martes, 31 de diciembre de 2019

Recovery LIVE! From Sea to Shining Sea: Workforce Efforts to Build Healthy Communities through the National Health Service Corps Tickets, Wed, Jan 8, 2020 at 2:00 PM | Eventbrite

Recovery LIVE! From Sea to Shining Sea: Workforce Efforts to Build Healthy Communities through the National Health Service Corps Tickets, Wed, Jan 8, 2020 at 2:00 PM | Eventbrite

SAMHSA: Substance Abuse and Mental Health Services Administration

Recovery LIVE!

From Sea to Shining Sea: Workforce Efforts to Build Healthy Communities through the National Health Service Corps


Thursday | January 8, 2020 | 2:00–3:00 p.m. EST


SAMHSA’s Bringing Recovery Supports to Scale Technical Assistance Center Strategy (BRSS TACS) invites you to learn about the Health Resources & Services Administration’s National Health Service Corps (NHSC) program.

NHSC began in 1972 with the aim of building healthy communities by placing qualified healthcare practitioners in underserved areas of the United States. Today, the program continues to address healthcare worker shortages in rural, urban, and tribal communities, in an effort to ensure access to care for everyone, prevent disease and illness, and care for vulnerable and underserved people.

Currently, more than 4,000 of the 13,000 members of the corps are mental and substance use disorder (SUD) clinicians. Recent awards from the U.S. Department of Health and Human Services will enable the NHSC to support an additional 1,250 clinicians who will provide SUD treatment in an effort to combat the opioid epidemic in underserved communities.        

Searchable on the Health Workforce Connector, there are more than 20,000 health care facilities approved by the NHSC. Eligible clinicians may apply for loan repayment during one cycle each year if they are employed at an NHSC-approved facility. Awards will be prioritized to those practicing in areas of greatest need. Eligible professions include:
  • Physicians
  • Physicians assistants
  • Nurse practitioners
  • License clinical social workers
  • Licensed professional counselors
  • Health service psychologists
  • Marriage & family therapists
  • Psychiatric nurse specialists
  • SUD counselors
  • Registered nurses
  • Pharmacists
Presenters will discuss the increasing need for providers who can treat mental and substance use disorders in underserved communities, describe their own experience in the NHSC, and provide information on the application process.

Join us for this free, interactive virtual event, moderated by CAPT Wanda Finch, Health Services Officer in the U.S. Public Health Service.


Register For The Virtual Event


Presenters:

Malissa Lewis, Chief, Loan Repayment Branch, Division of National Health Service Corps, Bureau of Health Workforce, Health Resources and Services Administration

Dr. Mbeja Lomotey, DrPH, Substance Use Disorder Public Health Analyst, Division of Regional Operations, Bureau of Health Workforce, Health Resources and Services Administration

Heather Rogers, LPC, National Health Service Corps Recipient at Change Point Integrated Health in Snowflake, AZ

BMC Biomedical Engineering | Home

BMC Biomedical Engineering | Home

BMC Biomedical Engineering

Journal of Nanobiotechnology | Home page

Journal of Nanobiotechnology | Home page

Journal of Nanobiotechnology

Articles

BMC Biotechnology | Home page

BMC Biotechnology | Home page

BMC Biotechnology

Articles

Journal of Translational Medicine | Home page

Journal of Translational Medicine | Home page

Journal of Translational Medicine

Articles

Relationship between the effects of food on the pharmacokinetics of oral antineoplastic drugs and their physicochemical properties | Journal of Pharmaceutical Health Care and Sciences | Full Text

Relationship between the effects of food on the pharmacokinetics of oral antineoplastic drugs and their physicochemical properties | Journal of Pharmaceutical Health Care and Sciences | Full Text

Journal of Pharmaceutical Health Care and Sciences

Relationship between the effects of food on the pharmacokinetics of oral antineoplastic drugs and their physicochemical properties

  • 227 Accesses

Abstract

Background

Food is known to affect drug absorption by delaying gastric emptying time, altering gastrointestinal pH, stimulating bile flow, increasing splanchnic blood flow, or physically interacting with drugs. Although food is known to affect the pharmacokinetics of oral antineoplastic drugs, the relationship between the effects of food and the physicochemical properties of drugs remains unclear.

Methods

In this study, we surveyed the literature on three kinds of pharmacokinetic changes, AUC ratio, Cmax ratio and Tmax ratio, in the fasted and fed state for 72 oral antineoplastic drugs that were listed on the drug price standard in May 2018 in Japan. We further predicted the physicochemical properties from the 2D chemical structure of the antineoplastic drugs using in silico predictions.

Results

As a result of analyzing the relationship between the effects of food and physicochemical properties, we found that compounds that show increased absorption in the fed state had higher logP and lower solubility in fasted-state simulated intestinal fluid (FaSSIF). However, compounds with delayed absorption had higher solubility in FaSSIF. Furthermore, as a result of decision tree analysis, it was classified as AUC increase with logP ≥4.34. We found that an AUC increase in the fed state did not occur with compounds with low lipid solubilities (logP < 1.59). From these results, it is predicted that 7 compounds out of the 24 compounds for which the effects of food are unknown are at risk for increased absorption in the fed state and that no increase in absorption would occur in 13 compounds.

Conclusion

In this study, we found that drugs that will show increased absorption in the fed state and drugs for which absorption is not dependent on food can generally be predicted by logP. These results suggest that logP can be a useful parameter for predicting the effects of food on drug absorption.

Physical, chemical, and microbiological stability study of diluted atropine eye drops | Journal of Pharmaceutical Health Care and Sciences | Full Text

Physical, chemical, and microbiological stability study of diluted atropine eye drops | Journal of Pharmaceutical Health Care and Sciences | Full Text

Journal of Pharmaceutical Health Care and Sciences

Physical, chemical, and microbiological stability study of diluted atropine eye drops

  • 368 Accesses

Abstract

Background

Atropine eye drops are indicated for juvenile myopia progression, cycloplegia, amblyopia, and strabismus. According to the package insert, 10 mg/mL atropine eye drops must be diluted for pediatric patients to prevent systemic adverse effects. Compounding units in hospital pharmaceutical departments or community pharmacies are compelled to prepare this essential medication; however, validated atropine stability data is limited and the shelf life after preparation is extremely short. As it is a long-term treatment, a longer shelf life is necessary to improve patient care. This study aimed to demonstrate the physical, chemical, and microbiological stability of diluted atropine eye drops over a period of six months.

Methods

Preparation consists of dilution of a 10 mg/mL atropine solution (Nitten Atropine Ophthalmic Solution 1%; Nitten Pharmaceutical Co., Ltd.) in 0.9% NaCl to concentrations of 0.1, 1.0, 2.5, and 5.0 mg/mL, followed by a sterilizing filtration procedure and then an aseptic filling process of 5 mL in 5 mL polyethylene eyedropper bottles. The entire process is carried out in an overpressure isolator. All concentration products were kept for six months at 25 °C or 5 °C. Visual inspection was conducted and pH, osmolality, and atropine concentration were measured at day 0, day 14, day 28, and every month until six months. Atropine concentration was measured using liquid chromatography tandem mass spectrometry. The sterility was monitored using a method adapted from the Japanese Pharmacopoeia sterility assay.

Results

Atropine remained within ±5% of the target value in the six batches. Osmolality (285 mOsm/kg) as well as pH (5.88) were kept constant. No variations in solution characteristics (crystallization, discoloration) were noted. Sterility was maintained.

Conclusions

This study validated the physical, chemical, and microbiological stability of 0.1, 1.0, 2.5, and 5.0 mg/mL atropine sulfate eye drops conserved inside polyethylene eyedroppers for six months at 25 °C or 5 °C.