches to reversing these trends of declining life expectancy, excess chronic disease and disproportionate risk taking, it behooves us to examine the potential underlying reasons for this decline. Three key parts of the men’s health puzzle relate to income, employment and education, which paradoxically have evidence of both cause and effect in this context. As I discussed in my previous blog, male labor force participation has dropped from 80% in 1970 to 68% in 2020. While this is partly due to the fact that men disproportionately work in fields impacted by automation, poor health also plays a significant role: 26% of men of prime working age report being unable to work because of sickness, compared to 18% of women. Men are also falling behind in educational attainment: In 1972, the proportion of men to women receiving bachelor’s degrees favored men by 12 percent but by 2021, only 4 in 10 college students were men. This gap, which is also widening globally, is even greater for Black and Hispanic men in the U.S. These changes are occurring as our country, and indeed much of the world, is undergoing a transition to economies driven by knowledge and high technology.

Advancing Generic Drug Development: Translating Science to Approval 2024 SEPTEMBER 24 - 25, 2024

https://www.fda.gov/drugs/news-events-human-drugs/advancing-generic-drug-development-translating-science-approval-2024-09242024

Disease Awareness and Prescription Drug Communications on Television: Evidence for Conflation and Misleading Product Impressions

https://www.fda.gov/drugs/spotlight-cder-science/disease-awareness-and-prescription-drug-communications-television-evidence-conflation-and-misleading?utm_medium=email&utm_source=govdelivery Spotlight on CDER Science Examines Impact of Disease Awareness and Prescription Drug Television Communications on Consumer Conflation In this Spotlight on CDER Science, CDER researchers conducted two experimental studies among adult asthma patients to determine how the similarity, proximity, and frequency of exposure to a disease awareness communication and prescription drug television advertisement impact consumer perception and understanding of the benefits and risks of a prescription drug. Consumers sometimes conflate the information in disease awareness communications with information presented in prescription drug promotional materials. Previous CDER research has found that conflation occurs when disease awareness and drug promotional materials are viewed in print or on the web. Knowing which advertising features cause conflation is important because it offers an opportunity for pharmaceutical companies to consider these features when developing prescription drug advertising and disease awareness communications.

Pediatric Inflammatory Bowel Disease: Developing Drugs for Treatment JULY 2024

https://www.fda.gov/regulatory-information/search-fda-guidance-documents/pediatric-inflammatory-bowel-disease-developing-drugs-treatment?utm_medium=email&utm_source=govdelivery FDA issued a draft guidance for industry, “Pediatric Inflammatory Bowel Disease: Developing Drugs for Treatment,” to help sponsors in the clinical development of drugs to treat pediatric patients with inflammatory bowel disease (IBD). Specifically, this guidance provides the agency’s recommendations for clinical study attributes for pediatric ulcerative colitis or pediatric Crohn’s disease treatments, including: study design, study population, efficacy considerations, and safety assessments. This is the agency’s first guidance focused on clinical studies for pediatric IBD treatments. When finalized, this guidance will represent FDA’s current thinking on this topic. We encourage interested parties to submit comments by September 16, 2024, to ensure consideration before FDA begins work to finalize this guidance.

Still time to contain artemisinin resistance in Africa The Lancet Microbe

https://www.thelancet.com/journals/lanmic/issue/vol5no7/PIIS2666-5247(24)X0008-7

miércoles, 17 de julio de 2024

Webinar - July 25: Using AHRQ Resources To Enhance Surgical Team Communication

Webinar - July 25: Using AHRQ Resources To Enhance Surgical Team Communication: SOPS Webcasts

Webinar, July 24: Medication Without Harm - How Digital Healthcare Tools Can Support Providers and Improve Patient Safety

Webinar, July 24: Medication Without Harm - How Digital Healthcare Tools Can Support Providers and Improve Patient Safety: Health IT news

Optimizing the use of dose error reduction software on intravenous infusion pumps.

https://psnet.ahrq.gov/issue/optimizing-use-dose-error-reduction-software-intravenous-infusion-pumps

Building a resilient patient safety culture: a large healthcare organization's approach to systematically reviewing serious harm events.

https://psnet.ahrq.gov/issue/building-resilient-patient-safety-culture-large-healthcare-organizations-approach

Evaluating the prevalence of four recommended practices for suicide prevention following hospital discharge.

https://psnet.ahrq.gov/issue/evaluating-prevalence-four-recommended-practices-suicide-prevention-following-hospital

Identifying and measuring administrative harms experienced by hospitalists and administrative leaders.

https://psnet.ahrq.gov/issue/identifying-and-measuring-administrative-harms-experienced-hospitalists-and-administrative

Use of Telehealth Among Medical Visits in the United States: Results From the 2021 Medical Expenditure Panel Survey

https://www.acpjournals.org/doi/10.7326/M24-0137

Barriers and facilitators to guideline concordant dental antibiotic prescribing in the United States: A qualitative study of the National Dental PBRN

https://pubmed.ncbi.nlm.nih.gov/38558016/

Completion Rates and Timeliness of Diagnostic Colonoscopies for Rectal Bleeding in Primary Care

https://pubmed.ncbi.nlm.nih.gov/37940753/

A Nationally Representative Summary of 2020 Changes in the Use of Health Care in the United States

https://pubmed.ncbi.nlm.nih.gov/38345888/

A systematic review of experimentally tested implementation strategies across health and human service settings: evidence from 2010-2022

https://pubmed.ncbi.nlm.nih.gov/38915102/

Patient perceptions of and experiences with stigma using telehealth for opioid use disorder treatment: a qualitative analysis

https://pubmed.ncbi.nlm.nih.gov/38937779/

The emergency department trigger tool: Multicenter trigger query validation

https://pubmed.ncbi.nlm.nih.gov/38497320/

Development of a multimodal geomarker pipeline to assess the impact of social, economic, and environmental factors on pediatric health outcomes

https://pubmed.ncbi.nlm.nih.gov/38733117/

Patient Partnership Tools to Support Medication Safety in Community-Dwelling Older Adults: Protocol for a Nonrandomized Stepped Wedge Clinical Trial

https://pubmed.ncbi.nlm.nih.gov/38684080/

Political restoration The Lancet Planetary Health

https://www.thelancet.com/journals/lanplh/issue/vol8no7/PIIS2542-5196(24)X0008-X

FDA | NIH : Regulatory Do’s and Don’ts: Tips from FDA SEPTEMBER 4, 2024

https://www.fda.gov/drugs/news-events-human-drugs/fda-nih-regulatory-dos-and-donts-tips-fda-09042024?utm_medium=email&utm_source=govdelivery The webinar aims to educate early-stage companies (small businesses) new to the regulatory landscape at the FDA. This activity is intended to provide an overview on resources and programs that FDA has developed across CBER, CDER, and CDRH that can help academic life-science accelerators and early-stage, oncology-related companies, develop new anticancer-therapeutics, devices, and diagnostics. The target audience is entrepreneurs new to the FDA regulatory world that could benefit from support in better understanding when to contact the Agency during preclinical development. Additionally, there will be a Q&A session at the end of each session for the audience to ask questions.

FDA Rare Disease Innovation Hub to Enhance and Advance Outcomes for Patients

https://www.fda.gov/news-events/fda-voices/fda-rare-disease-innovation-hub-enhance-and-advance-outcomes-patients?utm_medium=email&utm_source=govdelivery FDA Rare Disease Innovation Hub to Enhance and Advance Outcomes for Patients An estimated 10,000+ rare diseases affect more than 30 million people – approximately one out of every 10 people – in the U.S., and about half of these people are children. Many rare conditions are life threatening, and most do not have approved treatments. Fundamental to the mission of the U.S. Food and Drug Administration is to engage patients and caregivers – to understand their unique perspectives and experiences and keep these front of mind as we review medical products for rare disease patients. The Rare Disease Innovation Hub Recent rapid advances in the identification of promising drug targets and development of gene therapies offer momentum and potential to meet the needs of patients with rare diseases. In 2023, over half of all the novel drugs and biologics approved by the FDA’s Center for Drug Evaluation and Research (CDER) and the FDA’s Center for Biologics Evaluation and Research (CBER) were to prevent, diagnose or treat a rare disease or condition. While there have been important advances in treatments for rare diseases, more needs to be done. Many rare diseases lack treatment options and therefore many patients have high unmet medical needs. This requires new approaches to expedite development and approval of safe and effective drugs and biologics. We see huge potential in establishing a new model, within the FDA, to leverage cross-agency expertise and greatly enhance our intercenter connectivity to spur the development of treatments for rare diseases. To that end, we plan to establish a Rare Disease Innovation Hub (the Hub). The Hub will work across rare diseases but will especially focus on products intended for smaller populations or for diseases where the natural history is variable and not fully understood, as we recognize that development of therapies for these conditions can be particularly challenging. The Hub would have three primary functions: Serve as a single point of connection and engagement with the rare disease community, including patient and caregiver groups, trade organizations, and scientific/academic organizations, for matters that intersect CDER and CBER. The Hub will help the larger rare disease community navigate important intersections across the FDA that affect patients with rare diseases, such as medical devices, including diagnostic tests, and combination products. Enhance intercenter collaboration to address common scientific, clinical and policy issues related to rare disease product development, including relevant cross-disciplinary approaches related to product review, and promote consistency across offices and Centers. Advance regulatory science with dedicated workstreams for consideration of novel endpoints, biomarker development and assays, innovative trial design, real world evidence, and statistical methods.

Viewpoint: England’s Precision Breeding Act ‘remains an empty shell and serves no functional purpose’ — Will politics scuttle crop gene editing future? Mario Caccamo | July 16, 2024

https://geneticliteracyproject.org/2024/07/16/englands-precision-breeding-act-remains-an-empty-shell-and-serves-no-functional-purpose-will-politics-scuttle-crop-gene-editing-future/?mc_cid=95f3d33965&mc_eid=b73600b7ac

Book review: “Tell Me When It’s Over,” by Paul Offit Henry Miller, Kathleen Hefferon | July 16, 2024

https://geneticliteracyproject.org/2024/07/16/book-review-tell-me-when-its-over-by-paul-offit/?mc_cid=95f3d33965&mc_eid=b73600b7ac

‘Weapon of the future’: AI-powered war machines fuel potential new era of ‘killer robots’ Adam Satariano, Paul Mozur | New York Times | July 15, 2024

https://geneticliteracyproject.org/2024/07/15/weapon-of-the-future-ai-powered-war-machines-fuel-potential-new-era-of-killer-robots/?mc_cid=95f3d33965&mc_eid=b73600b7ac

Introduction to FDA’s Office of Trade and Global Partnerships JULY 23, 2024

https://www.fda.gov/drugs/news-events-human-drugs/introduction-fdas-office-trade-and-global-partnerships-07232024?utm_medium=email&utm_source=govdelivery

What’s New for Biologics - Guidance Agenda: Guidance Documents CBER is Planning to Publish During Calendar Year 2024

https://www.fda.gov/vaccines-blood-biologics/news-events-biologics/whats-new-biologics?utm_medium=email&utm_source=govdelivery

Clinical Conditions With Frequent, Costly Hospital Readmissions by Payer, 2020 STATISTICAL BRIEF #307 April 2024 H. Joanna Jiang, Ph.D., and Marguerite L. Barrett, M.S.

https://hcup-us.ahrq.gov/reports/statbriefs/sb307-readmissions-2020.jsp

martes, 16 de julio de 2024

From Awareness to Action: Tackling the Rising Burden of Common Chronic Diseases

https://www.fda.gov/news-events/fda-voices/awareness-action-tackling-rising-burden-common-chronic-diseases?utm_medium=email&utm_source=govdelivery Since graduating from medical school in 1978, I’ve seen medicine and healthcare change in unimaginable ways for the better. However, one of the most alarming changes is the recent decline in life expectancy in our country, largely due to the cumulative impact of common chronic diseases (CCDs), combined with excessive rates of suicide, drug overdose and gun violence, and, of course, COVID-19. How can it be that our prowess in technology is not translating into better health and longevity for the American public? Chronic Disease Day, marked earlier this month, originated in part from the recognition of these trends, now resulting in a serious state of affairs: 7 of the 10 leading causes of death in the U.S. are CCDs. But the recognition of the importance of chronicity of disease is a relatively new issue. The focus of my early career was heart attacks, which at that time killed about 50% of those affected. Today, due to advances in treatments for heart attacks that have transformed the field of cardiology with significant support from U.S. Food and Drug Administration policies supporting innovation and evidence generation, the vast majority of people survive heart attacks. However, many of these survivors go on to develop chronic conditions like heart failure. Chronic diseases of the heart, lung, kidneys, liver, and metabolism (such as obesity and diabetes) account for the vast majority of deaths in this country. Even many patients with cancer now can often expect to be long term survivors, although many cancer survivors continue to have chronic manifestations of the cancer or related diseases.

In Conversation With...Amy Helwig about Health Plan Patient Safety Initiatives Amy Helwig, MD, MS, FAAFP, Zoe Sousane, BS, Sarah Mossburg, RN, PhD | July 10, 2024

https://psnet.ahrq.gov/perspective/conversation-withamy-helwig-about-health-plan-patient-safety-initiatives Editor’s note: Amy Helwig, MD, MS, FAAFP, is the Chief Quality Officer at Commonwealth Care Alliance. We spoke to her about the health plan’s role in monitoring and improving patient safety.

Health Plan Patient Safety Initiatives Amy Helwig, MD, MS, FAAFP, Zoe Sousane, BS, Sarah Mossburg, RN, PhD | July 10, 2024

https://psnet.ahrq.gov/perspective/health-plan-patient-safety-initiatives Health Plan Patient Safety Initiatives This Perspective essay and interview explores the health plan’s role in improving #patientsafety, including how health plans are monitoring patient safety and health plan-level initiatives to improve patient safety.

Missed Compartment Syndrome after Steep Lithotomy Position for Laparoscopic Gynecological Surgery Christian Bohringer, MB BS and Gustavo Chavez, MD | July 10, 2024

https://psnet.ahrq.gov/web-mm/missed-compartment-syndrome-after-steep-lithotomy-position-laparoscopic-gynecological Missed Compartment Syndrome after Steep Lithotomy Position for Laparoscopic Gynecological Surgery In this WebM&M Case, a 36-year-old woman with class 2 obesity underwent a difficult laparoscopic hysterectomy, performed in the lithotomy position with a steep head down (Trendelenburg) position. Intermittent pneumatic compression devices were placed on both calves to prevent venous thrombosis (DVT), but on awakening from general anesthesia, the patient complained of severe pain in the right leg. The gynecologist made a presumptive diagnosis of DVT and put her on subcutaneous dalteparin at therapeutic dosing and acetaminophen and oral morphine for pain relief. The patient continued to complain of severe pain and paresthesias in her right calf and doppler ultrasound scan was negative for DVT. The next day the orthopedic on-call team was consulted and diagnosed compartment syndrome of the right leg. The patient required fasciectomy of the right leg and excision of necrotic muscle tissue, with a prolonged hospital stay. The commentary discusses how patient positioning during surgery can increase the risk for surgical complications, the role of interdisciplinary teamwork to achieve optimal positioning, and the importance of early identification of compartment syndrome to prevent permanent injury.

Hemorrhagic Shock after Elective Spine Surgery: Failure to Rescue after Limited Response to Nursing Concerns. Scott Zakaluzny, MD, FACS | July 10, 2024

https://psnet.ahrq.gov/web-mm/hemorrhagic-shock-after-elective-spine-surgery-failure-rescue-after-limited-response-nursing Hemorrhagic Shock after Elective Spine Surgery: Failure to Rescue after Limited Response to Nursing Concerns In this WebM&M Spotlight Case with CE/MOC, a 67-year-old man with severe low back pain was admitted to the hospital for anterior lumbar interbody fusion (ALIF) with bone autograft from the iliac crest. The surgical team had difficulty achieving intraoperative hemostasis and the patient left the operating room (OR) with the bone graft donor site open and oozing blood. He was still bleeding in the postanesthesia care unit (PACU), where the nurse called the attending physician three times to report hypotension and oozing blood. Each time, the surgeon ordered hetastarch for volume expansion. Over the next 14 hours, the patient’s blood pressure remained at or below 90/60 with a weak and thready pulse and continued complaints of back and pelvic pain. The next morning, the patient was unresponsive and in hypovolemic shock. Electrocardiography confirmed a non-ST segment elevation myocardial infarction (NSTEMI). The patient was transferred to an intensive care unit and resuscitative efforts were initiated, but the patient expired from multiorgan failure resulting from hypovolemic shock.

What “Death Panels” Can Teach Us About Health Misinformation Drew Altman Published: Jul 16, 2024

https://www.kff.org/from-drew-altman/what-death-panels-can-teach-us-about-health-misinformation/?utm_campaign=KFF-Drew-Columns&utm_medium=email&_hsenc=p2ANqtz-_XgtAAK3Nn8gKAec6usrxwDZxcYFciswmJHaeHpgj2Td8iKRwjKuTxgzwgUUAK319K1oN7AzeoXefw9M90HIbgMAc_ig&_hsmi=315874529&utm_content=315874529&utm_source=hs_email What “Death Panels” Can Teach Us About Health Misinformation In 2009, former governor Sarah Palin took a provision in the Affordable Care Act (ACA) allowing Medicare payment for doctors to spend time discussing end-of-life issues with patients, sprinkled it with pixie dust, and turned it into the idea that there were “death panels” in Obamacare. It was like pouring gasoline on the already fiery partisan battles about the law. Republican politicians started to echo the myth. Death panels were quickly all over the news. In an entirely well-intentioned effort to play umpire for the American people, the news media sought to provide the facts including, and especially, by debunking the lie about death panels. Pundits, reporters and experts on television news and newspaper stories provided the truth—there were no death panels in the law. Some of the facts may have reached the public, but what people mostly “heard” was a constant refrain: DEATH PANELS. In the end, the lie was elevated—not debunked—and the news agenda was hijacked by the misinformation it was trying to correct. For Palin’s misinformation gambit to succeed, it had to tap into something real (there is usually a shred of belief or fact underlying misinformation people can grab on to.) In this case, it was the dislike the far right had for President Obama and for the federal government. And it was true that doctors were to have conversations with seniors about the end of life, something almost everyone in health care was calling for, although these were about honoring patient’s wishes and, notably, the provision authorizing Medicare payment was not included in the final law. One way we know about the amplification of the death panel myth is from our polling (the kind of polling we are replicating now in our health misinformation tracking polls). In 2010, a remarkable 41% of the public said they believed there were death panels in the ACA. And the lie persisted: in 2014, the same number said there were death panels in the law. In 2019, the number was still 38%. By 2023, as the law became more popular and Obama faded from the scene, the number who believed the lie fell to 8%. But the myth still had some staying power: 70% still said they weren’t sure if there were death panels in the ACA. The Palin death panels example is now eerily familiar. Most of the misinformation in health today is initially generated by a small number of actors and, despite the impression that it is everywhere, is viewed by a relatively small number of people on social media. An even smaller number actively engage with it by posting about it or sharing it with others. It’s when misinformation then gets mixed into politics and news media coverage and amplified that it can take off, reach significant numbers of people, and have a larger national effect. The big, if somewhat unique, example of this multiplier effect was with the COVID-19 vaccine. Former president Trump, some other Republican governors, and conservative media outlets made the vaccine a symbol of resistance to the heavy hand of the federal government, and made not getting the shot an affirmation of personal freedom, sharply dividing the country along partisan lines on the COVID vaccine (Understanding the US failure on coronavirus—an essay by Drew Altman | The BMJ). The result: in our monthly Vaccine Monitor surveys throughout the pandemic, party affiliation was the strongest predictor of almost any position we asked about on COVID. Most cases of health misinformation, however, are not fueled by a president and do not capture the attention of the entire nation. Vaccines are also a somewhat unique case too, because there has long been a well-organized anti-vaccine movement. Take as one more example, the “Meet Baby Olivia” video. Baby Olivia was a video on fetal development, which was posted on Facebook in 2021 by the anti-abortion group Live Action. The American College of Obstetricians and Gynecologists said the video was “designed to manipulate the emotions of viewers rather than to share evidence-based, scientific information about embryonic and fetal development.” At its highpoint, in June 2022, the Baby Olivia video generated 4,700 comments on Facebook, and as a guestimate based on similar social media posts, maybe three or four times that much overall engagement in the form of likes, shares or comments. That’s a lot of people at a town hall or campaign rally, but a minuscule number both on Facebook on any given day and in terms of potential impact on the public. But then, like a smaller scale version of the dynamic we saw play out with death panels, Baby Olivia became a political issue. A legislative proposal was made in North Dakota and then in nine more states requiring that schools show baby Olivia or a similar video to students. Media coverage of the controversy surrounding the legislation mushroomed. Baby Olivia escaped its initial niche on Facebook and became a much bigger phenomena. It may be that we are exaggerating the impact of a lot of sensationalistic, untrue, and ideologically motivated misinformation on social media, partly because it can be so outrageous, when it actually reaches small numbers of already like-minded people who seek it out. What may matter far more is how it sometimes spreads outward from social media to politics, finds prominent political surrogates, and garners general media attention. That’s when it reaches much larger populations who may be uncertain about what’s true and what is not and can be persuaded by it. Media segmentation along partisan lines and the chase for clicks create a perverse incentive that can amplify misinformation further: the more outrageous and sensational the misinformation, the more visibility it and its purveyors are likely to get. Political and news media amplification then leads to renewed social media attention, creating an unvirtuous cycle of misinformation. The best solution is to prevent misinformation, and those who peddle it, from getting a foothold on social media in the first place. However, policing misinformation on social media is largely the job of social media platform companies who, under cover of the tech swoon, have been backing away from self-regulation. The government does not have the authority to regulate misinformation on the platforms in the U.S., although a recent Supreme Court decision gave the government license to continue to communicate with platform companies about misinformation for now. The news media will and should cover compelling and timely health politics stories, such as anti-Obamacare rallies or state laws requiring anti-abortion videos in schools. As the death panel experience shows, sometimes it can be tricky to do so without inadvertently elevating misinformation and those who spread it. However, the primary focus of reporters and editors is on their beats and stories, not confronting misinformation. Fact checking in news organizations is organized as a separate function and product, and its purpose is narrower; it is mostly about holding candidates and elected officials accountable for wrong numbers and statements. There are a few journalists who have made misinformation a beat or a regular focus, and very few in health (including several in our newsroom). And while it’s not health misinformation, you can see the media struggling to walk the line between calling out extreme misinformation on social media and elevating it in the aftermath of the Trump assassination attempt. More fundamentally, the news media generally sees itself as being in the business of covering the news, not educating the public or addressing deficits in public knowledge. How to navigate the misinformation minefield is one of the issues we plan to take up working with the journalism community across the country in our new Health Misinformation and Trust Initiative.