Proposals to keep CAR-T side effects under control

One of the more dangerous aspects of CAR-T therapy is its potency: As  engineered T cells proliferate quickly in the body, aimed at killing off tumor cells, they can also wreak havoc on patients by producing extraordinary levels of inflammation. 

But a pair of new studies suggests that a molecular on/off switch for CAR-T therapy could be effective in taming the cells: A small molecule drug, dasatinib, can rapidly, precisely, and reversibly halt CAR-T function in mice. 

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