Perturbations in imprinted methylation from assisted reproductive technologies but not advanced maternal age in mouse preimplantation embryos | Clinical Epigenetics | Full Text

Perturbations in imprinted methylation from assisted reproductive technologies but not advanced maternal age in mouse preimplantation embryos | Clinical Epigenetics | Full Text

Featured article: Perturbations in imprinted methylation from ARTs but not advanced maternal age in mouse preimplantation embryos

Over the last several decades, the average age of first-time mothers has risen steadily. With increasing maternal age comes a decrease in fertility, which in turn has led to an increase in the use of assisted reproductive technologies by these women. However, there has been little investigation on the effects of advanced maternal age, with or without ARTs, on genomic imprinting. These authors hypothesized that ARTs and advanced maternal age, separately and together, alter imprinted methylation in mouse preimplantation embryos.