sábado, 31 de mayo de 2025
Summit shows mixed results from key study of lung cancer drug Ivonescimab has been closely tracked for its blockbuster potential ++
https://www.statnews.com/2025/05/30/summit-shows-ivonescimab-lung-cancer-mixed-results/
Next-gen COPD drug from Sanofi, Regeneron shows mixed results in Phase 3 trials
The companies are looking for their next Dupixent
https://www.statnews.com/2025/05/30/itepekimab-sanofi-regeneron-copd-dupixent-aerify/
American Doctors Are Moving to Canada To Escape the Trump Administration By Brett Kelman Illustration by Oona Zenda May 30, 2025
https://kffhealthnews.org/news/article/american-doctors-moving-canada-escape-trump-administration-manitoba/
I’m Stephanie Armour, a Washington, D.C.-based KFF Health News senior correspondent covering health policy and the people behind it. Send tips to sarmour@kff.org.
By Stephanie Armour
The Trump administration’s anti-regulatory approach and cost-cutting moves risk unraveling a critical system of checks and balances that helps ensure the safety of the U.S. food supply, industry experts told KFF Health News.
An E. coli outbreak that occurred late last year — for which the investigation was concluded in February — signals how, with the FDA changes, more people could get sick with foodborne illnesses as companies and growers face less regulatory oversight and fewer consequences for selling tainted food products, according to interviews with consumer advocates, researchers, and former employees at the FDA and U.S. Department of Agriculture.
In addition, the administration withdrew a proposed regulation to reduce the presence of salmonella in raw poultry, a plan that could have saved more than $13 million annually by preventing roughly 3,000 illnesses. It is also disbanding a Department of Justice unit that pursues civil and criminal actions against companies that sell contaminated food and is reassigning its attorneys, according to a former FDA official, a publicly posted memo from the head of the department’s criminal division, and a white paper by the law firm Gibson Dunn.
“It’s all about destruction and not about efficiency,” said Siobhan DeLancey, who worked in the agency’s Office of Foods and Veterinary Medicine for more than 20 years before being laid off in April. “We’re going to see the effects for years. It will cost lives.”
Officials from the Department of Health and Human Services did not comment on the record for this article but have maintained that food safety is a priority.
Staffing cuts mean delays in publicizing deadly outbreaks, said Susan Mayne, an adjunct professor at the Yale School of Public Health who retired from the FDA in 2023. DeLancey said new requirements from the Trump administration for reviewing agency announcements became so arduous that it took weeks to get approval for alerts that should have been going out much sooner.
The November 2024 outbreak caused by E. coli bacteria in lettuce sickened nearly 90 people and killed one person. But after the investigation was completed under the Trump administration, the FDA redacted any information identifying the grower or processor. The FDA said in its February internal summary that the grower wasn’t named because no product remained on the market.
The information is still important because it can prevent further cases, pressure growers to improve sanitation, and identify repeat offenders, said Bill Marler, a Seattle lawyer who specializes in food-safety litigation.
“The whole ‘Make America Healthy Again,’ the focus on taking food color dyes out of cereal?” said Chris George, of Avon, Indiana, whose son was hospitalized in the outbreak. “How about we take E. coli out of our lettuce, so it doesn’t kill our kids?”
viernes, 30 de mayo de 2025
Preliminary analysis of the impact of lab results on large language model generated differential diagnoses
https://pubmed.ncbi.nlm.nih.gov/40102561/
An AHRQ-funded study published in NPJ Digital Medicine found that including lab results significantly improved the accuracy of differential diagnoses generated by large language models. Researchers tested five models—GPT-4, GPT-3.5, Claude-2, Llama-2-70b, and Mixtral-8x7B—using 50 clinical vignettes based on real patient cases. Each model generated a list of possible diagnoses with and without lab data. Adding lab results improved diagnostic accuracy by up to 30 percent across models. GPT-4 performed the best, achieving 55 percent Top-1 accuracy and 79 percent lenient accuracy. The models correctly interpreted common lab tests such as liver function and toxicology panels. These findings underscore the potential of large language models as supplemental diagnostic tools and the importance of structured clinical data in AI-driven decision support.
Quality Improvement to Identify and Address Food Insecurity During Pediatric Hospitalizations
https://pubmed.ncbi.nlm.nih.gov/39492624/
Identifying and helping families who are experiencing food insecurity, or a lack of consistent access to enough food, is not yet done as part of routine clinical care at children’s hospitals across the country. In an AHRQ-funded study published in Hospital Pediatrics, researchers aimed to increase food insecurity screening for hospitalized children from 0 to 60 percent and provide location-based food resources to eligible families. Researchers screened 2,800 patients in a tertiary, freestanding children’s hospital from 2021 to 2023. With the Model for Improvement developed by Associates in Process Improvement, screening rates for food insecurity increased from 0 to 77 percent. Researchers concluded that integrating food insecurity screening is a feasible and effective approach to addressing the issue, leading to better health outcomes for children.
Recording of Safety Culture in Healthcare Webinar Available
https://www.ahrq.gov/action-alliance/index.html
Safety Culture in Healthcare: Measuring and Responding, a webinar sponsored by the AHRQ-led National Action Alliance for Patient and Workforce Safety, highlights the importance of safety culture and teamwork in healthcare settings. This webinar, held April 15, was the third in a three-part series on safety culture in healthcare. Speakers from AHRQ, Duke Center for the Advancement of Well-being Science and Westat discussed how strategies such as conflict resolution and leader engagement are essential for improving healthcare worker well-being and patient outcomes. Panelists answered audience questions on how to get physicians to participate in the patient safety culture surveys and recommended ways to encourage a teamwork climate. Access the recording and presenter materials from this event.
Measuring and Responding to Safety Culture Across Healthcare
https://www.ahrq.gov/action-alliance/webinars/measuring-safety-culture.html
EvidenceNOW Projects
https://www.ahrq.gov/evidencenow/index.html
Primary care providers face mounting pressure to deliver better outcomes with limited resources. AHRQ’s EvidenceNOW initiative helps practices overcome these challenges with evidence-based strategies that work in real-world settings. From improving heart health to advancing behavioral health integration, EvidenceNOW offers tailored guidance for small and medium-sized practices, including access to performance feedback, quality improvement coaching and easy-to-implement clinical tools designed to build sustainable improvements in quality and patient care. The EvidenceNOW Model is a blueprint for delivering external support to primary care practices to improve healthcare quality and implement new evidence into care delivery. It is also designed to help primary care practices increase their capacity for quality improvement with the goals of improving patient and practice health
Person-Centered Care Planning for People with Multiple Chronic Conditions: Current State and Future Directions June 9, 2025 3:30 PM - 4:30 PM EDT
https://cma.ahrq.gov/cma/welcome.jsp?code=mcc
June 9, 3:30-4:30 p.m. ET: Person-Centered Care Planning for People With Multiple Chronic Conditions: Current State and Future Directions. This webinar will discuss how clinicians, interdisciplinary team members and health system managers can align care with older adult patients’ goals and priorities.
AHRQ Safety Program for HAI Prevention
https://safetyprogram4hai-prevention.ahrq.gov/page/home
Register for Upcoming Webinars
AHRQ Safety Program for HAI Prevention: CLABSI Recruitment Webinars. Learn how participants in the program will receive expert support to prevent infections and promote safety culture.
June 5, 10:30-11 a.m. ET
June 11, 1:30-2 p.m. ET
June 24, noon-12:30 p.m. ET
AHRQ in the Professional Literature ++++++++
AHRQ in the Professional Literature
Ophthalmology examinations in children with skull fractures and underlying focal hemorrhage. Breeden K, Christian CW, Wood JN, et al. Pediatr Emerg Care. 2025 Mar 12. [Epub ahead of print.] Access the abstract on PubMed®.
https://pubmed.ncbi.nlm.nih.gov/40071580/
"Everything is electronic health record-driven": the role of the electronic health record in the emergency department diagnostic process. James TG, Mangus CW, Parker SJ, et al. JAMIA Open. 2025 Apr;8(2):ooaf029. Epub 2025 Apr 23. Access the abstract on PubMed®.
https://pubmed.ncbi.nlm.nih.gov/40270489/
Association between left ventricular assist device infections and number of shared patients among care providers: a network analysis. Hawkins RB, Stewart JW, Kim KD, et al. Ann Thorac Surg. 2025 May 10. [Epub ahead of print.] Access the abstract on PubMed®.
https://pubmed.ncbi.nlm.nih.gov/40355020/
Ambulatory medication safety events in high-risk patients with diabetes before and after a COVID-19 clinic slowdown. Young RA, Blair S, Teigen K, et al. J Patient Saf. 2025 Jun 1;21(4):240-5. Epub 2025 Apr 10. Access the abstract on PubMed®.
https://pubmed.ncbi.nlm.nih.gov/40202390/
Development of secure infrastructure for advancing generative artificial intelligence research in healthcare at an academic medical center. Ng MY, Helzer J, Pfeffer MA, et al. J Am Med Inform Assoc. 2025 Mar;32(3):586-8. Access the abstract on PubMed®.
https://pubmed.ncbi.nlm.nih.gov/39836496/
Antibiotic Diversity Index: a novel metric to assess antibiotic variation among hospitalized children. Markham JL, Hall M, Shah SS, et al. J Hosp Med. 2025 Jan;20(1):8-16. Epub 2024 Aug 4. Access the abstract on PubMed®.
https://pubmed.ncbi.nlm.nih.gov/39099133/
The foundational capabilities of large language models in predicting postoperative risks using clinical notes. Alba C, Xue B, Abraham J, et al. NPJ Digit Med. 2025 Feb 11;8(1):95. Access the abstract on PubMed®.
https://pubmed.ncbi.nlm.nih.gov/39934379/
A survey of team culture and learning organization in the resuscitation of neonates with congenital anomalies: a single center experience. Bostwick A, Ades A, Rodriguez-Paras C, et al. Resusc Plus. 2025 Mar;22:100877. Epub 2025 Jan 24. Access the abstract on PubMed®.
https://pubmed.ncbi.nlm.nih.gov/39990957/
Registration for June 5 Virtual Meeting for the AHRQ Software Developers Meeting - Common Formats
https://cma.ahrq.gov/cma/registration.jsp;jsessionid=xaywyaTgLDpxbCie7p71fUWqclNf-wM4gyGTkMlwV5Xw7lbFcdyk!1057371006?eventid=360
The Agency for Healthcare Research and Quality (AHRQ) is pleased to invite you to this fully virtual Software Developers Meeting – AHRQ Common Formats.
Please join us to discuss implementation of the Common Formats with members of the public, including software developers and other interested parties. Agenda topics will include discussing implementation of FHIR and an update on the evaluation of the Common Formats for Event Reporting – Diagnostic Safety version 1.0.
This will be an opportunity for active participation and discussion.
When:
Thursday, June 5, 2025, 12:00 – 2:00 PM Eastern Time
Registration closes June 4. Registration is required to access the meeting!
Improving public health in the ASEAN +...
https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(25)00123-9/fulltext?dgcid=raven_jbs_etoc_email
TheLancet.com will be undergoing maintenance on Saturday, May 31st from 8am to 12pm US Eastern (4 hours). During this timeframe, we ask that you refrain from logging in or registering to avoid any difficulty with this functionality. We apologise for the inconvenience.
Jun 2025
Volume 10Number 6e433-e536
https://www.thelancet.com/journals/lanpub/issue/vol10no6/PIIS2468-2667(25)X0006-2
Technology for global immunisation The Lancet Digital Health +...
https://www.thelancet.com/journals/landig/article/PIIS2589-7500(25)00063-9/fulltext?dgcid=raven_jbs_etoc_email
TheLancet.com will be undergoing maintenance on Saturday, May 31st from 8am to 12pm US Eastern (4 hours). During this timeframe, we ask that you refrain from logging in or registering to avoid any difficulty with this functionality. We apologise for the inconvenience.
May 2025
Volume 7Number 5
https://www.thelancet.com/journals/landig/issue/vol7no5/PIIS2589-7500(25)X0005-4
jueves, 29 de mayo de 2025
AI-based mammography is here, and it has a trust problem Radiologists’ skepticism is in part driven by the limited evidence on how the new technology improves cancer outcomesAI-based mammography is here, and it has a trust problem Radiologists’ skepticism is in part driven by the limited evidence on how the new technology improves cancer outcomes
miércoles, 28 de mayo de 2025
CDSiC & Clinicians +++
https://cdsic.ahrq.gov/cdsic/clinicians?utm_source=May2025Newsletter&utm_medium=EmailNewsletter&utm_campaign=MayNewsletter4
Measurement and Outcomes Workgroup: Patient-Centered Clinical Decision Support Planning and Reporting Tool
https://cdsic.ahrq.gov/cdsic/planning-reporting-tool?utm_source=May2025Newsletter&utm_medium=EmailNewsletter&utm_campaign=MayNewsletter1
Scaling, Measurement, and Dissemination of CDS Workgroup: Approaches to Measuring Patient-Centered CDS Workflow and Lifeflow Impact
https://cdsic.ahrq.gov/cdsic/workflow-lifeflow?utm_source=May2025Newsletter&utm_medium=EmailNewsletter&utm_campaign=MayNewsletter3
martes, 27 de mayo de 2025
Register for June 25 Webcast on New CAHPS Tools for Patient Experience Measurement
https://cma.ahrq.gov/cma/welcome.jsp?code=cahps_px_measurement_web
This free webcast from AHRQ’s Consumer Assessment of Healthcare Providers and Systems (CAHPS®) program will detail new innovative tools to enhance patient experience measurement. Learn about the latest surveys in development, as well as newly released surveys. Additionally, this session will showcase a variety of CAHPS resources designed to support effective survey administration, analysis, and action planning.
Speakers:
Aruna Jhasti, MPH, Health Scientist Administrator, Agency for Healthcare Research and Quality
Stephanie Fry, CPXP, Associate Vice President, Westat
Julie Brown, Director of Survey Market Development, RAND
Dale Shaller, MPA, (Moderator), Principal, Shaller Consulting
For questions, please contact the CAHPS User Network at cahps1@westat.com or 1-800-492-9261.
A Harvard scientist built a database of 2,100 NIH grant terminations. Then his own funding was cut Q&A with Scott Delaney: Lost grants represent ‘a life’s worth of work’A Harvard scientist built a database of 2,100 NIH grant terminations. Then his own funding was cut Q&A with Scott Delaney: Lost grants represent ‘a life’s worth of work’
What Baby KJ means for the CRISPR gene editing industry After custom repair to infant’s genome, experts make pessimistic and optimistic cases for the field
https://www.statnews.com/2025/05/26/what-kj-muldoon-crispr-gene-editing-treatment-means-for-interventional-genetics/
At a major genome editing summit, spotlight turns to the value of human life
Committee calls for charter on technologies like CRISPR that protects human dignity
https://www.statnews.com/2025/05/27/global-observatory-genome-editing-summit-crispr-ethics-human-dignity/
Federal Cuts Ripple Through a Bioscience Hub in Rural Montana By Katheryn Houghton May 27, 2025
Federal Cuts Ripple Through a Bioscience Hub in Rural Montana
The Trump administration’s mass federal layoffs and cancellation of research grants are having effects in communities far from Washington, D.C.
https://kffhealthnews.org/news/article/rocky-mountain-laboratories-hamilton-montana-nih-funding-research-rural/
lunes, 26 de mayo de 2025
domingo, 25 de mayo de 2025
Recommended CME For You +++ +++ +++
The Road to Biosimilars in Rare Hematologic Conditions CME
The Road to Biosimilars in Rare Hematologic Conditions
Authors: Srikanth Nagalla, MD, MS
https://www.medscape.org/viewarticle/1001793?sso=true&uac=148436CN&src=mkmcmr_driv_invit_mscpedu
Guiding Our Patient's Path: Managing First Relapse in Diffuse Large B-Cell Lymphoma Outside of CAR Ts CME
Guiding Our Patient's Path: Managing First Relapse in Diffuse Large B-Cell Lymphoma Outside of CAR Ts
Authors:
Wendy Osborne, MBBS (Hons), MRCP, FRCPath; Natacha Bolaños; Gareth Gregory, MBBS, PhD; Gilles Salles, MD, PhD
https://www.medscape.org/viewarticle/1002120?sso=true&uac=148436CN&src=mkmcmr_driv_invit_mscpedu
Expert Interview: Best Practices for AL Amyloidosis Management in the Community CME
Expert Interview: Best Practices for AL Amyloidosis Management in the Community
Authors: Shahzad Raza, MD, FACP
https://www.medscape.org/viewarticle/expert-interview-best-practices-al-amyloidosis-management-2025a10002fg?page=1&sso=true&uac=148436CN&src=mkmcmr_driv_invit_mscpedu
Which Patients With HR+/HER2- EBC Benefit From Intensification of Therapy? Expert Recommendations for Clinical Assessment CME
Which Patients With HR+/HER2- EBC Benefit From Intensification of Therapy? Expert Recommendations for Clinical Assessment
Authors: Joyce A. O’Shaughnessy, MD
https://www.medscape.org/viewarticle/which-patients-hr-her2-ebc-benefit-intensification-therapy-2025a10002qz?page=1&sso=true&uac=148436CN&src=mkmcmr_driv_invit_mscpedu
Clinical Case Scenarios in HR-Positive, HER2-Negative Early Breast Cancer: Assess the Risk of Recurrence and Eligibility for Adjuvant Therapy CME
Clinical Case Scenarios in HR-Positive, HER2-Negative Early Breast Cancer: Assess the Risk of Recurrence and Eligibility for Adjuvant Therapy
Authors:
Seth Wander, MD, PhD; Manali Bhave, MD
https://www.medscape.org/viewarticle/1002194?sso=true&uac=148436CN&src=mkmcmr_driv_invit_mscpedu
Clinical Cases in HR-Positive, HER2-Negative Early Breast Cancer: Applying the Latest Evidence CME
Clinical Cases in HR-Positive, HER2-Negative Early Breast Cancer: Applying the Latest Evidence
Authors:
William J. Gradishar, MD; Aditya Bardia, MD, MPH, FASCO; Seth Wander, MD, PhD
https://www.medscape.org/viewarticle/1002256?sso=true&uac=148436CN&src=mkmcmr_driv_invit_mscpedu
Navigating New Horizons in PNH and ITP: Perspectives for the Community CME
Navigating New Horizons in PNH and ITP: Perspectives for the Community
Authors: Sandra E. Kurtin, PhD, ANP-C, AOCN, FAPO; Cindy Neunert, MD, MSCS; Srikanth Nagalla, MD, MS
https://www.medscape.org/viewarticle/navigating-new-horizons-pnh-and-itp-perspectives-community-2025a10004g2?page=1&sso=true&uac=148436CN&src=mkmcmr_driv_invit_mscpedu
Determining the Risk of Recurrence in HR+/HER2- Early Breast Cancer Without Axillary Dissection CME
Determining the Risk of Recurrence in HR+/HER2- Early Breast Cancer Without Axillary Dissection
Authors:
Sara M. Tolaney, MD, MPH; Elizabeth A. Mittendorf, MD, PhD, MHCM; Leah H. Portnow, MD
https://www.medscape.org/viewarticle/1002279?sso=true&uac=148436CN&src=mkmcmr_driv_invit_mscpedu
The Rise of Protein Degraders for Hematologic Malignancies: Exploring the Latest Data From ASH 2024 CME
The Rise of Protein Degraders for Hematologic Malignancies: Exploring the Latest Data From ASH 2024
Authors:
Sagar Lonial, MD, FACP; Constatine Tam, MBBS, MD, FRACP, FRCPath; Julio Chavez, MD, MS
https://www.medscape.org/viewarticle/1002295?sso=true&uac=148436CN&src=mkmcmr_driv_invit_mscpedu
Managing Adverse Events of Oral Adjuvant Therapies in Patients With HR+/HER2- Early Breast Cancer CME
Managing Adverse Events of Oral Adjuvant Therapies in Patients With HR+/HER2- Early Breast Cancer
Authors: Joyce A. O’Shaughnessy, MD
https://www.medscape.org/viewarticle/managing-adverse-events-oral-adjuvant-therapies-patients-hr-2025a1000563?page=1&sso=true&uac=148436CN&src=mkmcmr_driv_invit_mscpedu
Understanding And Addressing Health Worker Burnout And Moral Injury Patricia Pittman Candice Chen Lauren Muñoz Wendy Dean Jessica Perlo Janice Blanchard Margaret Ziemann Randl Dent Simon Talbot Julia Strasser Kelly NedrowUnderstanding And Addressing Health Worker Burnout And Moral Injury Patricia Pittman Candice Chen Lauren Muñoz Wendy Dean Jessica Perlo Janice Blanchard Margaret Ziemann Randl Dent Simon Talbot Julia Strasser Kelly Nedrow
Disaster Preparedness, Response, Recovery, and Mitigation ++++++
https://www.samhsa.gov/mental-health/disaster-preparedness?utm_source=SAMHSA&utm_campaign=845dbb9bcb-EMAIL_CAMPAIGN_2025_05_20_04_11&utm_medium=email&utm_term=0_-845dbb9bcb-167840245
Coping After Disaster
The American Psychiatric Association shares steps people can take to support their mental well-being following disasters. It also includes an abundance of resources on specific situations, such as mass shootings and infectious disease outbreaks, as well as resources on managing stress and grief. The page concludes with valuable information and resources on helping children cope with disasters.
https://www.psychiatry.org/patients-families/coping-after-disaster-trauma?utm_source=SAMHSA&utm_campaign=845dbb9bcb-EMAIL_CAMPAIGN_2025_05_20_04_11&utm_medium=email&utm_term=0_-845dbb9bcb-167840245
Disasters and Children
On this web page, the American Academy of Pediatrics provides its recommendations on addressing the needs of children during disasters. It also links to resources and tools that can be used by healthcare professionals, families, and communities to treat and protect children during these potentially life-altering events.
https://www.aap.org/disasters?utm_source=SAMHSA&utm_campaign=845dbb9bcb-EMAIL_CAMPAIGN_2025_05_20_04_11&utm_medium=email&utm_term=0_-845dbb9bcb-167840245
Coping with Disaster
This Ready.gov web page provides information on how disasters can impact mental health, including the mental health of children. It includes sections on understanding disaster events, recognizing signs of disaster-related stress, easing stress, helping children cope with disasters, and reassuring children after a disaster. It also provides information on how children react to disaster by age.
https://www.ready.gov/coping-disaster?utm_source=SAMHSA&utm_campaign=845dbb9bcb-EMAIL_CAMPAIGN_2025_05_20_04_11&utm_medium=email&utm_term=0_-845dbb9bcb-167840245
SAMHSA’s Disaster Behavioral Health Information Series
The Disaster Behavioral Health Information Series from the SAMHSA Disaster Technical Assistance Center (DTAC) shares a wealth of resources on mental health conditions related to disaster events. This resource collection is continuously monitored and updated to bring the public the most relevant and timely resources from the disaster behavioral health field.
https://www.samhsa.gov/technical-assistance/dtac/disaster-behavioral-health-information-series-resource-center?utm_source=SAMHSA&utm_campaign=845dbb9bcb-EMAIL_CAMPAIGN_2025_05_20_04_11&utm_medium=email&utm_term=0_-845dbb9bcb-167840245
National Child Traumatic Stress Network
https://www.nctsn.org/?utm_source=SAMHSA&utm_campaign=845dbb9bcb-EMAIL_CAMPAIGN_2025_05_20_04_11&utm_medium=email&utm_term=0_-845dbb9bcb-167840245
The National Child Traumatic Stress Network has myriad resources available for families and healthcare professionals on how to help children and families recover from the adverse effects of disasters, and terrorism and violence. These resources are tailored to specific types of events, such as hurricanes, floods, wildfires, and acts of mass violence, since different disasters can have different mental health impacts
sábado, 24 de mayo de 2025
Statistical Brief 561: Expenditures for Key Diet-Related Health Conditions, 2021-2022.
https://www.meps.ahrq.gov/mepsweb/index.jsp
https://www.meps.ahrq.gov/mepsweb/data_stats/download_data_files.jsp
https://www.meps.ahrq.gov/mepsweb/data_stats/MEPS_topics.jsp
https://www.meps.ahrq.gov/mepsweb/data_stats/publications.jsp
https://www.meps.ahrq.gov/mepsweb/about_meps/releaseschedule.jsp
AHRQ Safety Program for HAI Prevention
https://safetyprogram4hai-prevention.ahrq.gov/page/home
AHRQ Safety Program for HAI Prevention: CLABSI Recruitment Webinar
June 5, 10:30-11 a.m. ET
June 11, 1:30-2 p.m. ET
June 24, noon-12:30 p.m. ET
The Impact of Consolidation and Ownership on Primary Care
https://www.ahrq.gov/ncepcr/about/pcr-webinar-series/consolidation-ownership.html
Recording Available for NCEPCR Webinar on Health Systems Research
On April 3, the National Center for Excellence in Primary Care Research (NCEPCR) hosted a webinar on the Impact of Consolidation and Ownership on Primary Care. AHRQ-funded researchers shared the results of three different projects that assessed the impact of health system ownership of primary care practices and its influence on patient health outcomes, including Medicare beneficiaries and patients with complex conditions. Amelia Bond, Ph.D., from Weill Cornell Medical College, spoke about vertical integration of health systems. Her research showed that between 2012 and 2022, the share of office visits declined, while federally qualified health centers, rural health clinics and hospital-based outpatient departments visits increased. Jane Zhu, M.D., M.P.P., from Oregon Health and Science University, presented data related to changes in total spending per practice associated with private equity acquisition. Her work assessed current workforce impact, especially due to shortages in primary care providers and Medicare program effects. E. Marshall Brooks, Ph.D., from the Virginia Commonwealth University, worked directly with practices in Virginia. His anthropological mixed methodology offered a complementary point of view for achieving high quality primary care and whole health.
https://www.ahrq.gov/sites/default/files/wysiwyg/ncepcr/webinars/consolidation-ownership-slides.pdf
Medications for opioid use disorder and other evidence-based service offerings in faith-affiliated treatment centers: Implications for implementation partnerships
https://pubmed.ncbi.nlm.nih.gov/39522767/
An AHRQ-funded project, led by two authors in recovery, examined barriers, stigma and treatment options for substance use disorder. Their examination of faith-affiliated treatment centers in the Journal of Substance Use and Addiction Treatment—which they found to provide more inpatient and residential care but less outpatient and medication-based treatment—suggested opportunities for government collaboration and expanded opioid use disorder treatment options.
Further publications from this project include—
An International Journal of Drug Policy critique of the National Council for Mental Wellbeing’s guideline prioritizing individuals with five years of recovery for public-facing roles, arguing it excludes those seeking nontraditional recovery paths or struggling with recovery.
A Journal of Diversity in Higher Education study of 17 undergraduate students in recovery attending a university without a collegiate recovery program who reported success through role models, flexible courses and supportive faculty despite facing stigma and access challenges.
A Journal of Substance Use and Addiction Treatment commentary acknowledging the lead authors’ own success with abstinence-based treatment while advocating for greater acceptance, access and government oversight of alternate recovery paths.
The authors’ findings highlighted the need for inclusive, evidence-based recovery support that embraces diverse pathways and reduces barriers to treatment.
Beyond the 5-year recovery mark: Perspectives of researchers with lived and living experience on public engagement and discourse
https://pubmed.ncbi.nlm.nih.gov/39341070/
Barriers and facilitators to higher education applications and admissions among people in recovery.
https://psycnet.apa.org/record/2025-66796-001?doi=1
CAHPS End-of-Life Care Survey
CAHPS End-of-Life Care Survey: .block-topics-expandable-text.boxlinks .topics-btn-text { font-size: 1.3em; font-weight: 600; padding: 20px 50px 20px 20px; font-family: "Public Sans Semibold", sans-serif; margin-top: 20px; } button.topics-btn[aria-expanded="false"]:after { content: ""; display: inline-block; background-image: url(/themes/custom/ahrq_bootstrap_barrio/pattern-lab/source/images/theme_core/plus-solid_5B616B.png); background-repeat: no-repeat; background-size: contain; width: 20px; height: 20px; position: absolute; float: right; ri
Healthy Hearts in Manufacturing: Improving Cardiovascular Care in Worksite Health Clinics
https://reporter.nih.gov/search/aQGOBwCMz0CHi0EkmxhqzA/project-details/10915578
“Manufacturing communities have significantly higher rates of smoking, obesity, physical inactivity, diabetes and cardiovascular deaths,” according to AHRQ grantee Megan McHugh, Ph.D., professor of emergency medicine at Northwestern University’s Feinberg School of Medicine.
Dr. McHugh, who is also director of the School’s Manufacturing and Health Research Program, believes that the work environment, lifestyle issues and, in some communities, limited access to healthcare are causing these deficiencies. She has made it her mission to improve health outcomes in manufacturing communities by implementing strategies that address these issues while also aiming to reduce the cost of care for employers. Dr. McHugh began by targeting heart disease, the leading cause of death in the United States.
With her five-year AHRQ grant, she works directly with large manufacturers’ worksite health centers to improve heart care by implementing proven interventions for high blood pressure and tobacco cessation. Dr. McHugh and her team are currently partnering with these centers to offer evidence-based interventions drawn from AHRQ’s EvidenceNOW initiative, which provides a blueprint for delivering external support to primary care practices to improve care delivery.
The project, Healthy Hearts in Manufacturing, has already yielded some early findings. Specifically, worksite health centers have the capacity to accommodate more patients, can bring patients back for routine followups more easily than community-based primary care and experience less pressure to keep patient visits brief. Preliminary results also suggest lower rates of burnout among worksite health center clinicians compared with those in community-based primary care.
AHRQ in the Professional Literature ++++++++
AHRQ in the Professional Literature
From stable teamwork to dynamic teaming in the ambulatory care diagnostic process. Tannenbaum SI, Thomas EJ, Bell SK, et al. Diagnosis. 2025 Feb 1;12(1):17-24. Epub 2024 Oct 21. Access the abstract on PubMed®.
vhttps://pubmed.ncbi.nlm.nih.gov/39427234/
New performance measurement framework for realizing patient-centered clinical decision support: qualitative development study. Dullabh P, Zott C, Gauthreaux N, et al. J Med Internet Res. 2025 Apr 30;27:e68674. Access the abstract on PubMed®.
https://pubmed.ncbi.nlm.nih.gov/40306630/
Precision emergency medicine in health care delivery and access: framework development and research priorities. Salhi RA, Kocher KE, Greenwood-Ericksen M, et al. Acad Emerg Med. 2025 Apr;32(4):444-53. Epub 2024 Oct 8. Access the abstract on PubMed®.
https://pubmed.ncbi.nlm.nih.gov/39380335/
Estimated burden of metabolic dysfunction-associated steatotic liver disease in US adults, 2020 to 2050. Le P, Tatar M, Dasarathy S, et al. JAMA Netw Open. 2025 Jan 2;8(1):e2454707. Access the abstract on PubMed®.
https://pubmed.ncbi.nlm.nih.gov/39821400/
Is access to crisis teams associated with changes in behavioral health mortality? Newton H, Beetham T, Busch SH. Health Aff Sch. 2025 Jan 15;3(1):qxaf003. Epub 2025 Jan 15. Access the abstract on PubMed®.
https://pubmed.ncbi.nlm.nih.gov/39877431/
Preliminary analysis of the impact of lab results on large language model generated differential diagnoses. Bhasuran B, Jin Q, Xie Y, et al. NPJ Digit Med. 2025 Mar 18;8(1):166. Access the abstract on PubMed®.
https://pubmed.ncbi.nlm.nih.gov/40102561/
Pediatric randomized clinical trials in community hospitals: strategies to enhance site participation and engagement. McDaniel CE, Coon ER, Paciorkowski N, et al. Hosp Pediatr. 2025 Mar;15(3):e83-e7. Access the abstract on PubMed®.
https://pubmed.ncbi.nlm.nih.gov/39999186/
The association of intraoperative and early postoperative events with risk of pneumonia following cardiac surgery. Barnett NM, Liesman DR, Strobel RJ, et al. J Thorac Cardiovasc Surg. 2024 Oct;168(4):1144-54.e3. Epub 2023 Oct 4. Access the abstract on PubMed®.
https://pubmed.ncbi.nlm.nih.gov/37797934/
viernes, 23 de mayo de 2025
Morning Briefing: Today's News Summaries Friday, May 23 2025 UPDATED 9:19 AM ++++++
Morning Briefing: Today's News Summaries
Friday, May 23 2025 UPDATED 9:19 AM
Alarm Bells Sound Over Deep Health Care Cuts In House-Passed Tax Bill
https://kffhealthnews.org/morning-breakout/alarm-bells-sound-over-deep-health-care-cuts-in-house-passed-tax-bill/
RFK Jr.'s MAHA Commission Draws Dark Picture Of Kids' Health In Report
https://kffhealthnews.org/morning-breakout/rfk-jr-s-maha-commission-draws-dark-picture-of-kids-health-in-report/
FDA Advisory Panel Recommends Monovalent Covid Vaccine For Fall
https://kffhealthnews.org/morning-breakout/fda-advisory-panel-recommends-monovalent-covid-vaccine-for-fall/
US Alcohol-Associated Cancer Deaths Doubled Over Last Three Decades
https://kffhealthnews.org/morning-breakout/us-alcohol-associated-cancer-deaths-doubled-over-last-three-decades/
Trying To Win More GLP-1 Patients, Novo Nordisk Looks To Telehealth
https://kffhealthnews.org/morning-breakout/trying-to-win-more-glp-1-patients-novo-nordisk-looks-to-telehealth/
Inspection Of VA In Fla. Finds Expired Equipment, Unsecured Medications
https://kffhealthnews.org/morning-breakout/inspection-of-va-in-fla-finds-expired-equipment-unsecured-medications/
Publishing excellence with The Lancet Primary Care
Thursday, 29/05/2025 · 10:00 Atlantic Time (Canada) (GMT -3:00)
Cost: Free
https://www.bigmarker.com/lancet-webinars/publishing-excellence-with-the-lancet-primary-care?utm_bmcr_source=hubspot_email_reg2_publishingexcellence_lanprcpe&_hsmi=362619159&_hsenc=p2ANqtz-_LwvRR4UkCVgcxVdc817s1At01guy7N3vHTJPy_Py6hx_BlwUv7HF5xtYZO4tKlDUms1wQijk_rlL5s3ymekwRypNN8Q&hsCtaAttrib=189013414708
FDA Grand Rounds: Anti-biofilm Technologies for Enhancing the Safety of Medical Device Surfaces - Detalles jue, 29 may 13:00 - 14:00 GMT-3 En línea
https://events.gcc.teams.microsoft.com/event/a0adfaf1-857c-4cbb-8fb9-e20efa81de00@7d2fdb41-339c-4257-87f2-a665730b31fc?utm_medium=email&utm_source=govdelivery
Title: FDA Grand Rounds - Anti-biofilm Technologies for Enhancing the Safety of Medical Device Surfaces
Date: Thursday, May 29, 2025
Time: 12:00 pm - 1:00 pm ET
Webcast
About the Speaker:
Jayaleka J. Amarasinghe, Ph.D.
Microbiologist
Winchester Engineering and Analytical Center (WEAC)
Office of Specialty Laboratories & Enforcement Support (OSLES)
Office of the Chief Scientist (OCS)
Office of the Commissioner (OC)
Dr. Jayaleka Amarasinghe is a microbiologist at the Winchester Engineering and Analytical Center (WEAC), within Office of Specialty Laboratories & Enforcement Support (OSLES), the Office of the Chief Scientist (OCS), in Winchester, Massachusetts. Since joining the FDA in 2014, she has led pioneering research on characterization of biofilms associated with medical device surfaces, driving efforts to develop innovative, antimicrobial-free strategies aimed at enhancing medical device safety. Dr. Amarasinghe earned her undergraduate degree in Biology from Bay Path University in Longmeadow, Massachusetts, and her Ph.D. in Oral Biology from the University at Buffalo, State University of New York. She also completed a postdoctoral fellowship in Infectious Diseases at the New York State Department of Health. Her work has been crucial in advancing novel approaches to anti-biofilm technologies for medical devices.
About the Presentation:
Biofilms are communities of microorganisms encased in extracellular polymeric substances that adhere to surfaces, such as medical devices, contributing to chronic infections. Their resistance to conventional antimicrobials makes biofilms particularly difficult to eradicate, highlighting the urgent need for novel approaches. This presentation explores two innovative technologies evaluated at WEAC/FDA to address biofilms on medical device surfaces: photothermal ablation using gold nanorod coatings and electrical stimulation aimed at disrupting biofilm formation.
For more event information and to register:
MS Teams Webinar Registration
Association Between Outcomes and Dental Services in People Receiving Treatments That Cause Medication-Related Osteonecrosis of the Jaw: A Rapid Response Review
Association Between Outcomes and Dental Services in People Receiving Treatments That Cause Medication-Related Osteonecrosis of the Jaw: A Rapid Response Review: This rapid response aims to summarize the evidence from current literature on the impact of dental services and oral health management for people at risk of developing MRONJ.
Association Between Outcomes and Dental Services in People Receiving Treatment for Human Immunodeficiency Virus: A Rapid Response Review
https://effectivehealthcare.ahrq.gov/products/dental-immunodeficiency-virus/rapid-research
miércoles, 21 de mayo de 2025
martes, 20 de mayo de 2025
Guidance: Draft and Revised Draft Product-Specific Guidances
https://www.federalregister.gov/public-inspection/2025-09068/guidance-draft-and-revised-draft-product-specific-guidances?utm_medium=email&utm_source=govdelivery
Today, FDA published a new batch of product-specific guidances (PSGs). PSGs provide recommendations for developing generic drugs and generating evidence to support abbreviated new drug application (ANDA) approvals. FDA publishes PSGs to help facilitate generic drug development, streamline ANDA assessment, and support greater access to safe, effective, and high-quality treatments. Improving access to generic medicines supports the agency’s mission to advance public health, as outlined in our Drug Competition Action Plan, and accelerating the development and approval of generic drugs also advances the goals of the President’s Executive Order 14273, Lowering Drug Prices by Once Again Putting Americans First.
Today’s batch of 48 PSGs (34 new and 14 revised) contains:
37 PSGs for products with no approved ANDAs (including 6 complex products)
13 PSGs for complex products (10 new and 3 revised PSGs)
PSGs for products used for treatment of postpartum depression, Duchenne muscular dystrophy, and other conditions.
Additional noteworthy PSGs are described below, including PSGs that were supported by GDUFA-funded research. These PSGs include reference products used for the treatment of conditions such as bronchoconstriction, asthma, chronic obstructive pulmonary disease, allergic reactions, and other conditions.
When finalized, the PSGs in today’s batch will describe the agency’s current thinking and recommendations on how to develop generic drug products that are expected to be therapeutically equivalent to specific reference listed drugs. FDA considers comments to the public docket before finalizing PSGs.
Newly Updated – Upcoming PSGs
Today, FDA also updated the “Upcoming Product-Specific Guidances for Generic Drug Product Development” web page, which includes new and revised PSGs under development and includes the planned revision categories and brief descriptions of the revisions. As stated in the GDUFA III Commitment Letter, eligible applicants may request a PSG teleconference to obtain FDA’s feedback on the potential impact of a new or revised PSG on its development program and a subsequent PSG meeting following feedback received at the PSG teleconference. See the guidance for industry Product-Specific Guidance Meetings Between FDA and ANDA Applicants Under GDUFA for more information. The web page also provides information about the agency’s plans for issuing new or revised PSGs in the coming year for all generic drug products (complex and non-complex), along with anticipated publication dates, consistent with FDA’s GDUFA III commitments.
Noteworthy PSGs in Today’s Batch:
New PSG for Treatment or Prevention of Bronchoconstriction and to Reduce Risk of Exacerbations in Patients with Asthma Albuterol Sulfate; Budesonide Inhalation Metered Aerosol (Reference Listed Drug (RLD): AIRSUPRA, NDA 214070)
New PSG for Maintenance Treatment of Chronic Obstructive Pulmonary Disease Budesonide; Formoterol Fumarate Inhalation Metered Aerosol (RLD: SYMBICORT AEROSPHERE, NDA 216579)
New and Revised PSGs for Epinephrine
Revised PSG for Temporary Relief of Mild Symptoms of Intermittent Asthma Epinephrine Inhalation Metered Aerosol (RLD: PRIMATENE MIST, NDA 205920)
New PSG for Emergency Treatment of Type I Allergic Reactions Epinephrine Nasal Spray (RLD: NEFFY, NDA 214697)
New PSG for Hypotension Associated with Septic Shock Epinephrine Intravenous Solution (RLD: ADRENALIN, NDA 215875)
New PSGs for new dosage forms approved via Suitability Petitions Carbinoxamine Maleate Oral Disintegrating Tablet (RLD: CLISTIN, NDA 008955) Metformin Hydrochloride Oral Chewable Tablet (RLD: GLUCOPHAGE, NDA 020357)
These PSGs will streamline generic drug development efforts for a wide-range of products such as providing alternate approaches to more burdensome clinical studies potentially accelerating the availability of important drug products including more patient-friendly formulations while maintain the necessary standards for safety and efficacy.
https://www.fda.gov/drugs/guidances-drugs/upcoming-product-specific-guidances-generic-drug-product-development?utm_medium=email&utm_source=govdelivery
Half the Data, Half the Science: The Cost of Ignoring Sex Differences in Preclinical Research ++++
https://www.pharmasalmanac.com/articles/half-the-data-half-the-science-the-cost-of-ignoring-sex-differences-in-preclinical-research
Bringing Clinical Trial Enrollment to the Point of Diagnosis
https://www.pharmasalmanac.com/articles/bringing-clinical-trial-enrollment-to-the-point-of-diagnosis
Nature’s Nanocarriers: The Evolving Role of Exosomes in Targeted Drug Delivery
https://www.pharmasalmanac.com/articles/natures-nanocarriers-the-evolving-role-of-exosomes-in-targeted-drug-delivery
Gene Therapy at a Crossroads: Rethinking AAV Amid Industry Resets
https://www.pharmasalmanac.com/articles/gene-therapy-at-a-crossroads-rethinking-aav-amid-industry-resets
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