martes, 17 de octubre de 2017

Differences Between Younger and Older US Adults With Multiple Chronic Conditions

Differences Between Younger and Older US Adults With Multiple Chronic Conditions

Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People

Differences Between Younger and Older US Adults With Multiple Chronic Conditions

Mary L. Adams, MS, MPH

Suggested citation for this article: Adams ML. Differences Between Younger and Older US Adults With Multiple Chronic Conditions. Prev Chronic Dis 2017;14:160613. DOI:


Adults with multiple (≥2) chronic conditions (MCCs) account for a large portion of US health care costs. Despite the increase in MCC rates with age, most people with MCCs are working age. The study objective was to compare adults with MCCs who were younger than 65 years with those aged 65 years or older on selected measures to better understand the differences between groups and inform interventions that could lower health care costs.
Data from respondents to the 2015 Behavioral Risk Factor Surveillance System data (N = 201,711) were used to compare adults aged 65 or older with MCCs with those younger than 65 with MCCs in unadjusted and adjusted analyses on chronic conditions, quality of life measures, disability status, access to health care, and modifiable risk factors. MCCs were based on up to 12 chronic conditions (heart disease, stroke, asthma, arthritis, chronic obstructive pulmonary disease, high cholesterol, cognitive impairment, diabetes, depression, chronic kidney disease, cancer other than skin, and hypertension).
Consistent with 80% of all adults being younger than 65, more than 60% of adults with MCCs were younger than 65 years. Compared with adults aged 65 or older with MCCs, those younger than 65 were more likely to report asthma, cognitive impairment, depression, smoking, obesity, poorer access to health care, disability, and worse quality of life in both unadjusted and adjusted analysis.
To decrease the burden of chronic diseases, adults younger than 65 with MCCs should get the treatment they need to reduce the chance of developing more chronic conditions as they age. The ultimate goal is to improve health status and reduce health care costs for everyone with MCCs.


Rates of multiple chronic conditions (MCCs), defined as having 2 or more co-occurring chronic conditions, tend to increase with age (1), resulting in increasing Medicare costs (2). As a consequence, considerable information on MCCs comes from Medicare claims data (3,4) for adults aged 65 years or older. A recent review of 163 studies (5) that included adults of all ages noted that despite the increase in MCC rates with age, most people with MCCs are working age. Other studies found that medical expenditures for chronic conditions among nonelderly adults and adults aged 65 or older were similar, averaging approximately $3,700 for those with 2 or 3 chronic conditions and $8,900 for those with 4 or more (6). Another study (7) found larger relative increases in MCCs over time among those aged 25 to 44 years compared with older adults and different chronic conditions by age group.
Lifestyle factors such as smoking and obesity (8–10) increase the risk of many chronic conditions included in measures of MCCs. Some chronic conditions, such as diabetes, depression, high blood pressure, and high cholesterol, are also risk factors for MCCs (5). Any of these risk factors can increase the likelihood of developing additional chronic conditions in adults of any age. When considered collectively, these findings suggest the need for a better understanding of MCCs among younger adults to develop effective strategies to prevent more chronic conditions from developing and better manage existing ones. This understanding in turn could mitigate any increase in future health care costs.
The objective of this study was to compare adults younger than 65 with MCCs with those aged 65 years or older with MCCs on selected measures. Measures included disability status, quality of life measures, chronic conditions, risk factors, and access to health care to add to information that is known about adults younger than 65 with MCCs. Because there is no standard list of chronic conditions to include, the study used different definitions of MCCs: one that considers diabetes, high blood pressure, high cholesterol, and depression as chronic conditions, and one that does not.


We examined data from the 2015 Behavioral Risk Factor Surveillance System (BRFSS) data (11) on 434,382 respondents aged 18 years or older in the 50 states and the District of Columbia. BRFSS data have been shown to be comparable to those of other surveys, with most self-reported measures showing good or better validity (12). For all measures used, responses of “don’t know” or refusal to answer were excluded. The median response rate for cellular telephone and landline surveys combined for the 50 states and the District of Columbia was 46.6%, ranging from 33.9% in California to 61.1% in Utah (13). Data were weighted to be representative of the total adult population of each state by age, race/ethnicity, sex, marital status, education, home ownership, and type of telephone service. Chronic conditions were chosen to be as consistent as possible with commonly cited lists (14,15) and availability on the BRFSS. The MCC based on 5 chronic conditions (MCC5) included cardiovascular disease (CVD; heart attack, angina, coronary heart disease, or stroke), asthma, chronic obstructive pulmonary disease (COPD), arthritis, and cognitive impairment while MCC12 split CVD into heart disease and stroke and added diabetes, high blood pressure, depression, high cholesterol, chronic kidney disease, and cancer other than skin. All chronic conditions except cognitive impairment were defined as having “ever been told”; women who were told they had diabetes only when pregnant were considered not to have diabetes. Cognitive impairment was defined as a yes response to “Because of a physical, mental, or emotional problem, do you have difficulty remembering, concentrating, or making decisions?” This question has been asked by the US Census Bureau since 2008 and is now asked as 1 of 6 disability questions on all federal surveys (16). This cognitive impairment measure is consistent with other measures of cognitive impairment but should not be considered cognitive decline, because the question lacks a time frame (17,18). Respondents who reported any 2 or more of the 5 chronic conditions were considered to have MCC5 (n = 69,487), and those who reported any 2 or more of the 12 were considered to have MCC12 (n = 201,711).
Demographic measures were sex, age (18–64 y and ≥65 y), race/ethnicity (non-Hispanic white, black or African American, Hispanic of any race, American Indian/Alaska Native, and other), education level (college graduate, some college, high school graduate, <high school graduate), annual household income (≥$75,000, $50,000–$74,999, $25,000–$49,999, $15,000–24,999, <$15,000, or unknown), and employment status (employed/self-employed, out of work, homemaker, student, retired, or unable to work). The list of measures that were compared by age group included each of the chronic conditions included in the MCCs; disability (limited in any way in any activities because of physical, mental, or emotional problems); 4 difficulty measures (difficulty seeing, walking, bathing or dressing, or doing errands alone); obesity (body mass index ≥30 kg/m2 based on self-reported height and weight); current smoking; no leisure time physical activity (in the past month); no health insurance; no personal physician; a barrier to health care (needing to see a doctor in past year but unable to because of cost); having a routine check-up in the past 2 years; and quality of life measures including fair or poor general health, frequent (14 or more days in the past 30 days) poor mental health (referred to as frequent mental distress [FMD]), frequent poor physical health (FPD), and frequent activity limitation (FAL).
Stata version 14.1 (StataCorp LP) was used for all weighted data analysis to account for the complex sample design of the BRFSS, and Pearson χ2 tests were used to determine significance at P<.05. Age group comparisons (<65 y vs ≥65 y) were made for adults with MCC12 and those without MCC12 and also for adults with MCC5. Logistic regression was conducted, controlling for demographic and other selected measures, to confirm unadjusted results.


The weighted percentage of all survey respondents younger than age 65 was 80.3% (Table 1). Although the percentage of adults with MCCs who were younger than age 65 was less than that for all adults, 61.4% of adults with MCC5 and 63.8% with MCC12 were younger than 65 years. Other demographic, health status, and insurance status characteristics varied between all adults and those with MCCs. Results of age group comparisons (Table 2) indicated that compared with adults aged 65 or older, younger adults were more likely to report a total of 18 measures including 10 that showed similar results for adults with and without MCC12 and 8 that only showed significantly worse results among adults ages 18 to 64 years with MCC12 (5 measures related to disability and 3 indicating poorer quality of life). Although adults with and without MCC12 were not directly compared, for all measures except health care access, adults with MCC12 in both age groups appeared worse off than those without MCC12 (Table 2). Results for measures among adults with MCC5 were similar but often higher for both age groups compared with results for MCC12 (Appendix).
Logistic regression analysis for the 10 measures that showed similar results for adults with and without MCC12 resulted in adjusted odds ratios (AORs) comparing younger with older adults that ranged from 1.49 (95% confidence interval [CI], 1.36–1.63) for FMD to 4.79 (95% CI, 4.01–5.71) for being uninsured (Table 3). For the 8 outcomes that showed significant age differences among adults with MCC12 but not among those without MCC12, only the AORs for disability, fair or poor general health, FAL, and being unable to work that compared respondents aged 18 to 64 years versus those aged 65 years or older among adults with MCC12 were higher than 1.00 (Table 3). AORs comparing non-elderly versus elderly adults with MCC12 for difficulty seeing and FPD were not significantly different from 1.00, but AORs for difficulty dressing and running errands were less than 1.00 indicating adults aged 65 or older with MCC12 were more likely to report those outcomes. Results for MCC5 were similar to those for MCC12 (Appendix).


Among adults with 2 MCCs there were significant differences by age group in 18 measures, indicating that adults younger than 65 were worse off than adults aged 65 or older. Results were similar whether diabetes, depression, hypertension, high cholesterol (which could also be risk factors) were included in the MCC (MCC12) or not (MCC5). For 14 of those measures among adults with MCC12 (3 component chronic conditions, 2 risk factors, 4 access to health care measures, 2 disability/employment measures, and 3 quality of life measures) age group differences remained after adjustment for demographic and health measures. These included 10 measures that had similar results for adults with and without MCC12 and 4 measures (disability, being unable to work, fair or poor health and FAL) that showed significant age differences only among adults with the MCC.
Some of these age differences for adults with MCCs can be easily explained by similar differences among adults without the MCC, but the results could still be important. For example, most uninsured adults are younger than 65 years, and younger adults with MCCs were more likely than older adults to report a cost barrier to their health care in the past year. Younger adults with MCCs were also less likely to report a recent routine check-up than adults aged 65 or older with MCCs. These are all important findings in light of the continuing need to manage and treat existing chronic conditions and diagnose incident ones. This finding appears to be somewhat inconsistent with results showing that medical care expenditures for chronic conditions for adults aged 18 to 44, 45 to 64, and 65 or older with MCCs were similar at approximately $9,000 for those with 4 or more chronic conditions and approximately $4,000 for those with 2 or 3 (6). However, those data included only expenditures for those who received care for their chronic conditions, and younger adults with MCCs were less likely than older adults with similar numbers of MCCs to be treated (6). Thus, some people (eg, the uninsured, those reporting a cost barrier to care in this study) may have been unable to get needed treatment for their chronic conditions.
Quality of life measures have been studied before using BRFSS data (19), and results indicated that people with 3 or more chronic conditions and those with CVD or diabetes were more likely to report poorer quality of life than those with fewer or different chronic conditions; however, this analysis did not compare age groups. Although not directly compared, adults with MCC12 in our study appeared more likely to report poorer quality of life than adults without MCC12. Some of our study findings may result from age differences in the composition of the MCCs (eg, more depression and cognitive impairment among younger adults), which might have a greater effect on mental health compared with other chronic conditions. In particular, higher rates of depression among younger adults may be a crucial factor, because depression is the leading cause of disability worldwide (20). That fact would not fully explain results, however, because only MCC12 included depression whereas MCC5 did not, and rates of FMD were higher for both age groups among adults with MCC5 compared with adults with MCC12. Differences in reported quality of life could also result from different contexts, because younger adults were much more likely to be employed than older adults. For example, interpretation of activity limitations may depend on age, employment status, or both. However, even when controlling for measures including employment status and depression, these age differences remained for 14 measures representing a range of outcomes. These results may also reflect the direct or indirect impact of other factors such as smoking or obesity that are also higher among younger adults and may affect health and disability status. Whatever the cause of the differences, results highlight the current impact of MCCs on younger adults.
The higher rates of asthma, depression, and cognitive impairment among younger adults with MCCs were not totally unexpected. Age-related differences in MCCs using hospital discharge data indicated, for example, that among adults 18 to 44 years, the dyad of depression and substance abuse was most common (21). Our results, which lack information on substance abuse, are consistent with the earlier finding, by showing that compared with elderly adults, depression was more common among working age adults with or without MCCs. Along with depression, risk factors of obesity and smoking were also higher among younger adults with and without MCCs. Rates of hypertension, high cholesterol, and diabetes were all lower among younger adults with MCCs, but because these risk factors can also be risk factors for other chronic conditions (8–10), they may still be important. The presence of these well-recognized risk factors suggests that interventions are needed to target nonelderly adults with MCCs to reduce their risk of developing additional chronic conditions as they age.
The inclusion of cognitive impairment in the measures is consistent with lists of chronic conditions that include dementia, autism, and schizophrenia (14), or addiction, mental illnesses, cognitive impairment, and developmental disabilities (15), any of which can complicate management of co-occurring chronic conditions. A somewhat unexpected finding was the high rate of cognitive impairment among younger adults with MCCs. This rate could result from lower rates of other chronic conditions or factors such as lack of sleep, side effects of medication, or use of illicit drugs and may not be associated with future risk of dementia (9,10). Whatever the cause, being cognitively impaired may affect someone’s ability to self-manage other chronic conditions (22).
Findings from this study add to existing information on MCCs among all adults. First, results showed that despite the fact that rates of MCCs increase with age, most adults with MCCs by these definitions were younger than age 65. Second, younger adults with these MCCs were more likely to report 14 measures, including disability and poorer quality of life, than were older adults with the same MCCs. Some age differences found in this study for adults with MCCs can be explained by similar differences between the age groups among adults without the MCC, but they may still be important. Although poorer access to health care was common among all adults younger than 65, this factor could affect management and treatment of existing chronic conditions and identification of new ones. Younger adults were also more likely than older adults to report risk factors that can increase risk of developing additional chronic conditions and thus higher rates of MCCs in the future.
Limitations of this study include the use of self-reported data and the sample being limited to noninstitutionalized adults, which likely excluded many older adults with MCCs in long-term care. Some respondents may have been unaware of a diagnosis, in which case MCCs may have been underreported. Autism, hepatitis, HIV/AIDS, osteoporosis, psychotic disorders, addiction and developmental disabilities that are not measured on the BRFSS were excluded. A strength of the study was its use of data from a large population-based survey of US adults, which makes results generalizable to all states.
Findings from this study show the extent of the burden of MCCs on nonelderly adults who represent more than 60% of all adults with MCCs. Any strategies to manage and treat chronic conditions may be affected by the poorer access to health care reported by younger adults. Interventions to address the risk factors of hypertension, high cholesterol, diabetes, depression, obesity, and smoking are needed to reduce or delay the development of additional chronic conditions. Successful interventions can reduce the burden of chronic conditions and reduce present and future health care costs from MCCs.


No financial support was received for this work.

Author Information

Corresponding Author: Mary L. Adams, MS, MPH, On Target Health Data LLC, 247 N Stone St, West Suffield, CT 06093. Telephone: 860-370-9035. Email:


  1. Barnett K, Mercer SW, Norbury M, Watt G, Wyke S, Guthrie B. Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study. Lancet 2012;380(9836):37–43. CrossRef PubMed
  2. Thorpe KE, Ogden LL, Galactionova K. Chronic conditions account for rise in Medicare spending from 1987 to 2006. Health Aff (Millwood) 2010;29(4):718–24. CrossRef PubMed
  3. Centers for Medicare and Medicaid Services. Chronic conditions among Medicare beneficiaries, chartbook, 2012 edition; 2012. Accessed July 19, 2017.
  4. Lochner KA, Cox CS. Prevalence of multiple chronic conditions among Medicare beneficiaries, United States, 2010. Prev Chronic Dis 2013;10:120137. CrossRef PubMed
  5. Willadsen TG, Bebe A, Køster-Rasmussen R, Jarbøl DE, Guassora AD, Waldorff FB, et al. The role of diseases, risk factors and symptoms in the definition of multimorbidity — a systematic review. Scand J Prim Health Care 2016;34(2):112–21. CrossRef PubMed
  6. Machlin SR, Soni A. Health care expenditures for adults with multiple treated chronic conditions: estimates from the Medical Expenditure Panel Survey, 2009. Prev Chronic Dis 2013;10:120172. CrossRef PubMed
  7. Ford ES, Croft JB, Posner SF, Goodman RA, Giles WH. Co-occurrence of leading lifestyle-related chronic conditions among adults in the United States, 2002–2009. Prev Chronic Dis 2013;10:120316. CrossRef PubMed
  8. Brownson RC, Remington PL, Wegner MV. Chronic disease epidemiology and control. 3rd edition. Washington (DC): American Public Health Association; 2010.
  9. Adams ML, Grandpre J. Dose-response gradients between a composite measure of six risk factors and cognitive decline and cardiovascular disease. Prev Med 2016;91:329–34. CrossRefPubMed
  10. Baumgart M, Snyder HM, Carrillo MC, Fazio S, Kim H, Johns H. Summary of the evidence on modifiable risk factors for cognitive decline and dementia: a population-based perspective. Alzheimers Dement 2015;11(6):718–26. CrossRef PubMed
  11. Centers for Disease Control and Prevention. Behavioral Risk Factor Surveillance System. Accessed October 26, 2014.
  12. Pierannunzi C, Hu SS, Balluz L. A systematic review of publications assessing reliability and validity of the Behavioral Risk Factor Surveillance System (BRFSS), 2004–2011. BMC Med Res Methodol 2013;13(1):49. CrossRef PubMed
  13. Centers for Disease Control and Prevention. Behavioral Risk Factor Surveillance System 2013 summary data quality report; 2014. Accessed July 19, 2017.
  14. Goodman RA, Posner SF, Huang ES, Parekh AK, Koh HK. Defining and measuring chronic conditions: imperatives for research, policy, program, and practice. Prev Chronic Dis 2013;10:120239.CrossRef PubMed
  15. US Department of Health and Human Services. Multiple chronic conditions — a strategic framework: optimum health and quality of life for individuals with multiple chronic conditions. Washington (DC): US Department of Health and Human Services; 2010.
  16. US Census Bureau. American Community Survey (ACS). History. Accessed December 21, 2016.
  17. Rabin LA, Smart CM, Crane PK, Amariglio RE, Berman LM, Boada M, et al. Subjective cognitive decline in older adults: an overview of self-report measures used across 19 international research studies. J Alzheimers Dis 2015;48(Suppl 1):S63–86. CrossRef PubMed
  18. Jessen F, Amariglio RE, van Boxtel M, Breteler M, Ceccaldi M, Chételat G, et al. ; Subjective Cognitive Decline Initiative (SCD-I) Working Group. A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer’s disease. Alzheimers Dement 2014;10(6):844–52. CrossRef PubMed
  19. Chen H-Y, Baumgardner DJ, Rice JP. Health-related quality of life among adults with multiple chronic conditions in the United States, Behavioral Risk Factor Surveillance System, 2007. Prev Chronic Dis 2011;8(1):A09. PubMed
  20. Depression. World Health Organization; 2017. Accessed July 19, 2017.
  21. Steiner CA, Friedman B. Hospital utilization, costs, and mortality for adults with multiple chronic conditions, Nationwide Inpatient Sample, 2009. Prev Chronic Dis 2013;10:120292.CrossRef PubMed
  22. Grober E, Hall CB, Hahn SR, Lipton RB. Memory impairment and executive dysfunction are associated with inadequately controlled diabetes in older adults. J Prim Care Community Health 2011;2(4):229–33. CrossRef PubMed

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