Pharmacologic and Nonpharmacologic Treatments for Posttraumatic Stress Disorder: An Update of the PTSD Repository Evidence Base

https://effectivehealthcare.ahrq.gov/products/ptsd-pharm-non-pharm-treatment/research Pharmacologic and Nonpharmacologic Treatments for Posttraumatic Stress Disorder: An Update of the PTSD Repository Evidence Base (Systematic Review Update, released on September 30, 2025) The U.S. Department of Veterans Affairs (VA) has established a long-term partnership to commission AHRQ to utilize its Evidence-based Practice Centers to develop update reviews to inform the VA’s PTSD-Repository – a publicly accessible clinical trials database maintained by the National Center for PTSD (NCPTSD). Thirty-four randomized controlled trials (RCTs) were added in this 2025 update.