Heart Disease
February is Heart Disease Awareness Month: Be One in a Million - February 5, 2015
CDC information: Be one in a million this American Heart Month
CDC information: Genomics and Heart Disease
Find FH: The FH Foundation, AMGEN and Stanford University launch the Find FH initiative (Flag, Identify, Network, Deliver),
Jan 29
Recent Genomic Insights
American Heart Association Cardiovascular Genome-Phenome Study ![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Ivor Benjamin et al. Circulation, January 2015
Ivor Benjamin et al. Circulation, January 2015
Editorial: Primordial prevention of cardiovascular disease.
Matthew W. Gillman. Circulation January 2015
Matthew W. Gillman. Circulation January 2015
A genetic basis for coronary artery disease.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Roberts R. Trends Cardiovasc Med. 2014 Oct 17.
Roberts R. Trends Cardiovasc Med. 2014 Oct 17.
Race, common genetic variation, and therapeutic response disparities in heart failure.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Taylor MR, et al. JACC Heart Fail. 2014 Dec;2(6):561-72. Doi
Taylor MR, et al. JACC Heart Fail. 2014 Dec;2(6):561-72. Doi
Coronary heart disease and genetic variants with low phospholipase A2 activity.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Polfus LM, Gibbs RA, Boerwinkle E. N Engl J Med. 2015 Jan 15;372(3):295-6.
Polfus LM, Gibbs RA, Boerwinkle E. N Engl J Med. 2015 Jan 15;372(3):295-6.
PLA2G10 gene variants, sPLA2 activity and coronary heart disease risk.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Guardiola M, et al. Circ Cardiovasc Genet. 2015 Jan 12
Guardiola M, et al. Circ Cardiovasc Genet. 2015 Jan 12
Familial hypercholesterolemia-epidemiology, diagnosis, and screening.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Singh S, Bittner V. Curr Atheroscler Rep. 2015 Feb;17(2):482.
Singh S, Bittner V. Curr Atheroscler Rep. 2015 Feb;17(2):482.
Familial Hypercholesterolemia: Call to Action and Recent Insights - December 18, 2014
CDC paper: Reducing the burden of disease and death from familial hypercholesterolemia: A call to action.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Knowles JW, et al Am Heart J. 2014 Dec;168(6):807-11
Knowles JW, et al Am Heart J. 2014 Dec;168(6):807-11
Proceedings of the FH Foundation's inaugural Familial Hypercholesterolemia Summit: Awareness to Action,
the FH Foundation (2014)
A framework for bridging the gap in the care of familial hypercholesterolaemia in the community: pragmatic and economic perspectives.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Purchase S, et al Int J Evid Based Healthc. 2014 Dec
Purchase S, et al Int J Evid Based Healthc. 2014 Dec
Mortality among patients with familial hypercholesterolemia: a registry-based study in Norway, 1992-2010.
Mundal L, et al J Am Heart Assoc. 2014 Dec 2;3(6).
Mundal L, et al J Am Heart Assoc. 2014 Dec 2;3(6).
Familial hypercholesterolemia in Brazil: Cascade screening program, clinical and genetic aspects.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Jannes CE, et al. Atherosclerosis. 2014 Nov 14;238(1):101-107
Jannes CE, et al. Atherosclerosis. 2014 Nov 14;238(1):101-107
Canadian Cardiovascular Society position statement on familial hypercholesterolemia.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Genest J, et al. Can J Cardiol. 2014 Dec;30(12):1471-81
Genest J, et al. Can J Cardiol. 2014 Dec;30(12):1471-81
Recommendations for the management of patients with familial hypercholesterolemia.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Feldman DI, et al. Curr Atheroscler Rep. 2015 Jan;17(1):473
Feldman DI, et al. Curr Atheroscler Rep. 2015 Jan;17(1):473
Systematic detection of familial hypercholesterolaemia in primary health care: A community based prospective study of three methods.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Kirke AB, et al. Heart Lung Circ. 2014 Sep 30
Kirke AB, et al. Heart Lung Circ. 2014 Sep 30
Prevalence and clinical correlates of familial hypercholesterolemia founder mutations in the general population.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Lahtinen AM, et al. Atherosclerosis. 2014 Nov 18;238(1):64-69
Lahtinen AM, et al. Atherosclerosis. 2014 Nov 18;238(1):64-69
Therapy: PCSK9 inhibitors for treating familial hypercholesterolaemia.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Mabuchi H, Nohara A. Nat Rev Endocrinol. 2014 Nov 18
Mabuchi H, Nohara A. Nat Rev Endocrinol. 2014 Nov 18
Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Nature. 2014 Dec 10
Nature. 2014 Dec 10
Molecular basis for familial hypercholesterolemia,
Brown and Goldstein Video (Sept 2014)
Familial Hypercholesterolemia: Saving Lives Through Early Detection - September 25, 2014
New CDC paper: Reducing the burden of disease and death from familial hypercholesterolemia: A call to action![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Joshua W. Knowles, Emily C. O'Brien, Karen Greendale, Katherine Wilemon, Jacques Genest, Laurence S. Sperling, William A. Neal, Daniel J. Rader, Muin J. Khoury. American Heart Journal 2014 Sept 16
Joshua W. Knowles, Emily C. O'Brien, Karen Greendale, Katherine Wilemon, Jacques Genest, Laurence S. Sperling, William A. Neal, Daniel J. Rader, Muin J. Khoury. American Heart Journal 2014 Sept 16
What is familial hypercholesterolemia? Information from the CDC Public Health Genomics toolkit.
History of discovery- The LDL receptor![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Joseph L. Goldstein and Michael S. Brown Arteriosclerosis, Thrombosis, and Vascular Biology. 2009; 29: 431-438
Joseph L. Goldstein and Michael S. Brown Arteriosclerosis, Thrombosis, and Vascular Biology. 2009; 29: 431-438
Understanding familial hypercholesterolemia,
Preventive Cardiology, July 2014
What are state public health programs doing about reducing burden of familial hypercholesterolemia? Information from CDC clickable state map
Helping patients with familial hypercholesterolemia find healthcare providers,
information from the FH Foundation
Heart Disease: Recent Genomic Insights and a Million Hearts - August 14, 2014
CDC information: Heart disease and prevention
CDC information: Heart disease and family history
CDC Medscape Expert Commentary
: Can we save a million hearts?
Tom Frieden, CDC Director, Aug 11
MillionHearts Initiative:
US Department of Health and Human Services
CDC blog post: A million hearts, a thousand genes and your family history
Did you know? >1000 genes have been reported in relation to risk and outcomes of coronary heart disease, including >100 genomewide association studies. To find out more, visit the HuGE Navigator
Find out which genetic conditions and tests are associated with coronary artery disease
from the GeneTests website
Recent Findings
Piecing together the puzzle of coronary artery disease.
Esther Lau. Nature Reviews Genetics, August 5, 2014
Esther Lau. Nature Reviews Genetics, August 5, 2014
Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease.
Ville-Petteri Mäkinen et al. PLOS Genetics, July 2014
Ville-Petteri Mäkinen et al. PLOS Genetics, July 2014
A long noncoding RNA protects the heart from pathological hypertrophy.
Pei Han, et al. Nature, August 10, 2014
Pei Han, et al. Nature, August 10, 2014
ICYMI podcast: Novel biomarkers for acute myocardial infarction: Is MicroRNA the
new kid on the block?
July 2014
new kid on the block?
No hay comentarios:
Publicar un comentario