- 12 Jan 2019 Japanese encephalitis & other - India (01)
- 12 Jan 2019 Diarrheal shellfish poisoning - Namibia: (ER), alert
- 12 Jan 2019 Trypanosomiasis (Chagas disease) - Sri Lanka: canine, 1st rep., preliminary, RFI
- 12 Jan 2019 Measles update (03): Europe, Americas, Asia, Africa, vaccine
- 12 Jan 2019 Dengue/DHF update (02): Asia, Pacific, Australia, research
- 11 Jan 2019 Foot & mouth disease - Morocco: (BK) bovine, serotype pending, OIE
- 11 Jan 2019 MERS-CoV (05): Eastern Mediterranean region, EMRO
- 11 Jan 2019 Newcastle disease, poultry - USA: (CA) commercial flocks
- 11 Jan 2019 Bluetongue - Europe: Germany (RP) bovine, st 8, spread
- 11 Jan 2019 Diphtheria - Germany: toxigenic, cutaneous, siblings, suspected ex Somalia
- 11 Jan 2019 Anthrax - Tanzania: (SO) bovine, human
- 11 Jan 2019 Foot & mouth disease - Russia: (PR) porcine, st O, OIE
- 11 Jan 2019 Lassa fever - West Africa (03): Nigeria
- 11 Jan 2019 Foot & mouth disease - Tunisia: (JE, KS) bovine, ovine, st O, spread, OIE
- 11 Jan 2019 Ebola update (04): Congo DR (NK,IT) cases, WHO, travel, treatment
- 10 Jan 2019 Anthrax - Malawi (02): (MA) hippopotamus, last cases?
- 10 Jan 2019 Poliomyelitis update (03): global (Mozambique), Pakistan 2018
- 10 Jan 2019 Typhoid fever - USA: ex Pakistan, multidrug resistance, CDC 2018
- 10 Jan 2019 Bovine tuberculosis - Canada: (BC) bovine, new strain
- 10 Jan 2019 African swine fever - Europe (04): Belgium (LX) wild boar, spread conf
- 10 Jan 2019 Influenza (01): WHO global update, H3N2, oncology ward, 2017
- 10 Jan 2019 Acute flaccid myelitis - North America (01): USA, update
- 10 Jan 2019 Hepatitis A - USA (02): (OH, IN, FL)
- 09 Jan 2019 Equine influenza - Nigeria: (SO) serotype pending, OIE
- 09 Jan 2019 Potato yellow blotch virus - UK: new potyvirus
- 09 Jan 2019 Yellow fever - Africa: Nigeria, WHO
- 09 Jan 2019 Gonococcal disease - UK: antibiotic resistance, ceftriaxone/azithromycin
- 09 Jan 2019 Plague - USA: (WY) feline
- 09 Jan 2019 MERS-CoV (04): Saudi Arabia (MK)
- 09 Jan 2019 Cholera, diarrhea & dysentery update: Africa, Asia
- 09 Jan 2019 Poliomyelitis update (02): DR Congo, cVDPV, WHO, China, vaccine challenges
- 09 Jan 2019 Leishmaniasis - Syria: (HM) cutaneous
- 09 Jan 2019 Porcine epidemic diarrhea - North America: Canada (AB) 1st report
- 09 Jan 2019 Avian influenza (02): India (BR, OR) zoo and wild birds, HPAI H5N1, OIE
- 09 Jan 2019 Kyasanur Forest disease - India (02): (KA) human, monkey, update
- 09 Jan 2019 Ebola update (03): Congo DR (NK,IT) cases, summaries
- 08 Jan 2019 Severe fever w/ thrombocytopenia synd. - South Korea: poss. aerosol transmission
- 08 Jan 2019 Rift Valley fever: vertical transmission, comments, details
- 08 Jan 2019 Measles update (02): Pacific, Europe, Americas, Middle East, comment
- 08 Jan 2019 Avian influenza, human (01): Nepal (KT), poultry susp, RFI
- 08 Jan 2019 Avian influenza (01): Iran (MN) HPAI, poultry, H5N8, spread, OIE
- 08 Jan 2019 Anthrax - India: (OR) elephant calf, susp
- 08 Jan 2019 Die-off, fish - Australia: (NS) oxygen depletion susp
- 08 Jan 2019 Hantavirus - Americas (03): Chile (LG) ex Argentina (CH)
- 08 Jan 2019 Lassa fever - West Africa (02): Togo (KA)
- 08 Jan 2019 Mengla virus - China: (YN) bat
- 07 Jan 2019 Flavescence doree, grapevine - Switzerland: (GE)
- 07 Jan 2019 Newcastle disease - USA: (ID) columbids
- 07 Jan 2019 African swine fever - Europe (03): Belgium (LX) wild boar, spread, OIE
- 07 Jan 2019 MERS-CoV (03): Saudi Arabia (RI)
- 07 Jan 2019 Anthrax - Russia: (YN) genomic strain identifications
- 07 Jan 2019 Lassa fever - West Africa (01): Nigeria
- 07 Jan 2019 Leishmaniasis, cutaneous - Libya: (MS)
- 06 Jan 2019 Hantavirus - Americas (02): Panama WHO 2018 review
- 06 Jan 2019 Anthrax - Kenya (02): (ME) livestock, human
- 06 Jan 2019 Crimean-Congo hem. fever - East Africa: Uganda (MZ)
- 06 Jan 2019 Kyasanur Forest disease - India: (KA) human
- 06 Jan 2019 Anthrax - Zimbabwe: (MW) bovine, human
- 05 Jan 2019 Ebola update (02): Congo DR (NK, IT) cases, summaries
- 05 Jan 2019 Peste des petits ruminants - Algeria: (ET) ovine, caprine, spread
- 05 Jan 2019 MERS-CoV (02): Kenya, animal reservoir, camel, serosurveillance, genotyping
- 05 Jan 2019 Ricin - USA: (WA) possible public exposure
- 05 Jan 2019 Hantavirus - Americas (01): Argentina (CH)
- 05 Jan 2019 Measles vaccine - India: (MH) adverse events, RFI
- 05 Jan 2019 Undiagnosed hemorrhagic fever - Sweden: ex Burundi
- 05 Jan 2019 Rubella - Japan
- 04 Jan 2019 MERS-CoV (01): Saudi Arabia (RI)
- 04 Jan 2019 Poliomyelitis update (01): global
- 04 Jan 2019 Hepatitis A - USA (01): (KY, TN)
- 04 Jan 2019 New in IJID (01): January 2019
- 04 Jan 2019 African swine fever - Asia (01): China, domestic, spread, FAO, Taiwan ex China
- 04 Jan 2019 Rubella - Spain: (AR)
- 04 Jan 2019 African swine fever - Europe (02): Ukraine, domestic, wild boar, OIE
- 03 Jan 2019 Anthrax - Kenya: (ME) livestock, human
- 03 Jan 2019 Chikungunya (01): Americas, Africa, Asia
- 03 Jan 2019 Salmonellosis - USA: (MI) live poultry, mail-order hatchery
- 03 Jan 2019 Botulism - USA: (CA) wound, injection drug related
- 03 Jan 2019 Ebola update (01): Congo DR (NK, IT) cases, summaries, Uganda
- 03 Jan 2019 African swine fever - Europe (01): Belgium (LX) wild boar, spread, OIE, RFI
- 03 Jan 2019 Dengue/DHF update (01): Americas
- 02 Jan 2019 Measles update (01): Americas, Africa, Southeast Asia
- 02 Jan 2019 Anthrax - Malawi: (MA) hippopotamus, more cases
- 02 Jan 2019 Undiagnosed deaths, elephant - Tanzania: RFI
- 02 Jan 2019 Rabies (01): Americas, Dominican Republic (PN) human death
- 01 Jan 2019 Undiagnosed death, elephant - USA: (OH) herpesvirus, susp.
- 01 Jan 2019 Schmallenberg virus - Asia: Iran, equine, serology
- 31 Dec 2018 Monkeypox - Africa (17): Nigeria
- 31 Dec 2018 Ebola update (158): Congo DR (NK, IT) cases, summary, response
- 31 Dec 2018 Measles update (81): Europe, Americas, Africa
- 31 Dec 2018 Yellow fever - Africa (30): Nigeria
- 31 Dec 2018 Meningitis, meningococcal - Nigeria (04): fatal, serogroup C
- 31 Dec 2018 Infectious salmon anemia - Chile: (AI)
- 30 Dec 2018 Yellow fever - Africa (29): Zambia (LS) fake cards
- 29 Dec 2018 Rabies (58): Americas, USA (NC) bear
- 29 Dec 2018 Sphingomonas koreensis, MDR - USA: (MD) nosocomial, fatal, contaminated water
- 29 Dec 2018 Schistosomiasis: infection enhances HIV transmission
- 29 Dec 2018 Equine herpesvirus - North America (27): USA (IN) equine
- 29 Dec 2018 Ebola update (157): Congo DR (NK, IT) cases, summaries, response, USA (NE)
- 29 Dec 2018 Pythiosis - USA (03): (VA) equine, Chincoteague pony deaths
- 29 Dec 2018 Chronic wasting disease, cervid - USA (26): (ND, TN)
- 29 Dec 2018 Foot & mouth disease - Israel (13): (HZ) st O, spread, vaccine valency
- 29 Dec 2018 Hepatitis A - USA (65): (KY, WV, AL)
- 29 Dec 2018 African swine fever - Asia (47): China, domestic, spread, FAO
- 29 Dec 2018 Foot & mouth disease - Algeria (08): (EB) ovine, suspected, control, vaccination
- 29 Dec 2018 Newcastle disease, poultry - USA (17): (CA)
- 29 Dec 2018 Malaria - Uzbekistan: WHO certified malaria-free
- 28 Dec 2018 Lassa fever - West Africa (50): Benin (LI)
- 28 Dec 2018 Listeriosis - Europe (07): Norway
- 28 Dec 2018 Poliomyelitis update (62): (Nigeria, Niger) cVDPV2
- 28 Dec 2018 MERS-CoV (52): Saudi Arabia (RI) WHO
- 28 Dec 2018 Measles update (80): Europe, Pacific, Asia, Americas, Middle East
- 28 Dec 2018 Pertussis (11): USA, Australia
- 28 Dec 2018 Avian influenza (118): India (BR) backyard, HPAI H5N1, OIE
- 28 Dec 2018 Typhoid fever - Pakistan (07): multidrug resistance, WHO
- 28 Dec 2018 Avian influenza (117): Viet Nam (DC) backyard, HPAI H5N1, OIE
- 28 Dec 2018 Ebola update (156): Congo DR (NK, IT) cases, unrest
- 28 Dec 2018 Influenza (33): WHO global update, Georgia, India
- 28 Dec 2018 Newcastle disease - Bulgaria: (BR) wild bird, OIE
- 28 Dec 2018 Bacterial blight, hazelnut - Portugal: 1st rep (AV)
- 27 Dec 2018 Radiation, bovine - Japan: (FS), long-term exposure
- 27 Dec 2018 African swine fever - Asia (46): China (GD, FJ), spread, Taiwan alertness
- 27 Dec 2018 Brucellosis - USA (08): (PA) bovine, human
- 26 Dec 2018 Foot & mouth disease - Tunisia: bovine, ovine, st O, OIE
- 26 Dec 2018 Ebola update (155): Congo DR (NK, IT) cases, response
- 26 Dec 2018 Zika virus (12): Americas, Africa, Pacific, Asia research, observations
- 26 Dec 2018 Classical swine fever - Japan (09): (GF) spread, wild, domestic, control
- 26 Dec 2018 Avian influenza, human (24): China (GD, GX) H9N2
- 25 Dec 2018 Strangles, equine - USA (07): (FL)
- 24 Dec 2018 African swine fever - Europe (65): Belgium (LX) wild boar, spread, France alert
- 24 Dec 2018 Trypanosomiasis - South Africa (02): ex Zambia, ex Malawi
- 24 Dec 2018 Ebola update (154): Congo DR (NK, IT) cases, election, women
- 23 Dec 2018 Measles update (79): Middle East, Americas, Europe, Pacific
- 23 Dec 2018 Marburg virus disease - Sierra Leone (02): bats, additional information
- 23 Dec 2018 Hantavirus - Americas (67): Argentina (CH)
- 23 Dec 2018 Cassava brown streak viruses, reservoir hosts - Mozambique
- 23 Dec 2018 Yellow fever - Africa (28): South Sudan (GB) WHO
- 23 Dec 2018 Newcastle disease, poultry - USA (16): (CA) commercial
- 23 Dec 2018 Influenza (32): seasonal, USA, Italy
- 22 Dec 2018 African swine fever - Asia (45): Taiwan ex China, tainted food
- 22 Dec 2018 Classical swine fever - Japan (08): (AI) spread, wild boar
- 22 Dec 2018 Peste des petits ruminants - Burundi (02): caprine, ovine, spread
- 22 Dec 2018 Ebola update (153): Congo DR (NK,IT) vaccine
- 22 Dec 2018 African swine fever - Asia (44): China (GD) domestic, spread, OIE
- 21 Dec 2018 E. coli EHEC - France (03): O26, unpasteurized cheese, more cases
- 21 Dec 2018 Undiagnosed deaths, bovine - India (04): (OR) RFI
- 21 Dec 2018 Die-off, seal - USA (04): (ME) phocine distemper virus
- 21 Dec 2018 Marburg virus disease - Sierra Leone: bat
- 21 Dec 2018 African swine fever - Asia (43): China, domestic, spread, FAO
- 21 Dec 2018 Hepatitis A - Australia (05): (VI) MSM
- 21 Dec 2018 Peste des petits ruminants - Algeria: ovine, caprine, OIE
- 21 Dec 2018 Contaminated stem cell - USA: infection, unapproved use
- 21 Dec 2018 Tick-borne encephalitis - Czech Republic (02)
- 21 Dec 2018 Diphtheria - Americas (04): PAHO/WHO update
- 21 Dec 2018 Avian influenza (116): India (OR) poultry, wild bird, HPAI H5N1, OIE
- 21 Dec 2018 Diphtheria - Yemen (06): (AD)
- 21 Dec 2018 African swine fever - Europe (64): Belgium (LX) wild boar, spread, control, OIE
- 21 Dec 2018 MERS-CoV (51): Saudi Arabia (RI)
- 21 Dec 2018 Poliomyelitis update (61): global (Nigeria), comment on social media
- 21 Dec 2018 Vaccine logistics - Vanuatu: (TF) drone delivery
- 21 Dec 2018 Foodborne illness, undiagnosed fatalities - India (02): (KA) chemicals found
- 20 Dec 2018 Buruli ulcer - Australia (04): (QL)
- 20 Dec 2018 Chronic wasting disease, cervid - USA (25): (NE)
- 20 Dec 2018 Ebola update (152): Congo DR (NK,IT)
- 20 Dec 2018 Piscine reovirus - North America (03): USA (WA) salmon
- 20 Dec 2018 Japanese encephalitis & other - India (23): (MH)
- 20 Dec 2018 Measles update (78): Europe, Americas, Africa
- 19 Dec 2018 African swine fever - Asia (42): China (GD) domestic, spread
- 19 Dec 2018 Cholera, diarrhea & dysentery update (49): Africa
- 19 Dec 2018 Salmonellosis, st. Coeln - Austria
- 19 Dec 2018 Acute flaccid myelitis - Europe: UK
- 19 Dec 2018 Foot & mouth disease - Israel (12): (HZ) bovine, boar, gazelle, st O, OIE
- 19 Dec 2018 Acute flaccid myelitis - North America (12): USA, update
- 19 Dec 2018 Malaria - India (05): (KL) P. falciparum, macaque
- 19 Dec 2018 Poliomyelitis update (60): Pakistan, negative impact of social media
- 19 Dec 2018 Ebola update (151): Congo DR (NK,IT) cases, background
- 18 Dec 2018 Anthrax, BioThrax, post-exp vaccine - Canada: official approval
- 18 Dec 2018 Legionellosis - USA (16): (WI) fatal, nosocomial
- 18 Dec 2018 Hepatitis A - USA (64): (NM,AZ)
- 18 Dec 2018 Schistosomiasis - Philippines: (LE)
- 18 Dec 2018 Trypanosomiasis (Chagas disease) - Brazil (03): (TO) foodborne
- 18 Dec 2018 Greening disease, orange - India: (MH)
- 18 Dec 2018 MERS-CoV (50): Saudi Arabia (RI), EMRO Nov 2018 update
- 17 Dec 2018 Lassa fever - West Africa (49): Nigeria
- 17 Dec 2018 Hepatitis A - USA (63): (KY)
- 17 Dec 2018 Malaria - South Africa: sustained transmission
- 17 Dec 2018 Undiagnosed disease, rice - Bangladesh: (CG)
- 17 Dec 2018 Undiagnosed illness - India: (JK) fatal, children, diphtheria susp, RFI
- 16 Dec 2018 Yellow fever - Africa (27): Nigeria (ED)
- 16 Dec 2018 Lassa Fever - West Africa (48): Benin (BO) ex Nigeria
- 16 Dec 2018 Vaping solution ingestion - UK (Scotland): serious toxicity
- 16 Dec 2018 Kyasanur Forest disease - India (12): (KA) human, monkey
- 15 Dec 2018 Ebola update (150): Congo DR (NK, IT) cases, summary, Guinea
- 15 Dec 2018 Toxicity, feed - USA: (SD) bovine
- 15 Dec 2018 Avian influenza (115): India (OR) poultry, HPAI H5N1
- 15 Dec 2018 Strangles, equine - Canada (05): (NB)
- 15 Dec 2018 Chronic wasting disease, cervid - USA (24): (MT)
- 15 Dec 2018 African swine fever - Asia (41): China, domestic swine, spread, control, FAO
- 15 Dec 2018 Diphtheria - Philippines: increased cases, 4 regions
- 15 Dec 2018 African swine fever - Asia (40): China (QH) domestic swine, spread, OIE
- 15 Dec 2018 Leishmaniasis, visceral - Israel: (HZ) feline, canine
- 14 Dec 2018 Avian influenza (114): USA (MD) poultry, susp., RFI
- 14 Dec 2018 Foodborne illness, undiagnosed fatalities - India, RFI
- 14 Dec 2018 Histomoniasis, turkeys - USA: (GA) research
- 14 Dec 2018 Ebola update (149): Congo DR (NK, IT) cases, summaries, WHO, accounts
- 14 Dec 2018 Anthrax - Kenya (07): (ME) livestock, human
- 14 Dec 2018 Reverse zoonotic disease transmission, sea birds - Antarctica
- 13 Dec 2018 MERS-CoV (49): Saudi Arabia (NJ, RI)
- 13 Dec 2018 Poliomyelitis update (59): global (Afghanistan, Papua New Guinea)
- 13 Dec 2018 Rabbit hemorrhagic disease - USA (02): (PA) rabbits, RHDV1
- 13 Dec 2018 Fusarium wilt, pigeon pea - India: (MH)
- 13 Dec 2018 Cholera, diarrhea & dysentery update (48): Asia (Yemen) WHO
- 13 Dec 2018 Botulism - Americas: canned corn, risk, recall
- 13 Dec 2018 Salmonellosis, st. Newport - USA (06): ground beef, alert, recall
- 13 Dec 2018 Bluetongue - Europe (06): Germany (BW), bovine, BTV-8, OIE
- 13 Dec 2018 Measles update (77): Americas, Europe, Pacific
- 13 Dec 2018 Hand, foot & mouth disease update (16): UK (England)
- 13 Dec 2018 Malaria, avian - UK: (England) penguin, zoo colony
- 13 Dec 2018 Rabbit hemorrhagic disease - USA (02): (PA) pet rabbit, RHDV, OIE
- 13 Dec 2018 Avian influenza (113): Iran (EA) HPAI, poultry, H5N8, OIE
Published Date: 2019-01-12 20:35:35
Subject: PRO/AH/EDR> Japanese encephalitis & other - India (01)
Archive Number: 20190112.6255835
Subject: PRO/AH/EDR> Japanese encephalitis & other - India (01)
Archive Number: 20190112.6255835
JAPANESE ENCEPHALITIS AND OTHER - INDIA (01)
********************************************
A ProMED-mail post
http://www.promedmail.org
ProMED-mail is a program of the
International Society for Infectious Diseases
http://www.isid.org
Date: Fri 11 Jan 2019 [in press]
Source: International Journal of Infectious Diseases [edited]
https://www.ijidonline.com/article/S1201-9712(19)30019-0/fulltext
Citation: Vasanthapuram Ravi, Shafeeq Keeran Shahul Hameed, Anita Desai, Reeta Subramaniam Mani, Vijayalakshmi Reddy, et al.: Dengue virus is an under-recognised causative agent of acute encephalitis syndrome (AES): Results from a 4-year AES surveillance study of Japanese encephalitis in selected states of India. International Journal of Infectious Diseases. 2019. doi: https://doi.org/10.1016/j.ijid.2019.01.008.
Highlights
- Dengue virus is one of the 3 most common agents identified in acute encephalitis syndrome (AES).
- Existing surveillance for AES does not include routine testing for dengue.
- Dengue accounts for 5% of AES cases in India, especially in the absence of laboratory evidence for other pathogens tested.
- Testing for dengue in AES cases must be included in routine surveillance.
Abstract
Background
AES surveillance in India has indicated that Japanese encephalitis virus (JEV) accounts for 5-35% of AES cases annually; the etiology remains unknown in the remaining cases. We implemented comprehensive AES surveillance to identify other etiological agents of AES, with emphasis on dengue virus.
Methods
Serum and cerebrospinal fluid (CSF) specimens were collected from patients enrolled prospectively in AES surveillance from 2014-2017 at selected sites of 3 high-burden states of India. All samples were initially tested for JEV IgM. Specimens negative for JEV by serology were tested for IgM to scrub typhus, dengue virus (DEN), and West Nile virus; all JEV IgM-negative CSF samples were tested by PCR for _S. pneumoniae_, _N. meningitidis_, _H. influenzae_, herpes simplex virus type 1, enteroviruses, and DEN.
Results
Of 10 107 AES patients, an etiology could be established in 49.2% of patients, including JEV (16%), scrub typhus (16%), and DEN (5.2%) as the top 3 agents. Among the DEN-positive cases (359/6892), 7 (2%) were positive only for dengue virus RNA: one in serum and 6 in CSF.
Conclusion
Among the pathogens identified, dengue accounted for 5% of all AES cases and was one of the 3 common etiological agents. These results underscore the importance of including dengue virus in routine testing of AES cases.
--
Communicated by:
ProMED-mail
<promed@promedmail.org>
[Frequently, in reports of JE cases in India, acute encephalitis syndrome (AES) of undefined etiology is often mentioned with JE cases, a minority of those hospitalized. The determination of the etiology or etiologies of AES has been confusing and elusive. Various etiological agents have been proposed in recent years as responsible for AES cases. AES has continued to be attributed to a variety of etiologies, including Reye syndrome-like disease, possible enterovirus infection from polluted water, heatstroke, lychee fruit consumption, and scrub typhus (_Orientia tsutsugamushi_). Recently, scrub typhus has been implicated in many AES cases. The above retrospective study indicates that scrub typhus is responsible for 16% and dengue for 5% of AES cases. Dengue, as the authors state, should be included in testing of AES cases.
Maps of India: http://www.mapsofindia.com/maps/india/india-political-map.htm and http://healthmap.org/promed/p/310. - Mod.TY]
********************************************
A ProMED-mail post
http://www.promedmail.org
ProMED-mail is a program of the
International Society for Infectious Diseases
http://www.isid.org
Date: Fri 11 Jan 2019 [in press]
Source: International Journal of Infectious Diseases [edited]
https://www.ijidonline.com/article/S1201-9712(19)30019-0/fulltext
Citation: Vasanthapuram Ravi, Shafeeq Keeran Shahul Hameed, Anita Desai, Reeta Subramaniam Mani, Vijayalakshmi Reddy, et al.: Dengue virus is an under-recognised causative agent of acute encephalitis syndrome (AES): Results from a 4-year AES surveillance study of Japanese encephalitis in selected states of India. International Journal of Infectious Diseases. 2019. doi: https://doi.org/10.1016/j.ijid.2019.01.008.
Highlights
- Dengue virus is one of the 3 most common agents identified in acute encephalitis syndrome (AES).
- Existing surveillance for AES does not include routine testing for dengue.
- Dengue accounts for 5% of AES cases in India, especially in the absence of laboratory evidence for other pathogens tested.
- Testing for dengue in AES cases must be included in routine surveillance.
Abstract
Background
AES surveillance in India has indicated that Japanese encephalitis virus (JEV) accounts for 5-35% of AES cases annually; the etiology remains unknown in the remaining cases. We implemented comprehensive AES surveillance to identify other etiological agents of AES, with emphasis on dengue virus.
Methods
Serum and cerebrospinal fluid (CSF) specimens were collected from patients enrolled prospectively in AES surveillance from 2014-2017 at selected sites of 3 high-burden states of India. All samples were initially tested for JEV IgM. Specimens negative for JEV by serology were tested for IgM to scrub typhus, dengue virus (DEN), and West Nile virus; all JEV IgM-negative CSF samples were tested by PCR for _S. pneumoniae_, _N. meningitidis_, _H. influenzae_, herpes simplex virus type 1, enteroviruses, and DEN.
Results
Of 10 107 AES patients, an etiology could be established in 49.2% of patients, including JEV (16%), scrub typhus (16%), and DEN (5.2%) as the top 3 agents. Among the DEN-positive cases (359/6892), 7 (2%) were positive only for dengue virus RNA: one in serum and 6 in CSF.
Conclusion
Among the pathogens identified, dengue accounted for 5% of all AES cases and was one of the 3 common etiological agents. These results underscore the importance of including dengue virus in routine testing of AES cases.
--
Communicated by:
ProMED-mail
<promed@promedmail.org>
[Frequently, in reports of JE cases in India, acute encephalitis syndrome (AES) of undefined etiology is often mentioned with JE cases, a minority of those hospitalized. The determination of the etiology or etiologies of AES has been confusing and elusive. Various etiological agents have been proposed in recent years as responsible for AES cases. AES has continued to be attributed to a variety of etiologies, including Reye syndrome-like disease, possible enterovirus infection from polluted water, heatstroke, lychee fruit consumption, and scrub typhus (_Orientia tsutsugamushi_). Recently, scrub typhus has been implicated in many AES cases. The above retrospective study indicates that scrub typhus is responsible for 16% and dengue for 5% of AES cases. Dengue, as the authors state, should be included in testing of AES cases.
Maps of India: http://www.mapsofindia.com/maps/india/india-political-map.htm and http://healthmap.org/promed/p/310. - Mod.TY]
See Also
2018----
Japanese encephalitis & other - India (23): (MH) 20181220.6216363
Japanese encephalitis & other - India (22): (MP) 20181112.6141152
Japanese encephalitis & other - India (21): (AS) 20181108.6132872
Japanese encephalitis & other - India (19): (MP) 20180827.5991109
Japanese encephalitis & other - India (18): (BR) 20180823.5981659
Japanese encephalitis & other - India (17): (AS) 20180818.5974190
Japanese encephalitis & other - India (16): (UP) 20180814.5964023
Japanese encephalitis & other - India (15): (AS) 20180812.5961217
Japanese encephalitis & other - India (14): (AS) 20180805.5948662
Japanese encephalitis & other - India (13): (UP) 20180711.5900435
Japanese encephalitis & other - India (12): (AS) 20180701.5883729
Japanese encephalitis & other - India (11): (AS) 20180628.5881510
Japanese encephalitis & other - India (10) 20180620.5866496
Japanese encephalitis & other - India (09): (AS) 20180618.5862346
Japanese encephalitis & other - India (08): (BR) 20180618.5860635
Japanese encephalitis & other - India (07): (MP) 20180614.5855342
Japanese encephalitis & other - India (06): (HP) 20180607.5844658
Japanese encephalitis & other - India (05): (KL) 20180605.5840545
Japanese encephalitis & other - India (04): (KL) 20180530.5827153
Japanese encephalitis & other - India (03): (AS) 20180523.5812921
Japanese encephalitis & other - India (02): (UP), typhus 20180416.5749050
Japanese encephalitis & other - India: (KA, UP) 20180110.55507
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