miércoles, 29 de junio de 2016

Evaluating Infection Prevention Strategies in Out-Patient Dialysis Units Using Agent-Based Modeling. - PubMed - NCBI

Evaluating Infection Prevention Strategies in Out-Patient Dialysis Units Using Agent-Based Modeling. - PubMed - NCBI



 2016 May 19;11(5):e0153820. doi: 10.1371/journal.pone.0153820. eCollection 2016.

Evaluating Infection Prevention Strategies in Out-Patient Dialysis Units Using Agent-Based Modeling.

Abstract

Patients receiving chronic hemodialysis (CHD) are among the most vulnerable to infections caused by multidrug-resistant organisms (MDRO), which are associated with high rates of morbidity and mortality. Current guidelines to reduce transmission of MDRO in the out-patient dialysis unit are targeted at patients considered to be high-risk for transmitting these organisms: those with infected skin wounds not contained by a dressing, or those with fecal incontinence or uncontrolled diarrhea. Here, we hypothesize that targeting patients receiving antimicrobial treatment would more effectively reduce transmission and acquisition of MDRO. We also hypothesize that environmental contamination plays a role in the dissemination of MDRO in the dialysis unit. To address our hypotheses, we built an agent-based model to simulate different treatment strategiesin a dialysis unit. Our results suggest that reducing antimicrobial treatment, either by reducing the number of patients receiving treatment or by reducing the duration of the treatment, markedly reduces overall colonization rates and also the levels of environmental contamination in thedialysis unit. Our results also suggest that improving the environmental decontamination efficacy between patient dialysis treatments is an effective method for reducing colonization and contamination rates. These findings have important implications for the development and implementation of future infection prevention strategies.

PMID:
 
27195984
 
PMCID:
 
PMC4873022
 
DOI:
 
10.1371/journal.pone.0153820

[PubMed - in process] 
Free PMC Article

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