A little CAR-T keeps mice young
Scientists hoping to prolong human life have trained their attention on senescent cells, the building blocks of life that have ceased to live and instead contribute to disease of aging. And CAR-T, famous for its effects on cancer, could be an effective way to get rid of those dead cells and improve health.
As STAT’s Sharon Begley reports, researchers dosed mice with a senescent cell-hunting CAR-T therapy and saw promising results. The mice, which had fibrotic livers, saw their senescent cells nearly vanish after 10 days. Tissue scarring improved, and their liver function bounced back toward normal.
There are loads of barriers between a single mouse study and using such a CAR-T method in humans, including safety, cost, and practicality. But the positive results provide yet more evidence that senescent cells are a viable target, which lends weight to the efforts of companies including Unity Biotechnology and Velabs Therapeutics.
Read more.
As STAT’s Sharon Begley reports, researchers dosed mice with a senescent cell-hunting CAR-T therapy and saw promising results. The mice, which had fibrotic livers, saw their senescent cells nearly vanish after 10 days. Tissue scarring improved, and their liver function bounced back toward normal.
There are loads of barriers between a single mouse study and using such a CAR-T method in humans, including safety, cost, and practicality. But the positive results provide yet more evidence that senescent cells are a viable target, which lends weight to the efforts of companies including Unity Biotechnology and Velabs Therapeutics.
Read more.
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