Sepsis: Public Health and Genomic Insights - September 3, 2015

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Sepsis

Sepsis: Public Health and Genomic Insights - September 3, 2015

CDC and Related Info

• The need for EMS to be on the lookout for pediatric sepsis
• CDC Sepsis page
• Sepsis Awareness Month: Fewer than half of Americans have heard of this devastating illness
• Genes reported in relation to sepsis, including genomewide association studies via theHuGE Navigator

Late-onset bloodstream infection and perturbed maturation of the gastrointestinal microbiota in premature infants.
Shaw AG et al. PLoS ONE 2015 (7) e0132923

Common variants of NFE2L2 gene predisposes to acute respiratory distress syndrome in patients with severe sepsis.
Acosta-Herrera M et al. Crit Care 2015 256

CDC information: Sepsis is a consequence of infection that is difficult to predict, diagnose, and treat.

A comprehensive time-course-based multicohort analysis of sepsis and sterile inflammation reveals a robust diagnostic gene set 
Sweeney TE et al, Sci Trans Med, May 13, 2015

Quicker sepsis diagnosis may be a step closer, by A Yeager, Science News, May 14

Functional polymorphisms in CD86 gene are associated with susceptibility to pneumonia-induced sepsis.
Wang C et al. APMIS 2015 May (5) 433-8

An ADAM10 promoter polymorphism is a functional variant in severe sepsis patients and confers susceptibility to the development of sepsis.
Cui L et al. Crit Care 2015 (1) 73

Association between IL-6-174G/C polymorphism and the risk of sepsis and mortality: a systematic review and meta-analysis.
Gao Jun-wei et al. PLoS ONE 2015 (3) e0118843

Impact of virulence genes on sepsis severity and survival in Escherichia coli bacteremia.
Mora-Rillo M et al. Virulence 2015 (1) 93-100

Clinical associations of host genetic variations in the genes of cytokines in critically ill patients.
Belopolskaya OB et al. Clin. Exp. Immunol. 2015 Jan 23.

An integrated transcriptome and expressed variant analysis of sepsis survival and death.
Tsalik EL et al. Genome Med 2014 (11) 111

Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study.
Rautanen Anna et al. Lancet Respir Med 2015 Jan (1) 53-60

Finding a needle in the haystack: leveraging bioinformatics to identify a functional genetic risk factor for sepsis death.
Meyer NJ et al. Crit. Care Med. 2015 Jan (1) 242-3

Association between interleukin-10 polymorphisms and sepsis: a meta-analysis.
Pan W et al. Epidemiol. Infect. 2015 Jan (2) 366-75

Sepsis Awareness: Genomics & Public Health - September 11, 2014

CDC media statement: Sepsis Awareness Month: Fewer than half of Americans have heard of this devastating illness, September 3, 2014 

CDC sepsis awareness page includes basic information, clinical guidelines, data and trends

Did you know? 274 genes have been reported in relation to risk and outcomes of sepsis, including 3 genomewide association studies. To find out more, visit the HuGE Navigator

Associations between interleukin-1 gene polymorphisms and sepsis risk: a meta-analysis. 
Zhang AQ, et al. BMC medical genetics 2014 15 (1): 1. 

Genome-wide expression profiles in very low birth weight infants with neonatal sepsis. 
Pediatrics (2014)

Genome-wide expression profiling in pediatric septic shock. 
Hector R. Wong Pediatric Research (2013)

Beyond single-marker analyses: mining whole genome scans for insights into treatment responses in severe sepsis. 
Man M, et al. Pharmacogenomics J. 2013 Jun;13(3):218-26.