Genomics|Update|Current: Cancer

Genomics|Update|Current

Cancer

Assessment of individuals with BRCA1 and BRCA2 large rearrangements in high-risk breast and ovarian cancer families 
Arnold AG, et al. Breast Cancer Res Treat 2014 May

Connecting patients, researchers and clinical genetics services: the experiences of participants in the Australian Ovarian Cancer Study (AOCS) 
Crook A, et al. Eur J Hum Genet 2014 May

Epidermal growth factor receptor tyrosine kinase (EGFR-TK) mutation testing in adults with locally advanced or metastatic non-small cell lung cancer: a systematic review and cost-effectiveness analysis 
Westwood M, et al. Health Technol Assess 2014 May;18(32):1-166

Genetics, biomarkers, hereditary cancer syndrome diagnosis, heterogeneity and treatment: A review.
Lynch HT et al. Curr Treat Options Oncol. 2014 May 15

How harmful is genetic testing for familial adenomatous polyposis (FAP) in young children; the parents' experience 
Kattentidt-Mouravieva AA, et al. Fam Cancer 2014 May

Intentions for risk-reducing surgery among high-risk women referred for BRCA1/BRCA2 genetic counseling 
Tong A, et al. Psychooncology 2014 May

Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk
Ben Zhang et al, Nature Genetics, May 18, 2014

Modifiers of cancer risk in BRCA1 and BRCA2 mutation carriers: Systematic review and meta-analysis
Friebel TM, et al.  J Natl Cancer Inst (2014) 106 (6): dju091 May 13

Surgery Isn't only option for women with ovarian cancer genes, Health Day, May 16

Non–small cell lung cancer and precision medicine: A model for the incorporation of genomic features into clinical trial design
Pasche B, et al. JAMA 2014 May 12

The population impact of familial cancer, a major cause of cancer.
Frank C, et al.  Int J Cancer. 2014 Apr 15;134(8):1899-906.

The validation and clinical implementation of BRCAplus: A comprehensive high-risk breast cancer diagnostic assay 
Chong HK, et al. PLoS One 2014;9(5):e97408

Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drug
Kris MG, et al. JAMA 2014 May 21

Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine.
Van Allen EM, et al. Nat Med. 2014 May 18.

New approach to analyzing tumor genome promises expanded results, NIH News, May 19