Pharmacogenomics Meets Precision Cardio-Oncology: Is There Synergistic Potential? - PubMed

Pharmacogenomics Meets Precision Cardio-Oncology: Is There Synergistic Potential? - PubMed

Pharmacogenomics Meets Precision Cardio-Oncology: Is There Synergistic Potential?

Jennifer K Hockings 1 2, Jessica A Castrillon 2, Feixiong Cheng 2 3 4

Affiliations 

• PMID: 32601683
 
• DOI: 10.1093/hmg/ddaa134

Abstract

An individual's inherited genetic make-up and acquired genomic variants may account for a significant portion of observable variability in therapy efficacy and toxicity. Pharmacogenomics (PGx) is the concept that treatments can be modified to account for these differences to increase chances of therapeutic efficacy while minimizing risk of adverse effects. This is particularly applicable to oncology in which treatment may be multi-modal. As each tumor type has a unique genomic signature that lends to inclusion of targeted therapy but treatment options may be associated with cumulative toxicity, such as cardiotoxicity, that can impact quality of life. A greater understanding of therapeutic agents impacted by PGx and subsequent implementation has the potential to improve outcomes and reduce risk of drug-induced adverse effects.

© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Similar articles

• Personalized medicine: Genetic risk prediction of drug response.

  Zhang G, Nebert DW.Pharmacol Ther. 2017 Jul;175:75-90. doi: 10.1016/j.pharmthera.2017.02.036. Epub 2017 Feb 14.PMID: 28213088 Free PMC article. Review.
• Precision Medicine in Oncology Pharmacy Practice.

  Saadeh C, Bright D, Rustem D.Acta Med Acad. 2019 Apr;48(1):90-104. doi: 10.5644/ama2006-124.246.PMID: 31264437 Review.
• Personalized medicine in cardio-oncology: the role of induced pluripotent stem cell.

  Sayed N, Ameen M, Wu JC.Cardiovasc Res. 2019 Apr 15;115(5):949-959. doi: 10.1093/cvr/cvz024.PMID: 30768178 Free PMC article. Review.
• A Review of African Americans' Beliefs and Attitudes About Genomic Studies: Opportunities for Message Design.

  Scherr CL, Ramesh S, Marshall-Fricker C, Perera MA.Front Genet. 2019 Jun 14;10:548. doi: 10.3389/fgene.2019.00548. eCollection 2019.PMID: 31258547 Free PMC article. Review.
• The Role of CYP450 Drug Metabolism in Precision Cardio-Oncology.

  Fatunde OA, Brown SA.Int J Mol Sci. 2020 Jan 17;21(2):604. doi: 10.3390/ijms21020604.PMID: 31963461 Free PMC article. Review.