The UCSC Genome Browser database: 2016 update.

Speir ML1, Zweig AS2, Rosenbloom KR2, Raney BJ2, Paten B2, Nejad P2, Lee BT2, Learned K2, Karolchik D2, Hinrichs AS2, Heitner S2, Harte RA3, Haeussler M2, Guruvadoo L2, Fujita PA4, Eisenhart C2, Diekhans M2, Clawson H2, Casper J2, Barber GP2, Haussler D5, Kuhn RM2, Kent WJ2.

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Abstract

For the past 15 years, the UCSC Genome Browser (http://genome.ucsc.edu/) has served the international research community by offering an integrated platform for viewing and analyzing information from a large database of genome assemblies and their associated annotations. The UCSC Genome Browser has been under continuous development since its inception with new data sets and software features added frequently. Some release highlights of this year include new and updated genome browsers for various assemblies, including bonobo and zebrafish; new gene annotation sets; improvements to track and assembly hub support; and a new interactive tool, the "Data Integrator", for intersecting data from multiple tracks. We have greatly expanded the data sets available on the most recent human assembly, hg38/GRCh38, to include updated gene prediction sets from GENCODE, more phenotype- and disease-associated variants from ClinVar and ClinGen, more genomic regulatory data, and a new multiple genome alignment.