lunes, 24 de septiembre de 2012

Cost-effectiveness of the 21-gene recurrence score... [Genet Med. 2012] - PubMed - NCBI

Cost-effectiveness of the 21-gene recurrence score... [Genet Med. 2012] - PubMed - NCBI

Genet Med. 2012 Sep 13. doi: 10.1038/gim.2012.119. [Epub ahead of print]

Cost-effectiveness of the 21-gene recurrence score assay in the context of multifactorial decision making to guide chemotherapy for early-stage breast cancer.

Source

1] Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA [2] Duke Cancer Institute, Duke University School of Medicine, Durham, North Carolina, USA.

Abstract

Purpose:New evidence is available regarding the utility of the 21-gene recurrence score assay in guiding chemotherapy use for node-negative, estrogen receptor-positive breast cancer. We applied this evidence in a decision-analytic model to re-evaluate the cost-effectiveness of the assay.Methods:We cross-classified patients by clinicopathologic characteristics from the Adjuvant! risk index and by recurrence score risk group. For non-recurrence score-guided treatment, we assumed patients receiving hormonal therapy alone had low-risk characteristics and patients receiving chemotherapy and hormonal therapy had higher-risk characteristics. For recurrence score-guided treatment, we assigned chemotherapy probabilities conditional on recurrence score risk group and clinicopathologic characteristics.Results:An estimated 40.4% of patients in the recurrence score-guided strategy and 47.3% in the non-recurrence score-guided strategy were expected to receive chemotherapy. The incremental gain in quality-adjusted life-years was 0.16 (95% confidence interval, 0.08-0.28) with the recurrence score-guided strategy. Lifetime medical costs to the health system were $2,692 ($1,546-$3,821) higher with the recurrence score-guided strategy, for an incremental cost-effectiveness ratio of $16,677/quality-adjusted life-year ($7,613-$37,219). From a societal perspective, the incremental cost-effectiveness was $10,788/quality-adjusted life-year ($6,840-$30,265).Conclusion:The findings provide supportive evidence for the economic value of the 21-gene recurrence score assay in node-negative, estrogen receptor-positive breast cancer.Genet Med advance online publication 13 September 2012Genetics in Medicine (2012); doi:10.1038/gim.2012.119.
PMID:
22975761
[PubMed - as supplied by publisher]

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