- The overall number of hospital stays involving an adverse drug event (ADE) remained relatively stable from 2010 to 2014, but stays shifted from ADEs that originated during the stay to ADEs that were present on admission. In 2014, 70.5 percent of ADEs were present on admission, compared with 61.0 percent in 2010.
- Antibiotics and anti-infectives, systemic agents, and hormones were the most common specific causes of ADE-related hospital stays.
- From 2010 to 2014, the rate of stays involving an ADE increased the most for ADEs caused by smooth muscle and respiratory drugs (up 24 percent) and decreased the most for ADEs caused by cardiovascular drugs (down 18 percent).
- Among ADEs that originated during the hospital stay:
- Rate of stays decreased 24 percent, but the average cost, length of stay, and mortality rate increased (27, 19, and 12 percent, respectively).
- Rate of stays decreased most for cardiovascular drugs; average costs and length of stay increased most for water, mineral, and uric acid metabolism drugs.
- Among ADEs that were present on admission:
- Rate of stays increased 16 percent, and average costs increased 15 percent; length of stay and mortality rate remained relatively stable.
- Rate of stays increased most for systemic agents; average costs increased most for sedatives or hypnotics.
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