Coronavirus Disease Portal|Home|PHGKB

Coronavirus Disease Portal|Home|PHGKB

 Spotlight on COVID-19

Rapid and Inexpensive Whole-Genome Sequencing of SARS-CoV2 using 1200 bp Tiled Amplicons and Oxford Nanopore Rapid Barcoding
NE Freed et al, BIORXIV, May 29, 2020

Rapid and cost-efficient whole-genome sequencing of SARS-CoV-2, the virus that causes COVID-19, is critical for understanding viral transmission dynamics. Here we show that using a new multiplexed set of primers in conjunction with the Oxford Nanopore Rapid Barcode library kit allows for faster, simpler, and less expensive SARS-CoV-2 genome sequencing.

Seek COVER: Development and validation of a personalized risk calculator for COVID-19 outcomes in an international network
RD Williams et al, MEDRXIV, May 29, 2020

The study sought to develop and externally validate COVID-19 Estimated Risk (COVER) scores that quantify a patient's risk of hospital admission, requiring intensive services, or fatality in the 30-days following diagnosis. The design was a multinational, distributed network cohorts from 13 data sources and 6 countries, mapped to a common data model.

Recurrent Positive Reverse Transcriptase–Polymerase Chain Reaction Results for Coronavirus Disease 2019 in Patients Discharged From a Hospital in China
R Hu et al, JAMA Network Open May 28, 2020

On the basis of our follow-up results, 11 of 69 patients with COVID-19 showed positive RT-PCR results after discharge, which suggests that some recovered patients may still be virus carriers even after they reach the basic discharge criteria.

Doctors race to understand inflammatory condition in kids
JC Frankel, Science, May 29, 2020

Researchers are combing the blood and sequencing the genomes of patients—and the virus, if it can be isolated from them—to search for clues to what makes some children susceptible and how to head off the worst symptoms. There's hope that what's learned from young patients might help the many adults in whom COVID-19 also triggers overreaction of the immune system.