Noninvasive preimplantation genetic testing for aneuploidies (niPGT-A) and the principle of primum non nocere - PubMed

Noninvasive preimplantation genetic testing for aneuploidies (niPGT-A) and the principle of primum non nocere - PubMed

Noninvasive preimplantation genetic testing for aneuploidies (niPGT-A) and the principle of primum non nocere

Jose G Franco Jr 1, Felipe Dieamant 1, Joao Batista A Oliveira 1

Affiliations 

• PMID: 32902935
 
• DOI: 10.5935/1518-0557.20200075

Free article

Abstract

Perhaps with the intention of obtaining larger amounts of free-DNA, some groups are routinely postponing and establishing free-DNA collection in culture medium for Noninvasive preimplantation genetic testing for aneuploidies (niPGT-A) to day 6 for all blastocysts. A meta-analysis served as the basis for such decision, since statistically similar live birth rates were observed when the transfers of euploid blastocysts were performed on day 5 versus day 6 However, the euploidy analysis was conducted in only two studies However, after including the two more studies we performed a new meta-analysis that clearly showed the risks of losing live births with the decision of adopting the 6th day as the endpoint for gathering free-DNA. We would be losing 1.71x more live births.

Keywords: Noninvasive preimplantation genetic test; PGT-A; niPGT-A.

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