By Jeannine Mjoseth
The National Institutes of Health (NIH) has awarded 16 four-year grants to academic and medical centers nationwide to begin the second phase of the Undiagnosed Diseases Network (UDN). The total investment planned for the UDN over the next four years will be approximately $100 million.
The UDN is a research study developed to improve and accelerate the diagnosis of rare and undiagnosed conditions. The grants will expand the network from seven to twelve clinical sites, increasing the geographical distribution of the nationwide network and the number of people with access to a UDN clinical site.
Since opening to applications in 2015, the network has already diagnosed over 200 cases that had long been mysteries to the medical community. "The UDN is pioneering a new personalized medicine model for helping those patients who have historically been the most difficult for the medical community to diagnose," said Dr. James M. Anderson, M.D., Ph.D., director of NIH's Division of Program Coordination, Planning, and Strategic Initiatives (DPCPSI), which provides financial support and joint leadership for the network via the NIH Common Fund. "By bringing together a nationwide network of top clinicians and laboratory researchers, the UDN is able to discover diagnoses for a significant fraction of these patients."
The UDN was launched to build on the success of the Undiagnosed Diseases Program (UDP) at the NIH Clinical Center. "The UDN takes advantage of cutting edge technologies such as genomic sequencing, metabolomics and assessing patient variants in model organisms to give clinicians new, powerful information to help understand the cause of extremely rare diseases," said Anastasia L. Wise, Ph.D., program director for the UDN and an epidemiologist in the National Human Genome Research Institute's Division of Genomic Medicine.
Five new clinical sites will join the existing six academic clinical sites at Baylor College of Medicine; Duke University Health System with Columbia University; Harvard Affiliate Hospitals; Stanford Medical Center; the University of California, Los Angeles; and Vanderbilt University Medical Center. Added to the NIH UDP from Phase I, the new network of 12 clinical sites will comprise Phase II of the UDN.
The five new clinical sites are:
- University of Washington (Seattle). Principal Investigators: Gail Jarvik, M.D., Ph.D., and Katrina Dipple, M.D., Ph.D.
- Children's Hospital of Philadelphia. Principal Investigators: Kathleen Sullivan, M.D., Ph.D., and Reed Pyeritz, M.D., Ph.D.
- University of Miami. Principal Investigators: Mustafa Tekin, M.D., and Stephan Zuchner, M.D., Ph.D.
- Washington University in St. Louis. Principal Investigator: Francis Sessions Cole, M.D.
- University of Utah (Salt Lake City). Principal Investigator: Lorenzo Botto, M.D.
In addition to the new clinical sites, new research cores will be a part of Phase II of the UDN. A new Metabolomics Core at the Mayo Clinic has been awarded (Principal Investigators: Ian Lanza, Ph.D. and Devin Oglesbee, Ph.D.), providing untargeted metabolomics and targeted biomarker analyses, as well as a new Model Organisms Screening Center at Washington University in St. Louis (Principal Investigators: Lilianna Solnica-Krezel Ph.D., and Tim Schedl, Ph.D.), increasing the zebrafish modeling capacity and adding C. elegansas a new model system for the UDN.
Phase II of the UDN will also retain the coordinating center at Harvard Medical School, the genome sequencing core at Baylor College of Medicine and the model organism screening center at Baylor College of Medicine and the University of Oregon. A complete list of funded awards can be found at https://commonfund.nih.gov/
The UDN awards are managed by NHGRI, the National Center for Advancing Translational Sciences and National Institute of Neurological Disorders and Stroke.
For more information about the UDN application process, visit https://undiagnosed.hms.
For more information about the UDN program, visit https://commonfund.nih.
.png)
No hay comentarios:
Publicar un comentario