What We Know from the Latest PEPFAR Data: Analysis of FY 2025 Quarter 4 Results Authors: Jennifer Kates, Anna Rouw, and Allyala Nandakumar Published: Apr 23, 2026

https://www.kff.org/global-health-policy/what-we-know-from-the-latest-pepfar-data-analysis-of-fy-2025-quarter-4-results/ Since the start of the second Trump administration, the President’s Emergency Plan for AIDS Relief (PEPFAR), the U.S. global HIV/AIDS program credited with saving 26 million lives, has undergone significant changes and disruptions as part of a broader foreign aid review. Recent changes include: a temporary stop work order and eventual limits to what services could be continued; the cancellation of numerous PEPFAR awards; and a reorganization of U.S. global health programs, including the launch of a new “America First Global Health Strategy” which is anchored to bilateral agreements with countries, a focus on frontline commodities and services, and a shift from disease-specific programming to a more integrated approach. While modeling estimates and field surveys have provided some information about the potential impact of these changes and disruptions, there has been limited data available for such assessments. PEPFAR’s flagship data platform has historically posted financial and program level results, including from PEPFAR’s Monitoring, Evaluation, and Reporting (MER) system (MER was launched more than a decade ago). However, the data platform was temporarily removed in early 2025 and, when restored, it did not include any program data from FY 2025.