jueves, 11 de abril de 2024

Let us to the TWISST; Plan, Simulate, Study and Act. April 10, 2024 Colman N, Hebbar KB. Pediatr Qual Saf. 2023;8(4):e664.

https://psnet.ahrq.gov/innovation/let-us-twisst-plan-simulate-study-and-act

Equity M&M - adaptation of the morbidity and mortality conference to analyze and confront structural inequity in internal medicine April 10, 2024

https://psnet.ahrq.gov/innovation/equity-mm-adaptation-morbidity-and-mortality-conference-analyze-and-confront-structural

Implicit bias and patient care: mitigating bias, preventing harm. April 10, 2024 Barber Doucet H, Wilson T, Vrablik L, et al. MedEdPORTAL. 2023;19:11343.

https://psnet.ahrq.gov/innovation/implicit-bias-and-patient-care-mitigating-bias-preventing-harm

Improving formal incivility reporting in ambulatory oncology: implementing the CIVIC Duty program. April 10, 2024 Gordon JN. Clin J Oncol Nurs. 2023;27(6):602-606.

https://psnet.ahrq.gov/innovation/improving-formal-incivility-reporting-ambulatory-oncology-implementing-civic-duty

Risk Mitigation Using the Anesthesia Risk Alert Program: Applying a Proactive Approach With Data Review & Collaborating With a Second Practitioner April 10, 2024

https://psnet.ahrq.gov/innovation/risk-mitigation-using-anesthesia-risk-alert-program-applying-proactive-approach-data

Long-term Care and Patient Safety Deb Bakerjian PhD, APRN, FAAN, FAANP, FGSA | April 10, 2024

https://psnet.ahrq.gov/primer/long-term-care-and-patient-safety

Misplaced Nasogastric Tube Resulting in Aspiration Anita Singh, MD and Cecilia Huang, MD | April 10, 2024

https://psnet.ahrq.gov/web-mm/misplaced-nasogastric-tube-resulting-aspiration

Hindsight is 20/20: Thrombolytics for Alcohol Intoxication Eric Signoff, MD, Noelle Boctor, MD, and David K. Barnes, MD, FACE | April 10, 2024

https://psnet.ahrq.gov/web-mm/hindsight-2020-thrombolytics-alcohol-intoxication

National Action Alliance for Patient and Workforce Safety

National Action Alliance for Patient and Workforce Safety

Should dignity preservation be a precondition for safety and a design priority for healing in inpatient psychiatry spaces? April 10, 2024

https://psnet.ahrq.gov/issue/should-dignity-preservation-be-precondition-safety-and-design-priority-healing-inpatient

Feeling safe in the context of digitalization in healthcare: a scoping review. April 10, 2024

https://psnet.ahrq.gov/issue/feeling-safe-context-digitalization-healthcare-scoping-review

Teamwork matters: team situation awareness to build high-performing healthcare teams, a narrative review. April 10, 2024

https://psnet.ahrq.gov/issue/teamwork-matters-team-situation-awareness-build-high-performing-healthcare-teams-narrative

The prevalence of incivility in hospitals and the effects of incivility on patient safety culture and outcomes: a systematic review and meta-analysis. April 10, 2024

https://psnet.ahrq.gov/issue/prevalence-incivility-hospitals-and-effects-incivility-patient-safety-culture-and-outcomes

A biased test kept thousands of Black people from getting a kidney transplant. April 10, 2024

https://psnet.ahrq.gov/issue/biased-test-kept-thousands-black-people-getting-kidney-transplant

Electronic Health Record Modernization Caused Pharmacy-Related Patient Safety Issues Nationally and at the VA Central Ohio Healthcare System in Columbus. April 10, 2024

https://psnet.ahrq.gov/issue/electronic-health-record-modernization-caused-pharmacy-related-patient-safety-issues

Should dignity preservation be a precondition for safety and a design priority for healing in inpatient psychiatry spaces? April 10, 2024

https://psnet.ahrq.gov/issue/should-dignity-preservation-be-precondition-safety-and-design-priority-healing-inpatient

Standardizing patient safety event reporting between care delivered or purchased by the Veterans Health Administration (VHA). April 10, 2024

https://psnet.ahrq.gov/issue/standardizing-patient-safety-event-reporting-between-care-delivered-or-purchased-veterans

Rural emergency medical services clinicians' perceptions and preferences in receiving clinical feedback from hospitals: a qualitative needs assessment. April 10, 2024

https://psnet.ahrq.gov/issue/rural-emergency-medical-services-clinicians-perceptions-and-preferences-receiving-clinical

Inappropriate diagnosis of pneumonia among hospitalized adults. April 10, 2024

https://psnet.ahrq.gov/issue/inappropriate-diagnosis-pneumonia-among-hospitalized-adults

Exploring the causes of COPD misdiagnosis in primary care: a mixed methods study. April 10, 2024

https://psnet.ahrq.gov/issue/exploring-causes-copd-misdiagnosis-primary-care-mixed-methods-study

Differences in donor heart acceptance by race and gender of patients on the transplant waiting list. April 10, 2024

https://psnet.ahrq.gov/issue/differences-donor-heart-acceptance-race-and-gender-patients-transplant-waiting-list

An analysis of incident reports related to electronic medication management: how they change over time. April 10, 2024

https://psnet.ahrq.gov/issue/analysis-incident-reports-related-electronic-medication-management-how-they-change-over-time

Decreasing prescribing errors in antimicrobial stewardship program-restricted medications. April 10, 2024

https://psnet.ahrq.gov/issue/decreasing-prescribing-errors-antimicrobial-stewardship-program-restricted-medications

Drug-drug interactions and actual harm to hospitalized patients: a multicentre study examining the prevalence pre- and post-electronic medication system implementation. April 10, 2024

https://psnet.ahrq.gov/issue/drug-drug-interactions-and-actual-harm-hospitalized-patients-multicentre-study-examining

Crowdsourcing a diagnosis? Exploring the accuracy of the size and type of group diagnosis: an experimental study. April 10, 2024

https://psnet.ahrq.gov/issue/crowdsourcing-diagnosis-exploring-accuracy-size-and-type-group-diagnosis-experimental-study

miércoles, 10 de abril de 2024

Combo Therapy Prolongs Survival in Patients With Gastric Cancer Christos Evangelou April 10, 2024

https://www.medscape.com/s/viewarticle/combo-therapy-prolongs-survival-patients-gastric-cancer-2024a10006to?src=

Intermediate Endpoints Predict Breast Cancer Survival Cristina Ferrario April 10, 2024

https://www.medscape.com/viewarticle/intermediate-endpoints-predict-breast-cancer-survival-2024a10006tt?src=

Managing CKD in Primary Care: Latest Guidelines Neil Skolnik, MD

https://www.medscape.com/viewarticle/1000576?src=

Is Your EMS System Leading the Way in Emergency Care? Robert D, Glatter, MD; Paul E. Pepe, MD, MPH; Benjamin (Ben) Weston, MD, MPH

https://www.medscape.com/viewarticle/1000391?src=

How Does Second Victim Syndrome Affect Surgeons? Joël Pitre, Dr April 04, 2024

https://www.medscape.com/viewarticle/how-does-second-victim-syndrome-affect-surgeons-2024a10006d6?ecd=mkm_ret_240410_mscpmrk-OUS_ICYMI_etid6430944&uac=148436CN&impID=6430944

Policy solutions to eliminate racial and ethnic child health disparities in the USA

https://pubmed.ncbi.nlm.nih.gov/38242598/

Trends in Psychological Distress and Outpatient Mental Health Care of Adults During the COVID-19 Era

https://pubmed.ncbi.nlm.nih.gov/38316009/

Adapting Cognitive Task Analysis Methods for Use in a Large Sample Simulation Study of High-Risk Healthcare Events

https://pubmed.ncbi.nlm.nih.gov/37941803/

Development of a Novel Telemedicine Tool to Reduce Disparities Related to the Identification of Preschool Children with Autism

https://pubmed.ncbi.nlm.nih.gov/38064003/

Drug Shortages Prior to and During the COVID-19 Pandemic

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2817210

The association between food access and frailty among older adults with gastrointestinal malignancies-The CARE Registry

https://pubmed.ncbi.nlm.nih.gov/38059840/

Mental health care provision in community health centers and hospital emergency department utilization

https://pubmed.ncbi.nlm.nih.gov/38243709/

Adapting a community pharmacy intervention to improve medication safety

https://pubmed.ncbi.nlm.nih.gov/37940099/

Continuous Medicaid Eligibility During the COVID-19 Pandemic and Postpartum Coverage, Health Care, and Outcomes

https://pubmed.ncbi.nlm.nih.gov/38457131/

Outcomes After Initiation of Medications for Alcohol Use Disorder at Hospital Discharge

https://pubmed.ncbi.nlm.nih.gov/38551564/

National Action Alliance: Webinars

National Action Alliance: Webinars

National Action Alliance for Patient and Workforce Safety

National Action Alliance for Patient and Workforce Safety

TeamSTEPPS Pocket Guide

TeamSTEPPS Pocket Guide: The TeamSTEPPS Pocket Guide provides quick reference to key TeamSTEPPS concepts and tools.

Making Healthcare Safer IV

Making Healthcare Safer IV: AHRQ’s fourth iteration of Making Healthcare Safer intends to address this issue by publishing evidence-based reviews of patient safety practices and topics as they are completed. This intentional release of updated reviews will aid healthcare organization leaders in prioritizing implementation of evidence-based practices in a timelier way. The report also will help researchers identify where more research is needed in a timelier way and assist policymakers in understanding which patient safety practices have the supporting evidence for promotion.

Evidence-based Practice Centers

Evidence-based Practice Centers: The Agency for Healthcare Research and Quality (AHRQ) created the Evidence-based Practice Centers (EPCs) in 1997 to conduct evidence reports for the Effective Health Care (EHC) Program. In December 2019, the latest 5-year contracts were awarded to 9 EPCs.

Making Healthcare Safer IV: Opioid Stewardship

Making Healthcare Safer IV: Opioid Stewardship

Making Healthcare Safer IV: Engaging Family Caregivers with Structured Communication for Safe Care Transitions

Making Healthcare Safer IV: Engaging Family Caregivers with Structured Communication for Safe Care Transitions

Failure To Rescue – Rapid Response Systems

Failure To Rescue – Rapid Response Systems

Register Now: April 29 Virtual Grand Rounds to Highlight Making Healthcare Safer IV Report

Register Now: April 29 Virtual Grand Rounds to Highlight Making Healthcare Safer IV Report: A virtual Grand Rounds on April 29 from noon to 2 p.m. ET will highlight findings in AHRQ’s Making Healthcare Safer IV Report, a suite of rapid evidence reports on patient safety harms and practices. The Grand Rounds series highlights the work of AHRQ’s Evidence-based Practice Center (EPC) Program, which promotes and facilitates the use of evidence in healthcare decisions.

EvidenceNOW: Managing Unhealthy Alcohol Use

EvidenceNOW: Managing Unhealthy Alcohol Use: The COVID-19 pandemic has added to the problem with increased isolation, unemployment, and other stresses contributing to increased alcohol use.

The Child HCAHPS Survey Database Data Use Agreement

https://cahpsdatabase.ahrq.gov/files/CH/Child-HCAHPS-Database-DUA.pdf

Apr. 12: Consumer Assessment of Healthcare Providers and Systems (CAHPS®) Child Hospital Survey Database Submission Closes

https://cahpsdatabase.ahrq.gov/files/CH/Child-HCAHPS-DataSpecifications.pdf

The CAHPS Child Hospital Survey Data Submission System Login

https://cahpsdatabase.ahrq.gov/CHDSS/login.aspx Participation in the CAHPS Child Hospital Survey Database is open to hospitals that administer the CAHPS Child Hospital Survey, provided the questionnaires are administered in a manner consistent with CAHPS guidance and the survey data are submitted according to CAHPS specifications.

Webinar Series: Strengthening Primary Care Research

Webinar Series: Strengthening Primary Care Research: This series of webinars focuses on how to strengthen AHRQ’s primary research. For recordings of the presentations and slides, reference the webinars.

National Center for Excellence in Primary Care Research

National Center for Excellence in Primary Care Research: AHRQ’s research to advance primary care infrastructure, delivery and outcomes. The National Center for Excellence in Primary Care Research (NCEPCR) is the intellectual home for primary care research at AHRQ. The NCEPCR is focused on the Nation's primary care system, providing evidence, practical tools, and other resources for researchers and evaluators, clinicians and clinical teams, quality improvement experts, and healthcare decision makers to improve the quality and safety of care. The NCEPCR is committed to listening to and learning from all members of the primary care community, including patients and families.

martes, 9 de abril de 2024

Patient with transplanted pig kidney had a ‘tense’ rejection episode before leaving the hospital Megan Molteni By Megan Molteni April 8, 2024

https://www.statnews.com/2024/04/08/xenotransplantation-pig-kidney-rejection-richard-slayman/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz--TOw3cKf55mZrL1Kt-QHNYMyrzCzJAkso40-NP9UF91N7aOhRn6aDBNi3DIWRsyVSJQzo1PXMw9wjbgC5cPfFCmpXBNw&_hsmi=301781285&utm_content=301781285&utm_source=hs_email

After years of just ‘running, running,’ a crisis led to a lupus diagnosis. Now she connects others Isabella Cueto By Isabella Cueto April 9, 2024

https://www.statnews.com/2024/04/09/lupus-autoimmune-diagnosis-treatment-lupuschat/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-_iDAKO4JTFIoeJ9bFwbl2MwBclBuJoAVaWZm5eokXqZaZFJcmUW4zhMCZdVCasArqarIOGn-eGBe7yYuNKZ2Au9lCn7A&_hsmi=301781285&utm_content=301781285&utm_source=hs_email

Medicaid redetermination cost community health centers an average of $600K each Annalisa Merelli By Annalisa Merelli April 8, 2024

https://www.statnews.com/2024/04/08/medicaid-redetermination-cost-community-health-centers-average-600k/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-9BSonjpPuAbehCvyIUf2xF0eSOJ0gA7WxDPOB13j01mk0XqvF7dsafQziCMYRXd-d0vCb0LC9aoY_V556vRV6sbbkOTw&_hsmi=301781285&utm_content=301781285&utm_source=hs_email

National Action Alliance for Patient and Workforce Safety

National Action Alliance for Patient and Workforce Safety

Registration for Progress Update: The National Action Alliance for Patient and Workforce Safety - What, Why and How? April 23, 12-1 PM ET

https://cma.ahrq.gov/cma/registration.jsp?eventid=220

Supporting social connections across the life course The Lancet Healthy Longevity

https://www.thelancet.com/journals/lanhl/issue/vol5no4/PIIS2666-7568(24)X0004-5

Prevalence of multimorbidity and polypharmacy among adults and older adults: a systematic review

https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(24)00007-2/fulltext?dgcid=hubspot_update_feature_updatealerts_lanhl&utm_campaign=update-lanhl&utm_medium=email&_hsenc=p2ANqtz--TZ4VUv-75WWpFGnEOQTW1DbmWnS-y59ws4Ur7KpZ1EPgYmMIBuWGJXGowrkC4-ZSxKLou4dRhx8269M9WvZsah3Hs3A&_hsmi=301594870&utm_content=301373452&utm_source=hs_email

Rapid growth of private hospitals in China: emerging challenges and opportunities to health sector management

https://www.thelancet.com/journals/lanwpc/article/PIIS2666-6065(23)00309-7/fulltext?dgcid=hubspot_update_feature_updatealerts_lanwpc&utm_campaign=update-lanwpc&utm_medium=email&_hsenc=p2ANqtz--eKnLQQ9Vd4Mt3m3_wNj-JKi9os6mmuGodi62JORDSb-aT_fLvndolbHrK4ws9OLEVtPRTLlWjadcWrpkHRanhiqEVVw&_hsmi=301597107&utm_content=301372732&utm_source=hs_email

Age-specific breast and ovarian cancer risks associated with germline BRCA1 or BRCA2 pathogenic variants – an Asian study of 572 families

https://www.thelancet.com/journals/lanwpc/article/PIIS2666-6065(24)00011-7/fulltext?dgcid=hubspot_update_feature_updatealerts_lanwpc&utm_campaign=update-lanwpc&utm_medium=email&_hsenc=p2ANqtz-_0GYksZk7l02S1YoHDmCmA-8eVmLYfDU10LtyC7RKfBHN2IcUPTui3zdLQRng_uKVcciHCMs2JhTgK7PnuaqvLqSDEtw&_hsmi=301597107&utm_content=301372732&utm_source=hs_email

Thursday, May 2 Neurofeedback Intervention Development: Opportunities and Challenges NIMH Virtual Workshop

https://www.eventbrite.com/e/neurofeedback-intervention-development-opportunities-and-challenges-nimh-virtual-workshop-tickets-876157399367?aff=oddtdtcreator Workshop: Neurofeedback Intervention Development: Opportunities and Challenges Date/Time: May 2, 2024, from 10:00 a.m.–4:00 p.m. ET Location: Virtual The National Institute of Mental Health’s Division of Translational Research will host a workshop that brings together researchers and federal officials to review the state of the science for neurofeedback (NF) intervention development for mental disorders, with an emphasis on real time fMRI approaches. The program will highlight recent developments in both early treatment development and later efficacy and effectiveness trials, as well as regulatory issues relevant to the approval and implementation of device-based interventions like NF. Panel presentations and discussion will aid in identifying new opportunities and challenges for NF development. The workshop is free and open to the scientific community and the public.

Labels reveal the truth: "Ultra-processed" and "high in sugar" deter shoppers

https://www.news-medical.net/news/20240408/Labels-reveal-the-truth-Ultra-processed-and-high-in-sugar-deter-shoppers.aspx

Expanding research and clinical options for children with cancer

https://www.news-medical.net/news/20240408/Expanding-research-and-clinical-options-for-children-with-cancer.aspx

Bruker showcases high-performance solutions at Analytica 2024 for research and analysis in applied, industrial and biopharma laboratories

https://www.news-medical.net/news/20240409/Bruker-showcases-high-performance-solutions-at-Analytica-2024-for-research-and-analysis-in-applied-industrial-and-biopharma-laboratories.aspx

City-country mortality gap widens amid persistent holes in rural health care access

https://www.news-medical.net/news/20240409/City-country-mortality-gap-widens-amid-persistent-holes-in-rural-health-care-access.aspx

After public push, CMS curbs health insurance agents’ access to consumer SSNs

https://www.news-medical.net/news/20240409/After-public-push-CMS-curbs-health-insurance-agentse28099-access-to-consumer-SSNs.aspx

CDER’s Office of Communications (OCOMM) Releases First Annual Report

https://www.fda.gov/media/177440/download?attachment=&utm_medium=email&utm_source=govdelivery

EvidenceNOW: Managing Unhealthy Alcohol Use

EvidenceNOW: Managing Unhealthy Alcohol Use: The COVID-19 pandemic has added to the problem with increased isolation, unemployment, and other stresses contributing to increased alcohol use.

Overview of Medications Used in the Treatment of Alcohol Use Disorder and Frequently Asked Questions

https://integrationacademy.ahrq.gov/sites/default/files/2022-11/Medications%20for%20Alcohol%20Use%20FAQ.pdf

Unhealthy Alcohol Use Tools & Resources

https://integrationacademy.ahrq.gov/products/substance-use-resources/environmental-scan/unhealthy-alcohol-use

The cost and value of cancer medicines in Ontario, Canada Christopher J Longov

https://www.thelancet.com/journals/lanonc/issue/vol25no4/PIIS1470-2045(24)X0004-2

A scoping review of web-based, interactive, personalized decision-making tools available to support breast cancer treatment and survivorship care

https://pubmed.ncbi.nlm.nih.gov/38538922/

Trends in Adolescent Suicide by Method in the US, 1999-2020

https://pubmed.ncbi.nlm.nih.gov/38551558/

March 18, 2024 Summary Basis for Regulatory Action - LENMELDY

https://www.fda.gov/vaccines-blood-biologics/news-events-biologics/whats-new-biologics?utm_medium=email&utm_source=govdelivery

Does the Drug Shortage White Paper Fall Short? By Kalie E. Richardson —

https://www.thefdalawblog.com/2024/04/does-the-drug-shortage-white-paper-fall-short/?utm_source=rss&utm_medium=rss&utm_campaign=does-the-drug-shortage-white-paper-fall-short

Regulatory Education for Industry (REdI) Annual Conference 2024: Innovation in Medical Product Development MAY 29 - 30, 2024

https://www.fda.gov/drugs/news-events-human-drugs/regulatory-education-industry-redi-annual-conference-2024-innovation-medical-product-development

lunes, 8 de abril de 2024

Impact of a relocation to a new critical care building on pediatric safety events. April 3, 2024

https://psnet.ahrq.gov/issue/impact-relocation-new-critical-care-building-pediatric-safety-events

Impact of performance and information feedback on medical interns' confidence-accuracy calibration. April 3, 2024

https://psnet.ahrq.gov/issue/impact-performance-and-information-feedback-medical-interns-confidence-accuracy-calibration

Risks in the analogue and digitally-supported medication process and potential solutions to increase patient safety in the hospital: a mixed methods study. April 3, 2024Risks in the analogue and digitally-supported medication process and potential solutions to increase patient safety in the hospital: a mixed methods study. April 3, 2024

https://psnet.ahrq.gov/issue/risks-analogue-and-digitally-supported-medication-process-and-potential-solutions-increase

Safety is the preservation of value. April 3, 2024

https://psnet.ahrq.gov/issue/safety-preservation-value

Support and recovery strategies for second victims. April 3, 2024

https://psnet.ahrq.gov/issue/support-and-recovery-strategies-second-victims

A narrative review of the well-being and burnout of U.S. community pharmacists. April 3, 2024

https://psnet.ahrq.gov/issue/narrative-review-well-being-and-burnout-us-community-pharmacists

Evaluation of the design and structure of electronic medication labels to improve patient health knowledge and safety: a systematic review. April 3, 2024

https://psnet.ahrq.gov/issue/evaluation-design-and-structure-electronic-medication-labels-improve-patient-health-knowledge

AI in Health: Huge Potential, Huge Risks. April 3, 2024

https://psnet.ahrq.gov/issue/ai-health-huge-potential-huge-risks

Implement strategies to prevent persistent medication errors and hazards: 2024. April 3, 2024

https://psnet.ahrq.gov/issue/implement-strategies-prevent-persistent-medication-errors-and-hazards-2024

OPQ’s 2023 Annual Report: an Upbeat Review of CDER’s Quality Efforts By John W.M. Claud —

https://www.thefdalawblog.com/2024/04/opqs-2023-annual-report-an-upbeat-review-of-cders-quality-efforts/?utm_source=rss&utm_medium=rss&utm_campaign=opqs-2023-annual-report-an-upbeat-review-of-cders-quality-efforts

domingo, 7 de abril de 2024

Improving Health Equity through Research and Action

https://www.ahrq.gov/sites/default/files/wysiwyg/cpi/about/health-equity/health-equity-factsheet.pdf

Fact Sheet: Advancing Health Equity Across HHS

https://www.hhs.gov/equity/fact-sheet-advancing-health-equity-across-hhs/index.html

Data Infographics

Data Infographics: AHRQ's data infographics provide visual snapshots of health care trend data. These infographics highlight findings from the Agency’s Medical Expenditure Panel Survey (MEPS), the Healthcare Cost and Utilization Project (HCUP), and other AHRQ data sources. AHRQ’s infographics are available free of charge for posting on web sites, in newsletters, and on other platforms.

Data Visualizations

Data Visualizations

Characteristics of Young Adults Aged 18-24 Who Had Ever Used an Electronic Nicotine Product, 2021 Statistical Brief #554 | February 2024 | Anita Soni, PhD, MBA, and Sandra L. Decker, PhD

https://meps.ahrq.gov/data_files/publications/st554/stat554.shtml

Communication of incidental imaging findings on inpatient discharge summaries after implementation of electronic health record notification system. April 3, 2024

https://psnet.ahrq.gov/issue/communication-incidental-imaging-findings-inpatient-discharge-summaries-after-implementation

Clinical informatics team members' perspectives on health information technology safety after experiential learning and safety process development: qualitative descriptive study. April 3, 2024

https://psnet.ahrq.gov/issue/clinical-informatics-team-members-perspectives-health-information-technology-safety-after

A narrative review of the well-being and burnout of U.S. community pharmacists. April 3, 2024

https://psnet.ahrq.gov/issue/narrative-review-well-being-and-burnout-us-community-pharmacists A narrative review of the well-being and burnout of U.S. community pharmacists. Wash A, Moczygemba LR, Brown CM, et al. J Am Pharm Assoc (2003). 2023;64(2):337-349. Improving healthcare provider well-being and reducing burnout is a focus of many patient safety efforts. This narrative review highlights research into well-being and burnout in community pharmacists, a segment of the healthcare workforce that was experiencing high rates of stress even before the pandemic. Despite many studies measuring community pharmacist burnout, there were no studies identified into interventions or strategies to improve well-being or reduce burnout.

Characteristics and contributing factors of diagnostic error in surgery: analysis of closed medico-legal cases and complaints in Canada. April 3, 2024

https://psnet.ahrq.gov/issue/characteristics-and-contributing-factors-diagnostic-error-surgery-analysis-closed-medico Characteristics and contributing factors of diagnostic error in surgery: analysis of closed medico-legal cases and complaints in Canada. Kwan JL, Calder LA, Bowman CL, et al. Can J Surg. 2024;67(1):e58-e65. Research into diagnostic errors frequently focuses on hospitals, emergency departments, and primary care, with less focus on surgical diagnostic errors. This study used medico-legal cases and complaints to characterize surgical diagnostic errors. Most errors occurred post-operatively (e.g., failure to recognize clinical deterioration) and were attributed to providers’ clinical decision-making.v

Racial implicit bias and communication among physicians in a simulated environment. April 3, 2024

https://psnet.ahrq.gov/issue/racial-implicit-bias-and-communication-among-physicians-simulated-environment Gonzalez CM, Ark TK, Fisher MR, et al. JAMA Netw Open. 2024;7(3):e242181. Clinicians' implicit racial bias can result in poor communication, poor patient care, and patients not returning for follow up. In this study, physicians participated in a simulated online patient visit, randomized to either a Black or white standardized patient (SP). Both the physician and SP were blinded to the true purpose of the study, which was to explore the association between the physician's implicit bias and the SP's rating of the physician's communication skills. Results show a significant association between physician bias and communication scores.

sábado, 6 de abril de 2024

The Importance of Disaster Behavioral Health: Why it Matters Main page content Date: April 01, 2024

https://www.samhsa.gov/blog/importance-disaster-behavioral-health-why-it-matters?utm_source=SAMHSA&utm_campaign=e9675a4083-EMAIL_CAMPAIGN_2024_04_04_01_18&utm_medium=email&utm_term=0_-e9675a4083-%5BLIST_EMAIL_ID%5D By: CAPT Maryann Robinson, Ph.D., RN, Director, Division of Trauma and Disaster Behavioral Health, Center for Mental Health Services, Anne Reim, M.P.H., Division of Trauma and Disaster Behavioral Health, Center for Mental Health Services and Maggie Jarry, M.Div., M.S., Senior Advisor, Division of Trauma and Disaster Behavioral Health, Center for Mental Health Services From devastating wildfires, tornadoes, and mudslides to mass shootings and terrorist attacks, it’s almost impossible to turn on the news these days without seeing a report about another disaster. Natural and human-caused disasters are increasing in frequency, duration, and severity. In 2023 alone, the United States experienced 114 federally declared disasters, including 28 separate weather and climate disasters that each caused at least $1 billion in damages. These disasters can have a deep impact on affected people and communities, especially when multiple disasters have occurred in the same area.

On-the-Spot: Hybrid Service Delivery — Virtual TA Session Friday, April 19, 2024 12 p.m.

https://attcnetwork.org/event/on-the-spot-hybrid-service-delivery-3/?utm_source=SAMHSA&utm_campaign=e9675a4083-EMAIL_CAMPAIGN_2024_04_04_01_18&utm_medium=email&utm_term=0_-e9675a4083-%5BLIST_EMAIL_ID%5D Hybrid service delivery is a mixture of in-person sessions with videoconferencing sessions and may include phone check-ins. Hybrid service delivery models are known for providing flexibility, especially to clients with access issues, such as clients living in rural areas or those with transportation issues. Join the online consultation session every third Friday of the month to ask questions and discuss/share hybrid service delivery tips for practitioners.

Brainstorming the Future: Using Generative AI in Your Substance Misuse Prevention Work — Webinar Wednesday, April 18, 2024 11 a.m. ET

https://pttcnetwork.org/event/brainstorming-the-future-using-generative-ai-in-your-substance-misuse-prevention-work/?utm_source=SAMHSA&utm_campaign=e9675a4083-EMAIL_CAMPAIGN_2024_04_04_01_18&utm_medium=email&utm_term=0_-e9675a4083-%5BLIST_EMAIL_ID%5D Dive into the world of generative artificial intelligence (AI) with an engaging 90-minute webinar that demystifies Large Language Models (LLMs) and their practical applications. This webinar will offer a blend of theory and hands-on activities, including article summarization and brainstorming AI-driven intervention strategies for substance misuse prevention scenarios.

Bullying Prevention in Elementary and Middle Schools: Leveraging Experts in Your Building — Webinar Wednesday, April 17, 2024 2 p.m. ET

https://mhttcnetwork.org/event/2024-speaker-series-presents-bullying-prevention-in-elementary-and-middle-schools-leveraging-experts-in-your-building-by-dr-sara-mcdaniel-event-registration/?utm_source=SAMHSA&utm_campaign=e9675a4083-EMAIL_CAMPAIGN_2024_04_04_01_18&utm_medium=email&utm_term=0_-e9675a4083-%5BLIST_EMAIL_ID%5D Session attendants will learn about the types of bullying, strategies to disrupt bullying in schools, and focus specifically on how to leverage school resource officers, bus drivers, and other safety personnel in their bullying prevention efforts.

Intimate Partner Violence in the Military and Veteran Community — Webinar Tuesday, April 16, 2024 12:30 - 2 p.m. ET

https://prainc.zoom.us/webinar/register/WN_8jnU3aeAST2KEm_-cOvmzw?utm_source=SAMHSA&utm_campaign=9d7396dc9e-EMAIL_CAMPAIGN_2024_02_23_06_45&utm_medium=email&utm_term=0_-9d7396dc9e-%5BLIST_EMAIL_ID%5D&utm_source=SAMHSA&utm_campaign=e9675a4083-EMAIL_CAMPAIGN_2024_04_04_01_18&utm_medium=email&utm_term=0_-e9675a4083-%5BLIST_EMAIL_ID%5D#/registration Join us for an informative webinar on the critical issue of Intimate Partner Violence (IPV) within the Service Members, Veterans, and their Families (SMVF) community. Learning objectives include – Explore the prevalence and impact of IPV within the SMVF community Review the resources available for IPV intervention and support Discover strategies to foster healing and recovery for those who have experienced IPV Understand approaches to guide people who carry out IPV towards healthier relationship behaviors Learn from best practices in identifying and addressing IPV

Trauma-Informed Teams — Webinar Tuesday April 16, 2024 10:45 p.m. ET

https://mhttcnetwork.org/event/trauma-informed-teams/?utm_source=SAMHSA&utm_campaign=e9675a4083-EMAIL_CAMPAIGN_2024_04_04_01_18&utm_medium=email&utm_term=0_-e9675a4083-%5BLIST_EMAIL_ID%5D To be effective and efficient, organizations must provide their services in ways that do not inadvertently re-traumatize the teams of workers providing support to their clients. Becoming trauma-informed means adapting practices, policies, physical spaces and more to make services more accessible for everyone, including the workers. This class helps learners conceptualize the nature of this problem and offers practices that reduce the risk of re-traumatization.

Motivation in Mental Health Recovery — Webinar Thursday, April 11, 2024 1 p.m. ET

https://mhttcnetwork.org/event/motivation-in-mental-health-recovery/?utm_source=SAMHSA&utm_campaign=e9675a4083-EMAIL_CAMPAIGN_2024_04_04_01_18&utm_medium=email&utm_term=0_-e9675a4083-%5BLIST_EMAIL_ID%5D This 2-hour webinar will focus on enhancing participants’ ability to improve an individual’s motivation and engagement in treatment. Participants will learn ways to empower their clients to change by drawing out their meaning, importance, and capacity for change.

Recovery Update: SAMHSA Invites you to the Office of Recovery Quarterly Recovery Exchange Meeting

https://www.zoomgov.com/meeting/register/vJItdOyqrjwtH45F_VgzYDVbTvGrkOXg-1s?utm_source=SAMHSA&utm_campaign=71df0bc679-EMAIL_CAMPAIGN_2024_04_03_07_28&utm_medium=email&utm_term=0_-71df0bc679-%5BLIST_EMAIL_ID%5D#/registration The Substance Abuse and Mental Health Services Administration (SAMHSA) invites you, to participate in SAMHSA’s Recovery Exchange Meeting on April 29 at 1 p.m. to 2 p.m. ET. This event will be hosted by the Office of Recovery (OR) within SAMHSA. Please join us as we bring recovery stakeholder together for an open dialogue. The OR will be sharing the launch of the new training & technical assistance initiative - The SAMHSA Program to Advance Recovery Knowledge (SPARK) - as well as upcoming events for Recovery month. We invite recovery leaders and allies from across the nation to be part of this conversation.

Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain: 2024 Update

Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain: 2024 Update: This is the third annual update of a living systematic review addressing the effectiveness and harms of plant-based treatments for chronic and subacute pain in adults and adolescents. The first systematic review was published in October of 2021, and the first and second updates were published in September of 2022 and August of 2023, respectively. As this review is "living," it uses methods to identify and synthesize recently published literature and adapt its scope on an ongoing basis. Included plant-based compounds are those that have potential analgesic effects as well as the potential for addiction, misuse, and serious adverse effects.

AHRQ EPC Program Grand Rounds - Making Healthcare Safer April 29, 2024 12:00 PM - 2:00 PM EDT at WebEx Meeting

https://cma.ahrq.gov/cma/welcome.jsp?code=epc_patientsafety

Failure To Rescue – Rapid Response Systems

Failure To Rescue – Rapid Response Systems

Making Healthcare Safer IV: Engaging Family Caregivers with Structured Communication for Safe Care Transitions

Making Healthcare Safer IV: Engaging Family Caregivers with Structured Communication for Safe Care Transitions: In Spring of 2023, AHRQ launched its fourth iteration of the MHS Report (MHS IV). Engaging Family Caregivers with Structured Communication for Safe Care Transitions was identified as high priority for inclusion in the MHS IV reports. The overall purpose of this review is to assess the effectiveness of using structured communication with family caregivers for safe care transitions. We will also report unintended harms of this PSP as described in relevant studies.

Making Healthcare Safer IV: Opioid Stewardship

Making Healthcare Safer IV: Opioid Stewardship

Evidence-based Practice Centers

Evidence-based Practice Centers: The Agency for Healthcare Research and Quality (AHRQ) created the Evidence-based Practice Centers (EPCs) in 1997 to conduct evidence reports for the Effective Health Care (EHC) Program. In December 2019, the latest 5-year contracts were awarded to 9 EPCs.

AHRQ's Making Healthcare Safer Reports: Shaping Patient Safety Efforts in the 21st Century

AHRQ's Making Healthcare Safer Reports: Shaping Patient Safety Efforts in the 21st Century: AHRQ’s three Making Healthcare Safer reports consolidate information for healthcare providers, health system administrators, researchers, and government agencies about practices that can improve patient safety across the healthcare system—from hospitals to primary care practices, long-term care facilities, and other healthcare settings.

How Primary Care Is Being Disrupted: A Video Primer By Julie Appleby and Hannah Norman and Oona Tempest APRIL 1, 2024

https://kffhealthnews.org/news/article/primary-care-disrupted-video-primer/?utm_campaign=KHN%20-%20Weekly%20Edition&utm_medium=email&_hsenc=p2ANqtz-8odigHmiSPLVLUlN-oqi_R-mWEcj0kDHZtf4GLBfinJitlCafta1w63mO_AO7-yeN21YY30RxM6sPOdkoxjHqP8A-D9Q&_hsmi=301421688&utm_content=301421688&utm_source=hs_email

Florida Limits Abortion — For Now EPISODE 341 APRIL 4, 2024

https://kffhealthnews.org/news/podcast/what-the-health-341-florida-abortion-court-rulings-april-4-2024/?utm_campaign=KFF-The-Latest&utm_medium=email&_hsenc=p2ANqtz-957XUfGN6jHd-AxCOxqjbAclcJrlZPz7C0PY2-mkJ4lfHePLlwn1XqqKLwYXfmhA91_ZdZGOlJrce6_HACT-i_xnYQOg&_hsmi=301432079&utm_content=301432079&utm_source=hs_email

End of Internet Subsidies for Low-Income Households Threatens Telehealth Access By Sarah Jane Tribble APRIL 4, 2024

https://kffhealthnews.org/news/article/internet-subsidy-ending-affordable-connectivity-program-telehealth/?utm_campaign=KFF-The-Latest&utm_medium=email&_hsenc=p2ANqtz-9YuSPqV2SKYmP7oZGRs0a4Op611rw2mgzi9N5CraRkJ2MDgotJkh2GOZstuW2Yaxce4dCZKj_CFDL2opoAhFY7kMsmog&_hsmi=301432079&utm_content=301432079&utm_source=hs_email

Biden Is Right About $35 Insulin Cap but Exaggerates Prior Costs for Medicare Enrollees By Samantha Putterman, PolitiFact APRIL 5, 2024

https://kffhealthnews.org/news/article/fact-check-president-biden-insulin-price-cap-half-true/?utm_campaign=KFF-The-Latest&utm_medium=email&_hsenc=p2ANqtz-_E_EAEDd3CkvX5qRGzdhnOTc7eGg1JhGk8Vm9cYZyCSP3fIZWvztQopAz3WysFjWMLaVovNYHz9XbtWf91ZjIQolaJfg&_hsmi=301432079&utm_content=301432079&utm_source=hs_email

More Kids Are Dying of Drug Overdoses. Could Pediatricians Do More to Help? By Martha Bebinger, WBUR APRIL 5, 2024

https://kffhealthnews.org/news/article/buprenorphine-children-teens-pediatricians-substance-use-disorder/?utm_campaign=KFF-The-Latest&utm_medium=email&_hsenc=p2ANqtz-9ODw590-wBzwmRv8XyFSDIOOeTodLBKxHA5b-pbbWgJWX0Cjk5zjsmIWpRfYosVnLAJkSeW1ijRIWKPSrC4I6cQiV_2A&_hsmi=301432079&utm_content=301432079&utm_source=hs_email

The Horrors of TMJ: Chronic Pain, Metal Jaws, and Futile Treatments By Brett Kelman and Anna Werner, CBS News APRIL 4, 2024

https://kffhealthnews.org/news/article/investigation-tmj-chronic-pain-metal-jaws-futile-treatments/?utm_campaign=KFF-The-Latest&utm_medium=email&_hsenc=p2ANqtz-8TKVjAPBfv_2n0aMtg3p5QZrr66-iNg0f7P6EzZ6x8iEBe-RUqS6LTV_yrapYX7CNlpD84SGKOOtPHSwNlGkFcxaaWKw&_hsmi=301432079&utm_content=301432079&utm_source=hs_email

Overpayment Outrage KFF Health News / Cox Media Group Investigation

https://kffhealthnews.org/overpayment-outrage/?utm_campaign=KFF-The-Latest&utm_medium=email&_hsenc=p2ANqtz-_ZeCix3oggm8oYlzsvFg8oLlYFg5Q4zY_a_UL6wlEt3kkWFywue2D1Iu6czMN-dejO8wV8WaVcVcOI6mf8rfFD6tEIcA&_hsmi=301432079&utm_content=301432079&utm_source=hs_email The Social Security Administration has been overpaying billions of dollars to people, many on disability — then demanding the money back, even if the government made the mistake, an investigation by KFF Health News and Cox Media Group revealed. The reporting has triggered a congressional hearing, additional Senate oversight of the agency, an apology from the head of the SSA to Congress, and an ongoing internal policy review.

Dietary Choices Are Linked to Higher Rates of Preeclampsia Among Latinas By Vanessa G. Sánchez APRIL 5, 2024

https://kffhealthnews.org/news/article/preeclampsia-latina-hispanic-women-diet-prevention/?utm_campaign=KFF-The-Latest&utm_medium=email&_hsenc=p2ANqtz-9r5zAornGOg_kbAl4B02amDWPAOX3qRVkvQfm_Xxp9Vb6IjZxV3XtN1JU6zRmcc9Qlo1SknLdQ_LcHLePSsRlqpRXMMg&_hsmi=301432079&utm_content=301432079&utm_source=hs_email

Women’s Views of Abortion Access and Policies in the Dobbs Era: Insights From the KFF Health Tracking Poll Audrey Kearney, Ashley Kirzinger, Liz Hamel, and Alina Salganicoff Published: Apr 05, 2024

https://www.kff.org/womens-health-policy/poll-finding/womens-views-of-abortion-access-and-policies-in-the-dobbs-era-insights-from-the-kff-health-tracking-poll/?utm_campaign=KFF-The-Latest&utm_medium=email&_hsenc=p2ANqtz-9ifLBLDjanwADxAGeG1lto_P_SUOoxnV5vHjXrElKIcbTSeGsKNzv4x6fhbal-4H6ULxpjraTo1B_lWvvYKOBJajFDYw&_hsmi=301432079&utm_content=301432079&utm_source=hs_email

Attacks on ER Workers Prompt Debate Over Tougher Penalties Sejal Parekh April 05, 2024

https://www.medscape.com/s/viewarticle/attacks-er-workers-prompt-debate-over-tougher-penalties-2024a10006i9?src=

viernes, 5 de abril de 2024

Hospital care costs are out of control. Price caps can help By Roslyn Murray and Andrew RyanApril 4, 2024

https://www.statnews.com/2024/04/04/price-caps-can-help-control-hospital-care-costs/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-8D19wYeSc1F-lwolhE0CXbAsJ0iBBAZg1luVdpHqZbaX_ANT-gmTvN0ZMFYbppIfIL3dMkhvoW8CICKfwc_6OXPEKXOw&_hsmi=301143010&utm_content=301143010&utm_source=hs_email

Parkinson’s disease may be helped by GLP-1 drug, new study finds Elaine Chen By Elaine Chen April 3, 2024

https://www.statnews.com/2024/04/03/parkinsons-glp1-diabetes-obesity-study/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-_rJQlxqb9qYJN4q3-5klPMokllf4Wt8DnCtdY9PT-TVaUzYB05PRei8Px76igJ4jRqHuOD4GeuJ4Tw0a9G52-gUiHRVA&_hsmi=301143010&utm_content=301143010&utm_source=hs_email

Florida accounts for 8% of U.S. abortions. With a forthcoming ban, where will patients go? Olivia Goldhill By Olivia Goldhill April 3, 2024

https://www.statnews.com/2024/04/03/florida-abortion-ban-where-will-patients-go/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-8kcLT0zf3_A4-aWSQ0LmAvnS2ohjvOUYoX2gsuuQTGr5GcoPqZFF9olNDclqBuU6kDqtBPq24_NB5LWoK7_5oTWrEhZg&_hsmi=301143010&utm_content=301143010&utm_source=hs_email

DNA test that predicts opioid addiction should be pulled off the market, critics urge the FDA Megan Molteni By Megan Molteni

https://www.statnews.com/2024/04/04/fda-avertd-dna-test-opioid-addiction-solvd-health/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-9C0b0xCTMKm1VZnew7iPzbilIRS-ySlCb3Clyk9qMRy60LveujGEUZ33jbJa7xP2IHXmdvHEcPnKojoeIgxkhp9wYb5A&_hsmi=301143010&utm_content=301143010&utm_source=hs_email Critics urge the FDA to pull a DNA test that predicts opioid addiction off the market Opioid use disorder takes more than 130 lives every single day, mostly from illicit fentanyl and heroin. STAT’s Lev Facher has documented obstacles to treatment, but today we hear about a different challenge in the government’s attempts to stall this public health disaster. Last year, the Food and Drug Administration approved a DNA test rejected by its advisory panel to help guide physicians’ opioid-prescribing decisions. Called AvertD, it uses a cheek swab and a computer algorithm to predict an individual’s genetic risk of opioid addiction. The problem is, 31 scientists write in a letter to FDA and to the Centers for Medicaid and Medicare Services, it doesn't work. Geneticists, public health researchers, and experts in addiction and device regulation say the test analyzes just 15 genetic markers, woefully inadequate to reliably predict an individual’s risk of opioid use disorder. “It’s not that it’s a not-very-good test, it’s that it’s 100% bogus,” said Andrew Kolodny, a public health researcher at Brandeis University and one of the letter's authors. STAT’s Megan Molteni has more, including potential harms from the test. https://www.statnews.com/category/war-on-recovery/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-9MZL6-3Frl2Tulcz0PxnvjGe4y4dGxpbYyn7FT5-l74Hb6JeGEyHGJZ-bDXj7XCeph9ABvTdzZGOMlelvYeYFdEshJlg&_hsmi=301143010&utm_content=301143010&utm_source=hs_email

FAIR Header Reference genome: a TRUSTworthy standard. Adam Wright et al. Brief Bioinform 2024 25(3)

https://phgkb.cdc.gov/PHGKB/phgHome.action?action=update

Opioid Use Disorder in Youth — Online Meeting Wednesday, April 10, 2024 5 p.m. ET

https://opioidresponsenetwork.org/events/?utm_source=SAMHSA&utm_campaign=e9675a4083-EMAIL_CAMPAIGN_2024_04_04_01_18&utm_medium=email&utm_term=0_-e9675a4083-%5BLIST_EMAIL_ID%5D#event=77425163;instance=20240410170000?popup=1

Accelerating the Reach of Youth Mental Health Innovations Through Implementation Science — Webinar Tuesday, April 9, 2024 2 p.m. ET

https://mhttcnetwork.org/event/accelerating-the-reach-of-youth-mental-health-innovations-through-implementation-science/?utm_source=SAMHSA&utm_campaign=e9675a4083-EMAIL_CAMPAIGN_2024_04_04_01_18&utm_medium=email&utm_term=0_-e9675a4083-%5BLIST_EMAIL_ID%5D Studies have estimated that it takes approximately 17 years for research to inform practice. Implementation science is the systematic study of methods to improve the translation of research to practice. This training will go over implementation science theories, methods, and frameworks that anyone can use to guide an implementation effort. Practical examples in youth mental health implementation within school-settings will be used to highlight innovative ways people can use implementation science in their own work.

Human Trafficking And Trauma-Responsive, Healing-Centered Care: A Learning Opportunity for Educators, Professionals, and Those Who Comprise School Communities — Webinar Series Monday, April 8, 2024 11 a.m. ET (1st session: Human Trafficking (HT) and the Impact on School Communities)

https://mhttcnetwork.org/event/human-trafficking-and-trauma-responsive-healing-centered-care/?utm_source=SAMHSA&utm_campaign=e9675a4083-EMAIL_CAMPAIGN_2024_04_04_01_18&utm_medium=email&utm_term=0_-e9675a4083-%5BLIST_EMAIL_ID%5D This series examines human trafficking from the perspective of equity. Trafficking is viewed as one indicator of community vulnerabilities such as housing shortages, lack of mental health resources, lack of consistent, viable employment and career opportunities; insufficient or absent transportation opportunities, lack of language support and resources, communities in which neighbors and residents have precarious or no documentation. The other two sessions include: Monday, April 15, 2024 11 a.m. ET: Responding to Victim and Survivor Trauma Monday, April 22, 2024 11 a.m. ET: Healing-Centered Care

Redesigned Pre-Submission Meetings in GDUFA III: Benefits for ANDA Submission and Approval MAY 9, 2024

https://www.fda.gov/drugs/news-events-human-drugs/redesigned-pre-submission-meetings-gdufa-iii-benefits-anda-submission-and-approval-05092024?utm_medium=email&utm_source=govdelivery

National Center for Excellence in Primary Care Research

National Center for Excellence in Primary Care Research: AHRQ’s research to advance primary care infrastructure, delivery and outcomes. The National Center for Excellence in Primary Care Research (NCEPCR) is the intellectual home for primary care research at AHRQ. The NCEPCR is focused on the Nation's primary care system, providing evidence, practical tools, and other resources for researchers and evaluators, clinicians and clinical teams, quality improvement experts, and healthcare decision makers to improve the quality and safety of care. The NCEPCR is committed to listening to and learning from all members of the primary care community, including patients and families.

jueves, 4 de abril de 2024

The Effectiveness of Artificial Intelligence in Assisting Mothers with Assessing Infant Stool Consistency in a Breastfeeding Cohort Study in China. Jieshu Wu et al. Nutrients 2024 16(6)

https://phgkb.cdc.gov/PHGKB/translationClip.action?action=nonGhome

Effectiveness and Cost-Effectiveness of Colorectal Cancer Screening With a Blood Test That Meets the Centers for Medicare & Medicaid Services Coverage Decision. Rosita van den Puttelaar et al. Gastroenterology 2024

https://phgkb.cdc.gov/PHGKB/translationClip.action?action=home

FAIR Header Reference genome: a TRUSTworthy standard. Adam Wright et al. Brief Bioinform 2024 25(3)

https://phgkb.cdc.gov/PHGKB/phgHome.action?action=update

Experience of the Five Largest Publicly Traded Companies Operating Medicaid Managed Care Plans During Unwinding Jada Raphael and Elizabeth Hinton Published: Apr 03, 2024

https://www.kff.org/medicaid/issue-brief/experience-of-the-five-largest-publicly-traded-companies-operating-medicaid-managed-care-plans-during-unwinding/?utm_campaign=KFF-The-Latest&utm_medium=email&_hsenc=p2ANqtz-8DAfoa9YOTQwtlmoqnW6qxo0V0UU-z75vfx_jI-Qa9b-vO3HCzaPcidh3aU-YFKp6sX7hMV5eXUDsJTFEe2c_z5VVCcA&_hsmi=301101433&utm_content=301101433&utm_source=hs_email

The ‘Pandemic Agreement’: What it is, What it isn’t, and What it Could Mean for the U.S. Josh Michaud, Jennifer Kates, and Anna Rouw Published: Apr 01, 2024

https://www.kff.org/global-health-policy/issue-brief/the-pandemic-agreement-what-it-is-what-it-isnt-and-what-it-could-mean-for-the-u-s/?utm_campaign=KFF-The-Latest&utm_medium=email&_hsenc=p2ANqtz-98SBq8JDLYADVJXr-MwLMQ6lWf8m1JTe15BXMVHaGoSyIhGmo3KOniGq99DdU-AldWLlVAy4V1HcY4mRLCV8L2cjOnSA&_hsmi=301101433&utm_content=301101433&utm_source=hs_email

Four Years After Shelter-in-Place, Covid-19 Misinformation Persists By Kwasi Gyamfi Asiedu, PolitiFact APRIL 1, 2024

https://kffhealthnews.org/news/article/fact-check-covid-19-misinformation-persists-vaccines-deaths/?utm_campaign=KFF-The-Latest&utm_medium=email&_hsenc=p2ANqtz-_h8-XlAwonwJL9cCqY6chsD7q_F_n1kCxWEohyPV1JcSiERqYADwfc6TvOcOttXJMMS2DlR0IhpGP0FbsYP-P3JKq1oA&_hsmi=301101433&utm_content=301101433&utm_source=hs_email

For-Profit Companies Open Psychiatric Hospitals in Areas Clamoring for Care By Tony Leys APRIL 1, 2024

https://kffhealthnews.org/news/article/for-profit-psychiatric-hospitals-mental-health-care-void/?utm_campaign=KFF-The-Latest&utm_medium=email&_hsenc=p2ANqtz--ntYjPwgNk_3OchZnInFWHkqJfOY8r0sNaPNZ6M0unUwl3uj4EWZEVxb7rLpydU4OftbQCegJkHrI-3eolk2oz7YkvOg&_hsmi=301101433&utm_content=301101433&utm_source=hs_email

Hospitals Cash In on a Private Equity-Backed Trend: Concierge Physician Care By Phil Galewitz APRIL 1, 2024

https://kffhealthnews.org/news/article/concierge-medicine-physician-practices-hospitals-private-equity/?utm_campaign=KFF-The-Latest&utm_medium=email&_hsenc=p2ANqtz-_tmLF2lNDMczMSXcfVYu1TfCi8GMHJgL0pSVtEmXRhhtkDHAUDHwVjhYccKvdgtdrnu51ps-FHj0aenoDAH3HW5XYbpQ&_hsmi=301101433&utm_content=301101433&utm_source=hs_email

Track Opioid Settlement Payouts — To the Cent — In Your Community By Aneri Pattani and Lydia Zuraw and Holly K. Hacker APRIL 2, 2024

https://kffhealthnews.org/news/article/opioid-settlement-payouts-state-county-city-tracker/?utm_campaign=KFF-The-Latest&utm_medium=email&_hsenc=p2ANqtz-99W8JAaXMX4FULUH03Zq4LqhMFI4sKpexEIvgVQIcE5zqokZoJ4drVb3K2uvqc3zCD7mKV4PRggtL9Qpt75yUsknMLRw&_hsmi=301101433&utm_content=301101433&utm_source=hs_email

More Patients Are Losing Their Doctors — And Trust in the Primary Care System By Lynn Arditi, The Public’s Radio APRIL 2, 2024

https://kffhealthnews.org/news/article/primary-care-patients-lose-doctors-trust-rhode-island/?utm_campaign=KFF-The-Latest&utm_medium=email&_hsenc=p2ANqtz-9v2P6MuZg4WerFK0asScfWKsKiVmWpRRFcneU8Y3B3Ebi5O-4mC7DzBjJ5Zhtb3P6hgHM23mMlPzIJxBXMNVATdrRAYg&_hsmi=301101433&utm_content=301101433&utm_source=hs_email

Primary Care Check Up: Why It Can Be Hard to Get an Appointment and How ...

The Health Wonk Shop: Primary Care Check Up: Why It Can Be Hard to Get an Appointment and How to Fix It Published: Apr 03, 2024 https://www.kff.org/other/event/april-3-virtual-event-primary-care-check-up-why-it-can-be-hard-to-get-an-appointment-and-how-to-fix-it/?utm_campaign=KFF-The-Latest&utm_medium=email&_hsenc=p2ANqtz--BT7A7b58MKX97rQ3xk00UazhVoOvmJggwiVO7sgHYQDCAkQAVt-VyuiiVzEJcYSaxIfm78y27uIeefpSspGrqSMX5cA&_hsmi=301101433&utm_content=301101433&utm_source=hs_email

Medical Debt Affects Much of America, but Colorado Immigrants Are Hit Especially Hard By Rae Ellen Bichell and Lindsey Toomer, Colorado Newsline APRIL 3, 2024

https://kffhealthnews.org/news/article/medical-debt-colorado-immigrants-credit-reports/?utm_campaign=KFF-The-Latest&utm_medium=email&_hsenc=p2ANqtz--6xVuEqpQ-_Jr0XcSz6eKPk4ihUxgqaTKtuoVWvAAmR9e3zOsW0utUUSDgqcPJicNl7DV3GWq0qLTipZUbcY-0vlta6g&_hsmi=301101433&utm_content=301101433&utm_source=hs_email

LGBT Adults’ Experiences with Discrimination and Health Care Disparities: Findings from the KFF Survey of Racism, Discrimination, and Health Alex Montero, Liz Hamel, Samantha Artiga, and Lindsey Dawson Published: Apr 02, 2024

https://www.kff.org/racial-equity-and-health-policy/poll-finding/lgbt-adults-experiences-with-discrimination-and-health-care-disparities-findings-from-the-kff-survey-of-racism-discrimination-and-health/?utm_campaign=KFF-The-Latest&utm_medium=email&_hsenc=p2ANqtz-_oiybqupnMlwhje_Gl-FPgUXU751Rva8A2anaEuLztgI4F1fcVE0Rb2vK_bEtpkx4UGdIRudnZwc6IWE6zKxG4lsk79Q&_hsmi=301101433&utm_content=301101433&utm_source=hs_email

Data-Driven Automated Classification Algorithms for Acute Health Conditions: Applying PheNorm to COVID-19 Disease

https://sentinelinitiative.org/news-events/publications-presentations/data-driven-automated-classification-algorithms-acute-0 Data-Driven Automated Classification Algorithms for Acute Health Conditions: Applying PheNorm to COVID-19 Disease: This manuscript, recently published in JAMIA, describes a project led by Joshua Smith, PhD and David Carrell, PhD who co-lead the Feature Engineering Core within the Innovation Center. The paper focuses on implementing an automated phenotyping approach, PheNorm, to symptomatic COVID-19 disease to evaluate its feasibility for rapid phenotyping of acute health conditions

Assessing the Risk of Intentional Self-Harm in Montelukast Users: An Updated Sentinel System Analysis Using ICD-10 Coding

https://sentinelinitiative.org/news-events/publications-presentations/assessing-risk-intentional-self-harm-montelukast-users Assessing the Risk of Intentional Self-Harm in Montelukast Users: An Updated Sentinel System Analysis Using ICD-10 Coding: International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) diagnosis codes are thought to have better accuracy for capturing suicide intent compared to ICD-9-CM codes. As an update to a previous study that used ICD-9-CM codes to identify intentional self-harm, Sentinel investigators recently assessed the risk of intentional self-harm events in patients aged 10 and older with asthma following use of either montelukast or inhaled corticosteroids as monotherapy. Intentional self-harm in this study was defined using ICD-10-CM diagnosis codes, and the analysis used inverse probability of treatment weighting to balance baseline covariates. Investigators performed subgroup analyses by age group, sex, psychiatric history, and whether exposure occurred prior to or after March 2020, when a boxed warning regarding neuropsychiatric adverse events was added to montelukast.

The Next Generation of Single Cell and Spatial Genomics Technologies Register Now Date: April 10th, 2024 Time: 15:00 CEST / 14:00 GMT

https://pages.10xgenomics.com/wbr-2024-03-event-emea-single-cell-and-spatial-webinar_LP.html

OPQ Issues Annual Report for 2023

https://www.fda.gov/media/177470/download?utm_medium=email&utm_source=govdelivery

Generic Drugs Forum (GDF) 2024: Regulatory Considerations to Enhance Generic Drug Access APRIL 10 - 11, 2024

https://www.fda.gov/drugs/news-events-human-drugs/generic-drugs-forum-gdf-2024-regulatory-considerations-enhance-generic-drug-access-04102024?utm_medium=email&utm_source=govdelivery

Clinical Pharmacology Considerations for Antibody-Drug Conjugates Guidance for Industry Guidance for Industry MARCH 2024

https://www.fda.gov/regulatory-information/search-fda-guidance-documents/clinical-pharmacology-considerations-antibody-drug-conjugates-guidance-industry?utm_medium=email&utm_source=govdelivery

Medical Device Development Tools (MDDT)

https://www.fda.gov/medical-devices/medical-device-development-tools-mddt?utm_medium=email&utm_source=govdelivery

FDA Approves New Antibiotic for Three Different Uses

https://www.fda.gov/news-events/press-announcements/fda-approves-new-antibiotic-three-different-uses?utm_medium=email&utm_source=govdelivery FDA Approves New Antibiotic for Three Different Uses Today, the U.S. Food and Drug Administration approved Zevtera (ceftobiprole medocaril sodium for injection) for the treatment of adults with Staphylococcus aureus bloodstream infections (bacteremia) (SAB), including those with right-sided infective endocarditis; adults with acute bacterial skin and skin structure infections (ABSSSI); and adult and pediatric patients three months to less than 18 years old with community-acquired bacterial pneumonia (CABP). “The FDA is committed to fostering new antibiotic availability when they prove to be safe and effective, and Zevtera will provide an additional treatment option for a number of serious bacterial infections,” said Peter Kim, M.D., M.S., director of the Division of Anti-Infectives in the FDA’s Center for Drug Evaluation and Research. “The FDA will continue our important work in this area as part of our efforts to protect the public health.” Zevtera’s efficacy in treating SAB was evaluated in a randomized, controlled, double-blind, multinational, multicenter trial. In the trial, researchers randomly assigned 390 subjects to receive Zevtera (192 subjects) or daptomycin plus optional aztreonam [the comparator] (198 subjects). The primary measure of efficacy for this trial was the overall success (defined as survival, symptom improvement, S. aureus bacteremia bloodstream clearance, no new S. aureus bacteremia complications and no use of other potentially effective antibiotics) at the post-treatment evaluation visit, which occurred 70 days after being randomly assigned an antibiotic. A total of 69.8% of subjects who received Zevtera achieved overall success compared to 68.7% of subjects who received the comparator. Zevtera’s efficacy in treating ABSSSI was evaluated in a randomized, controlled, double-blind, multinational trial. In the trial, researchers randomly assigned 679 subjects to receive either Zevtera (335 subjects) or vancomycin plus aztreonam [the comparator] (344 subjects). The primary measure of efficacy was early clinical response 48-72 hours after start of treatment. Early clinical response required a reduction of the primary skin lesion by at least 20%, survival for at least 72 hours and the absence of additional antibacterial treatment or unplanned surgery. Of the subjects who received Zevtera, 91.3% achieved an early clinical response within the necessary timeframe compared to 88.1% of subjects who received the comparator. Zevtera’s efficacy in treating adult patients with CABP was evaluated in a randomized, controlled, double-blind, multinational, multicenter trial. In the trial, researchers randomly assigned 638 adults hospitalized with CABP and requiring IV antibacterial treatment for at least 3 days to receive either Zevtera (314 subjects) or ceftriaxone with optional linezolid [the comparator] (324 subjects). The primary measurement of efficacy were clinical cure rates at test-of-cure visit, which occurred 7-14 days after end-of-treatment. Of the subjects who received Zevtera, 76.4% achieved clinical cure compared to 79.3% of subjects who received the comparator. An additional analysis considered an earlier timepoint of clinical success at Day 3, which was 71% in patients receiving Zevtera and 71.1% in patients receiving the comparator. Given the similar course of CABP in adults and pediatric patients, today’s approval of Zevtera in pediatric patients three months to less than 18 years with CABP was supported by evidence from the CABP trial of Zevtera in adults and a trial in 138 pediatric subjects three months to less than 18 years of age with pneumonia. For adults with SAB, the most common side effects of Zevtera included anemia, nausea, low levels of potassium in the blood (hypokalemia), vomiting, diarrhea, increased levels of certain liver tests (hepatic enzymes and bilirubin), increased blood creatinine, high blood pressure, low white blood cell count (leukopenia), fever, abdominal pain, fungal infection, headache and shortness of breath (dyspnea). For adults with ABSSSI, the most common side effects of Zevtera included nausea, diarrhea, headache, injection site reaction, increased levels of hepatic enzymes, rash, vomiting and altered taste (dysgeusia). For adults with CABP, the most common side effects of Zevtera included nausea, increased levels of hepatic enzymes, vomiting, diarrhea, headache, rash, insomnia, abdominal pain, vein inflammation (phlebitis), high blood pressure and dizziness. For pediatric patients with CABP, the most common side effects of Zevtera included vomiting, headache, increased levels of hepatic enzymes, diarrhea, infusion site reaction, vein inflammation (phlebitis) and fever. Patients should not use Zevtera if they have a known history of severe hypersensitivity to ceftobiprole or any of the components of Zevtera, or other members of the cephalosporin antibacterial class. Zevtera comes with certain warnings and precautions such as increased mortality in ventilator-associated bacterial pneumonia patients (an unapproved use), hypersensitivity reactions, seizures and other central nervous system reactions and Clostridioides difficile-associated diarrhea. Zevtera was granted Priority Review, Fast Track and Qualified Infectious Disease Product designations for the CABP, ABSSSI and SAB indications. The FDA granted the approval of Zevtera to Basilea Pharmaceutica International Ltd. Related Information Antimicrobial Resistance Information from FDA https://www.fda.gov/emergency-preparedness-and-response/mcm-issues/antimicrobial-resistance-information-fda?utm_medium=email&utm_source=govdelivery

Last Opportunity to Register for MEPS Data Users’ Workshop Data Users' Hands-on Workshop on April 9-11, 2024.

https://meps.ahrq.gov/mepsweb/about_meps/workshops_events.jsp

Listening to the Voice of the Patient: Using Multiple Feedback Methods to Complement CAHPS Survey Data

Listening to the Voice of the Patient: Using Multiple Feedback Methods to Complement CAHPS Survey Data: The webinar will discuss how patient experience professionals use multiple feedback methods to fully capture the patient voice. Speakers will describe how additional feedback methods complement CAHPS data, and how this integration of data sources informs their efforts to identify improvement areas and potential solutions.

ADHD Diagnosis and Treatment in Children and Adolescents Systematic Review Mar 25, 2024

https://effectivehealthcare.ahrq.gov/products/attention-deficit-hyperactivity-disorder/research

Failure To Rescue – Rapid Response Systems

Failure To Rescue – Rapid Response Systems: The Agency for Healthcare Research and Quality (AHRQ) Making Healthcare Safer (MHS) reports consolidate information for healthcare providers, health system administrators, researchers, and government agencies about practices that can improve patient safety across the healthcare system—from hospitals to primary care practices, long-term care facilities, and other healthcare settings. In spring 2023, AHRQ launched its fourth iteration of the MHS Report (MHS IV).

miércoles, 3 de abril de 2024

Machine learning-enabled maternal risk assessment for women with pre-eclampsia (the PIERS-ML model): a modelling study

https://www.thelancet.com/journals/landig/article/PIIS2589-7500(23)00267-4/fulltext?dgcid=hubspot_update_feature_updatealerts_landig&utm_campaign=update-landig&utm_medium=email&_hsenc=p2ANqtz-9j5CMP8jLyQLG9lsI8v_6kPgnt4WOVBdQjoSCtOtt4_f3qM9pXPVnwv8X8YcPuxh8LH2UtMs3I79dG7Ibhtfixda8s6A&_hsmi=300894142&utm_content=300845935&utm_source=hs_email

Foresight—a generative pretrained transformer for modelling of patient timelines using electronic health records: a retrospective modelling study

https://www.thelancet.com/journals/landig/article/PIIS2589-7500(24)00025-6/fulltext?dgcid=hubspot_update_feature_updatealerts_landig&utm_campaign=update-landig&utm_medium=email&_hsenc=p2ANqtz-9XsJLtJJrFJSMR0Da5e0mjUSHn0DXjzn-KxZQ90Bg1rzbfSfenbOZ29ONjAhqOytrKJiFRizwQWCq0fjoq_-twnBTbCQ&_hsmi=300894142&utm_content=300845935&utm_source=hs_email

Retraction remedy: a resource for transparent science The Lancet Digital Health

https://www.thelancet.com/journals/landig/issue/vol6no4/PIIS2589-7500(24)X0004-7

FDA Tells Congress What It Wants, What it Really Really Wants (it really really really wants a zigazig-ah) By Sara W. Koblitz —

https://www.thefdalawblog.com/2024/04/fda-tells-congress-what-it-wants-what-it-really-really-wants-it-really-really-really-wants-a-zigazig-ah/?utm_source=rss&utm_medium=rss&utm_campaign=fda-tells-congress-what-it-wants-what-it-really-really-wants-it-really-really-really-wants-a-zigazig-ah

Human Trafficking and Trauma-Responsive, Healing-Centered Care: A learning opportunity for educators, professionals, and those who comprise school communities

https://mhttcnetwork.org/event/human-trafficking-and-trauma-responsive-healing-centered-care/?utm_source=SAMHSA&utm_campaign=c0d5406080-EMAIL_CAMPAIGN_2024_03_28_07_58&utm_medium=email&utm_term=0_-c0d5406080-%5BLIST_EMAIL_ID%5D Course Series: SAMHSA-funded MHTTC’s Human Trafficking and Trauma-Responsive, Healing-Centered Care A learning opportunity for educators, professionals, and those who comprise school communities The SAMHSA-funded South Southwest Mental Health Technology Transfer Center (MHTTC) three-part series delves into human trafficking through an equity lens, considering it as one of several indicators of community vulnerabilities. These vulnerabilities encompass housing shortages, limited mental health resources, inconsistent job opportunities, lack of accessible transportation, language barriers, and communities where residents may lack proper documentation. The first session, "Human Trafficking and the Impact on School Communities," kicks off a three-part program. Its goal is to establish a foundation for recognizing human trafficking, delve into trauma-informed interventions for victims and survivors, and explore techniques for providing healing-centered care. Participants in these sessions will not only learn but also engage in pre- and post-learning activities, allowing them to reflect on and apply the presented concepts during the subsequent sessions of the series. Registrations will be processed in numerical order as seats for the session are limited. To attend Sessions 2 and 3, participants must attend and complete Session 1, Human Trafficking and the Impact on School Communities. Session 1: Human Trafficking (HT) and the Impact on School Communities — April 8, 2024, 11 a.m. ET Session 2: Responding to Victim and Survivor Trauma Workshop — April 15, 2024, 11 a.m. ET Session 3: Healing-Centered Care Workshop — April 22, 2024, 11 a.m. ET

Wastewater study sheds light on tracking cannabis use challenges

https://www.news-medical.net/news/20240403/Wastewater-study-sheds-light-on-tracking-cannabis-use-challenges.aspx

Advances and hurdles: The impact of AI on oncology care efficiency and mortality rates

https://www.news-medical.net/news/20240403/Advances-and-hurdles-The-impact-of-AI-on-oncology-care-efficiency-and-mortality-rates.aspx

Attacks on emergency room workers prompt debate over tougher penalties

https://www.news-medical.net/news/20240403/Attacks-on-emergency-room-workers-prompt-debate-over-tougher-penalties.aspx

Heat protections for California workers are in limbo after Newsom abandons rules

https://www.news-medical.net/news/20240403/Heat-protections-for-California-workers-are-in-limbo-after-Newsom-abandons-rules.aspx

Medical debt affects much of America, but Colorado immigrants are hit especially hard

https://www.news-medical.net/news/20240403/Medical-debt-affects-much-of-America-but-Colorado-immigrants-are-hit-especially-hard.aspx

Changes in the global hospitalisation burden of respiratory syncytial virus in young children during the COVID-19 pandemic: a systematic analysis

https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00630-8/fulltext?dgcid=hubspot_update_feature_updatealerts_laninf&utm_campaign=update-laninf&utm_medium=email&_hsenc=p2ANqtz--0oW2eHMcNqky7IAvQ7XzTigUW1NYAyP9nKsDw5myhBqFzXXq7xiwDY6F5x7x4J2-RmA_puxHAJeFMRaFO1FFwoAvJ8w&_hsmi=300878298&utm_content=300845929&utm_source=hs_email

Writing and reviewing for us in AI times The Lancet Infectious Diseases

https://www.thelancet.com/journals/laninf/issue/vol24no4/PIIS1473-3099(24)X0004-3

Efficacy of three benznidazole dosing strategies for adults living with chronic Chagas disease (MULTIBENZ): an international, randomised, double-blind, phase 2b trial

https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00629-1/abstract?utm_campaign=update-laninf&utm_medium=email&dgcid=hubspot_update_feature_updatealerts_laninf&_hsenc=p2ANqtz-92sTPMzT42BoW_Xnv2aoe2NpHFJb9Ba8DAp8rK0R34XsaovbhVaMkyc-yblZUpuzuRg1_bDZThRNO5AOLBMtgmjeNyzw&_hsmi=300878298&utm_content=300845929&utm_source=hs_email

CHIPS R&D National Advanced Packaging Manufacturing Program (NAPMP) Advanced Packaging Summit

https://www.nist.gov/news-events/events/chips-rd-national-advanced-packaging-manufacturing-program-napmp-advanced Advanced Packaging Summit April 18-19, 2024 Key technical challenges and strategic approaches in advanced packaging in the semiconductor sector. Location In-person at the NASA Ames Conference Center (NACC) in Moffett Field, CA and virtually. Audience For industry representatives, technical experts, researchers, and semiconductor industry alliances. We welcome both domestic and international participation, as fostering global collaboration and enriching the discussions on advancing semiconductor standards and innovation are paramount to success. Purpose This event will bring together technical experts from industry, academia, government, and industry alliances to identify key technical challenges and strategic approaches in advanced packaging. Next Steps Register now for the Advanced Packaging Summit. In-person capacity is limited to 240 attendees total, including speakers. Registration will close at 5:00pm PDT/8:00pm EDT next Thursday, April 11. Late registrations will not be accepted. We hope to see you in person, or virtually, at the NASA Ames Conference Center on April 18-19, 2024, for the Advanced Packaging Summit! Note to Foreign National registrants (both in-person and virtual): In preparation for your attendance to the CHIPS R&D National Advanced Packaging Manufacturing Program (NAPMP) Advanced Packaging Summit, you will receive a NASA Identity Invitation email and a Pass Phrase email. Please be responsive to upload your identification information to the secure system. Registration for the summit near the deadline might not allow sufficient time to process your attendance request.

Understanding CDER’s Postmarket Safety Surveillance Programs and Public Data

https://www.fda.gov/drugs/cder-conversations/understanding-cders-postmarket-safety-surveillance-programs-and-public-data?utm_medium=email&utm_source=govdelivery

Challenges and opportunities for Lynch syndrome cascade testing in the United States

Challenges and opportunities for Lynch syndrome cascade testing in the United States. Lauren E Passero et al. Fam Cancer 2024 3 From the abstract: " Lynch syndrome is an underdiagnosed genetic condition that increases lifetime colorectal, endometrial, and other cancer risk. Cascade testing in relatives is recommended to increase diagnoses and enable access to cancer prevention services, yet uptake is limited due to documented multi-level barriers. Individual barriers such as feelings of fear, guilt, and anxiety and limited knowledge about Lynch syndrome as well as interpersonal barriers including complex family dynamics and language barriers limit family communication about Lynch syndrome and prevent uptake of genetic screening for relatives. Organizational and environmental barriers including a shortage of genetics professionals, high costs, and fears of discrimination also reduce cascade testing. These multi-level barriers may disproportionately impact underserved populations in the United States," https://pubmed.ncbi.nlm.nih.gov/38548925/

Drug Trials Snapshots: NGENLA (somatrogon-ghla)

NGENLA is a human growth hormone for the treatment of children 3 years of age and older who are not growing because they have growth hormone deficiency (GHD). https://www.fda.gov/drugs/drug-approvals-and-databases/drug-trials-snapshots-ngenla GHD is a condition in which the body does not produce enough growth hormone (GH). Symptoms of GHD in children include poor growth and short stature.

Drug Trials Snapshots: WAINUA

WAINUA is a drug for the treatment of nerve damage in adult patients with hereditary transthyretin-mediated amyloidosis. Transthyretin-mediated amyloidosis is the buildup of abnormal deposits of a substance called amyloid in the body’s organs and tissues. Amyloid disrupts the function of organs and tissues. https://www.fda.gov/drugs/drug-approvals-and-databases/drug-trials-snapshots-wainua

Data Integrity for In Vivo Bioavailability and Bioequivalence Studies APRIL 2024

https://www.fda.gov/regulatory-information/search-fda-guidance-documents/data-integrity-in-vivo-bioavailability-and-bioequivalence-studies

October - December 2023 | Potential Signals of Serious Risks/New Safety Information Identified by the FDA Adverse Event Reporting System (FAERS)

https://www.fda.gov/drugs/questions-and-answers-fdas-adverse-event-reporting-system-faers/october-december-2023-potential-signals-serious-risksnew-safety-information-identified-fda-adverse

martes, 2 de abril de 2024

Otsuka’s digital treatment for depression cleared by FDA, as pharma tries to crack tricky market Mario Aguilar By Mario Aguilar April 1, 2024

https://www.statnews.com/2024/04/01/otsuka-digital-therapy-depression-gains-fda-clearance/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-8QusNOZgUD3EDCEaDL8Ho5yIFDhZWG1idfpnI4s0LiRxF_UtCxTCblL7-j3-D3J9IjM0cuIeR4DlZr4zdmYxMMkJmwyg&_hsmi=300762397&utm_content=300762397&utm_source=hs_email FDA clears digital health tool targeting depression Otsuka Pharmaceuticals became the first drug company to receive FDA clearance for a digital treatment targeting a mental health condition yesterday when its smartphone-based treatment for major depressive disorder symptoms won the agency’s nod. Rejoyn, developed with digital health company Click Therapeutics, is intended to be prescribed along with antidepressants. In its six-week program, patients undergo a cognitive-emotional training technique that asks them to identify and recall faces showing different emotions. The idea is to improve cognitive control over emotional processing, the company says, while people simultaneously receive cognitive behavioral therapy. Prescription digital therapeutics have yet to produce a blockbuster success, and several companies focused solely on this form of treatment have gone out of business. STAT’s Mario Aguilar explains that Rejoyn’s success may depend on how health care providers interpret the modest benefits shown in its clinical trial data. Read more. https://www.nature.com/articles/s41746-018-0025-5?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz--7amoF1nY63zypCFt8BuKAYUxmoTEmJCkRfHkmexz5Bw0qwiWDDHLyOIPYqtrj1aPQ3nuORbnVoZZYvzpLgiBJrv6gyQ&_hsmi=300762397&utm_content=300762397&utm_source=hs_email

New HHS guidance requires consent for pelvic, breast, and other sensitive examinations Annalisa Merelli By Annalisa Merelli April 1, 2024

https://www.statnews.com/2024/04/01/informed-consent-pelvic-exam-new-hhs-guidelines/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-9kBYPxuN1gQeIw4IbooiXxF4YB0tGHy2CsQ9tMsd4VR610QX_fOI4TpCsFXlrxKbTjjrP9u8IblFhVfbFQhEHVqfX4gw&_hsmi=300762397&utm_content=300762397&utm_source=hs_email Federal guidance requires consent for invasive medical exams For years, it hasn't been unusual for physicians in training to perform invasive examinations — pelvic, breast, prostate, or rectal — on anesthetized patients, often despite knowing patients had not given permission to do so. As important as this experience may be to medical education, patients, advocates, and lawmakers have pushed back to require specific, informed consent. Fourteen states have stepped in with their own rules, but some of them protect only female patients from unconsented exams or cover only medical students and trainees. Yesterday, the federal Centers for Medicare and Medicaid Services issued new guidance that expands protections across the country and specifies what’s required for patient consent. Without this consent, hospitals won’t be eligible for Medicare and Medicaid reimbursement. STAT’s Annalisa Merelli has more. https://www.cms.gov/files/document/qso-24-10-hospitals.pdf?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-_0Y5faGPeYKkYmuHZinBhz-Nta7UK-c8QG2dtnN8uDudUTINXu9F-xhmbzPFEaqgMWxCmf5MvepRqINH0_ofqWPjWe0A&_hsmi=300762397&utm_content=300762397&utm_source=hs_email

H5N1 avian flu found in Texas individual who apparently was infected by dairy cows Helen Branswell By Helen Branswell April 1, 2024

https://www.statnews.com/2024/04/01/bird-flu-h5n1-spread-to-humans-dairy-cattle/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-_LiMIaMFPBtwCYrh7bUy-SVz_qTEBsZxVh0YQTDPJ1_bMT0MnpJbtp7A0BaKVhNN92Sqn0yPTDteF_gzhVa_GfE0WZTA&_hsmi=300762397&utm_content=300762397&utm_source=hs_email Texas health officials reported yesterday that an individual who’d been in contact with cattle has contracted H5N1 avian flu, only the second case ever recorded in the U.S. Officials believe the cattle were infected with the bird flu, which until recently had spread from poultry to such mammals as big cats, bears, foxes, skunks, and seals. In the Texas case, symptoms are mild and limited to inflammation of the eye. Treatment consists of the influenza antiviral oseltamivir, sold as Tamiflu. “This infection does not change the H5N1 bird flu human health risk assessment for the U.S. general public, which CDC considers to be low,” the Centers for Disease Control and Prevention said in a statement. Three states — Texas, Kansas, and Michigan — have recently reported they have had confirmed H5N1 outbreaks in cattle; New Mexico and Idaho have also reported outbreaks in cattle presumed to have been caused by H5N1. The virus doesn’t kill the cattle, but infection lowers milk production and the animals’ feeding. If milk from infected animals made its way into the food chain, pasteurization could kill the virus, the CDC said. STAT’s Helen Branswell has more.

Understanding CDER’s Postmarket Safety Surveillance Programs and Public Data

https://www.fda.gov/drugs/cder-conversations/understanding-cders-postmarket-safety-surveillance-programs-and-public-data?utm_medium=email&utm_source=govdelivery FDA maintains a system of postmarket surveillance and risk assessment programs to identify and evaluate adverse drug reactions and medication errors that did not appear during the drug development process, and to learn more about known adverse drug reactions. As part of this effort, the agency receives and analyzes reports of adverse events – problems that patients have after they take a drug regardless of whether the drug caused the event or not – to determine if these adverse events were caused by a drug. CDER uses these reports, along with other sources of drug safety data, to monitor the safety of approved drugs and therapeutic biologic products. When new potential safety issues are identified, FDA conducts a thorough and rigorous review of the available data before determining what, if any, actions are appropriate.

FDA Resumes Posting Regulatory Science Policy Memos on Premarket Review Process Newly released memos focus on toxicology and chemistry related considerations.

https://www.fda.gov/tobacco-products/ctp-newsroom/fda-resumes-posting-regulatory-science-policy-memos-premarket-review-process?utm_campaign=ctp-pmta&utm_content=CTPStatement&utm_medium=email&utm_source=govdelivery&utm_term=stratcomms “We’ve heard loud and clear from stakeholders that opportunities exist to enhance the Center’s transparency,” said Brian King, Ph.D., M.P.H., director of the FDA’s Center for Tobacco Products. “Consistent with our commitment to do so, FDA is making previously internal memos available to the public to provide further clarity on the premarket review process. We intend to continue posting batches of memos like these on a rolling basis, as appropriate, moving forward."

The International Forum on Quality and Safety in Healthcare. January 15, 2024 Institute for Healthcare Improvement and British Medical Journal. ExCeL London, London, UK, April 10-12, 2024.

The International Forum on Quality and Safety in Healthcare. January 15, 2024 Institute for Healthcare Improvement and British Medical Journal. ExCeL London, London, UK, April 10-12, 2024. https://psnet.ahrq.gov/issue/international-forum-quality-and-safety-healthcare

Inpatient Transitions of Care: Challenges and Safety Practices Anna Satake PhD, MSN, GCNS, RN and Vanessa McElroy, MSN, PHN, ACM-RN, IQCI | March 27, 2024

https://psnet.ahrq.gov/primer/inpatient-transitions-care-challenges-and-safety-practices Transitions of care occur frequently during hospitalizations and present notable risks associated with communication, medication management, and caregiver preparedness. To address these risks, healthcare systems must create safety nets to ensure seamless transitions and patient-centered experience while decreasing the risk of medical errors, elevating the overall quality of care and bettering patient outcomes.

National Patient Safety Goals Ulfat Shaikh, MD, MPH, FAAP | March 27, 2024

https://psnet.ahrq.gov/primer/national-patient-safety-goals The National Patient Safety Goals (NPSG) were developed in response to the high prevalence of preventable medical errors in the United States. This primer describes the NPSGs, how they relate to other goals and priorities established by national organizations, and how health care systems can use these goals to drive patient safety improvement efforts.

Equity in Patient Safety Angela D. Thomas, DrPH, MPH, MBA; Merton Lee, PhD, PharmD; Sarah Mossburg, RN, PhD | March 27, 2024

https://psnet.ahrq.gov/perspective/equity-patient-safety Certain groups of people experience disproportionate, avoidable harm in our healthcare system. Over the course of 2023, research posted to #AHRQ PSNet has focused on the issue of equity in #patientsafety. This Year in Review Perspective discusses this body of research, through findings on clinician bias, technological tools, current initiatives directed at improving health equity, and in clinical areas such as obstetrics.

Communication During Transitions of Care Ayse P. Gurses; Sarah Mossburg; Zoe Sousane | March 27, 2024

https://psnet.ahrq.gov/perspective/communication-during-transitions-care Throughout 2023, the importance of communication during transitions of care was a recurrent theme among articles on AHRQ PSNet. This Year in Review Perspective for 2023 discusses strategies for effective communication during transitions of care, spanning interactions among healthcare professionals, across organizations, and with patients, families, and caregivers.

Ensuring Patient and Workforce Safety Culture in Healthcare John Murray, Joann Sorra, Bryan Gale, Sarah Mossburg | March 27, 2024

https://psnet.ahrq.gov/perspective/ensuring-patient-and-workforce-safety-culture-healthcare Throughout 2023, the importance patient safety culture and workforce safety culture were recurrent themes among articles on AHRQ PSNet. This Year in Review Perspective for 2023 discusses concepts of psychological safety and employee voice, individual and team factors, and leadership and organizational factors related to safety culture.

Artificial Intelligence and Patient Safety: Promise and Challenges Patrick Tighe, MD, MS; Bryan M. Gale, MA; Sarah E. Mossburg, RN, PhD | March 27, 2024

https://psnet.ahrq.gov/perspective/artificial-intelligence-and-patient-safety-promise-and-challenges

Cybersecurity and How to Maintain Patient Safety Barbara Pelletreau, RN; John Riggi; Bryan M. Gale, MA; Sarah E. Mossburg, RN, PhD | March 27, 2024

https://psnet.ahrq.gov/perspective/cybersecurity-and-how-maintain-patient-safety

I Just Want to Go Home: Understanding Delirium’s Impact on Treatment Preferences Karl Steinberg, MD, CMD, HMDC, HEC-C | March 27, 2024

I Just Want to Go Home: Understanding Delirium’s Impact on Treatment Preferences Karl Steinberg, MD, CMD, HMDC, HEC-C | March 27, 2024 https://psnet.ahrq.gov/web-mm/i-just-want-go-home-understanding-deliriums-impact-treatment-preferences In this WebM&M Case, a 76-year-old was readmitted for altered mental status after a recent hospitalization. He was experiencing hypoxia and required supplemental oxygen but was intermittently combative, repeatedly asked to go home and declined most medical interventions. His family, who lived a few hours away, acted as his medical decision-makers but were not able to travel to the hospital to see him. A treating clinician documented a discussion where the patient agreed to hospice enrollment however the palliative medicine consultant determined that he did not have capacity to make decisions due to delirium, nor was he clearly eligible for hospice. The care team and the patient’s family decided to continue to treat the patient’s underlying medical issues and to wait to see if his delirium improved. In subsequent days, the patient's mental status improved, and he was able to express opposition to hospice care. He was then transferred to a skilled nursing facility near his family for rehabilitation. The commentary discusses the importance of prompt identification and treatment of delirium, the role of shared decision-making with patients and their caregivers, and how clinicians should assess and address decisional capacity.

Navigating Chaos: Fatal Iatrogenic Liver Injury in a Patient Admitted for Leg Fractures Caitlin Loseth, MD | March 27, 2024

Navigating Chaos: Fatal Iatrogenic Liver Injury in a Patient Admitted for Leg Fractures Caitlin Loseth, MD | March 27, 2024 https://psnet.ahrq.gov/web-mm/navigating-chaos-fatal-iatrogenic-liver-injury-patient-admitted-leg-fractures In this WebM&M Case, a 60-year-old woman with a history of cirrhosis arrived at the emergency department (ED) with an open right ankle injury and moderate blood loss after falling at home. A tourniquet was placed and her initial point-of-care hemoglobin was 7 mg/dl, so a “massive transfusion protocol” was initiated. The patient progressed to cardiac arrest and chest tubes were placed on both sides of the chest. After return of spontaneous circulation, fluid was identified in the abdomen, so the patient was immediately transferred to the operating room (OR) for exploratory laparotomy. Bleeding was noted to be coming from lacerations in the lateral chest wall and in the right lateral aspect of the liver, which was enlarged and visibly cirrhotic with splenomegaly. Multiple packing maneuvers were attempted but definitive hemorrhage control could not be obtained. This commentary highlights the challenges in managing blunt trauma in actively bleeding patients with a history of cirrhosis and the importance of frameworks and protocols (e.g., Advanced Trauma Life Support [ATLS], Massive Transfusion Protocol [MTP]) to protect against misadventures in the trauma bay.

Uterine Artery Injury during Cesarean Delivery Leads to Cardiac Arrests and Emergency Hysterectomy Claudia López, MD and Véronique Taché, MD | March 27, 2024

Uterine Artery Injury during Cesarean Delivery Leads to Cardiac Arrests and Emergency Hysterectomy Claudia López, MD and Véronique Taché, MD | March 27, 2024 https://psnet.ahrq.gov/web-mm/uterine-artery-injury-during-cesarean-delivery-leads-cardiac-arrests-and-emergency In this WebM&M Spotlight Case with CE/MOC, a patient who was 39-weeks pregnant presented to the hospital in active labor, admitted to the Labor and Delivery unit and confirmed to have a full-term singleton fetus in vertex presentation. After several hours on oxytocin, the fetal head was still relatively high and the fetal heart rhythm suggested hypoxemia. The physician attempted delivery using a vacuum, but ultimately performed an emergency cesarean delivery of a healthy newborn. The procedure was complicated by the need to extend the lower uterine segment incision bilaterally for safe extraction of the fetus. The operator’s note described post-delivery repair of the right uterine incision but did not comment on the left side. Following the delivery, the patient was noted to be hypotensive and tachycardic and went into cardiac arrest. Another physician opened the patient’s incision and found nearly three liters of blood had collected in her abdomen, apparently due to complete transection of the left uterine artery. The commentary highlights the risk factors for obstetric hemorrhage, summarizes standardized risk assessments used to alert for potential obstetric hemorrhage and use of obstetric simulation training to improve team communication and performance.