Transforming the Landscape of Gynaecological Cancer: Advances in Prevention, Precision Surgery, and Innovative Systemic Therapies

https://www.thelancet.com/series-do/gynaecological-cancers-advances?dgcid=hubspot_email_conferencealerts_eclinmgyno26&utm_campaign=conferencealerts&utm_medium=email&_hsenc=p2ANqtz-_a4Rc9xGUNMAEiAGXdG0xoK0aA-qg-5stZCh3GlRxpLRrFW19eLY9qL9SxgRP60dfhuyGY8p2FDqBMOqu6ZhPpYbvq0g&_hsmi=423115945&utm_content=423115945&utm_source=hs_email A three-paper Series examines how new strategies and technologies are transforming gynaecological cancer care, with a focus on prevention, precision surgery, and innovative systemic therapies. Paper 1 explores global efforts toward cervical cancer elimination, including progress in HPV vaccination and screening, alternative vaccine strategies, and WHO screening guidelines. Authors also propose targeted actions to accelerate elimination through innovation and more equitable strategies. Paper 2 discusses how computer-assisted and image-guided technologies are redefining surgical lymph node staging in gynaecological cancers. Paper 3 reviews the rapidly evolving field of antibody-drug conjugates (ADCs) in gynaecological cancers. The authors summarise mechanisms of action and findings from clinical trials, and address safety considerations, predictive biomarkers, and future directions for integrating ADCs into personalized treatment strategies.