miércoles, 19 de octubre de 2016

AHRQ Tips for Grant Applicants | Agency for Healthcare Research & Quality

AHRQ Tips for Grant Applicants | Agency for Healthcare Research & Quality

AHRQ--Agency for Healthcare Research and Quality: Advancing Excellence in Health Care

AHRQ Tips for Grant Applicants

The Agency for Healthcare Research and Quality (AHRQ) funds grants on Health Services Research (HSR). The AHRQ Funding Opportunities Announcement (FOA) provides links to guides on how to create grant applications to AHRQ to supporting research to improve the quality, effectiveness, accessibility, and cost effectiveness of health care. These grants tips will give you a brief overview of where to find the announcements, our funding authorizes, how grants are reviewed (study sections), where to find AHRQ grantee, page limitations and review criteria.

AHRQ Mission

The Agency for Healthcare Research and Quality's (AHRQ) mission is to produce evidence to make health care safer, higher quality, more accessible, equitable, and affordable, and to work within the U.S. Department of Health and Human Services and with other partners to make sure that the evidence is understood and used. AHRQ priorities are described.

Grant Application Basics

What Authorities Do We Have To Fund Grants

Where To Find AHRQ Funding Announcements, Guidance and Updated Policy Notes

AHRQ Funding Opportunities Announcement (FOA)  Site
http://www.ahrq.gov/funding/fund-opps/index.html
Funding Opportunity Announcement (FOA) Guidance for R01, R03, R18 applications
http://www.ahrq.gov/funding/policies/foaguidance/index.html

How Are Grant Applications Reviewed

Description of Updated Review Criteria

Enhanced review criteria are generally described below:
Overall Impact.  Reviewers will provide an overall impact score to reflect their assessment of the likelihood for the project to exert a sustained, powerful influence on the research field(s) involved, in consideration of the following five core review criteria, and additional review criteria (as applicable for the project proposed).
Core Review Criteria.  Reviewers will consider each of the five review criteria below in the determination of scientific and technical merit, and give a separate score for each.  An application does not need to be strong in all categories to be judged likely to have major scientific impact.  For example, a project that by its nature is not innovative may be essential to advance a field.
Significance.  Does the project address an important problem or a critical barrier to progress in the field?  If the aims of the project are achieved, how will scientific knowledge, technical capability, and/or clinical practice be improved? How will successful completion of the aims change the concepts, methods, technologies, treatments, services, or preventative interventions that drive this field?
Investigator(s).  Are the PD/PI, collaborators, and other researchers well suited to the project?  Do the investigators have appropriate experience and training?  If the project is collaborative in nature, do the investigators have complementary and integrated expertise?  Are the leadership approach, governance, and organizational structure appropriate for the project?
Innovation.  Does the application challenge and seek to shift current research or clinical practice paradigms by utilizing novel theoretical concepts, approaches or methodologies, instrumentation, or interventions?  Are the concepts, approaches or methodologies, instrumentation, or interventions novel to one field of research or novel in a broad sense?  Is a refinement, improvement, or new application of theoretical concepts, approaches or methodologies, instrumentation, or interventions proposed?
Approach. Are the overall strategy, methodology, and analyses well-reasoned and appropriate to accomplish the specific aims of the project?  Are potential problems, alternative strategies, and benchmarks for success presented?  If the project is in the early stages of development, will the strategy establish feasibility and will particularly risky aspects be managed?
If the project involves clinical research, are the plans for 1) protection of human subjects from research risks, and 2) inclusion of minorities and members of both sexes/genders, as well as the inclusion of children, justified in terms of the scientific goals and research strategy proposed?
Environment: Will the scientific environment in which the work will be done contribute to the probability of success?  Are the institutional support, equipment and other physical resources available to the investigators adequate for the project proposed?  Will the project benefit from unique features of the scientific environment, subject populations, or collaborative arrangements?
Additional Review Criteria.  As applicable for the project proposed, reviewers will consider the following additional items in the determination of scientific and technical merit, but will not give separate scores for these items and should not consider them in providing an overall impact score.
Protections for Human Subjects.  For research that involves human subjects but does not involve one of the six categories of research that are exempt under 45 CFR Part 46, the committee will evaluate the justification for involvement of human subjects and the proposed protections from research risk relating to their participation according to the following five review criteria: 1) risk to subjects, 2) adequacy of protection against risks, 3) potential benefits to the subjects and others, 4) importance of the knowledge to be gained, and 5) data and safety monitoring, as appropriate, for the proposed research.
For research that involves human subjects and meets the criteria for one or more of the six categories of research that are exempt under 45 CFR Part 46, the committee will evaluate: 1) the justification for the exemption, 2) human subjects involvement and characteristics, and 3) sources of materials.
Budget and Period Support.  Reviewers will consider whether the budget and the requested period of support are fully justified and reasonable in relation to the proposed research.
Inclusion of Women and Minorities.  Reviewers will evaluate the proposed plans for inclusion of minorities and members of both genders. 
Inclusion of Priority Populations.  Reviewers will evaluate the proposed plans for inclusion of AHRQ priority populations (refer to the AHRQ policy notice for details).
Resubmission Applications.  When reviewing a Resubmission application (formerly called an amended application), the committee will evaluate the application as now presented, taking into consideration the responses to comments from the previous scientific review group and changes made to the project.
Renewal Applications.  When reviewing a Renewal application (formerly called a competing continuation application), the committee will consider the progress made in the last funding period. Select for more information.
A strong application will contain good ideas, address important issues, and generate confidence that the investigator(s) will make a significant impact.
CriteriaApplication
SignificanceResearch Strategy
  1. Significance
Investigator(s)Biosketch
InnovationResearch Strategy
  1. Innovation
ApproachResearch Strategy
  1. Approach
EnvironmentResources

Tips on Writing Your Grant Application

A strong application will contain good ideas, address important issues, and generate confidence that the investigator(s) will make a significant impact.
Do not insist on a hypothesis-driven approach if the project is sound and will move the field forward.
Focus is important, especially for new investigators. Avoid emphasizing minor technical details.
  • Uncertainty whether research will produce significant information.
  • Scientific basis not fully developed.
  • No apparent translatability of research into practice or policy.
  • Lack of a theoretical framework.
  • Overly ambitious research plan; volume of proposed work unrealistic.
  • Lack of original ideas.
  • Proposed methods not appropriate to answer research questions.
  • Research issues are more complex than investigator describes.
  • Too little detail in the research plan (leads to reviewers questioning investigators' ability to carry out the research).
  • Lack of focus in study hypotheses, aims and/or research plan.
  • Lack of generalizability of findings or methods.
  • Investigator lacks expertise in methodology.
  • Study team lacks expertise in all needed areas.
  • Proposed time and effort of study team members insufficient.
  • Lack of study controls.
  • Lack of adequate preliminary data.
  • Insufficient consideration of statistical needs.
  • Inadequate attention to protection of human subjects and/or population representation.
  • Lack of complete literature review.

How AHRQ Grants Are Funded

Examples of Funded Grants and Grantee Profiles

AHRQ Project Search (GOLD)
http://gold.ahrq.gov/projectsearch/

Page Limitations

For all Fellowship (F) Applications

Section of ApplicationPage Limits*
(if different from FOA, FOA supersedes)
Introduction to Resubmission or Revision Application (when applicable)1
Applicant's Background and Goals for Fellowship Training6
Specific Aims1
Research Strategy6
Respective Contributions1
Selection of Sponsor and Institution1
Training in the Responsible Conduct of Research1
Sponsor and Co-Sponsor Statements6
Letters of Support from Collaborators, Contributors, and Consultants6
Description of Institutional Environment and Commitment to Training
Note: This page limit includes the Additional Educational Information required for F30 and F31 applications.
2
Applications for Concurrent Support (when applicable)1
Biographical Sketch5
* FOA instructions always supersede these instructions.

For Individual Career Development Award (K, excluding K12) Applications

Section of ApplicationPage Limits*
(if different from FOA, FOA supersedes)
Introduction to Resubmission or Revision Application (when applicable)1
Candidate Information and Goals for Career Development and Research Strategy12 (for both attachments combined)
Specific Aims1
Training in the Responsible Conduct of Research1
Candidate's Plan to Provide Mentoring (Include only when required by the specific FOA, e.g., K24 and K05)6
Plans and Statements of Mentor and Co-mentor(s)6
Letters of Support from Collaborators, Contributors, and Consultants6
Description of Institutional Environment1
Institutional Commitment to Candidate's Research Career Development1
Biographical Sketch5
* FOA instructions always supersede these instructions.

For Institutional Training (T), International Training (D43D71 , U2R), Institutional Career Development (K12KL2), and Research Education (R25DP7) Applications

Section of ApplicationPage Limits*
(if different from FOA, FOA supersedes)
Introduction to Resubmission or Revision Application (when applicable)3
Introduction to Revision Application (when applicable)1
Specific Aims (Attachment 2 on PHS 398 Research Plan form; applies only to R25 and DP7)1
Research Education Program Plan (uploaded via the Research Strategy on PHS 398 Research Plan form)
For R25 and DP7 applications only
25
Program Plan (Attachment 2 on PHS 398 Research Training Program Plan form)
For D43D71U2RK12KL2 and all Training (T) only
25
Plan for Instruction in the Responsible Conduct of Research (Attachment 3 of PHS 398 Research Training Program Plan form)
For D43D71U2RK12KL2 and all Training (T) only
3
Biographical Sketch5
* FOA instructions always supersede these instructions.

For R01R03R21, and all other Applications

Section of ApplicationActivity CodesPage Limits*
(if different from FOA, FOA supersedes)
Introduction to Resubmission or Revision ApplicationsFor all Activity Codes (including each applicable component of a multi-component application)1
Specific AimsFor all Activity Codes that use an application form with the Specific Aims section (including each component of a multi-component application)1
Research StrategyFor Activity Codes R03R13U13R13, U13R21,R35R36R41R43SC2SC3X011X021, R506
 10
For Activity Codes DP3DP5G08G11G13RC2RC4RF1R01,R15R18R21/R33R24R28R33R34R42R44R61/R33SB1SC1SI2UB1UC2UH2,UH3UG1UC4UF1UG3/UH3UH2/UH3U01U18U24U2CU34U42U44X011X02112
For all other Activity CodesFollow FOA instructions
Commercialization PlanFor Activity Codes R42R44SB1UT1U44UB1 (Attachment 7 on SBIR/STTR Information form)12
Biographical SketchFor all Activity Codes (including DP1 and DP2 which previously had special page limits)5
* FOA instructions always supersede these instructions.
1. X01 and X02 FOAs can be either 6 or 12 pages. Review the FOA for details.
Important Note:  Always contact your program official cited in PA/RFA cited in the Funding Announcement. 

Page last reviewed October 2016
Internet Citation: AHRQ Tips for Grant Applicants. Content last reviewed October 2016. Agency for Healthcare Research and Quality, Rockville, MD. http://www.ahrq.gov/funding/process/grant-app-basics/apptips.html