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lunes, 2 de diciembre de 2019

Medical News | Medical Articles | Case Study: The First Criminal Conviction Using NGS

	Forensics & Toxicology
	The latest forensics & toxicology news from across News Medical

Case Study: The First Criminal Conviction Using NGS

In this interview with Dr. Peter de Knijff, he explains how his laboratory used next generation sequencing to resolve a difficult sexual assault case, leading to the first criminal conviction of its kind. The suspect was previously acquitted due to inconclusive results from traditional DNA typing methods.

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			Fingerprint sampling could help police distinguish between drug users and non-users Researchers have developed a tool that can determine whether someone has used heroin, even if they have washed their hands. The development, which was recently described in The Journal of Analytical Toxicology, could help police determine whether a person has taken heroin or inadvertently come into contact with it, for example, by shaking hands with someone who has handled it.

			Ionic Fluids for Microextraction in Forensic Toxicology In order to accurately quantify the concentration of trace analytes within a complex mixture, appropriate sample preparation is imperative. Some of the most common pretreatment methods that are used prior to analysis by high-performance liquid chromatography (HPLC) or gas chromatography with mass spectrometry (GC-MS) include liquid-liquid extraction (LLE) and solid phase extraction (SPE).

	Single vaping episode of cannabis could yield positive results in urine drug tests In a study of six adults, Johns Hopkins Medicine researchers report evidence that a single vaping episode of cannabis that is similar in chemical composition to that found in legal hemp products could possibly result in positive results on urine drug screening tests commonly used by many employers and criminal justice or school systems.

	New tool could help detect smaller concentrations of drug powders In 2017, more than 28,000 cases of fatal overdoses in the United States involved fentanyl. Just a pinch of the synthetic opioid, estimated to be 100 times stronger than morphine, can be lethal.

	A Thin-Film Microextraction Procedure for the Illicit Drug Screening of Biofluids A team from the University of Waterloo have developed a direct and fast means of quantifying drug levels in beverages and bodily fluids. Using a new analytical setup – dielectric barrier discharge (DBD), combined with high-resolution mass spectrometry – the team achieved an enhanced dynamic range of detection and lower limits of quantitation, compared to the prevailing techniques.