Soluble CD44 in oral rinses for the early detection of cancer: a prospective cohort study in high-risk individuals

https://pubmed.ncbi.nlm.nih.gov/39030509/ Soluble CD44 in oral rinses for the early detection of cancer: a prospective cohort study in high-risk individuals There are 54,000 new cases of oral cavity and oropharyngeal cancer in the United States and more than 476,000 worldwide each year. Oral cavity and oropharyngeal squamous cell carcinoma make up most tumors with five-year survival rates of 50% due to prevalence of late-stage diagnoses. Improved methods of early detection in high-risk individuals are urgently needed. This study aimed to assess the tumorigenic biomarkers soluble CD44 (solCD44) and total protein (TP) measured using oral rinses as affordable convenient screening tools for cancer detection. Author: Shahm Raslan, Drew H. Smith, Isildinha M. Reis, Sophia J. Peifer, Garrett Forman, Uche C. Ezeh, Priyashma Joshi, Margaret Koester, Isabella Buitron, Abdurrahman Al-Awady, Jerri Halgowich, Huaping Liu, Claudia Gordon, Monica Webb Hooper*, Larissa Sweeny, and Elizabeth J. Franzmann Journal: BMC Oral Health, July 19