The effect of computerised decision support alerts tailored to intensive care on the administration of high-risk drug combinations, and their monitoring: a cluster randomised stepped-wedge trial.

https://psnet.ahrq.gov/issue/effect-computerised-decision-support-alerts-tailored-intensive-care-administration-high-risk The effect of computerised decision support alerts tailored to intensive care on the administration of high-risk drug combinations, and their monitoring: a cluster randomised stepped-wedge trial. Bakker T, Klopotowska JE, Dongelmans DA, et al. Lancet. 2024;403(10425):439-449. Alert fatigue occurs when clinical decision support systems (CDSS) produce numerous low-relevance alerts, leading to high override rates and the risk of missing relevant alerts. In this study, alerts for high-risk drug-drug interactions (DDI) were tailored to the intensive care unit. The tailored alerts led to a 12% decrease in high-risk DDI administrations.