Incidence of drug-related adverse events related to the use of high-alert drugs: a systematic review of randomized controlled trials. June 19, 2024

https://psnet.ahrq.gov/issue/incidence-drug-related-adverse-events-related-use-high-alert-drugs-systematic-review Incidence of drug-related adverse events related to the use of high-alert drugs: a systematic review of randomized controlled trials. Menezes MS, Doria GAA, Valença-Feitosa F, et al. Explor Res Clin Social Pharm. 2024;14:100435. High-risk medications are classified as such due to their narrow therapeutic range and potential for serious adverse drug events (ADE). This review analyzes the results of randomized clinical trials to identify effective interventions to reduce ADE related to high-risk medications in hospitals. The most cited medications were warfarin, cyclophosphamide, and cyclosporine. The most common intervention was developing protocols for safe use.