Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain

Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain: IntroductionIn an effort to address the opioid epidemic, a prominent goal of current research is to identify alternative treatments with equal or better benefits for pain while avoiding potential unintended consequences that could result in harms. Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain (Systematic Review Update, released on August 4, 2025) The objective of this review is to update the evidence on benefits and harms of cannabinoids and other plant-based compounds to treat subacute and chronic pain in adults and adolescents using a living systematic review approach.