The Occurrence of Another Highly Pathogenic Avian Influenza (HPAI) Spillover from Wild Birds into Dairy Cattle

https://www.aphis.usda.gov/sites/default/files/dairy-cattle-hpai-tech-brief.pdf?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-_Wcg1ufoE3b2-F19Wkb7NI3s1hCwVctV_BQMQ8YJ1vWzHrBeknFAcv3579JUAmZrZSkQJryd7CMjRHJwhqJ1NonOMcAQ&_hsmi=346446342&utm_content=346446342&utm_source=hs_email More evidence re: bird flu transmissibility Genetic analysis of H5N1 bird flu viruses recently detected in dairy cows in Nevada shows at least some developed a mutation that has been seen in some human cases of H5N1 and is associated with adaptation of the virus to spread in mammals, the USDA reported Friday. That change hasn’t been seen in the version of the virus responsible for the large outbreak of bird flu in dairy cows, which has been ongoing for the past year. Citing an unnamed source, CNN reported on Saturday that a Nevada dairy worker tested positive for the virus, though that test needs to be confirmed by the CDC. The new Nevada herds were infected with a different version of the virus, one labeled genotype D1.1. (The one responsible for the main outbreak is B3.13.) Florian Krammer, a flu virologist at Mount Sinai’s Icahn School of Medicine, said it's likely there will be more spillovers. “The first seemed like a black swan event. But if it happens twice, I am sure it happens more often." Krammer said it will be important to study the transmissibility and severity of this version of the virus in ferrets, the best animal model for flu in humans. — Helen Branswell https://www.statnews.com/2025/02/05/usda-nevada-herds-different-bird-flu-strain-milk-testing/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz--YdxgSO_d-Qscsd-mItlw5YF6tZ8W0Iit1rotBT4VlDLQIU_-56kkaUdIvpkw6Y7KmQddC27BARq5jElK3am5btZP1Bw&_hsmi=346446342&utm_content=346446342&utm_source=hs_email Bird flu variant found in Nevada cows shows signs of adaptation to mammals By Brenda Goodman, CNN https://edition.cnn.com/2025/02/08/health/bird-flu-variant-nevada-human-case/index.html?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-9QxsH-AJ8lbVIZTYKmRGC1cJEv-fo6LjHCICPxs2ekUdaYVQLnSR87eaSKiPsVJLF7_uLVxpiVHGV7loBK28N31F7RWg&_hsmi=346446342&utm_content=346446342&utm_source=hs_email