miércoles, 29 de junio de 2016

Serious infections in hospitalized patients with psoriasis in the United States. - PubMed - NCBI

Serious infections in hospitalized patients with psoriasis in the United States. - PubMed - NCBI

 2016 Jun 17. pii: S0190-9622(16)30034-2. doi: 10.1016/j.jaad.2016.04.005. [Epub ahead of print]

Serious infections in hospitalized patients with psoriasis in the United States.



Patients with psoriasis have multiple risk factors for serious infections, including immune dysregulation, systemic immunosuppressive medications, and comorbid health conditions.


We sought to determine rates and predictors of serious infections in hospitalized psoriasis patients and quantify costs of care, length of stay, and mortality.


We conducted a cross-sectional study of the Nationwide Inpatient Sample from 2002 to 2012, containing a representative 20% sample of all hospitalizations in the United States.


In multivariate logistic regression models, psoriasis was associated with multiple serious infections, including methicillin-resistant Staphylococcus aureus (odds ratio [OR] 1.76, 95% confidence intervals [CI] 1.52-2.03), cellulitis (OR 3.21, 95% CI 3.12-3.30), herpes simplex virus infection (OR 2.21, 95% CI 1.70-2.89), infectious arthritis (OR 1.82, 95% CI 1.58-2.09), osteomyelitis (OR 1.31, 95% CI 1.18-1.46), meningitis (OR 1.31, 95% CI 1.16-1.47), encephalitis (OR 1.22, 95% CI 1.02-1.47), and tuberculosis (OR 1.34, 95% CI 1.20-1.49). Among patientswith psoriasis, rates of serious infections increased over all time intervals analyzed (P = .01) and were significantly higher compared with those without psoriasis across all time intervals (P < .0001). The mean length of stay (6.6 ± 0.1 days) and cost of care ($13,291 ± $166) for psoriasispatients with serious infections was higher than that of psoriasis patients without serious infections (4.6 ± 0.03 days; $11,003 ± $96; P < .0001).


The study was limited to inpatients. Medication data were not available.


Serious infections are increasing in incidence in US inpatients with psoriasis.
Copyright © 2016 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.


biologics; cost of care; hospitalization; length of stay; methotrexate; psoriasisserious infection

[PubMed - as supplied by publisher]

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