miércoles, 5 de octubre de 2016

Agitation, Delirium, and Cognitive Outcomes in Intracerebral Hemorrhage. - PubMed - NCBI

2016 Aug 5. pii: S0033-3182(16)30064-0. doi: 10.1016/j.psym.2016.07.004. [Epub ahead of print]

Agitation, Delirium, and Cognitive Outcomes in Intracerebral Hemorrhage.

Rosenthal LJ1, Francis BA2, Beaumont JL3, Cella D3, Berman MD3, Maas MB2, Liotta EM2, Askew R4, Naidech AM5.

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Abstract

BACKGROUND:

Delirium predicts higher long-term cognitive morbidity. We previously identified a cohort of patients with spontaneous intracerebral hemorrhage and delirium and found worse outcomes in health-related quality of life (HRQoL) in the domain of cognitive function.

OBJECTIVE:

We tested the hypothesis that agitation would have additional prognostic significance on later cognitive function HRQoL.

METHODS:

Prospective identification of 174 patients with acute intracerebral hemorrhage, measuring stroke severity, agitation, and delirium, with a standardized protocol and measures. HRQoL was assessed using the Neuro-QOL at 28 days, 3 months, and 1 year. Functional outcomes were measured with the modified Rankin Scale.

RESULTS:

Among the 81 patients with HRQoL follow-up data available, patients who had agitation and delirium had worse cognitive function HRQoL scores at 28 days (T scores for delirium with agitation 20.9 ± 7.3, delirium without agitation 30.4 ± 16.5, agitation without delirium 36.6 ± 17.5, and neither agitated nor delirious 40.3 ± 15.9; p = 0.03) and at 1 year (p = 0.006). The effect persisted in mixed models after correction for severity of neurologic injury, age, and time of assessment (p = 0.0006) and was not associated with medication use, seizures, or infection.

CONCLUSIONS:

The presence of agitation with delirium in patients with intracerebral hemorrhage may predict higher risk of unfavorable cognitive outcomes up to 1 year later.