New Request for Applications for FDA Orphan Products Natural History Studies Grants Program Deadline to submit applications: February 10, 2026

https://grants.nih.gov/grants/guide/rfa-files/RFA-FD-25-017.html?utm_medium=email&utm_source=govdelivery The Food and Drug Administration’s (FDA) Office of Orphan Products Development (OOPD) is pleased to announce a new funding opportunity for the Orphan Products Natural History Studies Grants Program to support efficient and innovative natural history studies that advance medical product development in rare diseases and conditions. This funding opportunity is intended to support prospective or retrospective, efficient, and innovative natural history studies with a focus on collaborative and standardized approaches to ensure data quality and interpretability. Through the support of natural history studies with high quality and interpretable data elements, FDA expects to address critical knowledge gaps, remove major barriers to progress in the field, exert a significant and broad impact on a specific rare disease or multiple rare diseases with similar pathophysiology, and facilitate rare disease product development. Natural History Studies Grants Program FDA Office of Orphan Products Development (OOPD) https://www.fda.gov/industry/orphan-products-grants-program/natural-history-studies-grants-program?utm_medium=email&utm_source=govdelivery