Girl’s case of lupus leads to new understanding of a perplexing disease Isabella Cueto By Isabella Cueto

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00261-1?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-_emSTJq3splzKD4ZJBu88HQ-y1D8PNtkwI5pEcMOgPBgzsySsgXUBVsjd00SuAl1SaEWf6g5nwcC1QOKQWjK1fx0rC6Q&_hsmi=306900761&utm_content=306900761&utm_source=hs_email New study provides a clue for better potential lupus treatments STAT’s chronic disease reporter Isa Cueto has described lupus as “a confounding and severe autoimmune disease.” It affects up to 1.5 million people in the U.S., causing problems in organs including the kidneys, spleen, heart, and brain. Some treatments for the disease are designed to suppress immune system proteins called interferons. But they don’t always work. To learn more about why that might be, researchers looked at hundreds of samples from just under 200 patients to analyze the activity level of three interferon types — I, II, and III. In a study published Monday in Cell Reports Medicine, they report that some symptoms are correlated with overactivity in specific types. Skin-related symptoms were correlated with overactivity of interferon I, while kidney inflammation were related to elevated activity in all three types. Other symptoms couldn’t be pinned down: Blood clots and low platelet counts didn’t have any particular association. Isa told me that this research seemed promising because experts would love to get clearer categories of systemic lupus in order to treat it in a more targeted way. Read more of her reporting on lupus and other chronic diseases. https://www.statnews.com/staff/isabella-cueto/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz--J8KrQDpTabR0Hnc96k7wxy1FxgXOVnY5k3GQvT1AySAQQtRuspTgzOYmfAtkobG6LJqZyuWN0yUcUneSvLNptKfBo2A&_hsmi=306900761&utm_content=306900761&utm_source=hs_email After years of just ‘running, running,’ a crisis led to a lupus diagnosis. Now she connects others Isabella Cueto By Isabella Cueto April 9, 2024 https://www.statnews.com/2024/04/09/lupus-autoimmune-diagnosis-treatment-lupuschat/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-_dUh1nZy3ozKv_e3lVieFH15cKlbqwkXdeg7eUJkRrYZA33EikE42HO83Dymuvip-YN_PldIs-7T3volTy60C-I_rDjA&_hsmi=306900761&utm_content=306900761&utm_source=hs_email Girl’s case of lupus leads to new understanding of a perplexing disease Isabella Cueto By Isabella Cueto https://www.statnews.com/2022/06/16/girls-case-of-lupus-leads-to-new-understanding-of-a-perplexing-disease/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-9H16-yh7hyJQeMoOQVMdYidXNEVrlz9MckmzrSqxuwodJzfYA5Wxs8PhWXpvW8O0nky_2Rg7Gc1Xp0OtOkeWsLopXghw&_hsmi=306900761&utm_content=306900761&utm_source=hs_email