A long look at long Covid (and other mysteries)

https://www.science.org/journal/stm?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-9EtLOpsc8JHynDIsxSirVtKIkaxGn3KhiypGgUAMmr0WNCw2m45Y2WTIVUJD4UFcmGBPVdjhELQjbKGTlOf1Eyhp-6mw&_hsmi=333852465&utm_content=333852465&utm_source=hs_email Initiating Long Covid RECOVERy https://www.science.org/doi/10.1126/scitranslmed.adr9971?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-8FqP7tMteKWycimeoutqgJRjGqCJwiYidxzJXNtJ0o0-aJDJOA8EN42xi6lETrzPwWYHgjJpB34pFcWaxyJW_90tM_hg&_hsmi=333852465&utm_content=333852465&utm_source=hs_email A long look at long Covid (and other mysteries) Ever since long Covid emerged in the pandemic’s first year, people suffering from other post-infection syndromes have been clamoring for serious attention to their illnesses, too, rather than the skepticism and stigma that have so often greeted myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), long-term Lyme disease, or other unexplained conditions. A new issue of Science Translational Medicine published yesterday considers these often debilitating syndromes together, whether leaders of federal health agencies are describing the NIH’s RECOVER initiative (criticized for its slow progress), immunobiologists are looking at sex differences in susceptibility, or infectious disease clinicians are making the case for sustained funding to study these chronic illnesses, separately and together with long Covid. Here's what they say: “Like medical mysteries of the past, this one too will be solved by science. How fast that occurs depends on continued attention and robust and rigorous scientific pursuit.”— NIH’s Jeanne Marrazzao, NHLBI’s Gary Gibbons, and NINDS’s Walter Koroshetz “Despite their potential to substantially contribute to our scientific understanding of [post-acute infection syndromes, or PAIS] and autoimmune diseases, current research has yet to extensively focus on the development of PAISs in transgender individuals, a group disproportionately afflicted with PAISs and one uniquely positioned to illuminate the interplay between biological sex differences and the impact of sex hormones on disease outcomes.”— Julio Silva and Akiko Iwasaki “The risks of conflating long Covid and ME/CFS go both ways; although there is hope that long Covid research will provide some of the answers needed to fully understand ME/ CFS, this should not come at the expense of investment in efforts to study pre-2020 ME/CFS, which may still be driven by distinct biology” — Michael Peluso, Maureen Hanson, and Steven Deeks NIH documents show how $1.6 billion long Covid initiative has failed so far to meet its goals By Betsy LadyzhetsMay 31, 2024 https://www.statnews.com/2024/05/31/long-covid-nih-recover-initiative-falls-short-on-causes-treatments/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-9oH2D6NnSFX1b2F1G-X32uEBzFciy5SCDOp7Og4E3Y_sj5oTegRDrFFmxTnLVgNEiwKP6-JBuq877RraEtBjFXyXKRZQ&_hsmi=333852465&utm_content=333852465&utm_source=hs_email Infection-associated chronic conditions: Why Long Covid is our best chance to untangle Osler’s web https://www.science.org/doi/10.1126/scitranslmed.ado2101?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-9xnU0eKV_ro6hCSffjPxcuPR0qzEpFC6EWqmuKzSnKaNlt9tcpNzeobiu83_LfqH4CFgIc5a3OMvpMOpk88Ka3WqYCqQ&_hsmi=333852465&utm_content=333852465&utm_source=hs_email Sex differences in postacute infection syndromes https://www.science.org/doi/10.1126/scitranslmed.ado2102?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-93aPxQonefiE0a_VLYu6OVOCpT0M2kHaLrfpkVeCK0S8PrRtxtQAweJvf8qefFop_--A8Ri6FZmJJus-zoG7jk-7ABBA&_hsmi=333852465&utm_content=333852465&utm_source=hs_email