domingo, 10 de agosto de 2014

AHRQ Patient Safety Network - Diagnostic Errors

AHRQ Patient Safety Network - Diagnostic Errors

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The past decade's quest to improve patient safety has chiefly addressed quantifiable problems such as medication errors, health care–associated infections, and postsurgical complications. Diagnostic error has received comparatively less attention, despite the fact that landmark patient safety studies have consistently found that diagnostic error is common. In the Harvard Medical Practice Study, diagnostic error accounted for 17% of preventable errors in hospitalized patients, and a systematic review of autopsy studies covering four decades found that approximately 9% of patients experienced a major diagnostic error that went undetected while the patient was alive. Taken together, these studies imply that thousands of hospitalized patients die every year due to diagnostic errors.
An extensive body of research has examined the causes of diagnostic error at the individual clinician level. This work has been informed by the field of cognitive psychology, which studies how individuals process information and subsequently develop plans. As applied to health care, we have learned that clinicians frequently use heuristics (shortcuts or "rules of thumb") to come up with a provisional diagnosis, especially when faced with a patient with common symptoms. While heuristics are ubiquitous and useful, researchers have used categories developed in cognitive psychology to classify several types of errors that clinicians commonly make due to incorrect applications of heuristics:
Cognitive BiasDefinitionExample
Availability heuristicDiagnosis of current patient biased by experience with past casesA patient with crushing chest pain was incorrectly treated for a myocardial infarction, despite indications that an aortic dissection was present.
Anchoring heuristic (premature closure)Relying on initial diagnostic impression, despite subsequent information to the contraryRepeated positive blood cultures with Corynebacterium were dismissed as contaminants; the patient was eventually diagnosed with Corynebacterium endocarditis.
Framing effectsDiagnostic decision-making unduly biased by subtle cues and collateral informationA heroin-addicted patient with abdominal pain was treated for opiate withdrawal, but proved to have a bowel perforation.
Blind obediencePlacing undue reliance on test results or "expert" opinionA false-negative rapid test for Streptococcus pharyngitis resulted in a delay in diagnosis.
While cognitive biases on the part of individual clinicians play a role in many diagnostic errors, underlying health care system problems also contribute to missed and delayed diagnoses. Missed or delayed diagnoses (particularly cancer diagnoses) are a prominent reason for malpractice claims, and much of the research into systems causes of diagnostic error arises from studies of closed malpractice claims in primary care,pediatricsemergency medicine, and surgery. Poor teamwork and communication between clinicians have been identified as predisposing factors for diagnostic error in emergency medicine and surgery. Lack of reliable systems for common outpatient clinical situations, such as triaging acutely ill patients by telephone and following up on test results, also increases the likelihood of diagnostic error.
Preventing Diagnostic Errors
Given that many diagnostic errors are caused by subtle biases in clinicians' thought processes, some diagnostic errors may be prevented by systems to mitigate the effect of these biases and provide physicians with objective information to assist with decision-making. Clinicians are frequently unaware of diagnostic errors that they have committed, particularly if they do not have an opportunity to see how their diagnoses turned out over time. Therefore, regular feedback to clinicians on their diagnostic performance is essential.
Unfortunately, reliable decision support or feedback systems do not yet exist. One of the earliest uses of information technology in medicine was decision support for clinical diagnosis, particularly for notoriously high-risk and difficult diagnoses such as acute myocardial infarction. However, computerized diagnostic decision support has not yet been proven to improve overall diagnostic accuracy, although active research continues in this area.
The autopsy has been the "gold standard" for diagnosis since medicine became a profession, but autopsy rates have progressively declined over the past few decades, to the point where a recent editorial raised concern over the "vanishing nonforensic autopsy." It is recommended that teaching institutions perform autopsies on 25% of inpatient deaths, but few academic hospitals reach this benchmark. The result: not only are clinicians not receiving feedback on their diagnoses, but pathologists are performing fewer and fewer autopsies during their training.
More progress has been made in addressing systems causes of diagnostic error. Information technology has improved clinicians' ability to follow up on diagnostic tests in a timely fashion, which should reduce the incidence of delayed diagnoses. Structured protocols for telephone triage,teamwork and communication training, and increased supervision of trainees may also lead to improved diagnostic performance. However, studies evaluating the effect of these interventions on diagnostic error rates are lacking.
Finally, there are aggressive efforts to teach clinicians and trainees about the relevant parts of cognitive psychology. The principal goal is to engage clinicians in "meta-cognition" (reflecting on their own thinking), with the hope that they will catch some of their own misuse of heuristics before they cause harm. There are few data to prove that this interesting strategy actually decreases error rates and harm. Recent systematic reviews have assessed the evidence base of interventions to prevent cognitive errors and systems problems that can lead to diagnostic error.
Current Context
Measurement of diagnostic accuracy is not performed or required in most clinical settings, although fields such as pathology and radiologyroutinely perform quality assurance by having clinicians independently review biopsies or images. Although calls for increasing the autopsy rate are increasing, as yet the recommended autopsy rate of 25% remains only a suggested benchmark and not a mandate. Some organizations, particularly physician-certifying boards like the American Board of Internal Medicine, have emphasized the possible role of board certification as a measure of diagnostic skills, since it is difficult to measure such skills through traditional tools used to measure quality and safety. In fact, current quality measurements do not take diagnostic accuracy into account at all, meaning that organizations could score well on quality measures even if many patients receive the correct treatment for an incorrect diagnosis. Recognizing this, a recent commentary termed diagnostic error "the next frontier for patient safety" and called for more research into solutions for individual and systems causes of diagnostic error.

What's New in Diagnostic Errors on AHRQ PSNet
The ethical imperative to think about thinking.
Stark M, Fins JJ. Camb Q Healthc Ethics. 2014 Jul 17; [Epub ahead of print].
Clinical questions raised by clinicians at the point of care: a systematic review.
Del Fiol G, Workman TE, Gorman PN. JAMA Intern Med. 2014;174:710-718.
What a doctor may miss by reaching for the MRI first.
Boodman SG, Kaiser Health News. Washington Post. May 19, 2014.
Placing Diagnosis Errors on the Policy Agenda.
Berenson RA, Upadhyay D, Kaye DR. Washington, DC: Urban Institute. Princeton, NJ: Robert Wood Johnson Foundation; 2014.
Diagnostic Error in Medicine 7th International Conference.
Society to Improve Diagnosis in Medicine. September 14–17, 2014; Atlanta Marriott Buckhead Hotel and Conference Center, Atlanta, GA.
Editor's Picks for Diagnostic Errors
From AHRQ WebM&M
Dependence vs. Pain.
Adam J. Gordon, MD, MPH. AHRQ WebM&M [serial online]. July 2008
In Conversation with...Joseph Britto, MD.
AHRQ WebM&M [serial online]. February 2007
Rapid Mis-St(r)ep.
Edward L. Kaplan, MD. AHRQ WebM&M [serial online]. February 2007
Crushing Chest Pain: A Missed Opportunity.
Mark Graber, MD. AHRQ WebM&M [serial online]. January 2004
A "Weak" Response.
Anna B. Reisman, MD. AHRQ WebM&M [serial online]. December 2004
The importance of cognitive errors in diagnosis and strategies to minimize them. Classic icon
Croskerry P. Acad Med. 2003;78:775-780.
Cognitive errors in diagnosis: instantiation, classification, and consequences. Classic icon
Kassirer JP, Kopelman RI. Am J Med. 1989;86:433-441.
Changes in rates of autopsy-detected diagnostic errors over time: a systematic review. Classic icon
Shojania KG, Burton EC, McDonald KM, Goldman L. JAMA. 2003;289:2849-2856.
Clinical impact and frequency of anatomic pathology errors in cancer diagnoses. Classic icon
Raab SS, Grzybicki DM, Janosky JE, et al. Cancer. 2005;104:2205-2213.
Missed and delayed diagnoses in the ambulatory setting: a study of closed malpractice claims. Classic icon
Gandhi TK, Kachalia A, Thomas EJ, et al. Ann Intern Med. 2006;145:488-496. 
Improving patient care. The cognitive psychology of missed diagnoses.
Redelmeier DA. Ann Intern Med. 2005;142:115-120.
Diagnostic errors—The next frontier for patient safety.
Newman-Toker DE, Pronovost PJ. JAMA. 2009;301:1060-1062.
How can we make diagnosis safer? Classic icon
Schiff GD, Leape LL. Acad Med. 2012;87:135-138.
System-related interventions to reduce diagnostic errors: a narrative review. Classic icon
Singh H, Graber ML, Kissam SM, et al. BMJ Qual Saf. 2012;21:160-170.
Cognitive interventions to reduce diagnostic error: a narrative review. Classic icon
Graber ML, Kissam S, Payne VL, et al. BMJ Qual Saf. 2012 21:535-557.
How Doctors Think. Classic icon
Groopman J. Boston, MA: Houghton Mifflin; 2007. ISBN: 0618610030.
What's the trouble? How doctors think.
Groopman J. The New Yorker. January 29, 2007;47:36-41.

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