DENGUE: CDC - Clinical and Laboratory Guidance - Dengue

Clinical & Laboratory Guidance
Clinical Guidance
Clinical recognition of and the differences in the courses of dengue infection, the signs and symptoms and the laboratory findings are detailed in the clinical page. Below are materials for clinicians, laboratorians and epidemiologists.

Clinical guidelines for the management of dengue infection
1. World Health Organization (WHO) Dengue global alert.
http://www.who.int/csr/disease/dengue/en/


2. WHO guidelines for the clinical management of dengue infection
http://www.who.int/csr/resources/publications/dengue/Denguepublication/en/

3. WHO guidelines for treatment of dengue fever/dengue hemorrhagic fever in small hospitals PDF (234 KB/33 pages)
http://www.searo.who.int/LinkFiles/Dengue_Guideline-dengue.pdf

4. Transcript of Dengue Hemorrhagic Fever: early recognition, diagnosis and hospital management. An audiovisual guide for health care workers responding to outbreaks. PDF (72.2 KB/14 pages)
http://www.who.int/csr/don/archive/disease/dengue_fever/dengue.pdf

5. U.S. Council for State and Territorial Epidemiologist (CSTE) 2009 dengue case definitions PDF (115 KB/15 pages)
http://www.cste.org/ps2009/09-ID-19.pdf

6. CSTE Nationally Notifable Condition PDF(10.7KB/2pages)
http://www.cdc.gov/dengue/resources/notifablediseaseCSTENNCList61109.pdf

Clinical management tools for clinicians

1. Information for health care practitioners PDF(1.13MB/4pages)
http://www.cdc.gov/dengue/resources/Dengue&DHF%20Information%20for%20Health%20Care%20Practitioners_2009.pdf

Requesting dengue laboratory testing and reporting

1. Instructions for collecting, preparing and mailing specimens for dengue testing at the CDC Dengue Laboratory (English PDF(134KB/7pages)and Spanish DOC (78KB/5pages)
ENGLISH: http://www.cdc.gov/Dengue/resources/TestpolEng_2.pdf

SPANISH: http://www.cdc.gov/Dengue/resources/Instructions%20testing%20Spanish_2008.doc


2. Hospitals, laboratories and health care centers in Puerto Rico that will draw serum samples (Spanish). DOC (104KB/1page)
http://www.cdc.gov/Dengue/resources/Lista%20Hospitales%20participantes%20recogido%20muestras%20dengue.doc


Patient educational materials
Your child or family member may have dengue fever (English PDF (237KB/1page) and Spanish PDF (238KB/1page)
SPANISH: http://www.cdc.gov/dengue/resources/CS_205910-A.Dengue.Patient%20Ed.Spn.FINAL.pdf

ENGLISH: http://www.cdc.gov/dengue/resources/CS_205910-A.Dengue%20patient%20Ed%20Eng.FINAL.pdf
more Clinical Guidance...:
http://www.cdc.gov/dengue/clinicalLab/clinical.html


Laboratory Guidance
Laboratory diagnosis of suspected dengue specimens involves isolation of the virus, using serological tests, or molecular methods. Detailed descriptions of the immunological response with primary and secondary infection, dengue testing algorithm for serum specimens and a description of each test.

Immunological response to dengue infection
Classical testing algorithms of dengue:
-MAC Elisa
-IgG Elisa
-Plaque Reduction and Neutralization Test (PRNT)
more Laboratory Guidance... please see:
http://www.cdc.gov/dengue/clinicalLab/laboratory.html


abrir aquí para acceder al documento CDC general:
CDC - Clinical and Laboratory Guidance - Dengue