Sepsis
Sepsis: Public Health and Genomic Insights - September 3, 2015
CDC and Related Info
- The need for EMS to be on the lookout for pediatric sepsis
- CDC Sepsis page
- Sepsis Awareness Month: Fewer than half of Americans have heard of this devastating illness
- Genes reported in relation to sepsis, including genomewide association studies via theHuGE Navigator
Late-onset bloodstream infection and perturbed maturation of the gastrointestinal microbiota in premature infants.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Shaw AG et al. PLoS ONE 2015 (7) e0132923
Shaw AG et al. PLoS ONE 2015 (7) e0132923
Common variants of NFE2L2 gene predisposes to acute respiratory distress syndrome in patients with severe sepsis.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Acosta-Herrera M et al. Crit Care 2015 256
Acosta-Herrera M et al. Crit Care 2015 256
CDC information: Sepsis is a consequence of infection that is difficult to predict, diagnose, and treat.
A comprehensive time-course-based multicohort analysis of sepsis and sterile inflammation reveals a robust diagnostic gene set ![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Sweeney TE et al, Sci Trans Med, May 13, 2015
Sweeney TE et al, Sci Trans Med, May 13, 2015
Quicker sepsis diagnosis may be a step closer,
by A Yeager, Science News, May 14
Functional polymorphisms in CD86 gene are associated with susceptibility to pneumonia-induced sepsis.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Wang C et al. APMIS 2015 May (5) 433-8
Wang C et al. APMIS 2015 May (5) 433-8
An ADAM10 promoter polymorphism is a functional variant in severe sepsis patients and confers susceptibility to the development of sepsis.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Cui L et al. Crit Care 2015 (1) 73
Cui L et al. Crit Care 2015 (1) 73
Association between IL-6-174G/C polymorphism and the risk of sepsis and mortality: a systematic review and meta-analysis.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Gao Jun-wei et al. PLoS ONE 2015 (3) e0118843
Gao Jun-wei et al. PLoS ONE 2015 (3) e0118843
Impact of virulence genes on sepsis severity and survival in Escherichia coli bacteremia.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Mora-Rillo M et al. Virulence 2015 (1) 93-100
Mora-Rillo M et al. Virulence 2015 (1) 93-100
Clinical associations of host genetic variations in the genes of cytokines in critically ill patients.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Belopolskaya OB et al. Clin. Exp. Immunol. 2015 Jan 23.
Belopolskaya OB et al. Clin. Exp. Immunol. 2015 Jan 23.
An integrated transcriptome and expressed variant analysis of sepsis survival and death.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Tsalik EL et al. Genome Med 2014 (11) 111
Tsalik EL et al. Genome Med 2014 (11) 111
Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Rautanen Anna et al. Lancet Respir Med 2015 Jan (1) 53-60
Rautanen Anna et al. Lancet Respir Med 2015 Jan (1) 53-60
Finding a needle in the haystack: leveraging bioinformatics to identify a functional genetic risk factor for sepsis death.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Meyer NJ et al. Crit. Care Med. 2015 Jan (1) 242-3
Meyer NJ et al. Crit. Care Med. 2015 Jan (1) 242-3
Association between interleukin-10 polymorphisms and sepsis: a meta-analysis.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Pan W et al. Epidemiol. Infect. 2015 Jan (2) 366-75
Pan W et al. Epidemiol. Infect. 2015 Jan (2) 366-75
Sepsis Awareness: Genomics & Public Health - September 11, 2014
CDC media statement: Sepsis Awareness Month: Fewer than half of Americans have heard of this devastating illness, September 3, 2014
Did you know? 274 genes have been reported in relation to risk and outcomes of sepsis, including 3 genomewide association studies. To find out more, visit the HuGE Navigator![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Associations between interleukin-1 gene polymorphisms and sepsis risk: a meta-analysis.
Zhang AQ, et al. BMC medical genetics 2014 15 (1): 1.
Genome-wide expression profiles in very low birth weight infants with neonatal sepsis.
Pediatrics (2014)
Zhang AQ, et al. BMC medical genetics 2014 15 (1): 1.
Genome-wide expression profiles in very low birth weight infants with neonatal sepsis.
Pediatrics (2014)
Genome-wide expression profiling in pediatric septic shock.
Hector R. Wong Pediatric Research (2013)
Hector R. Wong Pediatric Research (2013)
Beyond single-marker analyses: mining whole genome scans for insights into treatment responses in severe sepsis.
Man M, et al. Pharmacogenomics J. 2013 Jun;13(3):218-26.
Man M, et al. Pharmacogenomics J. 2013 Jun;13(3):218-26.
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