Endocr Rev, Vol. 33 (03_MeetingAbstracts): SUN-196
Copyright © 2012 by The Endocrine Society
Genomic Health Disparities, Type 2 Diabetes and Mexican-Americans
Liliana Uribe-Bruce, MD1, Maria Isabel Garcia, NP2, Monica Ruiz, MA2, Linda Gallo, PhD3, Johanna Euyoque, BA3, Patricia Gonzalez, PhD3, Addie Brewer Fortmann, MS3 and Athena Philis-Tsimikas, MD21 Genomics-Scripps Translational Science Institute, The Scripps Research Institute La Jolla, CA2 Community Programs and Research, The Scripps Whittier Diabetes Institute La Jolla, CA
3 Psychology, San Diego State University San Diego, CA
Background: Type 2 Diabetes (T2D) is a worldwide epidemic disproportionately burdening certain racial and ethnic groups. In the U.S, the prevalence of T2D is 12% in Hispanics, compared to 7% in non-Hispanic whites (1). The epidemic is due to lifestyle, environment, genetic and epigenetic factors. Although over 40 genetic risk markers for T2D have been identified, 95% of studies have been conducted exclusively in European-origin populations, creating a genomics health gap. (2)Project Aims: To elucidate genomic factors potentially related to the disproportionate risk for T2D among Hispanics, by fostering participation of this group in genomics research, and by creating a dedicated Genebank to allow this research.Methods: A community engaged research approach is being used to identify factors responsible for low participation in genomics research among medically underserved Mexican-Americans. Community response to recruitment effort is recorded. To create awareness and ensure informed consent when enrolling in the Genebank, a culturally and literacy-tailored educational tool has been developed and delivered in Spanish at community clinics. IRB approved community focus groups discussing knowledge and attitudes towards genomic research have been held, and a survey has been launched. The "Scripps San Diego Diabetes Genebank" is actively enrolling volunteers.Results: Close to 300 volunteers have already enrolled in the Genebank. About 70% are female, ages from 21 to 81 years old. 65% of those referred as candidates to participate in the Genebank have enrolled. 10% were excluded due to study regulations, 8% lost contact and 17% declined participation. Reasons to decline participation are: 13% lack of time or transportation, 7% fear of blood draws, 3% lack of perceived benefit, and 3% distrust for research. FOCUS GROUPS: Over 90% of participants have expressed interest in learning about their genomic makeup and allowing healthcare providers to use genomics to treat them or future generations. 35% have expressed concern about genomics research tampering with nature.Conclusions: Medically underserved Hispanics have positively responded and participated in genomics research in T2D, and expressed interest in learning about their genetic makeup, being approached by invitation that includes a culturally and literacy tailored education tool. Only 3% have expressed distrust for researchers, and 100% mention altruism as a reason to participate.
(1) CDC-2011 National Diabetes Fact Sheet. Accessed through the web on February 2012 at http://www.cdc.gov/diabetes/pubs/estimates11.htm#. (2) Bustamante C., et al. Genomics for the world. Nature, July 2011, vol. 475, p163.
Nothing to Disclose: LU-B, MIG, MR, LG, JE, PG, ABF, AP-T
*Please take note of The Endocrine Society’s news embargo policy at http://www.endo-society.org/endo2012/audience/media.cfm
Sources of Research Support: NIH CTSA grant UL1 RR025774.
.png)
No hay comentarios:
Publicar un comentario