Research advances in China improve health globally
September / October 2015 | Volume 14, Issue 5
by Shana Potash
With its ancient tradition of herbal remedies, combined with its cutting-edge biomedical research enterprise, China offers unique opportunities to advance scientific discoveries and improve health across the globe. China has been a valuable partner with the U.S. in medical research for more than 30 years.
NIH-funded scientists and colleagues at universities and health agencies in China continue to work together to better understand the cause of illnesses; find ways to improve treatments; and prevent and control the spread of infectious diseases. By studying traditional Chinese medicine, scientists have rediscovered valuable therapies, including a botanical that is the best weapon against malaria.
China is the world's most populous country, with 1.4 billion diverse residents spread across a vast and varied terrain. It has more elderly than any other country; different disease patterns, diet and lifestyle; and has experienced rapid economic growth that's impacted health.
Life expectancy in China today is about 75 years, nearly twice what it was only a half century ago. As China's population ages, noncommunicable diseases are becoming more of a concern. And, while the country has experienced economic gains, Chinese people are aging at income levels that are still lower than many industrialized countries. NIH is supporting a large-scale health and retirement survey in China to contribute to the understanding of global aging issues.
Cancer has been the focus of much of NIH's collaboration in China. NIH scientists are studying cancers that are more common there than in the U.S., such as those of the liver, biliary tract, stomach and esophagus. Many of the research endeavors began decades ago with the release of the Atlas of Cancer Mortality in the People's Republic of China, which revealed geographical patterns of cancer. Published in both Chinese and English, the findings were used in China for cancer control and research, and by scientists elsewhere who were studying, for example, how diet and the environment influence health.
More recently, NIH scientists have worked with their Chinese counterparts to recruit participants in large-scale population studies that provide a wealth of health data to interpret. The ongoing Shanghai Women's and Men's Studies have yielded valuable insights into the increased risk some genetic and lifestyle factors pose for causing cancer and other chronic diseases.
Stroke, the leading cause of death in China, is another significant research area. Also, infectious diseases including HIV/AIDS, influenza and malaria are the subject of NIH-supported research and training projects to build capacity, which helps prevent the spread of disease within the country and beyond its borders.
More Information
Resources and background information on NIH-supported research in China.
- China information, grants and resources from Fogarty
- Our Sustained and Productive Partnership with China
from the National Cancer Institute (NCI) Division of Cancer Epidemiology and Genetics Director's Corner on Global Health - NIAID Research in China
from the National Institute of Allergy and Infectious Diseases (NIAID) - National Institute on Aging (NIA) resources:
- Grant: China Health and Retirement Longitudinal Study (funded 2010-2019)
Investigators: Drs. Yaohui Zhao, John A Strauss and Gonghuan Yang
Institution: Peking University - Shades of Gray: A Cross-Country Study of Health and Well-Being of the Older Populations in SAGE Countries [including China], 2007-2010, released July 2012
- Report: Global Health and Aging, including data from China, released October 2011
Chinese health and research information and resources from other organizations.
- China country statistics, profile and news from the World Health Organization (WHO)
- People’s Republic of China health system review
PAHO/WHO Health Systems in Transition, September 2015
Resources and publications related to this article:
- The Shanghai Women's Health Study: Rationale, Study Design, and Baseline Characteristics
American Journal of Epidemiology, December 2005 (published online October 19, 2005) - Diet and chronic degenerative diseases: perspectives from China
American Society for Clinical Nutrition, May 1994 - Atlas of Cancer Mortality in the People's Republic of China: An Aid for Cancer Control and Research
International Journal of Epidemiology, June 1981
Resources and publications related to Chinese researchers discovered effectiveness of artemisinin against malaria:
- The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine
Nature Medicine, October 2011 - Artemisinin: Discovery from the Chinese Herbal Garden
Cell, September 16, 2011 (published online September 9, 2011) - From bark to weed: the history of artemisinin
Parasite, August 2011 (published online August 15, 2011) - Ancient Chinese anti-fever cure becomes panacea for malaria: An interview with Zhou Yiqing
Bulletin of the World Health Organization (WHO), October 2009 - Discovery, mechanisms of action and combination therapy of artemisinin
Expert Review of Anti-infective Therapy, October 2009 - Qinghaosu (Artemisinin): An Antimalarial Drug From China
Science, May 31, 1985 - Antimalaria studies on qinghaosu
Chinese Medical Journal, December 1979
Resources and publications related to Arsenic added to cancer therapy after studies in China:
- Acute promyelocytic leukemia: where did we start, where are we now, and the future
Blood Cancer Journal, April 2015 (published online April 17, 2015) - Provocative pearls in diagnosing and treating acute promyelocytic leukemia
Oncology, July 2012 - Arsenic trioxide in acute promyelocytic leukemia: potion not poison
Expert Review Anticancer Therapy, September 2011 - Chinese Folk Treatment Reveals Power of Arsenic to Treat Cancer, New Studies Under Way
Journal of the National Cancer Institute, May 2, 2007 - Supplement: Arsenic Trioxide
The Oncologist - Supplement 2, April 2001
Resources and publications related to Benzene research in China informs EPA regulation:
- NIH resources:
- Benzene-exposed workers in China
NCI Division of Cancer Epidemiology and Genetics - NCI's Epidemiologic Research on Benzene Contributes to New EPA Rule
Archive: NCI Cancer Bulletin, February 27, 2007
- Benzene-exposed workers in China
- Related publications:
- A retrospective cohort study of cause-specific mortality and incidence of hematopoietic malignancies in Chinese benzene-exposed workers
International Journal of Cancer, November 2015 (published online June 16, 2015) - Occupational Exposure to Benzene and Chromosomal Structural Aberrations in the Sperm of Chinese Men
Environmental Health Perspectives, November 15, 2011 - Benzene Exposure Near the U.S. Permissible Limit Is Associated with Sperm Aneuploidy
Environmental Health Perspectives, June 2010 - EPA Rule Slashes Toxics from Gasoline, Vehicles, and Portable Fuel Containers
EPA news, February 9, 2007 - Hematoxicity in workers exposed to low levels of benzene
Science, December 3, 2004 - Benzene and the dose-related incidence of hematologic neoplasms in China
Journal of the National Cancer Institute, July 16, 1997
Resources and publications related to Asian diet examined for clues to improve health:
- NIH resources:
- NCI fact sheet: Tea and Cancer Prevention: Strengths and Limitations of the Evidence
- Traditional Chinese Medicine and Cancer
NCI Office of Cancer Complementary and Alternative Medicine - Related publications:
- Cruciferous Vegetable Intake Is Inversely Correlated with Circulating Levels of Proinflammatory Markers in Women
Journal of the Academy of Nutrition and Dietetics, May 2014 (published online March 13, 2014) - Prospective cohort study of tea consumption and risk of digestive system cancers: results from the Shanghai Women's Health Study
American Journal of Clinical Nutrition, November 2012 (published online October 10, 2012) - Cruciferous vegetable consumption is associated with a reduced risk of total and cardiovascular disease mortality
American Journal of Clinical Nutrition, July 2011 (published online May 18, 2011)
Resources and publications related to Chinese study shows folic acid helps reduce stroke risk:
- Efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in China: the CSPPT randomized clinical trial
JAMA, April 7, 2015 - Prevention of neural-tube defects with folic acid in China. China-U.S. Collaborative Project for Neural Tube Defect Prevention
New England Journal of Medicine, November 11, 1999
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On behalf of the Fogarty International Center at the U.S. National Institutes of Health (NIH), the following funding opportunities, notices and announcements may be of interest to those working in the field of global health research. Updates are typically distributed once a week.
Top NIH Funding News
Important news from NIH for all grantees.
Funding Opportunities
NIH funding opportunities focusing on global health and foreign collaboration.
- Household Air Pollution (HAP) Health Outcomes Trial (UM1) (RFA-HL-16-012)
Application Receipt Date(s): January 19, 2016
This FOA seeks applications from institutions/organizations for a cooperative agreement research grant (UM1) to conduct a clinical trial across three or more Low and Middle Income Country (LMIC) settings to test improved stove and fuel interventions on health outcomes in exposed populations.
NIH funding opportunities for which foreign organizations, foreign components of U.S. organizations and/or other foreign components may apply.
- Characterization of Mycobacterial Induced Immunity in HIV-infected and Uninfected Individuals (R21) (PAR-15-360)
Application Receipt/Submission Date(s): January 11, 2016; January 11, 2017; and January 11, 2018 - Limited Competition: Understanding How Epigenetics and Infections Impact Autoimmunity and Diabetes in The Environmental Determinants of Diabetes In The Young Study (TEDDY) (UC4) (RFA-DK-15-506)
Application Receipt Date(s): March 03, 2016 - Population Dynamics Centers Research Infrastructure Program FY 2016 (P2C) (RFA-HD-16-017)
Application Receipt Date(s): December 21, 2015
Funding News
NIH funding news that may be relevant to global health researchers.
- Notice of National Biosafety Stewardship Month and Health and Safety Requirements for NIH Grantees (NOT-OD-15-163)
- Notice of Intent to Publish a Funding Opportunity Announcement for NLM Institutional Grants for Research Training in Biomedical Informatics and Data Science (T15) (NOT-LM-16-001)
- Notice Announcing the Availability of Common Data Elements for Research Related to Eating Disorders (NOT-MH-15-031)
- Notices related to funding for Sickle Cell Disease in Sub-Saharan Africa:
- Notice of Clarification for RFA-HL-17-006 Collaborative Consortium (U24) (NOT-HL-15-272)
- FAQs and Webinar for RFA-HL-17-006 Collaborative Consortium (U24) (NOT-HL-15-274)
Note: The webinar will be held Tuesday, October 20, 2015, at 9:00 AM Eastern Daylight Time. - FAQs for RFA-HL-17-007 Data Coordinating Center (U24) (NOT-HL-15-275)
- Notice of Participation of NIMHD in PAR-15-337 Exploratory Multi-site Palliative Care Research in Diverse Populations Utilizing the Palliative Care Research Cooperative (PCRC) Group (R21) (NOT-MD-15-020)
Upcoming Deadlines
- Fulbright-Fogarty Fellows in Public HealthFellowships application deadline: October 13, 2015
- Ecology and Evolution of Infectious Diseases (EEID)
Application deadline: November 18, 2015 - Planning for Regional Centers of Research Excellence in Non-communicable Diseases in Low and Middle Income Countries (P20) (RFA-CA-15-007)from the National Cancer Institute (NCI)
Application deadline: December 10, 2015 - New: Emerging Global Leader Award for LMIC scientists
Application deadline: December 16, 2015 - Global Brain Disorders Research R21 and R01
Application deadline: January 5, 2016 - Household Air Pollution (HAP) Health Outcomes Trial (UM1) (RFA-HL-16-012)
Application deadline: January 19, 2016 - International Research Scientist Development Award (IRSDA) for U.S. scientists
Application deadline: March 2, 2016
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