An approach to identify gene-environment interactions and reveal new biological insight in complex traits (Posted Apr 25, 2024 9AM)

https://phgkb.cdc.gov/PHGKB/specificPHGKB.action?topic=environmental&query=home From the abstract: " Here, we present a powerful new approach to screen for interactions across the genome, an approach that shares substantial similarity to the Mendelian randomization framework. We identify and confirm 5 loci (6 independent signals) interacted with either cigarette smoking or alcohol consumption for serum lipids, and empirically demonstrate that interaction and mediation are the major contributors to genetic effect size heterogeneity across populations. "