Disease burden and long-term trends of urinary tract infections: A worldwide report

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363895/?utm_campaign=morning_rounds&utm_medium=email&_hsmi=296624390&_hsenc=p2ANqtz-9tvQiEmawnTKOK226Uhp-7FzeVjM4-HGsKRYMWYHrCOAC38SCGCz3m87sGYPz2ysr63vOv_qztZ-EBtUKHdUsrFZyOmg&utm_content=296624390&utm_source=hs_email Study suggests answer for mystery of recurrent UTI pain with no infection Each year, more than 400 million urinary tract infections occur in people around the globe. And researchers have long been puzzled by a medical mystery: Some women susceptible to recurrent UTIs experience symptoms without any signs of bacteria, or after an infection has supposedly been cleared with antibiotics. A study published Friday in Science Immunology provides a potential molecular mechanism behind this phenomenon involving a surprise culprit: mast cells, which make the histamines that lead to nasty allergy symptoms. The immune cells may play a role in some classic UTI symptoms when they persist post-infection: pelvic pain and a frequent need to pee. Researchers hope the discovery (in mice) will have implications for potential new treatments as antibiotic resistance becomes a more prominent problem across medicine, but especially with UTI treatment. Read my story to learn more about what the study found, along with a wild coincidence for one of the UTI experts I spoke about it with.