Spotlight on COVID-19How Data Became One of the Most Powerful tools to fight an epidemic
S Johnson, New York Magazine, June 2020
S Johnson, New York Magazine, June 2020
As public-health experts have known since the 19th century, information can be the best medicine. What new data streams could help quell future outbreaks?
Initial Whole Genome Sequencing and Analysis of the Host Genetic Contribution to COVID-19 Severity and Susceptibility
F Wang et al, MEDRXIV, June 13, 2020
F Wang et al, MEDRXIV, June 13, 2020
This is the first host genetic study in China by deeply sequencing the 332 COVID-19 patients categorized by varying levels of severity. Gene loci associated with severity is located in TMEM189-UBE2V1 involved in the IL-1 signaling pathway. The p.Val197Met missense variant that affects the stability of the TMPRSS2 protein displays a decreasing allele frequency.
Using Digital Data to Protect and Promote the Most Vulnerable in the Fight Against COVID-19
R Chunara et al, Frot Public Health, June 12, 2020
R Chunara et al, Frot Public Health, June 12, 2020
The digital divide shows that the most vulnerable (e.g., elderly, certain socioeconomic or cultural groups) may not often have access to the same digital tools, nor follow the same patterns of illness and reporting as other populations. This may present issues when population-level inferences are to be made from such data.
Proteomic Profiling in Biracial Cohorts Implicates DC-SIGN as a Mediator of Genetic Risk in COVID-19
DH Katz et al, MEDRXIV, June 11, 2020
DH Katz et al, MEDRXIV, June 11, 2020
Recent work has identified two genetic risk loci that confer greater risk for respiratory failure in COVID-19: the ABO locus and the 3p21.31 locus. To understand how these loci might confer risk, we utilized proteomic profiling and genetic information from three cohorts including black and white participants to identify proteins influenced by these loci.
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