A novel mouse model carrying a certain human gene variant is now able to show us how certain cells of the immune system play key roles in helping some patients tolerate the HIV drug abacavir while other similar patients experience hypersensitivity to it. Scientists used the new mouse model to investigate a well-known clinical challenge in HIV treatment. Some HIV patients carry a certain allele, or gene variant, known as HLA-B*57:01. These patients are genetically predisposed to a hypersensitivity reaction, and they can experience skin rash, fever, malaise, and gastrointestinal disorders.
For more information, please visit: A Novel Mouse Model Offers Insights About Hypersensitivity to an HIV Drug.
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